Synthesis and CB1 receptor activities of dimethylheptyl derivatives of 2-arachidonoyl glycerol (2-AG) and 2-arachidonyl glyceryl ether (2-AGE)

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 8, 2006, Pages 2850-2858

  Parkkari, Teija ^a   Salo, Outi M H ^a   Huttunen, Kristiina M ^a   Savinainen, Juha R ^a   Laitinen, Jarmo T ^a   Poso, Antti ^a   Nevalainen, Tapio ^a   Järvinen, Tomi ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

2 AG; 2 AGE; 35S GTP S binding assay; Cannabinoid; CB1; Dimethylheptyl; Synthesis

Indexed keywords

1 (14,14 DIMETHYLICOSA 3,6,9,12 TETRAENYL) 3 (2 HYDROXY 1 HYDROXYMETHYLETHYL)UREA; 1,3 BIS(HYDROXY) 2 (15,15 DIMETHYLHENICOSA 4,7,10,13 TETRAENOIC ACID)PROPYL ESTER; 1,3 BIS(HYDROXY) 2 (16,16 DIMETHYLDOCOSA 5,8,11,14 TETRAENOIC ACID)PROPYL ESTER; 2 (15,15 DIMETHYLHENICOSA 4,7,10,13 TETRAENYLOXY)PROPANE 1,3 DIOL; 2 (16,16 DIMETHYLDOCOSA 5,8,11,14 TETRAENYLOXY)PROPANE 1,3 DIOL; 2 ARACHIDONOYL GLYCEROL; 2 ARACHIDONYL GLYCERYL ETHER; CANNABINOID 1 RECEPTOR; ENDOCANNABINOID; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); SULFUR 35; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING ASSAY; BRAIN MEMBRANE; CEREBELLUM; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; NONHUMAN; PHYSICAL CHEMISTRY; RAT; RECEPTOR INTRINSIC ACTIVITY; STRUCTURE ACTIVITY RELATION;

ARACHIDONIC ACIDS; ETHERS; GLYCERIDES; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); MAGNETIC RESONANCE SPECTROSCOPY; RECEPTOR, CANNABINOID, CB1; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

ANIMALIA;

EID: 33644772100     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.12.007     Document Type: Article

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