Early detection and treatment of schizophrenia: How early?

Acta Psychiatrica Scandinavica

Volumn 113, Issue SUPPL. 429, 2006, Pages 73-80

  Riecher Rossler A ^a   Gschwandtner, U ^a   Borgwardt, S ^a   Aston, J ^a   Pfluger M ^a   Rossler W ^b  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b UNIVERSITY HOSPITAL OF PSYCHIATRY   (Switzerland)

Author keywords

Early diagnosis; Early intervention; Ethics; Prevention; Psychotic disorders; Risk factors; Schizophrenia

Indexed keywords

CLINICAL FEATURE; CLINICAL RESEARCH; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DIAGNOSTIC APPROACH ROUTE; DISEASE DURATION; EARLY DIAGNOSIS; EYE MOVEMENT DISORDER; GENETIC SUSCEPTIBILITY; HUMAN; MENTAL DISEASE; MOTOR DYSFUNCTION; NEUROPHYSIOLOGY; NEUROPSYCHOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; PATIENT ASSESSMENT; PRIORITY JOURNAL; PSYCHOLOGICAL RATING SCALE; RISK ASSESSMENT; SCHIZOPHRENIA; SHORT SURVEY; SOCIAL ASPECT; VISUOMOTOR COORDINATION; DIFFERENTIAL DIAGNOSIS; PROGNOSIS; PSYCHOLOGY; RISK FACTOR; SCHIZOTYPAL PERSONALITY DISORDER;

DIAGNOSIS, DIFFERENTIAL; EARLY DIAGNOSIS; HUMANS; PROGNOSIS; RISK FACTORS; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SCHIZOTYPAL PERSONALITY DISORDER;

EID: 33644779114     PISSN: 0001690X     EISSN: 16000447     Source Type: Journal    
DOI: 10.1111/j.1600-0447.2005.00722.x     Document Type: Short Survey

References (78)

