Vascular and metabolic effects of methacholine in relation to insulin action in muscle

Diabetologia

Volumn 49, Issue 4, 2006, Pages 713-723

  Mahajan, H ^a   Kolka, C M ^a   Newman, J M B ^a   Rattigan, S ^a   Richards, S M ^a   Clark, M G ^a  

^a UNIVERSITY OF TASMANIA   (Australia)

Author keywords

Capillary recruitment; Glucose uptake; In vivo effects; Perfused muscle effects; Total blood flow; Vasodilatation

Indexed keywords

ADRENALIN; ARGININE; DEOXYGLUCOSE; GLUCOSE; INSULIN; METHACHOLINE; N(G) NITRO DEXTRO ARGININE METHYL ESTER; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE DONOR; SEROTONIN; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ARTERY BLOOD FLOW; ARTICLE; CAPILLARY FLOW; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG INFUSION; DRUG MECHANISM; FEMORAL ARTERY; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HINDLIMB; IN VITRO STUDY; IN VIVO STUDY; INFUSION PUMP; INSULIN LIKE ACTIVITY; LEG BLOOD FLOW; LOW DRUG DOSE; MALE; MUSCLE CELL; MUSCLE METABOLISM; MUSCLE PERFUSION; NONHUMAN; PRIORITY JOURNAL; RAT; TECHNIQUE; VASCULAR RESISTANCE; VASCULARIZATION; VASODILATATION;

ANIMALS; FEMORAL ARTERY; GLUCOSE; HINDLIMB; INSULIN; MALE; METHACHOLINE CHLORIDE; MUSCLES; NITRIC OXIDE; RATS; RATS, WISTAR; REGIONAL BLOOD FLOW; VASODILATION;

EID: 33644821652     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-005-0110-6     Document Type: Article

References (40)

