Parathyroid hormone regulation of Na+,K+-ATPase requires the PDZ 1 domain of sodium hydrogen exchanger regulatory factor-1 in opossum kidney cells

Journal of the American Society of Nephrology

Volumn 16, Issue 9, 2005, Pages 2598-2607

  Khundmiri, Syed Jalal ^a,f   Weinman, Edward J ^b,c   Steplock, Deborah ^b   Cole, Judith ^d   Ahmad, Aamir ^a   Baumann, Patrick D ^a   Barati, Michelle ^a   Rane, Madhavi J ^a   Lederer, Eleanor ^a,e  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c BALTIMORE VA MEDICAL CENTER   (United States)

^d UNIVERSITY OF MEMPHIS   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

^f UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); EZRIN; MITOGEN ACTIVATED PROTEIN KINASE; PARATHYROID HORMONE; PDZ PROTEIN; PROTEIN KINASE C ALPHA; RUBIDIUM 86; SMALL INTERFERING RNA; SODIUM PROTON EXCHANGE PROTEIN; PHOSPHOPROTEIN; PROTEIN SUBUNIT; RECOMBINANT PROTEIN; SODIUM HYDROGEN EXCHANGER REGULATORY FACTOR; SODIUM-HYDROGEN EXCHANGER REGULATORY FACTOR;

ALPHA CHAIN; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; KIDNEY CELL; NONHUMAN; OPOSSUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; WILD TYPE; ANIMAL; CELL LINE; CHEMISTRY; CYTOLOGY; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; KIDNEY; METABOLISM; MOUSE; NUCLEOTIDE SEQUENCE; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION;

ANIMALS; BASE SEQUENCE; CELL LINE; KIDNEY; MAP KINASE SIGNALING SYSTEM; MICE; NA(+)-K(+)-EXCHANGING ATPASE; OPOSSUMS; PARATHYROID HORMONE; PHOSPHOPROTEINS; PROTEIN KINASE C-ALPHA; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RECOMBINANT PROTEINS; RNA, SMALL INTERFERING; SODIUM-HYDROGEN ANTIPORTER; TRANSFECTION;

EID: 33644803595     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1681/ASN.2004121049     Document Type: Article

References (46)

