Differential progression of neonatal diethylstilbestrol-induced disruption of the hamster testis and seminal vesicle

Reproductive Toxicology

Volumn 21, Issue 3, 2006, Pages 225-240

  Hendry III, William J ^a   Weaver, Benjamin P ^a   Naccarato, Teran R ^a   Khan, Shafiq A ^b  

^a WICHITA STATE UNIVERSITY   (United States)

^b CLARK ATLANTA UNIVERSITY   (United States)

Author keywords

Diethylstilbestrol (DES); Endocrine disruption; Male reproductive system; Seminal vesicle; Testis

Indexed keywords

ANDROGEN; DIETHYLSTILBESTROL; ESTROGEN; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DYSPLASIA; EXTRACELLULAR MATRIX; FEMALE; GENITAL SYSTEM; HAMSTER; HISTOPATHOLOGY; MALE; MORPHOLOGY; NEUTROPHIL CHEMOTAXIS; NEWBORN; NONHUMAN; SEMINAL VESICLE DISEASE; STROMA CELL; TERATOGENICITY; TESTIS ATROPHY; TESTIS DISEASE; TESTOSTERONE BLOOD LEVEL; UPREGULATION; WESTERN BLOTTING;

ANIMALS; ANIMALS, NEWBORN; CRICETINAE; DIETHYLSTILBESTROL; ENDOCRINE DISRUPTORS; MALE; ORGAN SIZE; PROTEINS; SEMINAL VESICLES; TESTIS; TESTOSTERONE; TIME FACTORS;

ANIMALIA; CRICETINAE;

EID: 33644533188     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2005.09.014     Document Type: Article

References (71)

