-
1
-
-
0033571463
-
Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus
-
Ago, H., T. Adachi, A. Yoshida, M. Yamamoto, N. Habuka, K. Yatsunami, and M. Miyano. 1999. Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus. Structure Fold Des. 7:1417-1426.
-
(1999)
Structure Fold Des.
, vol.7
, pp. 1417-1426
-
-
Ago, H.1
Adachi, T.2
Yoshida, A.3
Yamamoto, M.4
Habuka, N.5
Yatsunami, K.6
Miyano, M.7
-
2
-
-
0036835773
-
Hepatitis C virus replicons: Potential role for drug development
-
Bartenschlager, R. 2002. Hepatitis C virus replicons: potential role for drug development. Nat. Rev. Drug Discov. 1:911-916.
-
(2002)
Nat. Rev. Drug Discov.
, vol.1
, pp. 911-916
-
-
Bartenschlager, R.1
-
3
-
-
0030065766
-
Mechanism of ubiquitin conjugating enzyme E2-230K: Catalysis involving a thiol relay?
-
Berleth, E. S., and C. M. Pickart. 1996. Mechanism of ubiquitin conjugating enzyme E2-230K: catalysis involving a thiol relay? Biochemistry 35:1664-1671.
-
(1996)
Biochemistry
, vol.35
, pp. 1664-1671
-
-
Berleth, E.S.1
Pickart, C.M.2
-
4
-
-
0029661442
-
Spatial proximity of Cys113, Cys172, and Cys422 in the metalloactivation domain of the ArsA ATPase
-
Bhattacharjee, H., and B. P. Rosen. 1996. Spatial proximity of Cys113, Cys172, and Cys422 in the metalloactivation domain of the ArsA ATPase. J. Biol. Chem. 271:24465-24470.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 24465-24470
-
-
Bhattacharjee, H.1
Rosen, B.P.2
-
5
-
-
0034623816
-
Efficient initiation of HCV RNA replication in cell culture
-
Blight, K. J., A. A. Kolykhalov, and C. M. Rice. 2000. Efficient initiation of HCV RNA replication in cell culture. Science 290:1972-1974.
-
(2000)
Science
, vol.290
, pp. 1972-1974
-
-
Blight, K.J.1
Kolykhalov, A.A.2
Rice, C.M.3
-
6
-
-
0036120573
-
Structural analysis of the hepatitis C virus RNA polymerase in complex with ribonucleotides
-
Bressanelli, S., L. Tomei, F. A. Rey, and R. De Francesco. 2002. Structural analysis of the hepatitis C virus RNA polymerase in complex with ribonucleotides. J. Virol. 76:3482-3492.
-
(2002)
J. Virol.
, vol.76
, pp. 3482-3492
-
-
Bressanelli, S.1
Tomei, L.2
Rey, F.A.3
De Francesco, R.4
-
7
-
-
0033539482
-
Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus
-
Bressanelli, S., L. Tomei, A. Roussel, I. Incitti, R. L. Vitale, M. Mathieu, R. De Francesco, and F. A. Rey. 1999. Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus. Proc. Natl. Acad. Sci. USA 96:13034-13039.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 13034-13039
-
-
Bressanelli, S.1
Tomei, L.2
Roussel, A.3
Incitti, I.4
Vitale, R.L.5
Mathieu, M.6
De Francesco, R.7
Rey, F.A.8
-
8
-
-
0030610686
-
3 dose-dependent dual effects on APL cells
-
3 dose-dependent dual effects on APL cells. Blood 89:3345-3353.
-
(1997)
Blood
, vol.89
, pp. 3345-3353
-
-
Chen, G.Q.1
Shi, X.G.2
Tang, W.3
Xiong, S.M.4
Zhu, J.5
Cai, X.6
Han, Z.G.7
Ni, J.H.8
Shi, G.Y.9
Jia, P.M.10
Liu, M.M.11
He, K.L.12
Niu, C.13
Ma, J.14
Zhang, P.15
Zhang, T.D.16
Paul, P.17
Naoe, T.18
Kitamura, K.19
Miller, W.20
Waxman, S.21
Wang, Z.Y.22
De The, H.23
Chen, S.J.24
Chen, Z.25
more..
