Testicular toxicity of DEHP, but not DEHA, is elevated under conditions of thioacetamide-induced liver damage

Reproductive Toxicology

Volumn 21, Issue 3, 2006, Pages 253-259

  Kang, Jin Seok ^a   Morimura, Keiichirou ^a   Toda, Chitose ^b   Wanibuchi, Hideki ^a   Wei, Min ^a   Kojima, Nakao ^b   Fukushima, Shoji ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b MEIJO UNIVERSITY   (Japan)

Author keywords

Di(2 ethylhexyl)adipate; Di(2 ethylhexyl)phthalate; Testicular toxicity; Thioacetamide

Indexed keywords

ADIPIC ACID BIS(2 ETHYLHEXYL) ESTER; ADIPIC ACID DERIVATIVE; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; THIOACETAMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIET; HISTOPATHOLOGY; LIVER INJURY; MALE; MORPHOLOGY; NONHUMAN; ORGAN WEIGHT; RAT; SEMINIFEROUS TUBULE; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; TERATOGENICITY; TESTIS ATROPHY;

ADIPIC ACIDS; ANIMALS; BODY WEIGHT; DIETHYLHEXYL PHTHALATE; EPIDIDYMIS; LIVER CIRRHOSIS, EXPERIMENTAL; MALE; ORGAN SIZE; PLASTICIZERS; RATS; RATS, INBRED F344; SPERMATOGENESIS; TESTIS; THIOACETAMIDE;

ANIMALIA;

EID: 33644539873     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2005.09.013     Document Type: Article

References (33)

