Local methacholine but not bradykinin potentiates insulin-mediated glucose uptake in muscle in vivo by augmenting capillary recruitment

Diabetologia

Volumn 47, Issue 12, 2004, Pages 2226-2234

  Mahajan, H ^a   Richards, S M ^a   Rattigan, S ^a   Clark, M G ^a  

^a UNIVERSITY OF TASMANIA   (Australia)

Author keywords

Global vasodilatation in muscle; Insulin and glucose delivery to muscle; Muscle blood flow; Specific regional vasodilatation in muscle

Indexed keywords

1 METHYLXANTHINE; BRADYKININ; DEOXYGLUCOSE; GLUCOSE; HUMAN INSULIN; INSULIN; METHACHOLINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY BLOOD FLOW; ARTICLE; BLOOD FLOW; CAPILLARY; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HEMODYNAMIC MONITORING; IN VIVO STUDY; MALE; MUSCLE; NONHUMAN; PRIORITY JOURNAL; RAT; SYSTOLIC BLOOD PRESSURE;

ANIMALS; BIOLOGICAL TRANSPORT; BRADYKININ; CAPILLARIES; GLUCOSE; GLUCOSE CLAMP TECHNIQUE; HYPERINSULINISM; INSULIN; KINETICS; MALE; METHACHOLINE CHLORIDE; MODELS, ANIMAL; MUSCLE, SKELETAL; RATS; RATS, WISTAR;

EID: 12944312224     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-004-1580-7     Document Type: Article

References (32)