1. P elosi AJ B irchwood M. Is early intervention for psychosis a waste of valuable resources? Br J Psychiatry 2003 182 196 198
2. H äfner H M aurer K L öffler W et al. The ABC schizophrenia study: a preliminary overview of the results Soc Psychiatry Psychiatr Epidemiol 1998 33 380 386
3. R iecher A M aurer K L öffler W et al. Gender differences in age at onset and course of schizophrenic disorders. A contribution to the understanding of the disease In H äfner H G attaz WF eds Search for the causes of schizophrenia Vol. 2 Berlin, Heidelberg, New York Springer 1991 15 33
4. M c G lashan TH. Psychosis treatment prior to psychosis onset: ethical issues Schizophr Res 2001 31 47 54
5. L arsen TK F riis S H aahr U et al. Early detection and intervention in first-episode schizophrenia: a critical review Acta Psychiatr Scand 2001 103 323 334
6. M alla AK N orman R. Early intervention in schizophrenia and related disorders: advantages and pitfalls Curr Opin Psychiatry 2002 15 17 23
7. M c G orry PD. Early psychosis reform: too fast or too slow Acta Psychiatr Scand 2002 106 249 251
8. M c G orry PD. The recognition and optimal management of early psychosis. An evidence-based reform World Psychiatry 2002 1,2 76 83
9. V erdoux H C ougnard A. The early detection and treatment controversy in schizophrenia research Curr Opin Psychiatry 2003 16 175 179
10. N orman R M alla AK. Duration of untreated psychosis: a critical examination of the concept and its importance Psychol Med 2001 31 381 400
11. H äfner H. Das Rätsel Schizophrenie. Eine Krankheit wird entschlüsselt München Beck Verlag 2001
12. B ottlender R M öller HJ. The impact of the duration of untreated psychosis on short- and long-term outcome in schizophrenia Curr Opin Psychiatry 2003 16 39 43
13. C larke M O'C allaghan E. Is earlier better? At the beginning of schizophrenia: timing and opportunities for early intervention In B uckley P ed Schizophrenia: contemporary clinical perspectives Psychiatr Clin North Am 2003 26 65 83
14. H äfner H M aurer K L öffler W R iecher -R össler A. The influence of age and sex on the onset and early course of schizophrenia Br J Psychiatry 1993 162 80 86
15. H äfner H N owotny B L öffler W an der H eiden W M aurer K. When and how does schizophrenia produce social deficits Eur Arch Psychiatry Clin Neurosci 1995 246 17 28
16. B rowne S C larke M G ervin M W addington JL L arkin C O'C allaghan E. Determinants of quality of life at first presentation with schizophrenia Br J Psychiatry 2000 176 173 176
17. U cok A P olat A G enc A C akiotar S T uran N. Duration of untreated psychosis may predict acute treatment response in first-episode schizophrenia J Psychiatr Res 2004 38 163 168
18. M alla AK N orman R M c L ean T S cholten D T ownsend L. A Canadian programme for early intervention in non-affective psychotic disorders Aust N Z J Psychiatry 2003 37 407 413
19. M alla AK N orman R M anchanda R et al. One year outcome in first episode psychosis: influence of DUP and other predictors Schizophr Res 2002 54 231 242
20. H arrigan SM M c G orry PD K rstev H. Does treatment delay in first-episode psychosis really matter Psychol Med 2003 33 97 110
21. V erdoux H L iraud F B ergey C A ssens F A balan F van O s J. Is the association between duration of untreated psychosis and outcome confounded? A two year follow-up study of first-admitted patients Schizophr Res 2001 49 231 241
22. D rake RJ H aley CJ A khtar S L ewis SW. Causes and consequences of duration of untreated psychosis in schizophrenia Br J Psychiatry 2000 177 511 515
23. L arsen TK M oe LC V ibe -H ansen L J ohannessen JO. Premorbid functioning versus duration of untreated psychosis in 1 year outcome in first-episode psychosis Schizophr Res 2000 45 1 9
24. M c G orry PD. Evaluating the importance of reducing the duration of untreated psychosis Aust N Z J Psychiatry 2000 34 145 149
25. A ddington J V an M astrigt S A ddington D. Duration of untreated psychosis: impact on 2-year outcome Psychol Med 2004 34 277 284
26. L ieberman JA P erkins D B elger A et al. The early stages of schizophrenia: speculations on pathogenesis, pathophysiology, and therapeutic approaches Biol Psychiatry 2001 50 884 897
27. S tahl M. Can psychopharmacologic treatments that relieve symptoms also prevent disease progression J Clin Psychiatry 2002 63 961 962
