Dissimilar PTH, gastrin, and calcitonin responses to oral calcium and peptones in hypocalciuric hypercalcemia, primary hyperparathyroidism, and normal subjects: A useful tool for differential diagnosis

Journal of Bone and Mineral Research

Volumn 21, Issue 3, 2006, Pages 406-412

  Bevilacqua, Maurizio ^a   Dominguez, Ligia J ^b   Righini, Velella ^a   Valdes, Valeria ^a   Vago, Tarcisio ^a   Leopaldi, Ennio ^a   Baldi, Gabriella ^a   Barrella, Massimo ^a   Barbagallo, Mario ^b  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF PALERMO   (Italy)

Author keywords

Calcitonin; Calcium sensing receptor; Familial hypocalciuric hypercalcemia; Gastrin; Primary hyperparathyroidism; PTH

Indexed keywords

AMINO ACID; CALCITONIN; CALCIUM; CALCIUM GLUBIONATE; CALCIUM SENSING RECEPTOR; GASTRIN; PARATHYROID HORMONE; PEPTONE; RECEPTOR ANTIBODY;

ABSENCE OF SIDE EFFECTS; ADULT; AGED; ALLOSTERISM; ARTICLE; CALCIUM HOMEOSTASIS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENETIC ANALYSIS; HORMONE RESPONSE; HUMAN; HYPERCALCEMIA; HYPOCALCIURIA; HYPOCALCIURIC HYPERCALCEMIA; MALE; MEAL; PRIMARY HYPERPARATHYROIDISM; PROTEIN EXPRESSION;

AGED; CALCITONIN; CALCIUM; DIAGNOSIS, DIFFERENTIAL; FEMALE; GASTRINS; HUMANS; HYPERPARATHYROIDISM; HYPOCALCEMIA; MALE; MIDDLE AGED; PARATHYROID HORMONE; PEPTIDE HORMONES; PEPTONES;

EID: 33644585472     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/JBMR.051210     Document Type: Article

References (58)

