Phenotypic Markers as Risk Factors in Schizophrenia: Neurocognitive Functions

Australian and New Zealand Journal of Psychiatry

Volumn 34, Issue , 2000, Pages S74-S85

  Michie, Patricia T ^a   Kent, Aaron ^a   Stienstra, Renee ^a   Castine, Rochelle ^b   Johnston, Julie ^a   Dedman, Kellie ^a   Wichmann, Helen ^b   Box, Juliette ^b   Rock, Daniel ^b   Rutherford, Elizabeth ^a   Jablensky, Assen ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b GRAYLANDS HOSPITAL   (Australia)

Author keywords

neurocognitive risk markers; schizophrenia; sustained attention deficits

Indexed keywords

ADULT; ATTENTION; CHILD; GENETIC MARKER; GENETIC SCREENING; GENETICS; HUMAN; NEUROPSYCHOLOGICAL TEST; PHENOTYPE; PSYCHOLOGY; REVIEW; RISK FACTOR; SCHIZOPHRENIA;

ADULT; ATTENTION; CHILD; GENETIC MARKERS; GENETIC SCREENING; HUMANS; NEUROPSYCHOLOGICAL TESTS; PHENOTYPE; RISK FACTORS; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY;

EID: 0034320104     PISSN: 00048674     EISSN: 14401614     Source Type: Journal    
DOI: 10.1080/000486700226     Document Type: Article

References (80)