28. A mminger GP E dwards J B rewer WJ H arrigan S M c G orry PD. Duration of untreated psychosis and cognitive deterioration in first-episode schizophrenia Schizophr Res 2002 54 223 230
29. N orman R T ownsend L M alla AK. Duration of untreated psychosis and cognitive functioning in first-episode patients Br J Psychiatry 2001 179 340 345
30. H o BC A licata D W ard J et al. Untreated initial psychosis: relation to cognitive deficits and brain morphology in first-episode schizophrenia Am J Psychiatry 2003 160 142 148
31. R und BR M elle I F riis S et al. Neurocognitive dysfunction in first-episode psychosis: correlates with symptoms, premorbid adjustment, and duration of untreated psychosis Am J Psychiatry 2004 161 466 472
32. W yatt RJ. Early intervention with neuroleptics may decrease the long-term morbidity of schizophrenia Schizophr Res 1991 5 201 202
33. B ottlender R S ato T J äger M et al. The impact of the duration of untreated psychosis prior to first psychiatric admission on the 15-year outcome in schizophrenia Schizophr Res 2003 62 37 44
34. M c G orry PD E dwards J M ihalopoulos C H arrigan SM J ackson HJ. EPPIC: an evolving system of early detection and optimal management Schizophr Bull 1996 22 305 326
35. R uhrmann S S chultze -L utter F K losterkötter J. Early detection and intervention in the initial prodromal phase of schizophrenia Pharmacopsychiatry 2003 36 Suppl. 3 162 167
36. H elgason L. Twenty years follow-up of first psychiatric presentation for schizophrenia: what could have been prevented? Acta Psychiatr Scand 1990 81 231 235
37. L incoln CV M c G orry PD. Who cares? Pathways to psychiatric care for young people experiencing a first episode of psychosis Psychiatr Serv 1995 46 1166 1171
38. Y ung AR P hillips LJ M c G orry PD et al. Prediction of psychosis. A step towards indicated prevention of schizophrenia Br J Psychiatry 1998 172 14 20
39. C andilis PJ. Early intervention in schizophrenia: three frameworks for guiding ethical inquiry Psychopharmacology 2003 171 75 80
40. H einimaa M L arsen TK. Psychosis: conceptual and ethical aspects of early diagnosis and intervention Curr Opin Psychiatry 2002 15 533 541
41. C annon TD H uttunen MO D ahlström M L armo I R äsänen P J uriloo A. Antipsychotic drug treatment in the prodromal phase of schizophrenia Am J Psychiatry 2002 159 1230 1232
42. M c G orry P Y ung AR P hillips LJ et al. Randomized controlled trial of interventions designed to reduce the risk of progression to first episode psychosis in a clinical sample with subthreshold symptoms Arch Gen Psychiatry 2002 59 921 928
43. W oods SW B reier A Z ipursky RB et al. Randomized trial of olanzapine versus placebo in the symptomatic acute treatment of the schizophrenic prodrome Biol Psychiatry 2003 54 453 464
44. M arshall M L ockwood A. Early intervention for psychosis (Cochrane review) Cochrane Libr 2004 issue 2, CD004718 2
45. C annon M J ones PB M urray RM. Obstetric complications and schizophrenia: historical and meta-analytic review Am J Psychiatry 2002 159 1080 1092
46. D avidson M W eiser M. Early diagnosis of schizophrenia - the first step towards secondary prevention Acta Psychiatr Scand 2000 101 7 10
47. I sohanni M J ones PB M oilanen K et al. Early developmental milestones in adult schizophrenia and other psychoses. A 31-year follow-up of the Northern Finland 1966 Birth Cohort Schizophr Res 2001 52 1 19
48. C annon M C aspi A M offitt TE et al. Evidence for early childhood, pan-development impairment specific to schizophreniform disorder Arch Gen Psychiatry 2002 59 449 456
49. E rlenmeyer -K imling L R ock D R oberts SA et al. Attention, memory and motor skills as childhood predictors of schizophrenia-related psychoses: The New York High Risk Project Am J Psychiatry 2000 157 1416 1422
50. N iemi LT S uvisaari JM T uulio -H enriksson A L önnqvist JK. Childhood developmental abnormalities in schizophrenia: evidence from high-risk studies Schizophr Res 2003 60 239 258
51. L ooser -O tt S A llen J E rlenmeyer -K imling L. The New York High-Risk Project: observations on the rating of early manifestations of schizophrenia Am J Med Genet 2001 105 25 27
52. K losterkötter J H ellmich M S teinmeyer EM S chultze -L utter F. Diagnosing schizophrenia in the initial prodromal phase Arch Gen Psychiatry 2001 58 158 164
53. Y ung AR P hillips LJ Y uen HP et al. Psychosis prediction: 12-month follow up of a high-risk (''prodromal'') group Schizophr Res 2003 60 21 32
