Methylenetetrahydrofolate reductase 677 C-T and homocysteine levels in Turkish patients with pseudoexfoliation

Clinical and Experimental Ophthalmology

Volumn 33, Issue 5, 2005, Pages 505-508

  Turaçli, M Erol ^a   Tekeli, Oya ^a   Özdemir, Filiz ^a   Akar, Nejat ^a  

^a ANKARA UNIVERSITY   (Turkey)

Author keywords

Genetic; Glaucoma; Homocysteine; Methylene tetrahydrofolate reductase; Pseudoexfoliation

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); HOMOCYSTEINE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2);

AGED; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME POLYMORPHISM; FEMALE; FLUORESCENCE POLARIZATION IMMUNOASSAY; GENOTYPE; HUMAN; HYPERHOMOCYSTEINEMIA; MAJOR CLINICAL STUDY; MALE; PROSPECTIVE STUDY; PSEUDOEXFOLIATION; REAL TIME POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE; TURKEY (REPUBLIC); VISUAL SYSTEM EXAMINATION; BLOOD; ETHNOLOGY; EXFOLIATION SYNDROME; GENETICS; GLAUCOMA; INTRAOCULAR PRESSURE; NUCLEOTIDE SEQUENCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM;

AGED; DNA MUTATIONAL ANALYSIS; EXFOLIATION SYNDROME; FEMALE; GENOTYPE; GLAUCOMA; HOMOCYSTEINE; HUMANS; HYPERHOMOCYSTEINEMIA; INTRAOCULAR PRESSURE; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); POLYMORPHISM, SINGLE NUCLEOTIDE; PROSPECTIVE STUDIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TURKEY;

EID: 33644794823     PISSN: 14426404     EISSN: 14429071     Source Type: Journal    
DOI: 10.1111/j.1442-9071.2005.01070.x     Document Type: Article

References (26)

1. Netland PA, Ye H, Streeten BW et al. Elastosis of the lamina cribrosa in pseudoexfoliation syndrome with glaucoma. Ophthalmology 1995; 102: 876-86.
2. Naumann GOH, Schlötzer-Schrehardt U, Küchle M. Pseudoexfoliation syndrome for the comprehensive ophthalmologist. Intraocular and systemic manifestations. Ophthalmology 1998; 105: 951-68.
3. Prince M, Ritch R. Clinical signs of the pseudoexfoliation syndrome. Ophthalmology 1986; 93: 803-7.
4. Ritch R, Schlötzer-Schrehardt U. Exfoliation syndrome. Surv Ophthalmol 2001; 45: 265-315.
5. Leibovitch I, Kurtz S, Shemesh G et al. Hyperhomocysteinemia in pseudoexfoliation glaucoma. J Glaucoma 2003; 12: 36-9.
6. Vessani RM, Ritch R, Liebmann JM et al. Plasma homocysteine is elevated in patients with exfoliation syndrome. Am J Ophthalmol 2003; 136: 41-6.
7. Bleich S, Junemann A, von Ahsen N et al. Homocysteine and risk of open-angle glaucoma. J Neural Transm 2002; 109: 1499-504.
8. Brown BA, Marx JL, Ward TP et al. Homocysteine: A risk factor for retinal venous occlusive disease. Ophthalmology 2002; 109: 287-90.
9. Welch GN, Loscalzo J. Homocyysteine and atherothrombosis. N Engl J Med 1998; 338: 1042-50.
10. Robinson K, Arheart K, Refsum H et al. Low circulating folate and vitamin B6 concentrations: Risk factors for stroke, peripheral vascular disease, and coronary artery disease. Eur COMAC Group. Circulation 1998; 97: 437-43.
11. Loscalzo J. The oxidant stress of hyperhomocysteinemia. J Clin Invest 1996; 98: 5-7.
12. Katzenschlager R, Burgmann H, Ehringer H et al. Vasospasmus: A rare manifestation of homocystinuria. Vasa 2000; 29: 84-6.
13. Ritch R. Exfoliation syndrome. Curr Opin Ophthalmol 2001; 12: 124-130.
14. Schlötzer-Schrehardt UM, Koca MR, Naumann GO et al. Pseudoexfoliation syndrome. Ocular manifestation of a systemic disorder? Arch Ophthalmol 1992; 110: 1752-6.
15. Streeten BW, Li ZY, Wallace RN. Pseudoexfoliative fibrillopathy in visceral organs of a patient with pseudoexfoliation syndrome. Arch Ophthalmol 1992; 110: 1757-62.
16. Mitchell P, Wang JJ, Smith W. Association of pseudoexfoliation syndrome with increased vascular risk. Am J Ophthalmol 1997; 124: 685-7.
17. Mudd SH. Vascular disease and homocysteine metabolism. N Eng J Med 1985; 313: 751-3.
18. Bos GM, den Heijer M. Hyperhomocysteinemia and venous thrombosis. Semin Thromb Hemost 1998; 24: 387-91.
19. Frosst P, Blom HJ, Milos R et al. A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995; 10: 111-13.
20. Goyette P, Sumner JS, Milos R et al. Human methylenetetrahydrofolate reductase: Isolation of cDNA, mapping and mutation identification. Nat Genet 1994; 7: 195-200.
21. Goyette P, Frosst P, Rosenblatt DS et al. Seven novel mutations in the methylenetetrahydrofolate reductase gene and genotyping/phenotyping correlations in severe methylenetetrahydrofolate reductase deficiency. Am J Hum Genet 1995; 56: 1052-9.
22. Engbersen AM, Franken DG, Boers GH et al. Thermolabile 5,10-methylenetetrahydrofolate reductase as a cause of mild hyperhomocysteinemia. Am J Hum Genet 1995; 56: 142-50.
23. Jacques PF, Bostom AG, Williams RR et al. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 1996; 93: 7-9.
24. Refsum H, Ueland PM, Nygard O, Vollset SE. Homocysteine and cardiovascular disease. Annu Rev Med 1998; 49: 31-62.
25. Harmon DL, Woodside JV, Yarnell JW et al. The common 'thermolabile'variant of methylene tetrahydrofolate reductase is a major determinant of mild hyperhomocysteinaemia. Q J Med 1996; 89: 571-7.
26. De Franchis R, Mancini FP, D'Angelo A et al. Elevated total plasma homocysteine and 677CT mutation of the 5,10-methylenetetrahydrofolate reductase gene in thrombotic vascular disease [Letter]. Am J Genet 1996; 59: 262-4.