Regulation of skin microvasculature angiogenesis, cell migration, and permeability by a specific inhibitor of PKCα

Journal of Investigative Dermatology

Volumn 126, Issue 2, 2006, Pages 460-467

  Bokhari, Sirosh M ^a   Zhou, Lisa ^a   Karasek, Marvin A ^a   Paturi, Sarita G ^a   Chaudhuri, Vaishali ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; ENZYME INHIBITOR; HISPIDIN; INTERLEUKIN 1BETA; ISOENZYME; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C ALPHA; PROTEIN KINASE C ALPHA INHIBITOR; PROTEIN KINASE C BETA; PROTEIN KINASE C BETA INHIBITOR; UNCLASSIFIED DRUG;

ANGIOGENESIS; ARTICLE; CELL FUNCTION; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CELL MIGRATION; CONTROLLED STUDY; CYTOPLASM; DRUG MECHANISM; DRUG SPECIFICITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME SPECIFICITY; ENZYMOLOGY; FUNCTIONAL PROTEOMICS; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; ISOENZYME ANALYSIS; MALE; NEWBORN; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN BLOOD VESSEL; TISSUE REPAIR; WESTERN BLOTTING; WOUND HEALING;

EID: 33644649000     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/sj.jid.5700071     Document Type: Article

References (46)