1. Halseth AE, Bracy DP, Wasserman DH (2000) Limitations to basal and insulin-stimulated skeletal muscle glucose uptake in the high-fat-fed rat. Am J Physiol Endocrinol Metab 279:E1064-E1071
2. Sjostrand M, Gudbjornsdottir S, Holmang A, Lonn L, Strindberg L, Lonnroth P (2002) Delayed transcapillary transport of insulin to muscle interstitial fluid in obese subjects. Diabetes 51:2742-2748
3. Baron AD, Steinberg H, Brechtel G, Johnson A (1994) Skeletal muscle blood flow independently modulates insulin-mediated glucose uptake. Am J Physiol 266:E248-E253
4. Rattigan S, Clark MG, Barrett EJ (1997) Hemodynamic actions of insulin in rat skeletal muscle: evidence for capillary recruitment. Diabetes 46:1381-1388
5. Steinberg HO, Brechtel G, Johnson A, Fineberg N, Baron AD (1994) Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release. J Clin Invest 94:1172-1179
6. Scherrer U, Randin D, Vollenweider P, Vollenweider L, Nicod P (1994) Nitric oxide release accounts for insulin's vascular effects in humans. J Clin Invest 94:2511-2515
7. Vincent MA, Barrett EJ, Lindner JR, Clark MG, Rattigan S (2003) Inhibiting NOS blocks microvascular recruitment and blunts glucose uptake in response to insulin. Am J Physiol 285:E123-E129
8. Clark MG, Wallis MG, Barrett EJ et al. (2003) Blood flow and muscle metabolism: a focus on insulin action. Am J Physiol Endocrinol Metab 284:E241-E258
9. Rattigan S, Clark MG, Barrett EJ (1999) Acute vasoconstriction-induced insulin resistance in rat muscle in vivo. Diabetes 48:564-569
10. Vincent MA, Barrett EJ (2002) Insulin-induced capillary recruitment precedes changes in skeletal muscle glucose uptake. Diabetes 51 [Suppl 2]:A31
11. Zhang L, Vincent MA, Richards SM et al. (2004) Insulin sensitivity of muscle capillary recruitment in vivo. Diabetes 53:447-453
12. Yki-Jarvinen H, Utriainen T (1998) Insulin-induced vasodilatation: physiology or pharmacology? Diabetologia 41:369-379
13. 18F]fluoro-deoxy-glucose and positron emission tomography. J Clin Invest 97:1741-1747
14. Natali A, Quinones GA, Pecori N, Sanna G, Toschi E, Ferrannini E (1998) Vasodilation with sodium nitroprusside does not improve insulin action in essential hypertension. Hypertension 31:632-636
15. Natali A, Bonadonna R, Santoro D et al. (1994) Insulin resistance and vasodilation in essential hypertension. Studies with adenosine. J Clin Invest 94:1570-1576
16. Sarabi M, Lind L, Millgard J et al. (1999) Local vasodilatation with methacholine, but not with nitroprusside, increases forearm glucose uptake. Physiol Res 48:291-295
17. Jarasch ED, Bruder G, Heid HW (1986) Significance of xanthine oxidase in capillary endothelial cells. Acta Physiol Scand 548 [Suppl]:39-46
18. Emmerson BT, Gordon RB, Cross M, Thomson DB (1987) Plasma oxipurinol concentrations during allopurinol therapy. Br J Rheumatol 26:445-449
19. Rattigan S, Appleby GJ, Miller KA et al. (1997) Serotonin inhibition of 1-methylxanthine metabolism parallels its vasoconstrictor activity and inhibition of oxygen uptake in perfused rat hindlimb. Acta Physiol Scand 161:161-169
20. Kraegen EW, James DE, Jenkins AB, Chisholm DJ (1985) Dose-response curves for in vivo insulin sensitivity in individual tissues in rats. Am J Physiol 248:E353-E362
21. James DE, Jenkins AB, Kraegen EW (1985) Heterogeneity of insulin action in individual muscles in vivo: euglycemic clamp studies in rats. Am J Physiol 248:E567-E574
22. Laakso M, Edelman SV, Brechtel G, Baron AD (1992) Impaired insulin-mediated skeletal muscle blood flow in patients with NIDDM. Diabetes 41:1076-1083
23. Serne EH, Gans RO, ter Maaten IC, ter Wee PM, Donker AJ, Stehouwer CD (2001) Capillary recruitment is impaired in essential hypertension and relates to insulin's metabolic and vascular actions. Cardiovasc Res 49:161-168
24. Baron AD, Tarshoby M, Hook G et al. (2000) Interaction between insulin sensitivity and muscle perfusion on glucose uptake in human skeletal muscle: evidence for capillary recruitment. Diabetes 49:768-774
25. Dawson D, Vincent MA, Barrett EJ et al. (2002) Vascular recruitment in skeletal muscle during exercise and hyperinsulinemia assessed by contrast ultrasound. Am J Physiol Endocrinol Metab 282:E714-E720
26. Rask-Madsen C, Ihlemann N, Krarup T et al. (2001) Insulin therapy improves insulin-stimulated endothelial function in patients with type 2 diabetes and ischemic heart disease. Diabetes 50:2611-2618
27. Vallance P, Collier J, Moncada S (1989) Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet 2:997-1000
28. Hirvonen L, Korobkin M, Sonnenschein RR, Wright DL (1964) Depression of contractile force of skeletal muscle by intra-arterial vasodilator drugs. Circ Res 14:525-535
29. Rattigan S, Wallis MG, Youd JM, Clark MG (2001) Exercise training improves insulin-mediated capillary recruitment in association with glucose uptake in rat hind limb. Diabetes 50:2659-2665
30. Steinberg HO, Baron AD (1999) Insulin-mediated vasodilation: why one's physiology could be the other's pharmacology. Diabetologia 42:493-495
31. Natali A (1997) Skeletal muscle blood flow and insulin action. Nutr Metab Cardiovasc Dis 7:105-109
32. Clerk LH, Vincent MA, Lindner JR, Clark MG, Rattigan S, Barrett EJ (2004) The vasodilatory actions of insulin on resistance and terminal arterioles and their impact on muscle glucose uptake. Diabetes Metab Res Rev 20:3-12