-
9
-
-
0036551428
-
Expanding the use of arsenic trioxide: Leukemias and beyond
-
Chen, Z., G. Q. Chen, Z. X. Shen, G. L. Sun, J. H. Tong, Z. Y. Wang, and S. J. Chen. 2002. Expanding the use of arsenic trioxide: leukemias and beyond. Semin. Hematol. 39:22-26.
-
(2002)
Semin. Hematol.
, vol.39
, pp. 22-26
-
-
Chen, Z.1
Chen, G.Q.2
Shen, Z.X.3
Sun, G.L.4
Tong, J.H.5
Wang, Z.Y.6
Chen, S.J.7
-
10
-
-
0024509701
-
Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
-
Choo, Q. L., G. Kuo, A. J. Weiner, L. R. Overby, D. W. Bradley, and M. Houghton. 1989. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 244:359-362.
-
(1989)
Science
, vol.244
, pp. 359-362
-
-
Choo, Q.L.1
Kuo, G.2
Weiner, A.J.3
Overby, L.R.4
Bradley, D.W.5
Houghton, M.6
-
11
-
-
0025899234
-
Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in culture
-
Cory, A. H., T. C. Owen, J. A. Barltrop, and J. G. Cory. 1991. Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in culture. Cancer Commun. 3:207-212.
-
(1991)
Cancer Commun.
, vol.3
, pp. 207-212
-
-
Cory, A.H.1
Owen, T.C.2
Barltrop, J.A.3
Cory, J.G.4
-
12
-
-
0028263005
-
Mechanism of inhibition of trypanothione reductase and glutathione reductase by trivalent organic arsenicals
-
Cunningham, M. L., M. J. Zvelebil, and A. H. Fairlamb. 1994. Mechanism of inhibition of trypanothione reductase and glutathione reductase by trivalent organic arsenicals. Eur. J. Biochem. 221:285-295.
-
(1994)
Eur. J. Biochem.
, vol.221
, pp. 285-295
-
-
Cunningham, M.L.1
Zvelebil, M.J.2
Fairlamb, A.H.3
-
13
-
-
0037179698
-
Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection
-
Fried, M. W., M. L. Shiffman, K. R. Reddy, C. Smith, G. Marinos, F. L. Goncales, Jr., D. Haussinger, M. Diago, G. Carosi, D. Dhumeaux, A. Craxi, A. Lin, J. Hoffman, and J. Yu. 2002. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N. Engl. J. Med. 347:975-982.
-
(2002)
N. Engl. J. Med.
, vol.347
, pp. 975-982
-
-
Fried, M.W.1
Shiffman, M.L.2
Reddy, K.R.3
Smith, C.4
Marinos, G.5
Goncales Jr., F.L.6
Haussinger, D.7
Diago, M.8
Carosi, G.9
Dhumeaux, D.10
Craxi, A.11
Lin, A.12
Hoffman, J.13
Yu, J.14
-
14
-
-
0029036955
-
The search for synergy: A critical review from a response surface perspective
-
Greco, W. R., G. Bravo, and J. C. Parsons. 1995. The search for synergy: a critical review from a response surface perspective. Pharmacol. Rev. 47:331-385.
-
(1995)
Pharmacol. Rev.
, vol.47
, pp. 331-385
-
-
Greco, W.R.1
Bravo, G.2
Parsons, J.C.3
-
15
-
-
0037430142
-
Very low concentrations of arsenite suppress poly(ADP-ribosyl)ation in mammalian cells
-
Hartwig, A., A. Pelzer, M. Asmuss, and A. Burkle. 2003. Very low concentrations of arsenite suppress poly(ADP-ribosyl)ation in mammalian cells. Int. J. Cancer 104:1-6.
-
(2003)
Int. J. Cancer
, vol.104
, pp. 1-6
-
-
Hartwig, A.1
Pelzer, A.2
Asmuss, M.3
Burkle, A.4
-
16
-
-
0014577385
-
Measurement of the potencies of drug mixtures
-
Hewlett, P. S. 1969. Measurement of the potencies of drug mixtures. Biometrics 25:477-487.
-
(1969)
Biometrics
, vol.25
, pp. 477-487
-
-
Hewlett, P.S.1
-
17
-
-
0028675536
-
Effects of co-expressing chaperone BiP on functional antibody production in the baculovirus system
-
Hsu, T. A., J. J. Eiden, P. Bourgarel, T. Meo, and M. J. Betenbaugh. 1994. Effects of co-expressing chaperone BiP on functional antibody production in the baculovirus system. Protein Expr. Purif. 5:595-603.