1. E.C. Dodds, L. Goldberg, W. Lawson, and R. Robinson Estrogenic activity of certain synthetic compounds Nature 141 1938 247 248
2. S.H. Swan Intrauterine exposure to diethylstilbestrol: long-term effects in humans Apmis 108 12 2000 793 804
3. A.L. Herbst, H. Ulfelder, and D.C. Poskanzer Adenocarcinoma of the vagina: association of maternal stilbestrol therapy with tumor appearance in young women New Engl J Med 284 1971 878 881
4. A.L. Herbst, H. Ulfelder, and D.C. Poskanzer Perinatal carcinogenesis Natl Cancer Inst Monograph 51 1971 25 35
5. R. Mittendorf Teratogen update: carcinogenesis and teratogenesis associated with exposure to diethylstilbestrol (DES) in utero Teratology 51 1995 435 445
6. M. Metzler The metabolism of diethylstilbestrol CRC Crit Rev Biochem 10 3 1981 171 212
7. J.A. McLachlan, R.R. Newbold, M.E. Burow, and S.F. Li From malformations to molecular mechanisms in the male: three decades of research on endocrine disrupters Apmis 109 4 2001 263 272
8. H.A. Bern Diethylstilbestrol (DES) syndrome: present status of animal and human studies J.J. Li S. Nandi Hormonal carcinogenesis 1991 Springer-Verlag New York 1 8
9. T.L. Greco, T.M. Duello, and J. Gorski Estrogen receptors, estradiol, and diethylstilbestrol in early development: the mouse as a model for the study of estrogen receptors and estrogen sensitivity in embryonic development of male and female reproductive tracts Endocr Rev 14 1 1993 59 71
10. M. Marselos, and L. Tomatis Diethylstilbestrol: II. pharmacology, toxicology and carcinogenicity in experimental animals Eur J Cancer 29A 1993 149 155
11. R. Newbold Cellular and molecular effects of developmental exposure to diethylstilbestrol: Implications for other environmental estrogens Environ Health Perspect Suppl. 7 1995 83 87
12. W.J. Hendry III, D.M. Sheehan, S.A. Khan, and J.V. May Developing a laboratory animal model for perinatal endocrine disruption: the hamster chronicles Exp Biol Med 227 2002 709 723
13. S. Karri, H. Johnson, W.J. Hendry 3rd, S.C. Williams, and S.A. Khan Neonatal exposure to diethylstilbestrol leads to impaired action of androgens in adult male hamsters Reprod Toxicol 19 1 2004 53 63
14. S.A. Khan, R.B. Ball, and W.J. Hendry III Effects of neonatal administration of diethylstilbestrol in male hamsters: disruption of reproductive function in adults after apparently normal pubertal development Biol Reprod 58 1998 137 142
15. W.J. Hendry III, B.L. DeBrot, X. Zheng, W.S. Branham, and D.M. Sheehan Differential activity of diethylstilbestrol vs. estradiol as neonatal endocrine disruptors in the female hamster (Mesocricetus auratus) reproductive tract Biol Reprod 61 1999 91 100
16. W.J. Hendry 3rd, W.S. Branham, and D.M. Sheehan Diethylstilbestrol versus estradiol as neonatal disruptors of the hamster (Mesocricetus auratus) cervix Biol Reprod 70 5 2004 1306 1316
17. A.L. Herbst, R.E. Scully, and S.J. Robboy Prenatal diethylstilbestrol exposure and human genital tract abnormalities Natl Cancer Inst Monograph 51 1979 25 35
18. P. Niklowitz, S. Khan, M. Bergmann, K. Hoffmann, and E. Nieschlag Differential effects of follicle-stimulating hormone and luteinizing hormone on Leydig cell function and restoration of spermatogenesis in hypophysectomized and photoinhibited Djungarian hamsters (Phodopus sungorus) Biol Reprod 41 5 1989 871 880
19. A.A. Ismail, G.D. Niswender, and A.R. Midgley Jr. Radioimmunoassay of testosterone without chromatography J Clin Endocrinol Metab 34 1 1972 177 184
20. J. Gobinet, N. Poujol, and C. Sultan Molecular action of androgens Mol Cell Endocrinol 198 1-2 2002 15 24
21. C.L. Wu, S.D. Kirley, H. Xiao, Y. Chuang, D.C. Chung, and L.R. Zukerberg Cables enhances cdk2 tyrosine 15 phosphorylation by Weel, inhibits cell growth, and is lost in many human colon and squamous cancers Cancer Res 61 19 2001 7325 7332
22. L.R. Zukerberg, R.L. DeBernardo, S.D. Kirley, M. D'Apuzzo, M.P. Lynch, and R.D. Littell Loss of cables, a cyclin-dependent kinase regulatory protein, is associated with the development of endometrial hyperplasia and endometrial cancer Cancer Res 64 1 2004 202 208
23. M.J. Wheelock, and K.R. Johnson Cadherins as modulators of cellular phenotype Annu Rev Cell Dev Biol 19 2003 207 235
24. S.H. Keller, and S.K. Nigam Biochemical processing of E-cadherin under cellular stress Biochem Biophys Res Commun 307 2 2003 215 223
25. K.M. Hajra, and E.R. Fearon Cadherin and catenin alterations in human cancer Genes Chromosomes Cancer 34 3 2002 255 268
