Gender-related differences in recovery of locomotor function after spinal cord injury in mice

Spinal Cord

Volumn 44, Issue 3, 2006, Pages 182-187

  Farooque, M ^a,b   Suo, Z ^a,b   Arnold, P M ^a,b   Wulser, M J ^a   Chou, C T ^a   Vancura, R W ^a   Fowler, S ^c   Festoff, B W ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF KANSAS   (United States)

Author keywords

Apoptosis; Estrogen; Neural recovery; Neuroinflammation; Oxidative damage

Indexed keywords

EOSIN; ESTROGEN; HEMATOXYLIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; AUTOMATION; CELL DEATH; CELL INFILTRATION; CITY; CONTROLLED STUDY; CONVALESCENCE; CORRELATION ANALYSIS; CYTOARCHITECTURE; FEMALE; FUNCTIONAL ASSESSMENT; FUNCTIONAL MORPHOLOGY; GENDER; HINDLIMB; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; LABORATORY; LEUKOCYTE MIGRATION; LOCOMOTION; MALE; MEDICAL RESEARCH; MEDICAL SCHOOL; MOLECULAR MECHANICS; MOTOR PERFORMANCE; MOUSE; NERVE COMPRESSION; NEUROBIOLOGY; NEUROPROTECTION; NONHUMAN; PATHOPHYSIOLOGY; PERFUSION; PRIORITY JOURNAL; RODENT; SCORING SYSTEM; SPINAL CORD BLOOD FLOW; SPINAL CORD INJURY; TISSUE PRESERVATION; TISSUE SECTION; UNITED STATES; UNIVERSITY HOSPITAL; VETERINARY MEDICINE; WALKING;

ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; HINDLIMB; MALE; MICE; MICE, INBRED C57BL; MOTOR ACTIVITY; NEUROLOGIC EXAMINATION; PSYCHOMOTOR PERFORMANCE; RECOVERY OF FUNCTION; SEVERITY OF ILLNESS INDEX; SEX CHARACTERISTICS; SPINAL CORD INJURIES; TIME FACTORS;

EID: 33644799305     PISSN: 13624393     EISSN: 14765624     Source Type: Journal    
DOI: 10.1038/sj.sc.3101816     Document Type: Article

References (40)

