Graft derived cells with double nuclei in the penumbral region of experimental brain trauma

Neuroscience Letters

Volumn 396, Issue 3, 2006, Pages 182-186

  Horváth, Eszter M ^a,b   Lacza, Zsombor ^a,b   Csordás, Attila ^b   Szabó, Csaba ^b   Kollai, Márk ^b   Busija, David W ^a  

^a WAKE FOREST UNIVERSITY HEALTH SCIENCES   (United States)

^b SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

Brain trauma; BrDU; Cell fusion; GFAP; Nestin; Neural stem cell transplantation

Indexed keywords

BROXURIDINE; GLIAL FIBRILLARY ACIDIC PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN INJURY; CELL DEATH; CELL FUSION; CELL ISOLATION; CELL LABELING; CELL NUCLEUS; CELL SIZE; CELL SURVIVAL; CONTROLLED STUDY; CYTOPLASM; EMBRYO; EMBRYONIC STEM CELL; IN VITRO STUDY; MALE; MOTOR CORTEX; NERVE CELL PLASTICITY; NEURAL STEM CELL; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; RAT; STAINING; STEM CELL TRANSPLANTATION;

ANIMALS; BRAIN INJURIES; BRAIN TISSUE TRANSPLANTATION; BROMODEOXYURIDINE; CELL COUNT; CELL DIVISION; CELL NUCLEUS; CELL TRANSPLANTATION; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; EMBRYO; FEMALE; GLIAL FIBRILLARY ACIDIC PROTEIN; IMMUNOHISTOCHEMISTRY; INDOLES; INTERMEDIATE FILAMENT PROTEINS; MALE; NERVE TISSUE PROTEINS; NEUROFILAMENT PROTEINS; PREGNANCY; RATS;

EID: 33644691642     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2005.11.044     Document Type: Article

References (30)