1. Brown EM 2000 Familial hypocalciuric hypercalcemia and other disorders with resistance to extracellular calcium. Endocrinol Metab Clin North Am 29:503-522.
2. Pearce SH 2002 Clinical disorders of extracellular calcium-sensing and the molecular biology of the calcium-sensing receptor. Ann Med 34:201-206.
3. Pearce SH, Trump D, Wooding C, Besser GM, Chew SL, Grant DB, Heath DA, Hughes IA, Paterson CR, Whyte MP, Thakker RV 1995 Calcium-sensing receptor mutations in familial benign hypercalcemia and neonatal hyperparathyroidism. J Clin Invest 96:2683-2692.
4. Hendy GN, D'Souza-Li L, Yang B, Canaff L, Cole DE 2000 Mutations of the calcium-sensing receptor (CASR) in familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia. Hum Mutat 16:281-296.
5. Cole DE, Vieth R, Trang HM, Wong BY, Hendy GN, Rubin LA 2001 Association between total serum calcium and the A986S polymorphism of the calcium-sensing receptor gene. Mol Genet Metab 72:168-174.
6. Jap TS, Wu YC, Jenq SF, Won GS 2001 A novel mutation in the calcium-sensing receptor gene in a Chinese subject with persistent hypercalcemia and hypocalciuria. J Clin Endocrinol Metab 86:13-15.
7. Nakayama T, Minato M, Nakagawa M, Soma M, Tobe H, Aoi N, Kosuge K, Sato M, Ozawa Y, Kanmatsuse K, Kokubun S 2001 A novel mutation in Ca2+-sensing receptor gene in familial hypocalciuric hypercalcemia. Endocrine 15:277-282.
8. Speer G, Toth M, Niller HH, Salamon D, Takacs I, Miheller P, Patocs A, Nagy Z, Bajnok E, Nyiri P, Lakatos P 2003 Calcium metabolism and endocrine functions in a family with familial hypocalciuric hypercalcemia. Exp Clin Endocrinol Diabetes 111:486-490.
9. Yamauchi M, Sugimoto T, Yamaguchi T, Yano S, Wang J, Bai M, Brown EM, Chihara K 2002 Familial hypocalciuric hypercalcemia caused by an R648 stop mutation in the calcium-sensing receptor gene. J Bone Miner Res 17:2174-2182.
10. Cetani F, Pardi E, Borsari S, Tonacchera M, Morabito E, Pinchera A, Marcocci C, Dipollina G 2003 Two Italian kindreds with familial hypocalciuric hypercalcaemia caused by loss-of-function mutations in the calcium-sensing receptor (CaR) gene: Functional characterization of a novel CaR missense mutation. J Clin Endocrinol Metab 58:199-206.
11. Pallais JC, Kifor O, Chen YB, Slovik D, Brown EM 2004 Acquired hypocalciuric hypercalcemia due to autoantibodies against the calcium-sensing receptor. N Engl J Med 351:362-369.
12. Kifor O, Moore FD, Delaney M, Garber J, Hendy GN, Butters R, Gao P, Cantor TL, Kifor I, Brown EM, Wysolmerski J 2003 A Syndrome of Hypocalciuric Hypercalcemia Caused by Auto-antibodies Directed at the Calcium-Sensing Receptor. J Clin Endocrinol Metab 88:60-72.
13. Brown EM, Hebert SC 1997 Calcium-receptor-regulated parathyroid and renal function. Bone 20:303-309.
14. Ray JM, Squires PE, Curtis SB, Meloche MR, Buchan AM 1997 Expression of the calcium-sensing receptor on human antral gastrin cells in culture. J Clin Invest 99:2328-2333.
15. Kameda Y, Mano H, Yamada Y, Takai H, Amizuka N, Kobori M, Izumi N, Kawashima H, Ozawa H, Ikeda K, Kameda A, Hakeda Y, Kumegawa M 1998 Calcium-sensing receptor in mature osteoclasts, which are bone resorbing cells. Biochem Biophys Res Commun 245:419-422.
16. Cheng I, Klingensmith ME, Chattopadhyay N, Kifor O, Butters RR, Soybel DI, Brown EM 1998 Identification and localization of the extracellular calcium-sensing receptor in human breast. J Clin Endocrinol Metab 83:703-707.
17. Brown EM, Hebert SC 1996 A cloned extracellular Ca(2+)-sensing receptor: Molecular mediator of the actions of extracellular Ca2+ on parathyroid and kidney cells? Kidney Int 49:1042-1046.
18. Brown EM, MacLeod RJ 2001 Extracellular calcium sensing and extracellular calcium signaling. Physiol Rev 81:239-297.
19. Hofer AM, Brown EM 2003 Extracellular calcium sensing and signalling. Nat Rev Mol Cell Biol 4:530-538.
20. Cole DE, Peltekova VD, Rubin LÀ, Hawker GA, Vieth R, Liew CC, Hwang DM, Evrovski J, Hendy GN 1999 A986S polymorphism of the calcium-sensing receptor and circulating calcium concentrations. Lancet 353:112-115.
21. 2+-sensing receptor. Proc Natl Acad Sci USA 97:4814-4819.
22. Buchan AM, Squires PE, Ring M, Meloche RM 2001 Mechanism of action of the calcium-sensing receptor in human antral gastrin cells. Gastroenterology 120:1128-1139.
23. Conigrave AD, Franks AH, Brown EM, Quinn SJ 2002 L-amino acid sensing by the calcium-sensing receptor: A general mechanism for coupling protein and calcium metabolism? Eur J Clin Nutr 56:1072-1080.
24. Conigrave AD, Mun HC, Delbridge L, Quinn SJ, Wilkinson M, Brown EM 2004 L-amino acids regulate parathyroid hormone secretion. J Biol Chem 279:38151-38159.
25. Bevilacqua M, Dominguez LJ, Righini V, Valdes V, Toscano R, Sangaletti O, Vago T, Baldi G, Barrella M, Bianchi-Porro G 2005 Increased gastrin and calcitonin secretion after oral calcium or peptones administration in patients with hypercalciuria: A clue to an alteration in calcium sensing receptor activity. J Clin Endocrinol Metab 90:1489-1494.
26. Schwartz SR, Futran ND 2004 Hypercalcemia hypocalciuria: A critical differential diagnosis for hyperparathyroidism. Otolaryngol Clin North Am 37:887-896.
27. Rickels MR, Mandel SJ 2004 Hypocalciuric hypercalcemia and autoantibodies against the calcium-sensing receptor. N Engl J Med 351:2237.
