Inhalation of dry powder mannitol improves clearance of mucus in patients with bronchiectasis

American Journal of Respiratory and Critical Care Medicine

Volumn 159, Issue 6, 1999, Pages 1843-1848

  Daviskas, Evangelia ^a,b   Anderson, Sandra D ^a,b   Eberl, Stefan ^a,b   Chan, H Kim ^a,b   Bautovich, George ^a,b  

^a ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

MANNITOL; MANNITOL BP; UNCLASSIFIED DRUG;

ADULT; AEROSOL; ARTICLE; BRONCHIECTASIS; CLINICAL ARTICLE; CONTROLLED STUDY; COUGHING; DRUG PENETRATION; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; INHALATIONAL DRUG ADMINISTRATION; MALE; MUCOCILIARY CLEARANCE; MUCUS; PRIORITY JOURNAL; SPIROMETRY;

EID: 0033039551     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.159.6.9809074     Document Type: Article

References (32)

1. 1. Lourenço, R. V., R. Loddenkemper, and R. W. Carton. 1972. Patterns of distribution and clearance in patients with bronchiectasis. Am. Rev. Respir. Dis. 106:857-866.
2. 2. Currie, D. C., D. Pavia, J. E. Agnew, M. T. Lopez-Vidriero, P. D. Diamond, P. J. Cole, and S. W. Clarke. 1987. Impaired tracheobronchial clearance in bronchiectasis. Thorax 42:126-130.
3. 3. Isawa, T., T. Teshima, T. Hirano, Y. Anazawa, M. Miki, K. Konno, and M. Motomiya. 1990. Mucociliary clearance and transport in bronchiectasis: global and regional assessment. J. Nucl. Med. 31:543-548.
4. 4. Salathe, M., T. G. O'Riordan, and A. Wanner. 1996. Treatment of mucociliary dysfunction. Chest 110:1048-1057.
5. 5. Pavia, D., M. L. Thomson, and S. W. Clarke. 1978. Enhanced clearance of secretions from the human lung after the administration of hypertonic saline aerosol. Am. Rev. Respir. Dis. 117:199-203.
6. 6. Daviskas, E., S. D Anderson, I. Gonda, S. Eberl, S. Meikle, J. P. Seale, and G. Bautovich. 1996. Inhalation of Hypertonic saline aerosol enhances mucociliary clearance in asthmatic and healthy subjects. Eur. Respir. J. 9:725-732.
7. 7. Robinson, M., J. A. Regnis, D. L. Bailey, M. King, G. Bautovich, and P. T. P. Bye. 1996. Effect of hypertonic saline, amiloride and cough on mucociliary clearance in patients with cystic fibrosis. Am. J. Respir. Crit. Care Med. 153:1503-1509.
8. 8. Anderson, S. D., J. D. Brannan, J. Spring, N. Spalding, L. T. Rodwell, H. K. Chan, I. Gonda, A. Walsh, and A. R. Clark. 1997. A new method for bronchial provocation testing in asthmatic subjects using a dry powder of mannitol. Am. J. Respir. Crit. Care Med. 156:758-765.
9. 9. Daviskas, E., S. D. Anderson, J. D. Brannan, H. K. Chan, S. Eberl, and G. Bautovich. 1997. Inhalation of dry-powder mannitol increases mucociliary clearance. Eur. Respir. J. 10:2449-2454.
10. 10. Quanjer, P. H., G. J. Tammeling, J. E. Cotes, O. F. Pederson, R. Peslin, and J. C. Yernault. 1993. Lung volumes and forced ventilatory flows. Eur. Respir. J. 6(Suppl. 16):5-40.
11. 11. Phipps, P. R., I. Gonda, and S. D. Anderson. 1992. Apparatus for the control of breathing during aerosol inhalation. J. Aerosol Med. 5:155-170.
12. 12. Bailey, D. L., B. F. Hutton, and P. J. Walker. 1987. Improved SPECT using simultaneous emission and transmission tomography. J. Nucl. Med. 28:844-851.
13. 13. Bailey, D. L., M. Robinson, S. R. Meikle, and P. T. P. Bye. 1996. Simultaneous emission and transmission measurements as an adjunct to dynamic planar gamma camera studies. Eur. J. Nucl. Med. 3:326-331.
