CD4+ T cell receptor repertoire perturbations in HIV-1 infection: Association with plasma viremia and disease progression

Clinical Immunology

Volumn 119, Issue 1, 2006, Pages 95-102

  Malhotra, Uma ^a,b   Huntsberry, Claire ^a   Holte, Sarah ^a   Lee, Jean ^a   Corey, Lawrence ^a,b   McElrath, M Juliana ^a,b  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Antiretroviral therapy; CD4+ T cells; HIV 1; Immune activation; T cell receptor repertoire

Indexed keywords

ANTIRETROVIRUS AGENT; CD4+ T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CD4+ T LYMPHOCYTE; CELL COUNT; CLINICAL ARTICLE; COMPARATIVE STUDY; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; CORRELATION ANALYSIS; CORRELATION COEFFICIENT; DISEASE COURSE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; PRIORITY JOURNAL; SPECTROSCOPY; STATISTICAL SIGNIFICANCE; T CELL DEPLETION; VIREMIA;

ANTI-RETROVIRAL AGENTS; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; COMPLEMENTARITY DETERMINING REGIONS; DISEASE PROGRESSION; HIV INFECTIONS; HIV-1; HUMANS; LEUKOCYTES, MONONUCLEAR; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RNA, VIRAL; VIRAL LOAD; VIREMIA;

EID: 33644763842     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2005.11.010     Document Type: Article

References (40)

