Effects of oral administration of water extract of Nigella sativa on the hypothalamus pituitary adrenal axis in experimental diabetes

International Journal of Pharmacology

Volumn 2, Issue 1, 2006, Pages 104-109

  Mansi, Kamal M S ^a  

^a AL AL BAYT UNIVERSITY   (Jordan)

Author keywords

Adrenocorticotropic hormone (ACTH); Alloxan; Corticosterone; Glucagon; Insulin; Nigella sativa

Indexed keywords

ALLOXAN; CORTICOSTERONE; CORTICOTROPIN; GLUCAGON; GLUCOSE; INSULIN; NIGELLA SATIVA EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; CELL PROTECTION; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; CORTICOTROPIN BLOOD LEVEL; DIABETES CONTROL; DIABETES MELLITUS; DIET RESTRICTION; DRUG ADMINISTRATION ROUTE; DRUG MECHANISM; GLUCAGON BLOOD LEVEL; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HYPOGLYCEMIA; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INSULIN BLOOD LEVEL; MALE; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; RAT; TREATMENT OUTCOME;

EID: 33644536418     PISSN: 18117775     EISSN: 18125700     Source Type: Journal    
DOI: 10.3923/ijp.2006.104.109     Document Type: Article

References (48)

1. Tich, R. and H. McDevit, 1996. Insulin dependent diabetes mellitus. Cell., 85: 291-297.
2. Bell, G.I. and K.S. Polonsky, 2001. Diabetes mellitus and genetically programmed defects in β-cell function. Nature, 414: 788-791.
3. Zimmet, P., K.G. Alberti and J. Shaw, 2001. Global and societal implications of diabetes epidemic. Nature, 414: 782-787.
4. Klip, A., A.D. Marette, T. Dimitrakouids, Ramlal and M. Varnic, 1992. Effect of diabetes on glucoregulation. From glucose transports to glucose metabolism in vivo. Diabetes Care, 15: 1747-1766.
5. Taskinen, M.R., S. Lahdenpera and M. Syvanne, 1996. New insights into lipid metabolism in non-insulin-dependent diabetes mellitus. An. Med., 28: 335-340.
6. Vlassara, H., M. Brownlee and A. Cerami, 1984. Accumulation of diabetic rat peripheral nerve myelin by macrophages increases with the presence of advanced glycosylation end products. J. Exp. Med., 160: 197-207.
7. Yabe-Nishimura, C., 1998. Aldose reductase in glucose toxicity: A potential target for the prevention of diabetic complication. Pharmacol. Rev., 50: 21-33.
8. Brownle, M., 2001. Biochemistry and molecular cell biology of diabetic complications. Nature., 414: 813-820.
9. Saks, D.B., 1997. Implication of the revised criteria for diagnosis and classification of diabetes mellitus. Clin. Chem., 43: 2230-2233.
10. Palmieri, V., J.N. Bella, D.K. Arentt, J. Liu, E.A. Oberman and M.Y. Schuck, 2001. Effect of type II diabetes mellitus on left ventricular geometry and systolic function in hypertensive subjects; Hypertension genetic Epidemiology network (Hyper GEN) Study; Circulation, 103: 102-107.
11. Yenigum, M., 1997. Cardiovascular diabetes. Istanbul University printing house, Istanbul, Turkey, 43: 2230-2233.
12. Garcia Leme, J., L. Hamamura, R.H. Migliorini and M.P. Leite, 1973. Experimental diabetes and inflammatory reactions in the rat. Agents Actions, 3: 380-381.
13. Garcia Leme, J. and S.P. Farsky, 1993. Hormonal control of inflammatory response. Mediators of Inflammation, 2: 181-198.