14. 14. Bailey, D. L., R. R. Fulton, C. B. Jackson, and B. F. Hutton. 1989. Dynamic geometric mean studies using a single headed rotating gamma camera. J. Nucl. Med. 30:1865-1869.
15. 15. Phipps, P. R., I. Gonda, D. L. Bailey, P. Borham, G. Bautovich, and S. D. Anderson. 1989. Comparisons of planar and tomographic gamma scintigraphy to measure the penetration index of inhaled aerosols. Am. Rev. Respir. Dis. 139:1516-1523.
16. 16. Altman, D. 1992. Practical Statistics for Medical Research, 1st ed. Chapman & Hall, London. 205-212, 325-333.
17. 17. Daviskas, E., S. D. Anderson, I. Gonda, H. K. Chan, P. Cook, and R. Fulton. 1995. Changes in mucociliary clearance during and after isocapnic hyperventilation in asthmatic and healthy subjects. Eur. Respir. J. 8:742-751.
18. 18. Puchelle, E., J. M. Zahm, and A. Bertrand. 1979. Influence of age on bronchial mucociliary transport. Scand. J. Respir. Dis. 60:307-313.
19. 19. de Iongh, R. U., and J. Rutland. 1995. Ciliary defects in healthy subjects, bronchiectasis and primary ciliary dyskinesia. Am. J. Respir. Crit. Care Med. 151:1559-1567.
20. 20. Wanner, A., M. Salathé, and T. G. O'Riordan. 1996. Mucociliary clearance in the airways. Am. J. Respir. Crit. Care Med. 154:1868-1902.
21. 21. Yankaskas, J. R., J. T. Gatzy, and R. C. Boucher. 1987. Effects of raised osmolarity on canine tracheal epithelial ion transport function. J. Appl. Physiol. 62:2241-2245.
22. 22. Winters, S. L., and D. B. Yeates. 1997. Roles of hydration, sodium and chloride in regulation of canine mucociliary transport system. J. Appl. Physiol. 83:1360-1369.
23. 23. Assouline, G., V. Leibson, and A. Danon. 1977. Stimulation of prostaglandin output from rat stomach by hypertonic solutions. Eur. J. Pharmacol. 44:271-273.
24. 24. Jongejan, R. C., J. C. de Jongste, R. C. Raatgee, T. Stijnen, I. L. Bonta, and K. F. Kerrebijn. 1991. Effect of hyperosmolarity on human isolated central airway. Br. J. Pharmacol. 102:931-937.
25. 25. Silber, G., D. Proud, J. Warner, R. Naclerio, A. Kagey-Sobotka, L. Lichtenstein, and P. Eggleston. 1988. In vivo release of inflammatory mediators by hyperosmolar solutions. Am. Rev. Respir. Dis. 137:606-612.
26. 26. Wanner, A., M. Sielczak, J. F. Mella, and W. M. Abraham. 1986. Ciliary responsiveness in allergic and nonallergic airways. J. Appl. Physiol. 60: 1967-1971.
27. 27. Wong, L. B., I. F. Miller, and D. B. Yeates. 1991. Pathways of substance P stimulation of canine tracheal ciliary beat frequency. J. Appl. Physiol. 70:267-273.
28. 28. Sepper, R., Y. T. Konttinen, P. Kemppinen, T. Sorsa, and K. K. Eklund. 1998. Mast cells in bronchiectasis. Ann. Med. 30:307-315.
29. 29. Wills, P., R. Hall, W.-m. Chan, and P. J. Cole. 1997. Sodium chloride increases the ciliary transportability of cystic fibrosis and bronchiectasis sputum on the mucus-depleted bovine trachea. J. Clin. Invest. 99:9-13.
30. 30. King, M. 1997. Mucoactive therapy: what the future holds for patients with cystic fibrosis. Pediatr. Pulmonol. 24:122-123.
31. 31. Conway, J. H., J. S. Fleming, S. Perring, and S. T. Holgate. 1992. Humidification as an adjunct to chest physiotherapy in aiding tracheo-bronchial clearance in patients with bronchiectasis. Respir. Med. 86:109-114.
32. 32. Tavakoli, S., S. J. Levine, and J. H. Shelbamer. 1997. Airway mucus secretion. In P. J. Barnes, M. M. Grunstein, A. R. Leff, and A. J. Woolcock, editors. Asthma. Lippincott-Raven Publishers, Philadelphia. 843-857.