-
(1994)
Protein Expr. Purif.
, vol.5
, pp. 595-603
-
-
Hsu, T.A.1
Eiden, J.J.2
Bourgarel, P.3
Meo, T.4
Betenbaugh, M.J.5
-
18
-
-
0034680928
-
Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of IκB kinase
-
Kapahi, P., T. Takahashi, G. Natoli, S. R. Adams, Y. Chen, R. Y. Tsien, and M. Karin. 2000. Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of IκB kinase. J. Biol. Chem. 275:36062-36066.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 36062-36066
-
-
Kapahi, P.1
Takahashi, T.2
Natoli, G.3
Adams, S.R.4
Chen, Y.5
Tsien, R.Y.6
Karin, M.7
-
19
-
-
0036435567
-
Expression of HCV structural proteins impairs IFN-mediated antiviral response
-
Keskinen, P., K. Melen, and I. Julkunen. 2002. Expression of HCV structural proteins impairs IFN-mediated antiviral response. Virology 299:164.
-
(2002)
Virology
, vol.299
, pp. 164
-
-
Keskinen, P.1
Melen, K.2
Julkunen, I.3
-
20
-
-
0031577528
-
An improved, rapid Northern protocol
-
Kevil, C. G., L. Walsh, F. S. Laroux, T. Kalogeris, M. B. Grisham, and J. S. Alexander. 1997. An improved, rapid Northern protocol. Biochem. Biophys. Res. Commun. 238:277-279.
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.238
, pp. 277-279
-
-
Kevil, C.G.1
Walsh, L.2
Laroux, F.S.3
Kalogeris, T.4
Grisham, M.B.5
Alexander, J.S.6
-
21
-
-
0035811625
-
Hepatitis C virus infection
-
Lauer, G. M., and B. D. Walker. 2001. Hepatitis C virus infection. N. Engl. J. Med. 345:41-52.
-
(2001)
N. Engl. J. Med.
, vol.345
, pp. 41-52
-
-
Lauer, G.M.1
Walker, B.D.2
-
22
-
-
0346096567
-
A reporter-based assay for identifying hepatitis C virus inhibitors based on subgenomic replicon cells
-
Lee, J.-C., C.-F. Chang, Y.-H. Chi, D.-R. Hwang, and J. T.-A. Hsu. 2004. A reporter-based assay for identifying hepatitis C virus inhibitors based on subgenomic replicon cells. J. Virol. Methods 116:27-33.
-
(2004)
J. Virol. Methods
, vol.116
, pp. 27-33
-
-
Lee, J.-C.1
Chang, C.-F.2
Chi, Y.-H.3
Hwang, D.-R.4
Hsu, J.T.-A.5
-
23
-
-
0037447831
-
Development of a cell-based assay for monitoring specific hepatitis C virus NS3/4A protease activity in mammalian cells
-
Lee, J. C., Y. F. Shih, S. P. Hsu, T. Y. Chang, L. H. Chen, and J. T. Hsu. 2003. Development of a cell-based assay for monitoring specific hepatitis C virus NS3/4A protease activity in mammalian cells. Anal. Biochem. 316:162-170.
-
(2003)
Anal. Biochem.
, vol.316
, pp. 162-170
-
-
Lee, J.C.1
Shih, Y.F.2
Hsu, S.P.3
Chang, T.Y.4
Chen, L.H.5
Hsu, J.T.6
-
24
-
-
0032876683
-
Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site
-
Lesburg, C. A., M. B. Cable, E. Ferrari, Z. Hong, A. F. Mannarino, and P. C. Weber. 1999. Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site. Nat. Struct. Biol. 6:937-943.
-
(1999)
Nat. Struct. Biol.
, vol.6
, pp. 937-943
-
-
Lesburg, C.A.1
Cable, M.B.2
Ferrari, E.3
Hong, Z.4
Mannarino, A.F.5
Weber, P.C.6
-
25
-
-
0034651580
-
Pathogenesis, natural history, treatment, and prevention of hepatitis C
-
Liang, T. J., B. Rehermann, L. B. Seeff, and J. H. Hoofnagle. 2000. Pathogenesis, natural history, treatment, and prevention of hepatitis C. Ann. Intern. Med. 132:296-305.
-
(2000)
Ann. Intern. Med.