14. Rayfield, E.J., M.J. Ault, G.T. Keusch, M.J. Brothers, C. Nechemias and H. Smith, 1982. Infection and diabetes: The case for glucose control. Am. J. Med., 72: 439-450.
15. Weitzman, E.D., D. Fukushima, C. Nogeire, H. Roffwarg, T.F. Gallagher and L. Hellman, 1971. Twenty-four-hour pattern of the episodic secretion of cortisol in normal subjects. J. Clin. Endocrinol. Metab., 33: 14-22.
16. Cameron, O.G., Z. Kronfol, J.F. Grenden and B.J. Carroll, 1984. Hypothalamic-pituitary-adrenocortical activity in patients with diabetes mellitus. Arch. Gen. Psychiatry., 41: 1090-1095.
17. Coiro, V., R. Volpi, L. Capretti, G. Speroni and P. Caffarra et al., 1995. Low-dose corticotrophin-releasing hormone stimulation test in diabetes mellitus with or without neuropathy. Metabolism., 44: 538-542.
18. Roy, M., B. Collier and A. Roy, 1990. Hypothalamic-pituitary-adrenal axis dysregulation among diabetic out-patients. Psychiatry Res., 31: 31-37.
19. Roy, M.S., A. Roy and W.T. Gallucci, 1993. The ovine corticotropin-releasing hormone-stimulation test in type I diabetic patients and controls: Suggestion of mild chronic hypercortisolism. Metabolism., 42: 696-670.
20. Fehm, H.L., R. Holl, E. Spath-Schwalbe, J. Born and K.H. Voigt, 1988. Ability of corticotropin releasing hormone to stimulate cortisol secretion independent from pituitary adrenocorticotropin. Life Sci., 42: 679-686.
21. Hudson, J.I., M.S. Hudson, A.J. Rothschild, L. Vignati, A.F. Schatzberg and J.C. Melby, 1989. Abnormal results of dexamethasone suppression tests in non-depressed patients with diabetes mellitus. Arch. Gen. Psychiatry., 41: 1086-1089.
22. Sapolsky, R.M., 1996 Stress, glucocorticoids and damage to the nervous system: The current state of confusion. Stress, 1:1-19.
23. Kadekaro, M., M. Ito and P.M. Gross, 1988. Local cerebral glucose utilization is increased in acutely adrenalectomized rats. Neuroendocrinology, 47: 329-334.3
24. Doyle, P., F. Rohner-Jeanrenaud and B. Jeanrenaud, 1993. Local cerebral glucose utilization in brains of lean and genetically obese (fa/fa) rats. Am. J. Physiol., 264: E29-E36.
25. Horner, H., D. Packan and R. Sapolsky, 1990. Glucocorticoids inhibit glucose transport in cultured hippocampal neurons and glia. Neuroendocrinol., 52: 57-6.
26. Reagan, L.P., A.M. Magarinos and B.S. McEwen, 1999. Neurological changes induced by stress in streptozotocin diabetic rats. Ann. NY. Acad. Sci., 893: 126-137.
27. McCall, A.L.,1992. The impact of diabetes on the CNS. Diabetes., 41: 557-570.
28. Ahmad, F., P.M.M. Khalid, M. Khan, A.K. Chaubey, Rastogi and J.R. Kidwai, 1995. Hypoglycemic activity of pterocarpus marsupium wood. J. Ethenopharm., 35: 71-75.
29. Khosia, P., D. Gupta and R.K. Nagpal, 1995. Effect of trigonella foenom graecum (fenugreet) on blood glucose in normal and diabetic rats. Ind. J. Physiol. Pharmacol., 39: 173-174.
30. Rai, V., U. Lyer and U.V. Mani, 1997. Effect of Tulasi (Ocimum Sanctum) leaf powder supplementation on blood sugar levels serum lipids and tissue lipids in diabetic rats. Plant Foods, Human Nut., 50: 9-16.
31. Manisckam, M.M., M.A. Ramanthan, J.P. Jahromi, J. Chasouria and A.B. Ray, 1997. Antihyperglycemic activity of phenolics from Pterocapus marsupium. J. Nature Products, 60: 609-610.