1. Anderson TJ, Meredith IT, Ganz P, Selwyn AP, Yeung AC (1994) Nitric oxide and nitrovasodilators: similarities, differences and potential interactions. J Am Coll Cardiol 24:555-566
2. Steinberg HO, Brechtel G, Johnson A, Fineberg N, Baron AD (1994) Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release. J Clin Invest 94:1172-1179
3. Sarabi M, Lind L, Millgard J et al (1999) Local vasodilatation with metacholine, but not with nitroprusside, increases forearm glucose uptake. Physiol Res 48:291-295
4. Etgen GJJ, Fryburg DA, Gibbs EM (1997) Nitric oxide stimulates skeletal muscle glucose transport through a calcium/contraction- and phosphatidylinositol-3-kinase-independent pathway. Diabetes 46:1915-1919
5. Young ME, Radda GK, Leighton B (1997) Nitric oxide stimulates glucose transport and metabolism in rat skeletal muscle in vitro. Biochem J 322:223-228
6. Natali A, Bonadonna R, Santoro D et al (1994) Insulin resistance and vasodilation in essential hypertension. Studies with adenosine. J Clin Invest 94:1570-1576
7. 18F]fluoro-deoxyglucose and positron emission tomography. J Clin Invest 97:1741-1747
8. Natali A, Quinones GA, Pecori N, Sanna G, Toschi E, Ferrannini E (1998) Vasodilation with sodium nitroprusside does not improve insulin action in essential hypertension. Hypertension 31:632-636
9. Pendergrass M, Fazioni E, Collins D, Defronzo RA (1998) IGF-I increases forearm blood flow without increasing forearm glucose uptake. Am J Physiol 275:E345-E350
10. Rattigan S, Clark MG, Barrett EJ (1997) Hemodynamic actions of insulin in rat skeletal muscle: evidence for capillary recruitment. Diabetes 46:1381-1388
11. Baron AD, Tarshoby M, Hook G et al (2000) Interaction between insulin sensitivity and muscle perfusion on glucose uptake in human skeletal muscle: evidence for capillary recruitment. Diabetes 49:768-774
12. Renkin EM (1984) Control of microcirculation and blood-tissue exchange. In: Renkin EM, Michel CC, Geiger SR (eds) Handbook of physiology - the cardiovascular system IV. American Physiological Society, Bethesda, pp 627-687
13. Mahajan H, Richards SM, Rattigan S, Clark MG (2004) Local methacholine but not bradykinin potentiates insulin-mediated glucose uptake in muscle in vivo by augmenting capillary recruitment. Diabetologia 47:2226-2234
14. Kraegen EW, James DE, Jenkins AB, Chisholm DJ (1985) Dose-response curves for in vivo insulin sensitivity in individual tissues in rats. Am J Physiol 248:E353-E362
15. James DE, Jenkins AB, Kraegen EW (1985) Heterogeneity of insulin action in individual muscles in vivo: euglycemic clamp studies in rats. Am J Physiol 248:E567-E574
16. Ruderman NB, Houghton CR, Hems R (1971) Evaluation of the isolated perfused rat hindquarter for the study of muscle metabolism. Biochem J 124:639-651
17. Colquhoun EQ, Hettiarachchi M, Ye JM et al (1988) Vasopressin and angiotensin II stimulate oxygen uptake in the perfused rat hindlimb. Life Sci 43:1747-1754
18. Clark MG, Colquhoun EQ, Rattigan S et al (1995) Vascular and endocrine control of muscle metabolism. Am J Physiol 268: E797-E812
19. Zhang L, Vincent MA, Richards SM et al (2004) Insulin sensitivity of muscle capillary recruitment in vivo. Diabetes 53:447-453
20. Halseth AE, Bracy DP, Wasserman DH (2000) Limitations to basal and insulin-stimulated skeletal muscle glucose uptake in the high-fat-fed rat. Am J Physiol 279:E1064-E1071
21. Holmang A, Muller M, Andersson OK, Lonnroth P (1998) Minimal influence of blood flow on interstitial glucose and lactate-normal and insulin-resistant muscle. Am J Physiol 274: E446-E452
22. Grubb B, Snarr JF (1977) Effect of flow rate and glucose concentration on glucose uptake rate by the rat limb. Proc Soc Exp Biol Med 154:33-36
23. Baron AD (1994) Hemodynamic actions of insulin. Am J Physiol 267:E187-E202
24. Natali A (1997) Skeletal muscle blood flow and insulin action. Nutr Metab Cardiovasc Dis 7:105-109
25. Baron AD, Tarshoby M, Hook G et al (2000) Interaction between insulin sensitivity and muscle perfusion on glucose uptake in human skeletal muscle: evidence for capillary recruitment. Diabetes 49:768-774
26. Chavoshan B, Sander M, Sybert TE, Hansen J, Victor RG, Thomas GD (2002) Nitric oxide-dependent modulation of sympathetic neural control of oxygenation in exercising human skeletal muscle. J Physiol 540:377-386
27. Vincent MA, Barrett EJ, Lindner JR, Clark MG, Rattigan S (2003) Inhibiting NOS blocks microvascular recruitment and blunts glucose uptake in response to insulin. Am J Physiol 285: E123-E129
28. Vincent MA, Clerk LH, Lindner JR et al (2004) Microvascular recruitment is an early insulin effect that regulates skeletal muscle glucose uptake in vivo. Diabetes 53:1418-1423
29. Baron AD, Steinberg HO, Chaker H, Leaming R, Johnson A, Brechtel G (1995) Insulin-mediated skeletal muscle vasodilation contributes to both insulin sensitivity and responsiveness in lean humans. J Clin Invest 96:786-792
30. Scherrer U, Randin D, Vollenweider P, Vollenweider L, Nicod P (1994) Nitric oxide release accounts for insulin's vascular effects in humans. J Clin Invest 94:2511-2515
31. Shankar R, Zhu JS, Ladd B, Henry D, Shen HQ, Baron AD (1998) Central nervous system nitric oxide synthase activity regulates insulin secretion and insulin action. J Clin Invest 102:1403-1412
32. Vicent D, Ilany J, Kondo T et al (2003) The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance. J Clin Invest 111:1373-1380
33. Frandsen U, Bangsbo J, Sander M et al (2001) Exercise-induced hyperaemia and leg oxygen uptake are not altered during effective inhibition of nitric oxide synthase with N(G)-nitro-L-arginine methyl ester in humans. J Physiol 531:257-264
34. Bradley SJ, Kingwell BA, McConell GK (1999) Nitric oxide synthase inhibition reduces leg glucose uptake but not blood flow during dynamic exercise in humans. Diabetes 48:1815-1821
35. Bruning TA, Hendriks MG, Chang PC, Kuypers EA, van Zwieten PA (1994) In vivo characterization of vasodilating muscarinic-receptor subtypes in humans. Circ Res 74:912-919
36. Bruning TA, Chang PC, Hendriks MG, Vermeij P, Pfaffendorf M, van Zwieten PA (1995) In vivo characterization of muscarinic receptor subtypes that mediate vasodilatation in patients with essential hypertension. Hypertension 26:70-77
37. Hendriks MG, Pfaffendorf M, van Zwieten PA (1993) Characterization of the muscarinic receptors in the mesenteric vascular bed of spontaneously hypertensive rats. J Hypertens 11:1329-1335
38. McCulloch AI, Bottrill FE, Randall MD, Hiley CR (1997) Characterization and modulation of EDHF-mediated relaxations in the rat isolated superior mesenteric arterial bed. Br J Pharmacol 120:1431-1438
39. Matsui M, Motomura D, Karasawa H et al (2000) Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M3 subtype. Proc Natl Acad Sci U S A 97:9579-9584
40. Matsui M, Motomura D, Fujikawa T et al (2002) Mice lacking M2 and M3 muscarinic acetylcholine receptors are devoid of cholinergic smooth muscle contractions but still viable. J Neurosci 22:10627-10632