1. L. Meyaard, S.A. Otto, R.R. Jonker, M.J. Mijnster, R.P. Keet, and F. Miedema Programmed death of T cells in HIV-1 infection Science 257 1992 217 219
2. T. Finkel, G. Tudor-Williams, and N. Banda Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes Nat. Med. 1 2 1995 129 134
3. Z. Grossman, M. Meier-Schellersheim, A.E. Sousa, R.M. Victorino, and W.E. Paul CD4+ T-cell depletion in HIV infection: are we closer to understanding the cause? Nat. Med. 8 2002 319 323
4. G. Silvestri, D.L. Sodora, and R.A. Koup Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia Immunity 18 2003 441 452
5. B. Autran, G. Carcelain, and S. Li Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease Science 277 1997 112 116
6. U. Malhotra, M.M. Berrey, and Y. Huang Effect of combination antiretroviral therapy on T-cell immunity in acute human immunodeficiency virus type 1 infection J. Infect. Dis. 181 2000 121 131
7. K.B. Anthony, C. Yoder, and J.A. Metcalf Incomplete CD4 T cell recovery in HIV-1 infection after 12 months of highly active antiretroviral therapy is associated with ongoing increased CD4 T cell activation and turnover J. Acquired Immune Defic. Syndr. 33 2003 125 133
8. G.R. Kaufmann, L. Perrin, and G. Pantaleo CD4 T-lymphocyte recovery in individuals with advanced HIV-1 infection receiving potent antiretroviral therapy for 4 years: the Swiss HIV Cohort Study Arch. Intern. Med. 163 2003 2187 2195
9. F. Dronda, S. Moreno, A. Moreno, J.L. Casado, M.J. Perez-Elias, and A. Antela Long-term outcomes among antiretroviral-naive human immunodeficiency virus-infected patients with small increases in CD4+ cell counts after successful virologic suppression Clin. Infect. Dis. 35 2002 1005 1009
10. L.K. Musey, J.N. Krieger, J.P. Hughes, T.W. Schacker, L. Corey, and M.J. McElrath Early and persistent human immunodeficiency virus type 1 (HIV-1)- specific T helper dysfunction in blood and lymph nodes following acute HIV-1 infection J. Infect. Dis. 180 1999 278 284
11. U. Malhotra, S. Holte, and S. Dutta Role for HLA class II molecules in HIV-1 suppression and cellular immunity following antiretroviral treatment J. Clin. Invest. 107 2001 505 517
12. C.J. Pitcher, C. Quittner, and D.M. Peterson HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression Nat. Med. 5 1999 518 525
13. D. Douek, J. Brenchley, and M. Betts HIV preferentially infects HIV-specific CD4+ T cells Nature 417 2002 95 98
14. R. Veazey, M. DeMaria, and L. Chalifoux Gastrintestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection Science 280 1998 427 431
15. J.J. Mattapallil, Z. Smit-McBride, M. McChesney, and S. Dandekar Intestinal intraepithelial lymphocytes are primed for gamma interferon and MIP-1beta expression and display antiviral cytotoxic activity despite severe CD4 (+) T-cell depletion in primary simian immunodeficiency virus infection J. Virol. 72 1998 6421 6429
16. R.S. Veazey, I.C. Tham, and K.G. Mansfield Identifying the target cell in primary simian immunodeficiency virus (SIV) infection: highly activated memory CD4 (+) T cells are rapidly eliminated in early SIV infection in vivo J. Virol. 74 2000 57 64
17. J.J. Mattapallil, D.C. Douek, B. Hill, Y. Nishimura, M. Martin, and M. Roederer Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection Nature 434 2005 1093 1097
18. E. Lai, P. Concannon, and L. Hood Conserved organization of the human and murine T-cell receptor beta-gene families Nature 331 1988 543 546
19. R.K. Wilson, E. Lai, P. Concannon, R.K. Barth, and L.E. Hood Structure, organization and polymorphism of murine and human T-cell receptor alpha and beta chain gene families Immunol. Rev. 101 1988 149 172
20. I. Puisieux, J. Even, C. Pannetier, F. Jotereau, M. Favrot, and P. Kourilsky Oligoclonality of tumor-infiltrating lymphocytes from human melanomas J. Immunol. 153 1994 2807 2818
21. A. Caignard, P.Y. Dietrich, and V. Morand Evidence for T-cell clonal expansion in a patient with squamous cell carcinoma of the head and neck Cancer Res. 54 1994 1292 1297
22. C. Pannetier, M. Cochet, S. Darche, A. Casrouge, M. Zoller, and P. Kourilsky The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments Proc. Natl. Acad. Sci. U. S. A. 90 1993 4319 4323
23. C. Pannetier, J. Even, and P. Kourilsky T-cell repertoire diversity and clonal expansions in normal and clinical samples Immunol. Today 16 1995 176 181
24. T. Schacker, A.C. Collier, J. Hughes, T. Shea, and L. Corey Clinical and epidemiologic features of primary HIV infection Ann. Intern. Med. 125 1996 257 264
25. T. Schacker, Primary HIV infection. Early diagnosis and treatment are critical to outcome. Postgrad Med 102 (1997) 143-6, 149-51.
26. M.M. Berrey, T. Schacker, and A.C. Collier Treatment of primary human immunodeficiency virus type 1 infection with potent antiretroviral therapy reduces frequency of rapid progression to AIDS J. Infect. Dis. 183 2001 1466 1475
27. R.L. Dewar, H.C. Highbarger, and M.D. Sarmiento Application of branched DNA signal amplification to monitor human immunodeficiency virus type 1 burden in human plasma J. Infect. Dis. 170 1994 1172 1179
28. Y. Akatsuka, E.G. Martin, A. Madonik, A.A. Barsoukov, and J.A. Hansen Rapid screening of T-cell receptor (TCR) variable gene usage by multiplex PCR: application for assessment of clonal composition Tissue Antigens 53 1999 122 134
29. C. Pannetier, J. Levraud, A. Lim, J. Even, and P. Kourilsky The immunoscope approach for the analysis of T cell repertoires J.R. Oksenberg The Antigen T Cell Receptor: Selected Protocols and Applications 1997 287 325
30. J.C. Gea-Banacloche, L. Martino, and J.M. Mican Longitudinal changes in CD4+ T cell antigen receptor diversity and naive/memory cell phenotype during 9 to 26 months of antiretroviral therapy of HIV-infected patients AIDS Res. Hum. Retroviruses 16 2000 1877 1886
31. S. Wei, P. Charmley, M.A. Robinson, and P. Concannon The extent of the human germline T-cell receptor V beta gene segment repertoire Immunogenetics 40 1994 27 36
32. M.M. Davis, and P.J. Bjorkman T-cell antigen receptor genes and T-cell recognition Nature 334 1988 395 402
33. S.H.C. Study Persistent apoptosis in HIV-1-infected individuals receiving potent antiretroviral therapy is associated with poor recovery of CD4 T lymphocytes J. Acquired Immune Defic. Syndr. 36 2004 671 677
34. S. Pahwa, V. Chitnis, and R.M. Mitchell CD4+ and CD8+ T cell receptor repertoire perturbations with normal levels of T cell receptor excision circles in HIV-infected, therapy-naive adolescents AIDS Res. Hum. Retroviruses 19 2003 487 495
35. M. Connors, J.A. Kovacs, and S. Krevat HIV infection induces changes in CD4+ T-cell phenotype and depletions within the CD4+ T-cell repertoire that are not immediately restored by antiviral or immune-based therapies Nat. Med. 3 1997 533 540
36. G. Gorochov, A.U. Neumann, and A. Kereveur Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy Nat. Med. 4 1998 215 221
37. M.L. Romiti, C. Cancrini, and G. Castelli-Gattinara Kinetics of the T-cell receptor CD4 and CD8 V beta repertoire in HIV-1 vertically infected infants early treated with HAART AIDS 15 2001 2075 2084
38. A.E. Sousa, J. Carneiro, M. Meier-Schellersheim, Z. Grossman, and R.M. Victorino CD4 T cell depletion is linked directly to immune activation in the pathogenesis of HIV-1 and HIV-2 but only indirectly to the viral load J. Immunol. 169 2002 3400 3406
39. L.J. Picker, and V.C. Maino The CD4 (+) T cell response to HIV-1 Curr. Opin. Immunol. 12 2000 381 386
40. A. Harari, S. Petitpierre, F. Vallelian, and G. Pantaleo Skewed representation of functionally distinct populations of virus-specific CD4 T cells in HIV-1-infected subjects with progressive disease: changes after antiretroviral therapy Blood 103 2004 966 972