1. Feraille E, Doucet A: Sodium-potassium-adenosinetriphosphatase-dependent sodium transport in the kidney: Hormonal control. Physiol Rev 81: 345-418, 2001
2. Zhang Y, Norian JM, Magyar CE, Holstein-Rathlou NH, Mircheff AK, McDonough AA: In vivo PTH provokes apical NHE3 and NaPi-2 redistribution and Na-K ATPase inhibition. Am J Physiol 276: F711-F719, 1999
3. Khundmiri SJ, Lederer ED: PTH and DA regulate Na-K ATPase through divergent pathways. Am J Physiol Renal Physiol 282: F512-F522, 2002
4. Mahon MJ, Segre GV: Stimulation by parathyroid hormone of a NHERF-1-assembled complex consisting of the parathyroid hormone I receptor, phospholipase Cbeta, and actin increases intracellular calcium in opossum kidney cells. J Biol Chem 279: 23550-23558, 2004
5. Mahon MJ, Donowitz M, Yun CC, Segre GV: Na (+)/H (+) exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling. Nature 417: 858-861, 2002
6. Weinman EJ: New functions for the NHERF family of proteins. J Clin Invest 108: 185-186, 2001
7. Weinman EJ, Steplock D, Tate K, Hall RA, Spurney RF, Shenolikar S: Structure-function of recombinant Na/H exchanger regulatory factor (NHE-RF). J Clin Invest 101: 2199-2206, 1998
8. Weinman EJ, Steplock D, Shenolikar S: NHERF-1 uniquely transduces the cAMP signals that inhibit sodium-hydrogen exchange in mouse renal apical membranes. FEBS Lett 536: 141-144, 2003
9. Shenolikar S, Voltz JW, Minkoff CM, Wade JB, Weinman EJ: Targeted disruption of the mouse NHERF-I gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate wasting. Proc Natl Acad Sci U S A 99: 11470-11475, 2002
10. Weinman EJ, Evangelista CM, Steplock D, Liu MZ, Shenolikar S, Bernardo A: Essential role for NHERF in cAMP-mediated inhibition of the Na+-HCO3- co-transporter in BSC-1 cells. J Biol Chem 276: 42339-42346, 2001
11. Weinman EJ, Steplock D, Shenolikar S: Acute regulation of NHE3 by protein kinase A requires a multiprotein signal complex. Kidney Int 60: 450-454, 2001
12. Wade JB, Liu J, Coleman RA, Cunningham R, Steplock DA, Lee-Kwon W, Pallone TL, Shenolikar S, Weinman EJ: Localization and interaction of NHERF isoforms in the renal proximal tubule of the mouse. Am J Physiol Cell Physiol 285: C494-C503, 2003
13. Weinman EJ, Minkoff C, Shenolikar S: Signal complex regulation of renal transport proteins: NHERF and regulation of NHE3 by PKA. Am J Physiol Renal Physiol 279: F393-F399, 2003
14. Weinman EJ, Steplock D, Donowitz M, Shenolikar S: NHERF associations with sodium-hydrogen exchanger isoform 3 (NHE3) and ezrin are essential for cAMP-mediated phosphorylation and inhibition of NHE3. Biochemistry 39: 6123-6129, 2000
15. Cunningham R, Steplock D, Wang F, Huang HEX, Shenolikar S, Weinman EJ: Defective PTH regulation of NHE3 activity and phosphate adaptation in cultured NHERF-1-/- renal proximal tubule cells. J Biol Chem 279: 37815-37821, 2004
16. Biber J: Emerging roles of transporter-PDZ complexes in renal proximal tubular reabsorption. Pflugers Arch 443: 3-5, 2001
17. Shenolikar S, Minkoff CM, Steplock DA, Evangelista C, Liu M, Weinman EJ: N-terminal PDZ domain is required for NHERF dimerization. FEBS Lett 489: 233-236, 2001
18. Murthy A, Gonzalez-Agosti C, Cordero E, Pinney D, Candia C, Gusella J, Ramesh V: NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins. J Biol Chem 273: 1273-1276, 1998
19. Hall RA, Spurney RF, Premont RT, Rahman N, Blitzer JT, Pitcher JA, Lefkowitz RJ: G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction. J Biol Chem 274: 24328-24334, 1999
20. Hernando N, Deliot N, Gisler SM, Lederer E, Weinman EJ, Biber J, Murer H: PDZ-domain interactions and apical expression of type IIa Na/P(i) cotransporters. Proc Natl Acad Sci U S A 99: 11957-11962, 2002
21. Tang Y, Tang J, Chen Z, Trost C, Flockerzi V, Li M, Ramesh V, Zhu MX: Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF. J Biol Chem 275: 37559-37564, 2000
22. Liedtke CM, Raghuram V, Yun CC, Wang X: Role of a PDZ1 domain of NHERF1 in the binding of airway epithelial RACK1 to NHERF1. Am J Physiol Cell Physiol 286: C1037-C1044, 2004
23. Weinman EJ, Wang Y, Wang F, Greer C, Steplock D, Shenolikar S: A C-terminal PDZ motif in NHE3 binds NHERF-1 and enhances cAMP inhibition of sodium-hydrogen exchange. Biochemistry 42: 12662-12668, 2003
24. Yoo D, Flagg TP, Olsen O, Raghuram V, Foskett JK, Welling PA: Assembly and trafficking of a multiprotein ROMK channel complex by PDZ interactions. J Biol Chem 279: 6863-6873, 2004
