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Volumn 47, Issue 13, 2006, Pages 2161-2164

Novel route to the synthesis of 4-quinolyl isothiocyanates

Author keywords

4 Quinolyl isothiocyanate; Silver thiocyanate; Thiocyanate

Indexed keywords

ISOTHIOCYANIC ACID DERIVATIVE; QUINOLINE DERIVATIVE; SILVER DERIVATIVE; TOLUENE;

EID: 33644556178     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2006.01.119     Document Type: Article
Times cited : (21)

References (46)
  • 2
    • 0000470094 scopus 로고
    • Recent reviews on isothiocyanates as synthetic intermediates: S. Sharma Sulfur Rep. 8 1989 327
    • (1989) Sulfur Rep. , vol.8 , pp. 327
    • Sharma, S.1
  • 8
    • 2942752388 scopus 로고    scopus 로고
    • G. Sommen Synlett 7 2004 1323 1324
    • (2004) Synlett , vol.7 , pp. 1323-1324
    • Sommen, G.1
  • 12
    • 0029837050 scopus 로고    scopus 로고
    • Recent reviews on chemoprevention of cancers by isothiocyanates: S.S. Hecht Adv. Exp. Med. Biol. 401 1996 1
    • (1996) Adv. Exp. Med. Biol. , vol.401 , pp. 1
    • Hecht, S.S.1
  • 35
    • 33644540425 scopus 로고    scopus 로고
    • note
    • The rapid stirring was crucial for the success of the reaction; otherwise, the reaction either progressed very slowly or completely ceased. A mixture of 4-chloroquinoline and silver thiocyanate in anhydrous toluene was stirred at 110°C for 12 h. The hot reaction mixture was filtered and washed three times with chloroform. The filtrate was concentrated under vacuum to afford the 4-quinolinyl isothiocyanate as an off-white solid. We thank a reviewer for the suggestion of using regular toluene. Reactions 1, 5, 7 and 11 were carried out in anhydrous toluene and regular toluene side by side. No obvious differences were noted in yields and proton NMR spectra between the two sets of reactions.
  • 36
    • 33644532474 scopus 로고    scopus 로고
    • note
    • 14


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.