1. Chapman LJ, Edell WS, Chapman JP. Physical anhedonia, perceptual aberration, and psychosis proneness. Schizophrenia Bulletin 1980; 6: 639–653.
2. Raine A. The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. Schizophrenia Bulletin 1991; 17: 555–564.
3. Faraone SV, Kremen WS, Lyons MJ, Pepple JR, Deisman LJ, Tsuang MT. Diagnostic accuracy and linkage analysis: How useful are schizophrenia spectrum phenotypes? American Journal of Psychiatry 1995; 152: 1286–1290.
4. Holzman PS, Proctor LR, Levy DL, Yasillo MJ, Meltzer HY, Hurt SW. Eye tracking dysfunctions in schizophrenic patients and their relatives. Archives of General Psychiatry 1974; 31: 143–151.
5. Holzman PS, Kringlen E, Matthysse S et al. A single dominant gene can account for eye tracking dysfunctions and schizophrenia in offspring of discordant twins. Archives of General Psychiatry 1988; 45: 641–647.
6. Clementz BA, Sweeney JA, Hirt M, Haas G. Pursuit gain and saccadic intrusions in first-degree relatives of probands with schizophrenia. Journal of Abnormal Psychology 1990; 99: 327–335.
7. Clementz BA, Grove WM, Iacono WG, Sweeney JA. Smooth-pursuit eye-movement dysfunction and liability for schizophrenia: implications for genetic modeling. Journal of Abnormal Psychology 1992; 101: 117–129.
8. Park S, Holzman PS, Goldman-Rakic PS. Spatial working memory deficits in the relatives of schizophrenic patients. Archives of General Psychiatry 1995; 52: 821–828.
9. Faraone SV, Seidman LJ, Kremen WS, Pepple JR, Lyions MJ, Tsuang MT. Neuropsychological functioning among the nonpsychotic relatives of schizophrenia patients: a diagnostic efficiency analysis. Journal of Abnormal Psychology 1995; 104: 286–304.
10. Laurent A, Moreaud O, Bosson J-L et al. Neuropsychological functioning among non-psychotic syblings and parents of schizophrenic patients. Psychiatry Research 1999; 87: 147–167.
11. Clementz BA, McDowell JE, Zisook S. Saccadic system functioning among schizophrenia patients and their first-degree biological relatives. Journal of Abnormal Psychology 1994; 103: 277–287.
12. Ross RG, Harris JG, Olincy A, Radant A, Adler LE, Freedman R. Familial transmission of two independent saccadic abnormalities in schizophrenia. Schizophrenia Research 1998; 30: 59–70.
13. Clementz BA, Geyer MA, Braff DL. Poor P50 suppression among schizophrenia patients and their first-degree biological relatives. American Journal of Psychiatry 1998; 155: 1691–1694.
14. Freedman R, Coon H, Myles-Worsley M et al. Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus. Proceedings of the National Academy of Sciences of the USA 1997; 94: 587–592.
15. Siegel C, Waldo M, Mizner G, Adler LE, Freedman R. Deficits in sensory gating in schizophrenic patients and their relatives. Evidence obtained with auditory evoked responses. Archives of General Psychiatry 1984; 41: 607–612.
16. Waldo M, Myles-Worsley M, Madison A, Byerley W, Freedman R. Sensory gating deficits in parents of schizophrenics. American Journal of Medical Genetics 1995; 60: 506–511.
17. Kidogami Y, Yoneda H, Asaba H, Sakai T. P300 in first degree relatives of schizophrenics. Schizophrenia Research 1991; 6: 9–13.
18. Kimble M, Lyons M, O'Donnell B, Nestor P, Niznikiewicz M, Toomey R. The effect of family status and schizotypy on electrophysiologic measures of attention and semantic processing. Biological Psychiatry 2000; 47: 402–412.
19. Blackwood DH, St Clair DM, Muir WJ, Duffy JC. Auditory P300 and eye tracking dysfunction in schizophrenic pedigrees. Archives of General Psychiatry 1991; 48: 899–909.
20. Frangou S, Sharma T, Alarcon G et al. The Maudsley Family Study, II: Endogenous event-related potentials in familial schizophrenia. Schizophrenia Research 1997; 23: 45–53.
21. Roxborough H, Muir WJ, Blackwood DH, Walker MT, Blackburn IM. Neuropsychological and P300 abnormalities in schizophrenics and their relatives. Psychological Medicine 1993; 23: 305–314.
22. Parasuraman R. The attentive brain: issues and prospects. In: Parasuman R, ed. The attentive brain. Cambridge: Bradford, 1998: 3–15.
23. Zubin J. Problem of attention in schizophrenia. In: Keitsman ML, Sutton S, Zubin J, eds. Experimental approaches to psychopathology. New York: Academic Press, 1975: 136–166.
24. Kraepelin E. Dementia praecox and paraphrenia. New York: Robert E. Krieger, 1919.
25. Cornblatt BA, Lenzenweger MF, Erlenmeyer-Kimling L. The Continuous Performance Test, Identical Pairs Version: 2. Contrasting attentional profiles of schizophrenic and depressed patients. Psychiatry Research 1989; 29: 65–85.
26. Nuechterlein K. Signal detection in vigilance tasks and behavioral attributes among offspring of schizophrenic mothers and among hyperactive children. Journal of Abnormal Psychology 1983; 92: 4–28.
27. Van den Bosch RJ, Rombouts RP, van Asma MJO. What determines continuous performance task performance? Schizophrenia Bulletin 1996; 22: 643–651.