25. Benharouga M, Sharma M, So J, Haardt M, Drzymala L, Popov M, Schwapach B, Grinstein S, Du K, Lukacs GL: The role of the C terminus and Na+/H+ exchanger regulatory factor in the functional expression of cystic fibrosis transmembrane conductance regulator in nonpolarized cells and epithelia. J Biol Chem 278: 22079-22089, 2003
26. Liedtke CM, Yun CH, Kyle N, Wang D: Protein kinase C epsilon-dependent regulation of cystic fibrosis transmembrane regulator involves binding to a receptor for activated C kinase (RACK1) and RACK1 binding to Na+/H+ exchange regulatory factor. J Biol Chem 277: 22925-22933, 2002
27. Lederer ED, Khundmiri SJ, Weinman EJ: Role of NHERF-1 in regulation of the activity of Na-K ATPase and sodium-phosphate co-transport in epithelial cells. J Am Soc Nephrol 14: 1711-1719, 2003
28. Breton S, Wiederhold T, Marshansky V, Nsumu NN, Ramesh V, Brown D: The B1 subunit of the H+ ATPase is a PDZ domain-binding protein. Colocalization with NHE-RF in renal B-intercalated cells. J Biol Chem 275: 18219-18224, 2000
29. Pushkin A, Abuladze N, Newman D, Muronets V, Sassani P, Tatishchev S, Kurtz I: The COOH termini of NBC3 and the 56-kDa H+-ATPase subunit are PDZ motifs involved in their interaction. Am J Physiol Cell Physiol 284: C667-C673, 2003
30. Weinman EJ, Steplock D, Wade JB, Shenolikar S: Ezrin binding domain-deficient NHERF attenuates cAMP-mediated inhibition of Na(+)/H(+) exchange in OK cells. Am J Physiol Renal Physiol 281: F374-F380, 2001
31. Mahon MJ, Cole JA, Lederer ED, Segre GV: Na+/H+ exchanger-regulatory factor 1 mediates inhibition of phosphate transport by parathyroid hormone and second messengers by acting at multiple sites in opossum kidney cells. Mol Endomnol 17: 2355-2364, 2003
32. Miyauchi A, Dobre V, Rickmeyer M, Cole J, Forte L, Hruska KA: Stimulation of transient elevations in cytosolic Ca2+ is related to inhibition of Pi transport in OK cells. Am J Physiol 259: F485-F493, 1990
33. Cole JA, Forte LR, Krause WJ, Thorne PK: Clonal sublines that are morphologically and functionally distinct from parental OK cells. Am J Physiol 256: F672-F679, 1989
34. Koyama H, Goodpasture C, Miller MM, Teplitz RL, Riggs AD: Establishment and characterization of a cell line from the American opossum (Didelphys virginiana). In Vitro 14: 239-246, 1978
35. Hird RB, Wakefield TW, Mukherjee R, Jones BU, Crawford FA, Andrews PC, Stanley JC, Spinale FG: Direct effects of protamine sulfate on myocyte contractile processes. Cellular and molecular mechanisms. Circulation 92: 433-446, 1995
36. Tran CM, Farley R: Photoaffinity labeling of the active site of the Na+/K(+)-ATPase with 4-azido-2-nitrophenyl phosphate. Biochemistry 35: 47-55, 1996
37. Khundmiri SJ, Dean WL, McLeish KR, Lederer ED: PTH-mediated regulation of Na+-K+-ATPase requires ERK-dependent translocation of PKCalpha. J Biol Chem 280: 8705-8713, 2005
38. Okafor MC, Mukhopadhyay P, Delamere NA: Studies on endothelin release and Na, K transport in porcine lens. Invest. Ophthalmol Vis Sci 43: 790-796, 2002
39. Khundmiri SJ, Rane MJ, Lederer ED: Parathyroid hormone regulation of type II sodium-phosphate cotransporters is dependent on an A kinase anchoring protein. J Biol Chem 278: 10134-10141, 2003
40. Khundmiri SJ, Bertorello AM, Delamere NA, Lederer ED: Clathrin-mediated endocytosis of Na+,K+-ATPase in response to parathyroid hormone requires ERK-dependent phosphorylation of Ser-11 within the alpha1-subunit. J Biol Chem 279: 17418-17427, 2004
41. Bernardo AA, Kear FT, Santos AV, Ma J, Steplock D, Robey RB, Weinman EJ: Basolateral Na(+)/HCO(3)(-) cotransport activity is regulated by the dissociable Na(+)/H(+) exchanger regulatory factor. J Clin Invest 104: 195-201, 1999
42. Kraemer DM, Strizek B, Meyer HE, Marcus K, Drenckhahn D: Kidney Na+, K+-ATPase is associated with moesin. Eur J Cell Biol 82: 87-92, 2003
43. Lopina OD: Interaction of Na,K-ATPase catalytic subunit with cellular proteins and other endogenous regulators. Biochemistry (Mosc) 66: 1122-1131, 2001
44. Thevananther S, Kolli AH, Devarajan P: Identification of a novel ankyrin isoform (AnkG190) in kidney and lung that associates with the plasma membrane and binds alpha-Na, K-ATPase. J Biol Chem 273: 23952-23958, 1998
45. Iida-Klein A, Guo J, Takemura M, Drake MT, Potts JT Jr, Abou-Samra A, Bringhurst FR, Segre GV: Mutations in the second cytoplasmic loop of the rat parathyroid hormone (PTH)/PTH-related protein receptor result in selective loss of PTH-stimulated phospholipase C activity. J Biol Chem 72: 6882-6889, 1997
46. Rochdi MD, Watier V, La Madeleine C, Nakata H, Kozasa T, Parent JL: Regulation of GTP-binding protein alpha q signaling by the ezrin-radixin-moesin- binding phosphoprotein-50 (EBP50). J Biol Chem 277: 40751-40759, 2002