26. S. Hirohashi, and Y. Kanai Cell adhesion system and human cancer morphogenesis Cancer Sci 94 7 2003 575 581
27. W.J. Nelson, and R. Nusse Convergence of Wnt, beta-catenin, and cadherin pathways Science 303 5663 2004 1483 1487
28. S. Menard, P. Casalini, M. Campiglio, S.M. Pupa, and E. Tagliabue Role of HER2/neu in tumor progression and therapy Cell Mol Life Sci 61 23 2004 2965 2978
29. P. Valenti, F. Berlutti, M.P. Conte, C. Longhi, and L. Seganti Lactoferrin functions: current status and perspectives J Clin Gastroenterol 38 6 Suppl. 2004 S127 S129
30. C.T. Teng Lactoferrin gene expression and regulation: an overview Biochem Cell Biol 80 1 2002 7 16
31. B.T. Pentecost, R.R. Newbold, C.T. Teng, and J.A. McLachlan Prenatal exposure of male mice to diethylstilbestrol alter the expression of the lactotransferrin gene in seminal vesicles Mol Endocrinol 2 12 1988 1243 1248
32. R.R. Newbold, B.T. Pentecost, S. Yamashita, K. Lum, J.V. Miller, and P. Nelson Female gene expression in the seminal vesicle of mice after prenatal exposure to diethylstilbestrol Endocrinology 124 5 1989 2568 2576
33. W.C. Beckman Jr., R.R. Newbold, C.T. Teng, and J.A. McLachlan Molecular feminization of mouse seminal vesicle by prenatal exposure to diethylstilbestrol: altered expression of messenger RNA J Urol 151 5 1994 1370 1378
34. M.S. Hayden, and S. Ghosh Signaling to NF-kappaB Genes Dev 18 18 2004 2195 2224
35. A. Kumar, Y. Takada, A.M. Boriek, and B.B. Aggarwal Nuclear factor-kappaB: its role in health and disease J Mol Med 82 7 2004 434 448
36. F. McKeon p63 and the epithelial stem cell: more than status quo? Genes Dev 18 5 2004 465 469
37. M.D. Westfall, and J.A. Pietenpol p63: molecular complexity in development and cancer Carcinogenesis 25 6 2004 857 864
38. F.J.J.V.I. Beier The discovery of uteroglobin and its significance for reproductive biology and endocrinology Ann N Y Acad Sci 923 2000 9 24
39. A.J. Vomachka, and G.S. Greenwald The development of gonadotropin and steroid hormone patterns in male and female hamsters from birth to puberty Endocrinology 105 4 1979 960 966
40. L.L. Miller, J.M. Whitsett, J.G. Vandenbergh, and D.R. Colby Physical and behavioral aspects of sexual maturation in male golden hamsters J Comp Physiol Psychol 91 2 1977 245 259
41. L.R. Mata Dynamics of the seminal vesicle epithelium Int Rev Cytol 160 1995 267 302
42. A. Limanowski, B. Miskowiak, and B. Otulakowski Effect of estrogenization in the first day of life on the reproductive system in male rats Histol Histopathol 9 1 1994 59 63
43. W.W. Leavitt, R.W. Evans, and W.J. Hendry III Etiology of DES-induced uterine tumors in the Syrian hamster WW. Leavitt Hormones and cancer 1982 Plenum Publishing Corporation New York 63 86
44. W.J. Hendry III, and W.W. Leavitt Altered morphogenesis of the immature hamster uterus following neonatal exposure to diethylstilbestrol Differentiation 52 1993 221 227
45. X. Zheng, and W.J. Hendry III Neonatal diethylstilbestrol treatment alters the estrogen-regulated expression of both cell proliferation and apoptosis-related protooncogenes (c-jun, c-fos, c-myc, bax, bcl-2 and bcl-x) in the hamster uterus Cell Growth Differ 8 1997 425 434
46. W.J. Hendry III, X. Zheng, W.W. Leavitt, W.S. Branham, and D.M. Sheehan Endometrial hyperplasia and apoptosis following neonatal diethylstilbestrol exposure and subsequent estrogen stimulation in both host and transplanted hamster uteri Cancer Res 57 1997 1903 1908
47. T. Turner, M. Edery, K.T. Mills, and H.A. Bern Influence of neonatal diethylstilbestrol treatment on androgen and estrogen receptor levels in the mouse anterior prostate, ventral prostate and seminal vesicle J Steroid Biochem 32 4 1989 559 564
48. T. Sato, A. Chiba, S. Hayashi, H. Okamura, Y. Ohta, and N. Takasugi Induction of estrogen receptor and cell division in genital tracts of male mice by neonatal exposure to diethylstilbestrol Reprod Toxicol 8 2 1994 145 153
49. L.K. Salo, S.I. Makela, G.M. Stancel, and R.S. Santti Neonatal exposure to diethylstilbestrol permanently alters the basal and 17 beta-estradiol induced expression of c-fos proto-oncogene in mouse urethroprostatic complex Mol Cell Endocrinol 126 2 1997 133 141
50. R.M. Sharpe, N. Atanassova, C. McKinnell, P. Parte, K.J. Turner, and J.S. Fisher Abnormalities in functional development of the Sertoli cells in rats treated neonatally with diethylstilbestrol: a possible role for estrogens in Sertoli cell development Biol Reprod 59 5 1998 1084 1094
