Hyperhomocysteinemia and venous thrombosis

Seminars in Thrombosis and Hemostasis

Volumn 24, Issue 4, 1998, Pages 387-391

  Bos, Gerard M J ^a,c   Den Heijer, Martin ^b  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b CPRLab   (Netherlands)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Homocysteine; Hyperhomocysteinemia; Placebo controlled trial; Venous thrombosis; Vitamins

Indexed keywords

HOMOCYSTEINE; METHIONINE; VITAMIN;

AMINO ACID SUBSTITUTION; CARDIOVASCULAR DISEASE; CASE CONTROL STUDY; HUMAN; HYPERHOMOCYSTEINEMIA; NEURAL TUBE DEFECT; PRIORITY JOURNAL; PROSPECTIVE STUDY; REVIEW; RISK FACTOR; VEIN THROMBOSIS;

EID: 0031658897     PISSN: 00946176     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-996027     Document Type: Review

References (29)

1. Mudd SH, Skovby F, Levy HL, et al. The natural history of homocystinuria due to cystathionine-beta-synthase deficiency. Am J Hum Genet 1985;37:1-31
2. Boers GHJ, Smals AGH, Trijbels JMF, et al. Heterozygosity for homocystinuria in premature peripheral and cerebral occlusive arterial disease. N Engl J Med 1985;313:709-715
3. Engbertsen AMT, Franken DG, Boers GHJ, Stevens EMB, Trijbels FJM, Blom HJ. Thermolabile 5,10-methylenetetrahydrofolate reductase as a cause of mild hyperhomocysteinemia. Am J Hum Genet 1995;56:142-150
4. Jacques PF, Bostom AG, Williams RR, et al. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 1996;93:7-9
5. den Heijer M, Bos GMJ, van der Boor RPG, et al. Mutated methylenetetrahydrofolate reductase and other determinants of plasma homocysteine before and after methionine loading in a general Dutch population. Submitted (a)
6. D'Angelo A, Selhub J. Homocysteine and thrombotic disease. Blood 1997;90:1-11
7. Wilcken DEL, Wilcken B. The pathogenesis of coronary artery disease - a possible role for methionine metabolism. J Clin Invest 1976;57:1079-1082
8. Boushy CJ, Beresford SA, Omenn GS, Motulsky AG. A quantative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA 1995;274:1049-1057
9. Brattström L, Tengborn L, Lagerstedt C, Israelsson B, Hultberg B. Plasma homocysteine in venous tromboembolism. Haemostasis 1991;21:51-57
10. Bienvenue T, Ankri A, Chadefaux B, Kamoun P. Plasma homocysteine assay in the exploration of thrombosis in young subjects. Presse Med 1991;20:985-988
11. den Heijer M, Blom HJ, Gerrits WBJ, et al. Is hyperhomocysteinemia a risk factor for recurrent venous thrombosis? Lancet 1995;345:882-885
12. den Heijer M, Koster T, Blom HJ, et al. Hyperhomocysteinemia as a risk factor for deep-vein thrombosis. N Engl J Med 1996; 334:759-762
13. Bienvenue T, Ankri A, Chadefaux B, Montalescot G, Kamoun P. Elevated total plasma homocysteine, a risk factor for thrombosis: Relation to coagulation and fibrinolytic parameters. Thromb Res 1993;70:123-129
14. Falcon CR, Cattaneo M, Panzeri D, Martinelli I, Mannucci PM. High prevalence of hyperhomocyst(e)inemia in patients with juvenile venous thrombosis. Arterioscler Thromb 1994;14: 1080-1083
15. Fermo I, Vigano D'Angelo S, Paroni R, Mazzola G, Calori G, D'Angelo A. Prevalence of moderate hyperhomocysteinemia in patients with early-onset venous and arterial occlusive disease. Ann Intern Med 1995;123:747-753
16. Amundsen T, Ueland PM, Waage A. Plasma homocysteine levels in patients with deep venous thrombosis. Haemostasis 1991;21:51
17. Cattaneo M, Martinelli I, Mannucci PM. Hyperhomocysteinemia as a risk factor for deep-vein thrombosis. N Engl J Med 1996; 335:974-975
18. Simoni P, Prandoni P, Burlina A, et al. Hyperhomocysteinemia and deep-vein thrombosis. A case control study. Thromb Haemost 1996;76:883-886
19. den Heijer M, Rosendaal FR, Blom HJ, Gerrits WBJ, Bos GMJ. Hyperhomocysteinemia and venous thrombosis: A quantative review. Submitted
20. D'Angelo A, Fermo I, Mazzola G, Paroni R, Di Minno G, Vigano'D'Angelo S. Isolated methionine intolerance is a risk factor for early-onset venous thromboembolic disease. Neth J Med 1998;52:S38
21. Ridker PM, Hennekens CH, Selhub J, Miletich JP, Malinow MR, Stampfer MJ. Interrelation of hyperhomocyst(e)inemia, factor V Leiden, and risk of future venous tromboembolism. Circulation 1997;95:1777-1782
22. Harpel PC, Zhang X, Borth W. Homocysteine and hemostasis: Pathogenic mechanisms predisposing to thrombosis. J Nutr 1996;126:1285S-1289S
23. Bos GMJ, Rijkers DTS, Willems H, den Heijer M, Gerrits W, Hemker HC. Can an elevated endogenous thrombin potential explain the elevated risk for venous thrombosis in case of hyperhomocysteinemia? Neth J Med 1998;52:S19
24. Brattström L. Vitamins as homocysteine-lowering agents. J Nutr 1996;126:1276S-1280S
25. Landgren F, Israelsson B. Lindgren A, Hultberg B, Andersson A, Brattström L. Plasma homocysteine in acute myocardial infarction: Homocysteine-lowering effect of folic acid. J Intern Med 1995;237:381-388
26. den Heijer M, Brouwer IA, Bos GMJ, et al. Vitamin suppletion reduces blood homocysteine levels: A controlled trial in patients with venous thrombosis and healthy volunteers. Arterioscl Thromb Vasc Biol 1998;18:356-361
27. den Heijer M, Bos GMJ, Gerrits WBJ, Blom HJ. Will a decrease of blood homocysteine by vitamin supplementation reduce the risk for vascular disease? Fibrinolysis 1994;8(Suppl. 2):91-92
28. Stampfer MJ, Malinow MR. Can lowering homocysteine levels reduce cardiovascular risk? N Engl J Med 1995;328-329
29. Willems HPJ, Bos GMJ, Gerrits WBJ, den Heijer M, Vloet S, Blom HJ. Stabilization of blood samples for total homocysteine with acidic citrate. Clin Chem 1998;44:342-345