28. Chen WJ, Liu SK, Chang CJ, Lien Y-J, Chang Y-H, Hwu H-G. Sustained attention deficit and schizotypal personality features in nonpsychotic relatives of schizophrenic patients. American Journal of Psychiatry 1998; 155: 1214–1220.
29. Rutschmann J, Cornblatt B, Erlenmeyer-Kimling L. Sustained attention in children at risk for schizophrenia: findings with two visual continuous performance tests in a new sample. Journal of Abnormal Child Psychology 1986; 14: 365–385.
30. Chen YH, Lam LCW, Chen RYL, Nguyen DGG, Chan CKY, Wilkins AJ. Neuropsychological correlates of sustained attention in schizophrenia. Schizophrenia Research 1997; 24: 299–310.
31. Mirsky AF, Lochhead SJ, Jones BP, Kugelmann S, Walsh D, Kendler KS. On familial factors in the attentional deficit in schizophrenia: a review and report of two new subject samples. Journal of Psychiatric Research 1992; 26: 383–403.
32. Cornblatt BA, Erlenmeyer-Kimling L. Global attentional deviance as a marker of risk for schizophrenia: specificity and predictive validity. Journal of Abnormal Psychology 1985; 94: 470–486.
33. Erlenmeyer-Kimling L, Cornblatt BA. A summary of attentional findings in the New York High-Risk project. Journal of Psychiatry Research 1992; 26: 405–426.
34. Cornblatt BA, Lenzenweger MF, Dworkin RH, Erlenmeyer-Kimling L. Childhood attentional dysfunctions predict social deficits in unaffected adults at risk for schizophrenia. British Journal of Psychiatry 1992; 161: 59–64.
35. Cornblatt BA, Keilp JG. Impaired attention, genetics, and the pathophysiology of schizophrenia. Schizophrenia Bulletin 1994; 20: 31–46.
36. Cornblatt BA, Winters L, Erlenmeyer-Kimling L. Attentional markers of schizophrenia: evidence from the New York High-Risk study. In: Schulz SC, Tammiga CA, eds. Schizophrenia: scientific progress. New York: Oxford University Press, 1989: 83–92.
37. Cornblatt BA, Obuchowski M, Andreasen A, Smith C. High-risk research in schizophrenia: new strategies, new designs. In: Lenzenweger MF, Dworkin RH, eds. Origins and development of schizophrenia: advances in experimental psychopathology. Washington DC: American Psychological Association, 1998: 349–383.
38. Orzack MH, Kornetsky C. Attention dysfunction in chronic schizophrenia. Archives of General Psychiatry 1966; 14: 323–326.
39. Orzack MH, Kornetsky C. Environmental and familial predictors of attention behavior in chronic schizophrenics. Journal of Psychiatric Research 1971; 9: 21–35.
40. Wohlberg GW, Kornetsky C. Sustained attention in remitted schizophrenics. Archives of General Pychiatry 1973; 28: 533–537.
41. Asarnow RF, MacCrimmon DJ. Residual performance deficit in clinical remitted schizophrenics: a marker of schizophrenia? Journal of Abnormal Psychology 1978; 87: 597–608.
42. Nuechterlein K, Dawson ME, Ventura J, Fogelson D, Gitlin M, Mintx J. Testing vulnerability indicators across clinical state. In: Hafner H, Gattax WF, eds. Search for the causes of schizophrenia, vol. 2. Heidelberg: Springer, 1991: 177–191.
43. Steinhauer SR, Zubin J, Condray R, Shaw DB, Peters JL, Van Kammen DP. Electrophysiological and behavioral signs of attentional disturbance in schizophrenics and their siblings. In: Tamminga CA, Schulz SC, eds. Advances in neuropsychiatry and psychopharmacology: vol. 1. Schizophrenia research. New York: Raven Press, 1991: 169–178.
44. Harvey PD, Keefe RSE, Moskowitz J, Putnam KM, Mohs RC, Davis KL. Attentional markers of vulnerability to schizophrenia: Performance of medicated and unmedicated patients and normals. Psychiatry Research 1990; 33:179–188.
45. Nestor PG, Faux SF, McCarley RW, Sands SF, Horvath TB, Peterson A. Neuroleptics improve sustained attention in schizophrenia: a study using signal detection theory. Neuropsychopharmacology 1991; 4: 45–149.
46. Laurent A, Saoud M, Bougerol T et al. Attentional deficits in patients with schizophrenia and in their non-psychotic first-degree relatives. Psychiatry Research 1999; 89: 147–159.
47. Lenzenweger MF, Cornblatt BA, Putnick ME. Schizotypy and sustained attention. Journal of Abnormal Psychology 1991; 100: 84–89.
48. Cornblatt BA, Erlenmeyer-Kimling L. Gobal attentional deviance as a marker of risk for schizophrenia: specificity and predictive validity. Journal of Abnormal Psychology 1954; 94: 470–486.
49. Freedman LR, Rock D, Roberts SA, Cornblatt BA, Erlenmeyer-Kimling L. The New York High-Risk Project: attention, anhedonia and social outcome. Schizophrenia Research 1998; 30: 1–9.
50. Erlenmeyer-Kimling L, Cornblatt BA, Rock D, Roberts S, Bell M, West A. The New York High-Risk project: anhedonia, attentional deviance, and psychopathology. Schizophrenia Bulletin 1993; 19: 141–153.
51. Cornblatt BA, Obuchowski M, Roberts S, Pollack S, Erlenmeyer-Kimling L. Cognitive and behavioral precursors of schizophrenia. Development and Psychopathology 1999; 11: 487–508.
52. McGhie A, Chapman J. Disorders of attention and perception in early schizophrenia. British Journal of Medical Psychology 1961; 34: 103–117.
