Enhancement of membrane fluidity in cholesterol-poor endothelial cells pre-treated with simvastatin

Endothelium: Journal of Endothelial Cell Research

Volumn 5, Issue 2, 1997, Pages 107-113

  Morita, Ikuo ^a   Sato, Ikuko ^a   Ma, Lijuan ^a   Murota, Sei Itsu ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Cholesterol; HMG CoA reductase inhibitor; Membrane fluidity; Proliferation; Simvastatin

Indexed keywords

CHOLESTEROL; HYPOCHOLESTEROLEMIC AGENT; LOW DENSITY LIPOPROTEIN; SIMVASTATIN;

ANIMAL CELL; ARTICLE; CAROTID ARTERY; CATTLE; CELL CULTURE; CELL MEMBRANE FLUIDITY; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; ENDOTHELIUM CELL; NONHUMAN;

ANIMALIA; BOS TAURUS;

EID: 0030988839     PISSN: 10623329     EISSN: None     Source Type: Journal    
DOI: 10.3109/10623329709079868     Document Type: Article

References (18)

1. Caplan, B. and Schwartz, C. (1973) Increased endothelial cell turnover in areas of in vivo evans blue uptake in the pig aorta. Atherosclerosis, 17, 401-417.
2. Chariot, P., Abadia, R., Danan, C. and Charpentier, C. (1993) Simvastatin-induced rhabdomyolysis followed by a melas syndrome. Am. J. Med., 94, 109-110.
3. Corsini, A., Raiteri, M., Soma, M., Fumagalli, R. and Paoletti, R. (1991) Simvastatin but not pravastatin inhibits the proliferation of rat aorta myocytes. Pharmacol. Res., 23, 173-180.
4. Corsini, A., Mazzotti, M., Raiteri, M., Soma, M., Gabbiani, G., Fumagalli, R. and Paoletti, R. (1993) Relationship between mevalonate pathway and arterial myocyte proliferation: in vitro studies with inhibitors of HMG-CoA reductase. Atherosclerosis, 101, 117-125.
5. Duits, N. and Bos, F. M. (1993) Depressive symptoms and cholesterol-lowering drugs. Lancet, 341, 114.
6. Engelberg, H. (1992) Low serum cholesterol and suicide. Lancet, 339, 727-729.
7. Falke, P., Mattiasson, I., Stavenow, L. and Hood, B. (1989) Effects of a competitive inhibitor (mevinolin) of 3-hydroxy-3-methylglutaryl coenzyme A reductase on human and bovine endothelial cells, fibroblasts and smooth muscle cells in vitro. Pharmacol. Toxicol., 64, 173-176.
8. Florentin, R., Nam, S., Lee, K., Lee, K. and Thomas, W. (1969) Increased mitotic activity in aortas of swine. After three days of cholesterol feeding. Arch. Path., 88, 463-469.
9. Goldstein, J. L. and Brown, M. S. (1990) Regulation of the mevalonate pathway. Nature, 343, 425-429.
10. Hansson, G. K. and Schwartz, S. M. (1983) Evidence for cell death in the vascular endothelium in vivo and in vitro. Am. J. Pathol., 112, 278-286.
11. Kanayasu-Toyoda, T., Morita, I., Hibino, H., Nakao-Hayashi, J., Ito, H. and Murota, S. (1993) Eicosapentaenoic acid abolishes the proatherogenic effects of cholesterol: effects on migration of bovine smooth muscle and endothelial cells in vitro. Prostaglandins Leukotrienes and Essential Fatty Accids, 48, 463-468.
12. Ma, L., Morita, I. and Murota, S. (1994) Enhancement of migration activity in cholesterol-poor endothelial cells by pre-treating with HMG-CoA reductase inhibitors. Biochem. Biophys. Res. Commun., 203, 1355-1361.
13. Morita, I., Kanayasu, T. and Murota, S. (1984) Kallikrein stimulates prostacyclin production in bovine vascular endothelial cells. Biochim. Biophys. Acta, 792, 304-309.
14. Pilchard, J., K, A., Schwarz, S. M., Medow, M. S. and Stemerman, M. B. (1991) Effect of low-density lipoprotein on endothelial cell membrane fluidity and mononuclear cell attachment. Am. J. Physiol., 260, C43-C49.
15. Sato-Suzuki, I. and Murota, S. Simvastatin inhibits the division and induces neurite-like outgrowth in PC 12 cells. Neuroscience Lett., in press.
16. Sheetz, M. P., Schindler, M. and Koppel, D. E. (1980) Lateral mobility of integral membrane proteins is increased in spherocytic erythrocytes. Nature, 285, 510-511.
17. Smith, G. D. and Pekkanen, J. (1992) Should there be a moratorium on the use of cholesterol lowering drugs? BMJ, 304, 431-434.
18. Soma, M. R., Corsini, A. and Paoletti, R. (1992) Cholesterol and mevalonic acid modulation in cell metabolism and multiplication. Toxicol. Lett., 64/65, 1-15.