1. Baines CP, Molkentin JD (2005) STRESS signaling pathways that modulate cardiac myocyte apoptosis. J Mol Cell Cardiol 38:47-62
2. Cannons JL, Yu LJ, Hill B, Mijares LA, Dombroski D, Nichols KE et al. (2004) SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1. Immunity 21:693-706
3. Chida K, Hara T, Hirai T, Konishi C, Nakamura K, Nakao K et al. (2003) Disruption of protein kinase Ceta results in impairment of wound healing and enhancement of tumor formation in mouse skin carcinogenesis. Cancer Res 63:2404-8
4. Deisher TA, Sato TT, Pohlman TH, Harlan JM (1993) A protein kinase C agonist, selective for the beta I isozyme, induces E-selectin and VCAM-1 expression on HUVEC but does not translocate PKC. Biochem Biophys Res Commun 193:1283-90
5. Dinarello CA (2002) The IL-1 family and inflammatory diseases. Clin Exp Rheumatol 20(Suppl 27):S1-3
6. Dutil EM, Newton AC (2000) Dual role of pseudosubstrate in the coordinated regulation of protein kinase C by phosphorylation and diacylglycerol. J Biol Chem 275:10697-701
7. Ferro T, Neumann P, Gertzberg N, Clements R, Johnson A (2000) Protein kinase C-alpha mediates endothelial barrier dysfunction induced by TNF-alpha. Am J Physiol Lung Cell Mol Physiol 278:L1107-17
8. Gonindard C, Bergonzi C, Denier C, Sergheraert C, Klaebe A, Chavant L et al. (1997) Synthetic hispidin, a PKC inhibitor, is more cytotoxic toward cancer cells than normal cells in vitro. Cell Biol Toxicol 13:141-53
9. Goodnight JA, Mischak H, Kolch W, Mushinski JF (1995) Immunocytochemical localization of eight protein kinase C isozymes overexpressed in NIH 3T3 fibroblasts. Isoform-specific association with microfilaments, Golgi, endoplasmic reticulum, and nuclear and cell membranes. J Biol Chem 270:9991-10001
10. Halet G (2004) PKC signaling at fertilization in mammalian eggs. Biochim Biophys Acta 1742:185-9
11. Han Y, Meng T, Murray NR, Fields AP, Brasier AR (1999) Interleukin-1-induced nuclear factor-kappaB-IkappaBalpha autoregulatory feedback loop in hepatocytes. A role for protein kinase calpha in post-transcriptional regulation of ikappabalpha resynthesis. J Biol Chem 274:939-47
12. Harrington EO, Brunelle JL, Shannon CJ, Kim ES, Mennella K, Rounds S (2003) Role of protein kinase C isoforms in rat epididymal microvascular endothelial barrier function. Am J Respir Cell Mol Biol 28:626-36
13. Hempel A, Lindschau C, Maasch C, Mahn M, Bychkov R, Noll T et al. (1999) Calcium antagonists ameliorate ischemia-induced endothelial cell permeability by inhibiting protein kinase C. Circulation 99:2523-9
14. Hewett PW, Murray JC (1993) Immunomagnetic purification of human microvessel endothelial cells using Dynabeads coated with monoclonal antibodies to PECAM-1. Eur J Cell Biol 62:451-4
15. Hofmann J (2004) Protein kinase C isozymes as potential targets for anticancer therapy. Curr Cancer Drug Targets 4:125-46
16. Holthofer H, Virtanen I, Kariniemi AL, Hormia M, Linder E, Miettinen A (1982) Ulex europaeus I lectin as a marker for vascular endothelium in human tissues. Lab Invest 47:60-6
17. Hormia M, Lehto VP, Virtanen I (1983) Identification of UEA I-binding surface glycoproteins of cultured human endothelial cells. Cell Biol Int Rep 7:467-75
18. House C, Kemp BE (1987) Protein kinase C contains a pseudosubstrate prototope in its regulatory domain. Science 238:1726-8
19. Huwiler A, Schulze-Lohoff E, Fabbro D, Pfeilschifter J (1993) Immunocharacterization of protein kinase C isoenzymes in rat kidney glomeruli, and cultured glomerular epithelial and mesangial cells. Exp Nephrol 1:19-25
20. Jackson CJ, Garbett PK, Nissen B, Schrieber L (1990) Binding of human endothelium to Ulex europaeus I-coated Dynabeads: application to the isolation of microvascular endothelium. J Cell Sci 96(Part 2):257-62
21. Jaken S (1996) Protein kinase C isozymes and substrates. Curr Opin Cell Biol 8:168-73
22. Kim N, Cao W, Song IS, Kim CY, Harnett KM, Cheng L et al. (2004) Distinct kinases are involved in contraction of cat esophageal and lower esophageal sphincter smooth muscles. Am J Physiol Cell Physiol 287:C384-94
23. Leitges M, Plomann M, Standaert ML, Bandyopadhyay G, Sajan MP, Kanoh Y et al. (2002) Knockout of PKC alpha enhances insulin signaling through PI3K. Mol Endocrinol 16:847-58
24. Lipton BH, Bensch KG, Karasek MA (1991) Microvessel endothelial cell transdifferentiation: phenotypic characterization. Differentiation 46:117-33
25. Makagiansar IT, Williams S, Dahlin-Huppe K, Fukushi J, Mustelin T, Stallcup WB (2004) Phosphorylation of NG2 proteoglycan by protein kinase C-alpha regulates polarized membrane distribution and cell motility. J Biol Chem 279:55262-70
26. Martiny-Baron G, Kazanietz MG, Mischak H, Blumberg PM, Kochs G, Hug H et al. (1993) Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976. J Biol Chem 268:9194-7
27. Michie AM, Nakagawa R (2005) The link between PKCalpha regulation and cellular transformation. Immunol Lett 96:155-62
28. Nishizuka Y (1988) The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature 334:661-5
29. Normand J, Karasek MA (1995) A method for the isolation and serial propagation of keratinocytes, endothelial cells, and fibroblasts from a single punch biopsy of human skin. In Vitro Cell Dev Biol Anim 31:447-55
30. Ono Y, Fujii T, Igarashi K, Kuno T, Tanaka C, Kikkawa U et al. (1989) Phorbol ester binding to protein kinase C requires a cysteine-rich zinc-finger-like sequence. Proc Natl Acad Sci USA 86:4868-71
31. Parekh DB, Ziegler W, Parker PJ (2000) Multiple pathways control protein kinase C phosphorylation. EMBO J 19:496-503
32. Romero LI, Zhang DN, Herron GS, Karasek MA (1997) Interleukin-1 induces major phenotypic changes in human skin microvascular endothelial cells. J Cell Physiol 173:84-92
33. Rosales OR, Isales C, Nathanson M, Sumpio BE (1992) Immunocytochemical expression and localization of protein kinase C in bovine aortic endothelial cells. Biochem Biophys Res Commun 189:40-6
34. Schaap D, Parker PJ, Bristol A, Kriz R, Knopf J (1989) Unique substrate specificity and regulatory properties of PKC-epsilon: a rationale for diversity. FEBS Lett 243:351-7
35. Stahel RA, Zangemeister-Wittke U (2003) Antisense oligonucleotides for cancer therapy-an overview. Lung Cancer 41 (Suppl 1):S81-8
36. Sukumaran SK, Prasadarao NV (2003) Escherichia coli K1 invasion increases human brain microvascular endothelial cell monolayer permeability by disassembling vascular-endothelial cadherins at tight junctions. J Infect Dis 188:1295-309
37. Suzuma K, Takahara N, Suzuma I, Isshiki K, Ueki K, Leitges M et al. (2002) Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization. Proc Natl Acad Sci USA 99:721-6
38. 2+ dependent protein kinase. Biochem Biophys Res Commun 135:397-402
39. Tsopanoglou NE, Pipili-Synetos E, Maragoudakis ME (1993) Protein kinase C involvement in the regulation of angiogenesis. J Vasc Res 30:202-8
40. Tuder RM, Karasek MA, Bensch KG (1990) Cyclic adenosine monophosphate levels and the function of skin microvascular endothelial cells. J Cell Physiol 142:272-83
41. Vallentin A, Prevostel C, Fauquier T, Bonnefont X, Joubert D (2000) Membrane targeting and cytoplasmic sequestration in the spatiotemporal localization of human protein kinase C alpha. J Biol Chem 275:6014-21
42. Wang A, Nomura M, Patan S, Ware JA (2002) Inhibition of protein kinase Calpha prevents endothelial cell migration and vascular tube formation in vitro and myocardial neovascularization in vivo. Circ Res 90:609-16
43. Wang HQ, Smart RC (1999) Overexpression of protein kinase C-alpha in the epidermis of transgenic mice results in striking alterations in phorbol ester-induced inflammation and COX-2, MIP-2 and TNF-alpha expression but not tumor promotion. J Cell Sci 112(Part 20):3497-506
44. Yokoyama G, Fujii T, Tayama K, Yamana H, Kuwano M, Shirouzu K (2005) PKCdelta and MAPK mediate G(1) arrest induced by PMA in SKBR-3 breast cancer cells. Biochem Biophys Res Commun 327:720-6
45. Yuan SY (2002) Protein kinase signaling in the modulation of microvascular permeability. Vasc Pharmacol 39:213-23
46. Zhou LY, Disatnik M, Herron GS, Mochly-Rosen D, Karasek MA (1996) Differential activation of protein kinase C isozymes by phorbol ester and collagen in human skin microvascular endothelial cells. J Invest Dermatol 107:248-52