51. H.O. Goyal, T.D. Braden, C.S. Williams, P. Dalvi, M.M. Mansour, and M. Mansour Abnormal morphology of the penis in male rats exposed neonatally to diethylstilbestrol is associated with altered profile of estrogen receptor-alpha protein, but not of androgen receptor protein: a developmental and immunocytochemical study Biol Reprod 70 5 2004 1504 1517
52. Y. Wang, R. Thuillier, and M. Culty Prenatal estrogen exposure differentially affects estrogen receptor-associated proteins in rat testis gonocytes Biol Reprod 71 5 2004 1652 1664
53. W.J. Hendry III, X. Zheng, W.W. Leavitt, W.S. Branham, and D.M. Sheehan Synthetic estrogen-mediated alterations in uterine cell fate J.L. Tilly J.F. Strauss III M. Tenniswood Serono International Symposium on Cell Death in Reproductive Physiology New York, Springer-Verlag Inc. 1997 272 291
54. D. Nonclercq, J. Zanen, G. Toubeau, G. Laurent, and J.A. Heuson-Stiennon Apoptosis and cell proliferation in the seminal vesicles and coagulating glands of male Syrian hamsters exposed to diethylstilboestrol (DES) Reprod Fertil Dev 11 2 1999 111 122
55. R. Nair, and C. Shaha Diethylstilbestrol induces rat spermatogenic cell apoptosis in vivo through increased expression of spermatogenic cell Fas/FasL system J Biol Chem 278 8 2003 6470 6481
56. C.H. Qiu, M. Ohe, N. Koibuchi, and S. Matsuzaki Apoptosis in the epididymal epithelium of adult male golden hamster exposed to diethylstilbestrol J Histochem Cytochem 52 2 2004 187 192
57. V. Yerly-Motta, J.J. Pavy, S.F. Bosset, F. Arbez-Gindre, and P. Herve Validity of PCNA immunostaining in normal and tumor cells: comparison with Ki-67 labeling J Histotech 22 1999 287 293
58. G. Maga, and U. Hubscher Proliferating cell nuclear antigen (PCNA): a dancer with many partners J Cell Sci 116 Pt 2003 3051 3060
59. J.R. Friedman, W.J. Fredericks, D.E. Jensen, D.W. Speicher, X.P. Huang, and E.G. Neilson KAP-1, a novel corepressor for the highly conserved KRAB repression domain Genes Dev 10 16 1996 2067 2078
60. S.S. Kim, Y.M. Chen, E. O'Leary, R. Witzgall, M. Vidal, and J.V. Bonventre A novel member of the RING finger family, KRIP-1, associates with the KRAB-A transcriptional repressor domain of zinc finger proteins Proc Natl Acad Sci USA 93 26 1996 15299 15304
61. P. Moosmann, O. Georgiev, B. Le Douarin, J.P. Bourquin, and W. Schaffner Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of K0X1 Nucleic Acids Res 24 24 1996 4859 4867
62. P. Weber, F. Cammas, C. Gerard, D. Metzger, P. Chambon, and R. Losson Germ cell expression of the transcriptional co-repressor TIFlbeta is required for the maintenance of spermatogenesis in the mouse Development 129 2002 2329 2337
63. J.M. Paramio, and J.L. Jorcano Beyond structure: do intermediate filaments modulate cell signalling? Bioessays 24 9 2002 836 844
64. Z. Nawaz, and B.W. O'Malley Urban renewal in the nucleus: is protein turnover by proteasomes absolutely required for nuclear receptor-regulated transcription? Mol Endocrinol 18 3 2004 493 499
65. K. Williams, J.S. Fisher, K.J. Turner, C. McKinnell, P.T. Saunders, and R.M. Sharpe Relationship between expression of sex steroid receptors and structure of the seminal vesicles after neonatal treatment of rats with potent or weak estrogens Environ Health Perspect 109 12 2001 1227 1235
66. M.D. Planas-Silva, Y. Shang, J.L. Donaher, M. Brown, and R.A. Weinberg AIB1 enhances estrogen-dependent induction of cyclin D1 expression Cancer Res 61 10 2001 3858 3862
67. J.T. Pai, M.S. Brown, and J.L. Goldstein Purification and cDNA cloning of a second apoptosis-related cysteine protease that cleaves and activates sterol regulatory element binding proteins Proc Natl Acad Sci USA 93 11 1996 5437 5442
68. L.H. Xu, X. Yang, R.J. Craven, and W.G. Cance The COOH-terminal domain of the focal adhesion kinase induces loss of adhesion and cell death in human tumor cells Cell Growth Differ 9 12 1998 999 1005
69. C.T. Teng, M.P. Walker, S.N. Bhattacharyya, D.G. Klapper, R.P. DiAugustine, and J.A. McLachlan Purification and properties of an estrogen-stimulated mouse uterine glycoprotein (approx. 70 kDa) Biochem J 240 1986 413 422
70. J.E. Murphy-Ullrich, V.A. Lightner, I. Aukhil, Y.Z. Yan, H.P. Erickson, and M. Hook Focal adhesion integrity is downregulated by the alternatively spliced domain of human tenascin J Cell Biol 115 4 1991 1127 1136
71. T. Kikukawa, B.D. Cowan, R.I. Tejada, and A.B. Mukherjee Partial characterization of a uteroglobin-like protein in the human uterus and its temporal relationship to prostaglandin levels in this organ J Clin Endocrinol Metab 67 2 1988 315 321