Bcl-2-mediated potentiation of neocarzinostatin-induced apoptosis: Requirement for caspase-3, sulfhydryl groups, and cleavable Bcl-2

Cancer Chemotherapy and Pharmacology

Volumn 57, Issue 3, 2006, Pages 357-367

  Mi, Zhiping ^a,b   Hong, Borah ^a,b   Mirnics, Zeljka Korade ^a,b   Tyurina, Yulia Y ^c   Kagan, Valerian E ^c   Liang, Ye ^a,b   Schor, Nina Felice ^a,b  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Apoptosis; Caspase 3; Chemotherapeutic agent; Enediyne; Reduced glutathione

Indexed keywords

CASPASE 3; PROTEIN BCL 2; THIOL GROUP; ZINOSTATIN; ANTINEOPLASTIC ANTIBIOTIC; CASP3 PROTEIN, HUMAN; CASP3 PROTEIN, RAT; CASPASE; GLUTATHIONE; NAPHTHALENE DERIVATIVE; PROTEIN BAX; PYRROLE DERIVATIVE; THIOGLO 1; THIOGLO-1; THIOL DERIVATIVE;

APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DNA REPLICATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MCF-7 CELL LINE; PC12 CELL LINE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; CELL STRAIN; DOSE RESPONSE; DRUG EFFECT; ENZYME ACTIVATION; FEMALE; GENE VECTOR; GENETIC TRANSFECTION; GENETICS; METABOLISM; OXIDATION REDUCTION REACTION; PHYSIOLOGY; RAT; TUMOR CELL LINE;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CASPASES; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; FEMALE; FLOW CYTOMETRY; GENETIC VECTORS; GLUTATHIONE; HUMANS; NAPHTHALENES; OXIDATION-REDUCTION; PC12 CELLS; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRROLES; RATS; SULFHYDRYL COMPOUNDS; TRANSFECTION; ZINOSTATIN;

EID: 33644837259     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/s00280-005-0054-z     Document Type: Article

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