1. HCWH Aggregate exposures to phthalates in humans 2002 Health Care Without Harm
2. B.C. Blount, M.J. Silva, S.P. Caudill, L.L. Needham, J.L. Pirkle, and E.J. Sampson Levels of seven urinary phthalate metabolites in a human reference population Environ Health Perspect 108 2000 979 982
3. M.C. Kohn, F. Parham, S.A. Masten, C.J. Portier, M.D. Shelby, and J.W. Brock Human exposure estimates for phthalates Environ Health Perspect 108 2000 A440 A442
4. K.M. Shea Pediatric exposure and potential toxicity of phthalate plasticizers Pediatrics 111 2003 1467 1474
5. P.M. Foster, E. Mylchreest, K.W. Gaido, and M. Sar Effects of phthalate esters on the developing reproductive tract of male rats Hum Reprod Update 7 2001 231 235
6. R. Kavlock, K. Boekelheide, R. Chapin, M. Cunningham, E. Faustman, and P. Foster NTP center for the evaluation of risks to human reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di(2-ethylhexyl) phthalate Reprod Toxicol 16 2002 529 653
7. R. Kavlock, K. Boekelheide, R. Chapin, M. Cunningham, E. Faustman, and P. Foster NTP center for the evaluation of risks to human reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-n-butyl phthalate Reprod Toxicol 16 2002 489 527
8. R.H. McKee, J.H. Butala, R.M. David, and G. Gans NTP center for the evaluation of risks to human reproduction reports on phthalates: addressing the data gaps Reprod Toxicol 18 2004 1 22
9. FDA Safety assessment of di(2-ethylhexyl)phthalate (DEHP) released from PVC medical devices 2001 Center for Devices and Radiological Health, U.S. Food and Drug Administration
10. P.E. Ganey, and R.A. Roth Concurrent inflammation as a determinant of susceptibility to toxicity from xenobiotic agents Toxicology 169 2001 195 208
11. J.S. Kang, H. Wanibuchi, K. Morimura, R. Puatanachokchai, E.I. Salim, and A. Hagihara Enhancement by estradiol 3-benzoate in thioacetamide-induced liver cirrhosis of rats Toxicol Sci 85 2005 720 726
12. M. Mitsuhashi, K. Morimura, H. Wanibuchi, S. Hayashi, A. Kiyota, and S. Wada Di-n-butyl phthalate is toxic to the male reproductive system and its toxicity is enhanced by thioacetamide induced liver injury J Toxicol Pathol 17 2004 177 185
13. A. Muller, F. Machnik, T. Zimmermann, and H. Schubert Thioacetamide-induced cirrhosis-like liver lesions in rats - usefulness and reliability of this animal model Exp Pathol 34 1988 229 236
14. J.S. Kang, K. Morimura, E.I. Salim, H. Wanibuchi, S. Yamaguchi, and S. Fukushima Persistence of liver cirrhosis in association with proliferation of nonparenchymal cells and altered location of alpha-smooth muscle actin-positive cells Toxicol Pathol 33 2005 329 335
15. N. Sanz, C. Diez-Fernandez, L. Fernandez-Simon, A. Alvarez, and M. Cascales Relationship between antioxidant systems, intracellular thiols and DNA ploidy in liver of rats during experimental cirrhogenesis Carcinogenesis 16 1995 1585 1593
16. M.L. Meistrich Evaluation of reproductive toxicity by testicular sperm head counts J Am Coll Toxicol 8 1989 551 567
17. D.K. Agarwal, S. Eustis, J.Ct. Lamb, J.R. Reel, and W.M. Kluwe Effects of di(2-ethylhexyl) phthalate on the gonadal pathophysiology, sperm morphology, and reproductive performance of male rats Environ Health Perspect 65 1986 343 350
18. R. Poon, P. Lecavalier, R. Mueller, V.E. Valli, B.G. Procter, and I. Chu Subchronic oral toxicity of di-n-octyl phthalate and di(2-ethylhexyl) phthalate in the rat Food Chem Toxicol 35 1997 225 239
19. T.J. Gray, and K.R. Butterworth Testicular atrophy produced by phthalate esters Arch Toxicol Suppl 4 1980 452 455
20. P.W. Albro, R.E. Chapin, J.T. Corbett, J. Schroeder, and J.L. Phelps Mono-2-ethylhexyl phthalate, a metabolite of di-(2-ethylhexyl) phthalate, causally linked to testicular atrophy in rats Toxicol Appl Pharmacol 100 1989 193 200
21. P. Sjoberg, U. Bondesson, T.J. Gray, and L. Ploen Effects of di-(2-ethylhexyl) phthalate and five of its metabolites on rat testis in vivo and in in vitro Acta Pharmacol Toxicol (Copenh) 58 1986 225 233
22. L.H. Li, W.F. Jester Jr., and J.M. Orth Effects of relatively low levels of mono-(2-ethylhexyl) phthalate on cocultured Sertoli cells and gonocytes from neonatal rats Toxicol Appl Pharmacol 153 1998 258 265
23. L.H. Li, W.F. Jester Jr., A.L. Laslett, and J.M. Orth A single dose of di-(2-ethylhexyl) phthalate in neonatal rats alters gonocytes, reduces sertoli cell proliferation, and decreases cyclin D2 expression Toxicol Appl Pharmacol 166 2000 222 229
24. B.T. Akingbemi, R.T. Youker, C.M. Sottas, R. Ge, E. Katz, and G.R. Klinefelter Modulation of rat Leydig cell steroidogenic function by di(2-ethylhexyl)phthalate Biol Reprod 65 2001 1252 1259
25. E. Mylchreest, M. Sar, D.G. Wallace, and P.M. Foster Fetal testosterone insufficiency and abnormal proliferation of Leydig cells and gonocytes in rats exposed to di(n-butyl) phthalate Reprod Toxicol 16 2002 19 28
26. P.W. Albro, and S.R. Lavenhar Metabolism of di(2-ethylhexyl)phthalate Drug Metab Rev 21 1989 13 34
27. I.F. Gaunt, and K.R. Butterworth Autoradiographic study of orally administered di-(2-ethylhexyl) phthalate in the mouse Food Chem Toxicol 20 1982 215 217
28. G.M. Pollack, R.C. Li, J.C. Ermer, and D.D. Shen Effects of route of administration and repetitive dosing on the disposition kinetics of di(2-ethylhexyl) phthalate and its mono-de-esterified metabolite in rats Toxicol Appl Pharmacol 79 1985 246 256
29. O.A. Teirlynck, and F. Belpaire Disposition of orally administered di-(2-ethylhexyl) phthalate and mono-(2-ethylhexyl) phthalate in the rat Arch Toxicol 57 1985 226 230
30. H.T. Abul, T.C. Mathew, F. Abul, H. Al-Sayer, and H.M. Dashti Antioxidant enzyme level in the testes of cirrhotic rats Nutrition 18 2002 56 59
31. M. Dalgaard, C. Nellemann, H.R. Lam, I.K. Sorensen, and O. Ladefoged The acute effects of mono(2-ethylhexyl)phthalate (MEHP) on testes of prepubertal Wistar rats Toxicol Lett 122 2001 69 79
32. M. Dalgaard, U. Hass, A.M. Vinggaard, K. Jarfelt, H.R. Lam, and I.K. Sorensen Di(2-ethylhexyl) adipate (DEHA) induced developmental toxicity but not antiandrogenic effects in pre- and postnatally exposed Wistar rats Reprod Toxicol 17 2003 163 170
33. EPA Public health goals for chemicals in drinking water: di-(2-ethylhexyl) adipate 2003 Office of Environmental Health Hazard Assessment, California Environmental Protection Agency