53. Shakow D. Adaptation in schizophrenia: the theory of segmental set. New York: Wiley, 1979.
54. Nuechterlein K, Edell WS, Norris M, Dawson ME. Attentional vulnerability indicators, thought disorder, and negative symptoms. Schizophrenia Bulletin 1986; 12: 408–426.
55. Cannon TD, Zorilla LE, Shtasek D et al. Neuropsychological functioning in siblings discordant for schizophrenia and healthy volunteers. Archives of General Psychiatry 1994; 51: 651–661.
56. Nestor PG, Faux SF, McCarley RW, Shenton ME, Sands SF. Measurement of visual sustained attention in schizophrenia using signal detection analysis and a newly developed computerized CPT task. Schizophrenia Research 1990; 3: 329–332.
57. Finkelstein JR, Cannon TD, Gur RE, Moberg P. Attentional dysfunctions in neuroleptic-naïve and neuroleptic-withdrawn schizophrenic patients and their siblings. Journal of Abnormal Psychology 1997; 106: 203–212.
58. Green MF. What are the functional consequences of neurocognitive deficits in schizophrenia? American Journal of Psychiatry 1996; 153: 321–330.
59. Keefe RSE, Silva SG, Perkins DO, Lieberman JA. The effects of atypical antipsychotic drugs on neurocognitive impairment in schizophrenia: a review and meta-analysis. Schizophrenia Bulletin 1999; 25: 201–222.
60. Medalia A, Aluma M, Tryon W, Merriam AE. Effectiveness of attention training in schizophrenia. Schizophrenia Bulletin 1998; 24: 147–152.
61. Wilkins AJ, Shallice T, McCarthy R. Frontal lesions and sustained attention. Neuropsychologia 1987; 25: 359–365.
62. Cabeza R, Nyberg L. Imaging cognition 2. An empirical review of 275 PET and fMRI studies. Journal of Cognitive Neuroscience 2000; 12: 1–47.
63. Morecraft RJ, Guela C, Mesulam MM. Architecture of connectivity within a cingulo-fronto-parietal neurocognitive network for directed attention. Archives of Neurology 1993; 50: 279–284.
64. Posner MI, Dehane S. Attentional networks. Trends in Neurosciences 1994; 17: 75–79.
65. LaBerge D. Attentional processing. Cambridge: Harvard University Press, 1995.
66. Siegel BJ, Nuechterlein KH, Abel L, Wu JC, Buchsbaum MS. Glucose metabolic correlates of continuous performance test performance in adults with a history of infantile autism, schizophrenics, and controls. Schizophrenia Research 1995; 17: 85–94.
67. Carter CS, Todd SB, Barch DM, Botvinick MM, Noll D, Cohen JD. Anterior cingulate cortex, error detection, and the online monitoring of performance. Science 1998; 280: 747–749.
68. Cohen RM, Semple WE, Gross M, King AC, Nordahl TE. Metabolic brain pattern of sustained auditory discrimination. Experimental Brain Research 1992; 92: 165–172.
69. Hager H, Volz HP, Gaser C, Mentzel H-J, Kaiser WA, Sauer H. Challenging the anterior attentional system with a continuous performance task: a functional magnetic resonance imaging approach. European Archives of Psychiatry Clinical Neuroscience 1998; 248: 161–170.
70. Keilp JG, Herrera J, Stritzke P, Cornblatt BA. The continuous performance test, identical pairs version (CPT-IP): 3. Brain functioning during performance of numbers and shapes subtasks. Psychiatry Research 1997; 74: 35–45.
71. Buchsbaum MS, Nuechterlein KH, Haier RJ et al. Glucose metabolic rate in normals and schizophrenics during continuous performance test assessed by positron emission tomography. British Journal of Psychiatry 1990; 156: 216–227.
72. Schroeder JN, Buchsbaum MS, Siegal BV et al. Patterns of cortical activity in schizophrenia. Psychological Medicine 1994; 24: 947–955.
73. Volpz HP, Gaser C, Hager F et al. Decreased frontal activation in schizophrenics during stimulation with the continuous performance test - a functional magnetic resonance imaging study. European Psychiatry 1999; 14: 17–24.
74. Frith CD, Friston KJ, Herold S et al. Regional brain activity in chronic schizophrenic patients during the performance of a verbal fluency task. British Journal of Psychiatry 1995; 67: 343–349.
75. Fletcher PC, McKenna PJ, Friston KJ, Frith CD, Dolan RJ. Abnormal cingulate modulation of frontotemporal connectivity in schizophrenia. Neuroimage 1999; 9: 337–342.
76. Benes FM. Is there a neuroanatomic basis for schizophrenia? Neuroscientist 1995; 1: 112–120.
77. Andreasen NC, Arndt S, Swayse V et al. Thalamic abnormalities in schizophrenia visualised through magnetic resonance imaging. Science 1994; 226: 294–298.
78. Chakos MH, Lieberman JA, Bilder RM et al. Increase in caudate nuclei volumes of first episode schizophrenic patients taking antipsychotic drugs. American Journal of Psychiatry 1994; 151: 1430–1436.
79. Turetsky B, Cowell P, Gur RC, Grossman RI, Shtasel DL, Gur RE. Frontal and temporal lobe brain volumes in schizophrenia. Relationship to symptoms and clinical subtype. Archives of General Psychiatry 1995; 52: 1061–1070.
80. Snodgrass JG, Corwin J. Pragmatics of measuring recognition memory: applications to dementia and amnesia. Journal of Experimental Psychology: General 1988; 117: 34–50.