32. Zubaida, A., A. Basil, A. Abdullah and Bomosa, 2001. Effect of Nigella sativa (Black seed) and thymoquin on blood glucose in albino rats Ann. Saudi Med., 21: 18-27.
33. Agel, M. and R. Shaheen, 1996. Effect of volatile oil of Nigella sativa seeds on the uterine smooth muscle of rat and guinea pig. J. Ethanopharmaco., 52: 23-26.
34. El-Tahir, K.E.H., M.M.S. Ashour and M.M. AL-Harbi, 1993. The cardiovascular actions of the volatile oil of the black seed (Nigella sativa) in rats. Elucidation of the mechanism(s). Gen. Pharmacol., 24: 1123-1131.
35. Hanafy, M. and M. Hatem, 1991. Studies on theantimicrobial activity of Nigella sativa seed (Black cumin). J. Ethopharmacol., 34: 275-278.
36. Zaou, A., Y. Cherrah, M.A. Lacaille, E. Dobous, A. Settaf, H. Amarouch and M. Hassar, 2000. Diuretic and hypotensive effects of Nigella sativa in the spontaneously hypertensive rat. Thrapie., 55: 379-382.
37. Tuk, J., 2003. Effect of Nigella sativa on liver necrosis. Vet. Anim. Sci., 27: 141-152.
38. Abdel, M.A., M. El Feki and E. Saleh, 1998. Effect of Nigella sativa, fish oil and localized on alloxan diabetic rats. Biochemical and histopath studies. J. Egypt. Ger. Soc. Zool., 23: 237-265.
39. Ismail, M., Y. Ozbek and R. Ustun, 2003. Effects of Nigella sativa on serum concentration TSH and glucose in induced diabetic rabbits. J. Irish Vet., 56: 446-484.
40. Farida, M., F.M. Al-Awadi and K.A. Gumaa, 1987. Studies on the activity of individual plants of an antidiabetic plant mixture. Acta Diabetol Lat., 24: 37-41.
41. Shapiro, E.T., K.S. Polonsky, G. Copinschi, D. Bosson, H. Tillil, J. Blackman, G. Lewis and E. Van Cauter, 1991. Nocturnal elevation of glucose levels during fasting in noninsulin-dependent diabetes. J. Clin. Endocrinol. Metab., 72: 444-454.
42. Scribner, K.A., S.F. Akana, C.D. Walker and M.F. Dallman, 1993. Streptozotocin-diabetic rats exhibit facilitated adrenocorticotropin responses to acute stress, but normal sensitivity to feedback by corticosteroids. Endocrinology., 133: 2667-674.
43. De Nicola, A.F., O. Fridman, E.J. Del Castillo and V.G. Foglia, 1976. The influence of streptozotocin diabetes on adrenal function in male rats. Horm Metab Res., 8: 388-392.
44. Chan, O., S. Chan, K. Inouye, M. Vranic and S.G. Matthews, 2001. Molecular regulation of the hypothalamo-pituitary-adrenal (HPA) axis in streptozotocin-induced diabetes: Effects of insulin treatment. Endocrinology., 142: 4872-4879.
45. Unger, R.H., 1978. Role of glucagon in the pathogenesis of diabetes: The status of the controversy. Metabolism., 27: 1691-1709.
46. Lefebvre, P.J.and A.S. Luyckx, 1979. Glucagon and diabetes: A reappraisal. Diabetologia., 16: 347-354.
47. Reagan, L.P., A.M. Magarinos, L. R. Lucas, A. Van Bueren A.L. McCall and B.S. McEwen, 1999. Regulation of GLUT-3 glucose transporter in the hippocampus of diabetic rats subjected to stress. Am. J. Physiol., 276: E879-E886.
48. Cryer, P.E.and J.E. Gerich, 1997. Hypoglycemia in Insulin-dependent Diabetes Mellitus: Interplay of Insulin Excess and Comprised Glucose Counterregulation. In: Porte, Jr.D. and R.S. Sherwin (Eds). Ellenberg and Rifkin's diabetes mellitus. Stamford, CT: Appleton and Lange, pp: 745-760.