1. M. Alvarez-Dolado, R. Pardal, J.M. Garcia-Verdugo, J.R. Fike, H.O. Lee, K. Pfeffer, C. Lois, S.J. Morrison, and A. Alvarez-Buylla Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes Nature 425 2003 968 973
2. E. Arenas Stem cells in the treatment of Parkinson's disease Brain Res. Bull. 57 2002 795 808
3. M. Brodhun, R. Bauer, and S. Patt Potential stem cell therapy and application in neurotrauma Exp. Toxicol. Pathol. 56 2004 103 112
4. J. Chen, P.R. Sanberg, Y. Li, L. Wang, M. Lu, A.E. Willing, J. Sanchez-Ramos, and M. Chopp Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats Stroke 32 2001 2682 2688
5. U. Englund, R.A. Fricker-Gates, C. Lundberg, A. Bjorklund, and K. Wictorin Transplantation of human neural progenitor cells into the neonatal rat brain: extensive migration and differentiation with long-distance axonal projections Exp. Neurol. 173 2002 1 21
6. C. Goetz, A. Hasan, W. Stummer, A. Heimann, and O. Kempski Experimental research photodynamic effects in perifocal, oedematous brain tissue Acta Neurochir. (Wien) 144 2002 173 179 (discussion 179)
7. J. Houghton, C. Stoicov, S. Nomura, A.B. Rogers, J. Carlson, H. Li, X. Cai, J.G. Fox, J.R. Goldenring, and T.C. Wang Gastric cancer originating from bone marrow-derived cells Science 306 2004 1568 1571
8. B. Huppertz, D.S. Tews, and P. Kaufmann Apoptosis and syncytial fusion in human placental trophoblast and skeletal muscle Int. Rev. Cytol. 205 2001 215 253
9. S. Koido, M. Ohana, C. Liu, N. Nikrui, J. Durfee, A. Lerner, and J. Gong Dendritic cells fused with human cancer cells: morphology, antigen expression, and T cell stimulation Clin. Immunol. 113 2004 261 269
10. Z. Lacza, E. Horvath, and D.W. Busija Neural stem cell transplantation in cold lesion: a novel approach for the investigation of brain trauma and repair Brain Res. Brain Res. Protoc. 11 2003 145 154
11. Z. Lacza, E.M. Horvath, K. Komjati, T. Hortobagyi, C. Szabo, and D.W. Busija PARP inhibition improves the effectiveness of neural stem cell transplantation in experimental brain trauma Int. J. Mol. Med. 12 2003 153 159
12. B.H. Lipton, and I.R. Konigsberg A fine-structural analysis of the fusion of myogenic cells J. Cell Biol. 53 1972 348 364
13. J.M. Luque, and M. Gimenez y Ribotta Neural stem cells and the quest for restorative neurology Histol. Histopathol. 19 2004 271 280
14. K. Mortensen, J. Lichtenberg, P.D. Thomsen, and L.I. Larsson Spontaneous fusion between cancer cells and endothelial cells Cell Mol. Life Sci. 61 2004 2125 2131
15. S. Nag The blood-brain barrier and cerebral angiogenesis: lessons from the cold-injury model Trends Mol. Med. 8 2002 38 44
16. M. Olsson, K. Bjerregaard, C. Winkler, M. Gates, A. Bjorklund, and K. Campbell Incorporation of mouse neural progenitors transplanted into the rat embryonic forebrain is developmentally regulated and dependent on regional and adhesive properties Eur. J. Neurosci. 10 1998 71 85
17. D.A. Peterson Umbilical cord blood cells and brain stroke injury: bringing in fresh blood to address an old problem J. Clin. Invest. 114 2004 312 314
18. M.F. Philips, G. Mattiasson, T. Wieloch, A. Bjorklund, B.B. Johansson, G. Tomasevic, A. Martinez-Serrano, P.M. Lenzlinger, G. Sinson, M.S. Grady, and T.K. McIntosh Neuroprotective and behavioral efficacy of nerve growth factor-transfected hippocampal progenitor cell transplants after experimental traumatic brain injury J. Neurosurg. 94 2001 765 774
19. A.J. Potgens, U. Schmitz, P. Bose, A. Versmold, P. Kaufmann, and H.G. Frank Mechanisms of syncytial fusion: a review Placenta 23 Suppl. A 2002 S107 S113
20. N. Rodic, M.S. Rutenberg, and N. Terada Cell fusion and reprogramming: resolving our transdifferences Trends Mol. Med. 10 2004 93 96
21. F. Rossi, and E. Cattaneo Opinion: neural stem cell therapy for neurological diseases: dreams and reality Nat. Rev. Neurosci. 3 2002 401 409
22. N. Terada, T. Hamazaki, M. Oka, M. Hoki, D.M. Mastalerz, Y. Nakano, E.M. Meyer, L. Morel, B.E. Petersen, and E.W. Scott Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion Nature 416 2002 542 545
23. S.F. Tzeng, and J.P. Wu Responses of microglia and neural progenitors to mechanical brain injury Neuroreport 10 1999 2287 2292
24. T. Veizovic, J.S. Beech, R.P. Stroemer, W.P. Watson, and H. Hodges Resolution of stroke deficits following contralateral grafts of conditionally immortal neuroepithelial stem cells Stroke 32 2001 1012 1019
25. M. Wahl, C. Gorlach, T. Hortobagyi, and Z. Benyo Effects of bradykinin in the cerebral circulation Acta Physiol. Hung. 86 1999 155 160
26. D.J. Webber, and S.L. Minger Therapeutic potential of stem cells in central nervous system regeneration Curr. Opin. Investig. Drugs 5 2004 714 719
27. J.M. Weimann, C.B. Johansson, A. Trejo, and H.M. Balu Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons after bone marrow transplant Nat. Cell Biol. 11 2003 959 966
28. A.E. Wurmser, and F.H. Gage Stem cells: cell fusion causes confusion Nature 416 2002 485 487
29. A.E. Wurmser, K. Nakashima, R.G. Summers, N. Toni, K.A. D'Amour, D.C. Lie, and F.H. Gage Cell fusion-independent differentiation of neural stem cells to the endothelial lineage Nature 430 2004 350 356
30. Q.L. Ying, J. Nichols, E.P. Evans, and A.G. Smith Changing potency by spontaneous fusion Nature 416 2002 545 548