54. Y ung AR P hillips LJ Y uen HP M c G orry PD. Risk factors for psychosis in an ultra high-risk group: psychopathology and clinical features Schizophr Res 2004 67 131 142
55. M ichie PT K ent A S tienstra R et al. Phenotypic markers as risk factors in schizophrenia: neurocognitive functions Aust N Z J Psychiatry 2000 34 Suppl. 74
56. T orrey EF. Studies of individuals with schizophrenia never treated with antipsychotic medications: a review Schizophr Res 2002 58 101 115
57. K im MS H a TH K won JS. Neurological abnormalities in schizophrenia and obsessive-compulsive disorder Curr Opin Psychiatry 2004 17 215 220
58. B yrne M C lafferty BA C osway R et al. Neuropsychology, genetic liability, and psychotic symptoms in those at high risk of schizophrenia J Abnorm Psychol 2003 112 38 48
59. E gan MF G oldberg TE G scheidle T et al. Relative risk of attention deficits in siblings of patients with schizophrenia Am J Psychiatry 2000 157 1309 1316
60. G schwandtner U A ston J B orgwardt S et al. Neuropsychological and neurophysiological findings in individuals suspected to be at risk for schizophrenia: preliminary results from the Basel early detection of psychosis study - Früherkennung von Psychosen (FEPSY) Acta Psychiatr Scand 2003 108 152 155
61. W olff AL O'D riscoll GA. Motor deficits and schizophrenia: the evidence from neuroleptic-naïve patients and populations at risk J Psychiatry Neurosci 1999 24 304 314
62. D azzan P M urray RM. Neurological soft signs in first-episode psychosis: a systematic review Br J Psychiatry 2002 181 s50 s57
63. M ohr F H ubmann W A lbus M et al. Neurological soft signs and neuropsychological performance in patients with first episode schizophrenia Psychiatry Res 2003 121 21 30
64. L awrie SM B yrne M M iller P et al. Neurodevelopmental indices and the development of psychotic symptoms in subjects at high risk of schizophrenia Br J Psychiatry 2001 178 425 530
65. C opolov D C rook J. Biological markers and schizophrenia Aust N Z J Psychiatry 2000 34 Suppl. 1 s108 s112
66. G ooding DC M iller MD K wapil TR. Smooth pursuit eye tracking and visual fixation in psychosis-prone individuals Psychiatry Res 2000 93 41 54
67. C urtis CE C alkins ME G rove WM F eil KJ I acono WG. Saccadic disinhibition in patients with acute and remitted schizophrenia and their first-degree biological relatives Am J Psychiatry 2001 158 100 106
68. T haker GK R oss DE C assady SL A dami HM M edoff DR S herr J. Saccadic eye movement abnormalities in relatives of patients with schizophrenia Schizophr Res 2000 45 235 244
69. L encer R T rillenberg -K recker T S chwinger E A rolt V. Schizophrenia spectrum disorders and eye tracking dysfunction in singleton and multiplex schizophrenia families Schizophr Res 2003 60 33 45
70. W ard PB. Structural brain imaging and the prevention of schizophrenia: can we identify neuroanatomical markers for young people at risk for the development of schizophrenia Aust N Z J Psychiatry 2000 34 Suppl. s127 s130
71. L encz T B ilder RM C ornblatt B. The timing of neurodevelopmental abnormality in schizophrenia: an integrative review of the neuroimaging literature CNS Spectr 2001 6 233 255
72. L awrie SM W halley HC A bukmeil SS et al. Temporal lobe volume changes in people at high risk of schizophrenia with psychotic symptoms Br J Psychiatry 2002 181 138 143
73. S eidman LJ F araone SV G oldstein JM et al. Left hippocampal volume as a vulnerability indicator for schizophrenia Arch Gen Psychiatry 2002 59 839 849
74. N iznikiewicz MA K ubicki M S henton ME. Recent structural and functional imaging findings in schizophrenia Curr Opin Psychiatry 2003 16 123 147
75. P antelis Ch V elakoulis D M c G orry PD et al. Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison Lancet 2003 361 281 288
76. M c G orry P Y ung AR P hillips LJ. ''Closing in''. What features predict the onset of first-episode psychosis within an ultra-high-risk-group In Z ipursky MD S chulz SC eds The early stages of schizophrenia Washington, London American Psychiatric Publishing 2002 q5 3 32
77. M elle I L arsen TK H aahr U et al. Reducing the duration of untreated first-episode psychosis Arch Gen Psychiatry 2004 61 143 150
78. G schwandtner U F reitag P F einendegen C et al. Chronisches subdurales Hämatom bei einem Patienten mit Verdacht auf Schizophrenie Der Nervenarzt published online 2003 Nov 13th 2004 75 691 693