Estrogen reduces leukocyte adhesion in the cerebral circulation of female rats

Journal of Cerebral Blood Flow and Metabolism

Volumn 19, Issue 10, 1999, Pages 1061-1065

  Santizo, Roberto ^a   Pelligrino, Dale A ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

17 estradiol; Adhesion molecules; Endothelial nitric oxide synthase (eNOS); Phorbol 12 myristate 13 acetate (PMA)

Indexed keywords

ESTRADIOL; ESTROGEN; PHORBOL 12 ACETATE 13 MYRISTATE; RHODAMINE 6G;

ANIMAL EXPERIMENT; ARTICLE; BRAIN CIRCULATION; BRAIN ISCHEMIA; BRAIN VEIN; CELL INFILTRATION; CONTROLLED STUDY; ESTROGEN ACTIVITY; FEMALE; LEUKOCYTE ADHERENCE; NEUROPROTECTION; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; RAT;

EID: 0033512596     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199910000-00001     Document Type: Article

References (24)

1. Alkayed NJ, Harukuni I, Kimes AS, London ED, Traystman RJ, Hum PD (1998) Gender-linked brain injury in experimental stroke. Stroke 29:159-165
2. Caulinglaser T, Watson CA, Pardi R, Bender JR (1996) Effects of 17 beta-estradiol on cytokine-induced endothelial cell adhesion molecule expression. J clin Invest 98:36-42
3. Collins T, Read MA, Neish AS, Whitley MZ, Thanos D, Maniatis T (1995) Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa b and cytokine-inducible enhancers. FASEB J 9:899-909
4. Decaterina R, Libby P, Peng HB, Thannickal VJ, Rajavashisth TB, Gimbrone MA, Shin WS, Liao JK (1995) Nitric oxide decreases cytokine-induced endothelial activation - nitric oxide selectively reduces endothelial expression of adhesion molecules and proin-flammatory cytokines. J Clin Invest 96:60-68
5. Dubal DB, Kashon ML, Pettigrew LC, Ren JM, Finklestein SP, Rau SW, Wise PM (1998) Estradiol protects against ischemic injury. J Cereb Blood Flow Metab 18:1253-1258
6. Fukuda H, Sawa Y, Kadoba K, Taniguchi K, Shimazaki Y, Matsuda H (1995) Supplement of nitric oxide attenuates neutrophil-mediated reperfusion injury. Circulation 92:413-416
7. Garcia JH, Liu KF, Yoshida Y, Lian J, Chen S, Delzoppo GJ (1994) Influx of leukocytes and platelets in an evolving brain infarct (wistar rat). Am J Pathol 144:188-199
8. Garciasegura LM, Cardona Gomez P, Naftolin F, Chowen JA (1998) Estradiol upregulates Bcl-2 expression in adult brain neurons. Neurorenort 9:593-597
9. Gidday JM, park TS, Shah AR, Gonzales ER (1998) Modulation of basal and postischemic leukocyte-endothelial adherence by nitric oxide. Stroke 29:1423-1429
10. Gridley KE, Green PS, Simpkins JW (1997) Low concentrations of estradiol reduce beta-amyloid (25-35)-induced toxicity, lipid peroxidation and glucose utilization in human SK-N-SH neuroblastoma cells. Brain Res 778:158-165
11. Heinel LA, Rubin S, Rosenwasser RH, Vasthare US, Tuma RF (1994) Leukocyte involvement in cerebral infarct generation after ischemia and reperfusion. Brain Res Bull 34:137-141
12. Hickey MJ, Kubes P (1997) Role of nitric oxide in regulation of leukocyte-endothelial cell interactions. Exp Physiol 82:339-348
13. Juurlink BHJ, Sweeney MI (1997) Mechanisms that result in damage during and following cerebral ischemia. Neurosci Biobehav Rev 21:121-128
14. Kochanek P and Hallenbeck J (1992) Polymorphonuclear leukocytes and monocytes/macrophages in the pathogenesis of cerebral ischemia and stroke. Stroke 23:1367-1379
15. Koenig HM, Pelligrino DA, Albrecht RF (1993) Halothane vasodilatation and nitric oxide in rat pial vessels. J Neurosurg Anesth 5:264-271
16. Kupatt C, Weber C, Wolf DA, Becker BF, Smith TW, Kelly RA (1997) Nitric oxide attenuates reoxygenation-induced ICAM-1 expression in coronary microvascular endothelium: role of NF kappa B. J Atol Cell Cardiol 29:2599-2609
17. Lasky LA (1992) Selectins: interpreters of cell-specific carbohydrate information during inflammation. Science 258:964-969
18. Lefer AM (1997) Nitric oxide: nature's naturally occurring leukocyte inhibitor. Circulation 95:553-554
19. Lefer AM, Lefer DJ (1996) The role of nitric oxide and cell adhesion molecules on the microcirculation in ischaemia-reperfusion. Cardiovasc Res 32:743-751
20. Lindauer U, Dreier J, Angstwurm K, Rubin I, Villringer A, Einhaupl KM, Dirnagl U (1996) Role of nitric oxide synthase inhibition in leukocyte-endothelium interaction in the rat pial microvasculature. J Cereb Blood Flow Metab 16:1143-1152
21. Okayama N, Coe L, Oshima T, Itoh M, Alexander JS (1999) Intracellular mechanisms of hydrogen peroxide-mediated neutrophil adherence to cultured human endothelial cells. Microvasc Res 57: 63-74
22. Pelligrino DA, Santizo R, Baughman VL, Wang Q (1998) Cerebral vasodilating capacity during transient forebrain ischemia: the effects of chronic estrogen depletion and repletion and the role of neuronal nitric oxide synthase. Neuroreport 9:3285-3291
23. Sharar SR, Winn RK, Harlan JM (1995) The adhesion cascade and anti-adhesion therapy: an overview. Semin Immunopathol 16:359-378
24. Simpkins JW, Rajakamar G, Zhang YQ, Simpkins CE, Greenwald D, Yu CJ, Bodor N, Day AL (1997) Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat. J Neurosurg 87:724-730