1. Payan HM, Conrad JR. Carotid ligation in gerbils. Influence of age, sex, and gonads. Stroke 1977; 8: 194-196.
2. Hall ED, Pazara KE, Linseman KL. Sex differences in postischemic neuronal necrosis in gerbils. J Cereb Blood Flow Metab 1991; 11: 292-298.
3. Roof RL, Hall ED. Estrogen-related gender difference in survival rate and cortical blood flow after impact-acceleration head injury in rats. J Neurotrauma 2000; 17: 1155-1169.
4. Hauben E, Mizrahi T, Agranov E, Schwartz M. Sexual dimorphism in the spontaneous recovery from spinal cord injury: a gender gap in beneficial autoimmunity? Eur J Neurosci 2002; 16: 1731-1740.
5. Alkayed NJ et al. Gender-linked brain injury in experimental stroke. Stroke 1998; 29: 159-165; discussion 166.
6. Stupfel M et al. Sex-related factors in acute hypoxia survival in one strain of mice. Aviat Space Environ Med 1984; 55: 136-140.
7. Farhat MY, Lavigne MC, Ramwell PW. The vascular protective effects of estrogen. FASEB J 1996; 10: 615-624.
8. Sivenius J et al. The European stroke prevention study: results according to sex. Neurology 1991; 41: 1189-1192.
9. Roof RL, Zhang Q, Glasier MM, Stein DG. Gender-specific impairment on Morris water maze task after entorhinal cortex lesion. Behav Brain Res 1993; 57: 47-51.
10. Yune TY et al. Systemic administration of 17beta-estradiol reduces apoptotic cell death and improves functional recovery following traumatic spinal cord injury in rats. J Neurotrauma 2004; 21: 293-306.
11. Farooque M, Hillered L, Holtz A, Olsson Y. Effects of moderate hypothermia on extracellular lactic acid and amino acids after severe compression injury of rat spinal cord. J Neurotrauma 1997; 14: 63-69.
12. Farooque M, Isaksson J, Olsson Y. Improved recovery after spinal cord trauma in ICAM-1 and P-selectin knockout mice. Neuroreport 1999; 10: 131-134.
13. Isaksson J, Farooque M, Olsson Y. Spinal cord injury in ICAM-1-deficient mice: assessment of functional and histopathological outcome. J Neurotrauma 2000; 17: 333-344.
14. Li GL, Farooque M, Holtz A, Olsson Y. Changes of beta-amyloid precursor protein after compression trauma to the spinal cord: an experimental study in the rat using immunohistochemistry. J Neurotrauma 1995; 12: 269-277.
15. Li GL, Farooque M, Holtz A, Olsson Y. Apoptosis of oligodendrocytes occurs for long distances away from the primary injury after compression trauma to rat spinal cord. Acta Neuropathol (Berlin) 1999; 98: 473-480.
16. Li GL et al. Apoptosis and expression of Bcl-2 after compression trauma to rat spinal cord. J Neuropathol Exp Neurol 1996; 55: 280-289.
17. Farooque M. Spinal cord compression injury in the mouse: presentation of a model including assessment of motor dysfunction. Acta Neuropathol (Berlin) 2000; 100: 13-22.
18. Farooque M, Hillered L, Holtz A, Olsson Y. Changes of extracellular levels of amino acids after graded compression trauma to the spinal cord: an experimental study in the rat using microdialysis. J Neurotrauma 1996; 13: 537-548.
19. Farooque M, Isaksson J, Olsson Y. Improved recovery after spinal cord injury in neuronal nitric oxide synthase-deficient mice but not in TNF-alpha-deficient mice. J Neurotrauma 2001; 18: 105-114.
20. Farooque M, Isaksson J, Olsson Y. White matter preservation after spinal cord injury in ICAM-1/P-selectin-deficient mice. Acta Neuropathol (Berlin) 2001; 102: 132-140.
21. Basso DM, Beattie MS, Bresnahan JC. Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection. Exp Neurol 1996; 139: 244-256.
22. Ma M, Basso DM, Walters P, Stokes BT, Jakeman LB. Behavioral and histological outcomes following graded spinal cord contusion injury in the C57B1/6 mouse. Exp Neurol 2001; 169: 239-254.
23. Hamers FPT, Lankhorst AJ, Gispen WH. A computer-assisted method for simple and precise analysis of interlimb coordination. J Neurotrauma 1998; 15: 873.
24. Fowler SC et al. A force-plate actometer for quantitating rodent behaviors: illustrative data on locomotion, rotation, spatial patterning, stereotypies, and tremor. J Neurosci Methods 2001; 107: 107-124.
25. Dubal DB, Shughrue PJ, Wilson ME, Merchenthaler I, Wise PM. Estradiol modulates bcl-2 in cerebral ischemia: a potential role for estrogen receptors. J Neurosci 1999; 19: 6385-6393.
26. Kauser K, Sonnenberg D, Tse J, Rubanyi GM. 17 beta-Estradiol attenuates endotoxin-induced excessive nitric oxide production in ovariectomized rats in vivo. Am J Physiol 1997; 273: H506-H509.
27. Valverde MA et al. Acute activation of Maxi-K channels (hSlo) by estradiol binding to the beta subunit. Science 1999; 285: 1929-1931.
28. Santizo R, Pelligrino DA. Estrogen reduces leukocyte adhesion in the cerebral circulation of female rats. J Cereb Blood Flow Metab 1999; 19: 1061-1065.
29. Beattie MS, Farooqui AA, Bresnahan JC. Review of current evidence for apoptosis after spinal cord injury. J Neurotrauma 2000; 17: 915-925.
30. Yong C et al. Apoptosis in cellular compartments of rat spinal cord after severe contusion injury. J Neurotrauma 1998; 15: 459-472.
31. Singer CA, Rogers KL, Dorsa DM. Modulation of Bcl-2 expression: a potential component of estrogen protection in NT2 neurons. Neuroreport 1998; 9: 2565-2568.
32. Alkayed NJ et al. Estrogen and Bcl-2: gene induction and effect of transgene in experimental stroke. J Neurosci 2001; 21: 7543-7550.
33. McColl MA, Charlifue S, Glass C, Lawson N, Savic G. Aging, gender, and spinal cord injury. Arch Phys Med Rehabil 2004; 85: 363-367.
34. Jackson AB, Dijkers M, Devivo MJ, Poczatek RB. A demographic profile of new traumatic spinal cord injuries: change and stability over 30 years. Arch Phys Med Rehabil 2004; 85: 1740-1748.
35. Pollard ME, Apple DF. Factors associated with improved neurologic outcomes in patients with incomplete tetraplegia. Spine 2003; 28: 33-39.
36. Scivoletto G, Morganti B, Molinari M. Sex-related differences of rehabilitation outcomes of spinal cord lesion patients. Clin Rehabil 2004; 18: 709-713.
37. Sipski ML, Jackson AB, Gomez-Marin O, Estores I, Stein A. Effects of gender on neurologic and functional recovery after spinal cord injury. Arch Phys Med Rehabil 2004; 85: 1826-1836.
38. Olney JW et al. The anti-excitotoxic effects of certain anesthetics, analgesics and sedative-hypnotics. Neurosci Lett 1986; 68: 29-34.
39. Proescholdt M, Heimann A, Kempski O. Neuroprotection of S(+) ketamine isomer in global forebrain ischemia. Brain Res 2001; 904: 245-251.
40. Regan RF, Guo Y. Estrogens attenuate neuronal injury due to hemoglobin, chemical hypoxia, and excitatory amino acids in murine cortical cultures. Brain Res 1997; 764: 133-140.