28. Bettica P, Bevilacqua M, Vago T, Norbiato G 1999 High prevalence of hypovitaminosis D among free-living postmenopausal women referred to an osteoporosis outpatient clinic in northern Italy for initial screening. Osteoporos Int 9:226-229.
29. Pacifici R, Rothstein M, Rifas L, Lau KH, Baylink DJ, Avioli LV, Hruska K 1990 Increased monocyte interleukin-1 activity and decreased vertebral bone density in patients with fasting idiopathic hypercalciuria. J Clin Endocrinol Metab 71:138-145.
30. Lazzaroni M, Sangaletti O, Del Soldato P, Bianchi Porro G 1985 Effect of pirenzepine and atropine on peptone meal-stimulated gastric secretion and plasma gastrin in healthy volunteers, patients with duodenal ulcer and vagotomized patients. Digestion 32:267-272.
31. Monti M, Scazzoso A, Bevilacqua M, Santi I, D'Aprile E, Saligari A, Norbiato G, Cunietti E 1992 Plasma monomeric calcitonin as a marker of disease activity in multiple myeloma patients with osteolysis. Int J Biol Markers 7:87-92.
32. Farnebo F, Enberg U, Grimelius L, Backdahl M, Schalling M, Larsson C, Farnebo LO 1997 Tumor-specific decreased expression of calcium sensing receptor messenger ribonucleic acid in sporadic primary hyperparathyroidism. J Clin Endocrinol Metab 82:3481-3486.
33. 2+-sensing receptor expression in parathyroid adenoma. Calcif Tissue Int 64:271-272.
34. Brown AJ, Ritter CS, Finch JL, Slatopolsky EA 1999 Decreased calcium-sensing receptor expression in hyperplastic parathyroid glands of uremic rats: Role of dietary phosphate. Kidney Int 55:1284-1292.
35. Meyer R 1954 The color, molecular solubility and phosphorus content in various commercial peptones and meat extracts. Z Hyg Infektionskr 140:19-28.
36. Tiegs RD, Body JJ, Barta JM, Heath H III 1986 Plasma calcitonin in primary hyperparathyroidism: Failure of C-cell response to sustained hypercalcemia. J Clin Endocrinol Metab 63:785-788.
37. Rajala MM, Klee GG, Heath H III 1991 Calcium regulation of parathyroid and C cell function in familial benign hypercalcemia. J Bone Miner Res 6:117-124.
38. Puscas I, Coltau M, Baican M, Domuta G, Hecht A 2001 Calcium, carbonic anhydrase and gastric acid secretion. Physiol Res 50:359-364.
39. Turner JJ, Wren AM, Jackson JE, Thakker RV, Meeran K 2002 Localization of gastrinomas by selective intra-arterial calcium injection. Clin Endocrinol (Oxf) 57:821-825.
40. Wada M, Komoto I, Doi R, Imamura M 2002 Intravenous calcium injection test is a novel complementary procedure in differential diagnosis for gastrinoma. World J Surg 26:1291-1296.
41. Hinkle KL, Bane GC, Jazayeri A, Samuelson LC 2003 Enhanced calcium signaling and acid secretion in parietal cells isolated from gastrin-deficient mice. Am J Physiol Gastrointest Liver Physiol 284:G145-G153.
42. Yao X, Forte JG 2003 Cell biology of acid secretion by the parietal cell. Annu Rev Physiol 65:103-131.
43. Goebel SU, Peghini PL, Goldsmith PK, Spiegel AM, Gibril F, Raffeld M, Jensen RT, Serrano J 2000 Expression of the calcium-sensing receptor in gastrinomas. J Clin Endocrinol Metab 85:4131-4137.
44. Igarashi T, Ogata E, Maruyama K, Fukuda T 2000 Effect of calcimimetic agent, KRN568, on gastrin secretion in healthy subjects. Endocr J 47:517-523.
45. Geibel JP, Wagner CA, Caroppo R, Qureshi I, Gloeckner J, Manuelidis L, Kirchhoff P, Radebold K 2001 The stomach divalent ion-sensing receptor scar is a modulator of gastric acid secretion. J Biol Chem 276:39549-39552.
46. Itami A, Kato M, Komoto I, Doi R, Hosotani R, Shimada Y, Imamura M 2001 Human gastrinoma cells express calcium-sensing receptor. Life Sci 70:119-129.
47. Tovey FI, Hall ML, Ell PJ, Hobsley M 1991 Postgastrectomy osteoporosis. Br J Surg 78:1335-1337.
48. Klinge B, Lehto-Axtelius D, Åkerman M, Håkanson R 1995 Structure of calvaria after gastrectomy. An experimental study in the rat. Scand J Gastroenterol 30:952-957.
49. Persson P, Gagnemo-Persson R, Chen D, Axelson J, Nylander AG, Johnell O, Håkanson R 1993 Gastrectomy causes bone loss in the rat: Is lack of gastric acid responsible? Scand J Gastroenterol 28:301-306.
50. Axelson J, Persson P, Gagnemo-Persson R, Håkansson R 1991 Importance of the stomach in maintaining calcium homeostasis in the rat. Gut 32:1298-1302.
51. Bussabarger RA, Freeman S, Ivy AC 1938 The experimental production of severe homogeneous osteoporosis by gastrectomy in puppies. Am J Physiol 121:137-148.
52. Maier GW, Kreis ME, Zittel TT, Becker HD 1997 Calcium regulation and bone mass loss after total gastrectomy in pig. Ann Surg 225:181-192.
53. Lehto-Axtelius D, Stenström M, Johnell O 1998 Osteopenia after gastrectomy, fundectomy, or antrectomy: An experimental study in the rat. Regul Pept 78:41-50.
54. 2+ second messenger response in osteoblastic cells. Regul Pept 97:153-161.
55. Davies M, Heys SE, Selby PL, Berry JL, Mawer EB 1997 Increased catabolism of 25-hydroxyvitamin D in patients with partial gastrectomy and elevated 1,25-dihydroxyvitamin D levels. Implications for metabolic bone disease. J Clin Endocrinol Metab 82:209-212.
56. Persson P, Håkanson R, Axelson J, Sundler F 1989 Gastrin releases a blood calcium-lowering peptide from the acid-producing part of the rat stomach. Proc Natl Acad Sci USA 86:2834-2838.
57. Hakanson R, Persson P, Axelson J 1990 Elevated serum gastrin after food intake or acid blockade evokes hypocalcemia. Regul Pept 28:131-136.
58. Pak CY, Kaplan R, Bone H, Townsend J, Waters O 1975 A simple test for the diagnosis of absorptive, resorptive, and renal hypercalciuria. N Engl J Med 292:497-500.