, vol.132
, pp. 296-305
-
-
Liang, T.J.1
Rehermann, B.2
Seeff, L.B.3
Hoofnagle, J.H.4
-
26
-
-
0345188811
-
Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line
-
Lohmann, V., F. Korner, J. Koch, U. Herian, L. Theilmann, and R. Bartenschlager. 1999. Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science 285:110-113.
-
(1999)
Science
, vol.285
, pp. 110-113
-
-
Lohmann, V.1
Korner, F.2
Koch, J.3
Herian, U.4
Theilmann, L.5
Bartenschlager, R.6
-
27
-
-
0036566529
-
Tetra-arsenic tetra-sulfide for the treatment of acute promyelocytic leukemia: A pilot report
-
Lu, D.-P., J.-Y. Qiu, B. Jiang, Q. Wang, K.-Y. Liu, Y.-R. Liu, and S.-S. Chen. 2002. Tetra-arsenic tetra-sulfide for the treatment of acute promyelocytic leukemia: a pilot report. Blood 99:3136-3143.
-
(2002)
Blood
, vol.99
, pp. 3136-3143
-
-
Lu, D.-P.1
Qiu, J.-Y.2
Jiang, B.3
Wang, Q.4
Liu, K.-Y.5
Liu, Y.-R.6
Chen, S.-S.7
-
28
-
-
0346451031
-
Current study of APL treatment in China
-
Lu, D. P., and Q. Wang. 2002. Current study of APL treatment in China. Int. J. Hematol. 76(Suppl. 1):316-318.
-
(2002)
Int. J. Hematol.
, vol.76
, Issue.SUPPL. 1
, pp. 316-318
-
-
Lu, D.P.1
Wang, Q.2
-
29
-
-
0027939470
-
A direct, general approach based on isobolograms for assessing the joint action of drugs in pre-clinical experiments
-
Machado, S. G., and G. A. Robinson. 1994. A direct, general approach based on isobolograms for assessing the joint action of drugs in pre-clinical experiments. Stat. Med. 13:2289-2309.
-
(1994)
Stat. Med.
, vol.13
, pp. 2289-2309
-
-
Machado, S.G.1
Robinson, G.A.2
-
30
-
-
0037299113
-
Current therapy for hepatitis C: Pegylated interferon and ribavirin
-
McHutchison, J. G., and M. W. Fried. 2003. Current therapy for hepatitis C: pegylated interferon and ribavirin. Clin. Liver Dis. 7:149-161.
-
(2003)
Clin. Liver Dis.
, vol.7
, pp. 149-161
-
-
McHutchison, J.G.1
Fried, M.W.2
-
31
-
-
0032547938
-
Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C
-
McHutchison, J. G., S. C. Gordon, E. R. Schiff, M. L. Shiffman, W. M. Lee, V. K. Rustgi, Z. D. Goodman, M. H. Ling, S. Cort, J. K. Albrecht, et al. 1998. Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. N. Engl. J. Med. 339:1485-1492.
-
(1998)
N. Engl. J. Med.
, vol.339
, pp. 1485-1492
-
-
McHutchison, J.G.1
Gordon, S.C.2
Schiff, E.R.3
Shiffman, M.L.4
Lee, W.M.5
Rustgi, V.K.6
Goodman, Z.D.7
Ling, M.H.8
Cort, S.9
Albrecht, J.K.10
-
32
-
-
0037099645
-
Mechanisms of action of arsenic trioxide
-
Miller, W. H., Jr., H. M. Schipper, J. S. Lee, J. Singer, and S. Waxman. 2002. Mechanisms of action of arsenic trioxide, Cancer Res. 62:3893-3903.
-
(2002)
Cancer Res.
, vol.62
, pp. 3893-3903
-
-
Miller Jr., W.H.1
Schipper, H.M.2
Lee, J.S.3
Singer, J.4
Waxman, S.5
-
33
-
-
0038481253
-
Arsenic/interferon specifically reverses 2 distinct gene networks critical for the survival of HTLV-1-infected leukemic cells
-
Nasr, R., A. Rosenwald, M. E. El-Sabban, B. Arnulf, P. Zalloua, Y. Lepelletier, F. Bex, O. Hermine, L. Staudt, H. de The, and A. Bazarbachi. 2003. Arsenic/interferon specifically reverses 2 distinct gene networks critical for the survival of HTLV-1-infected leukemic cells. Blood 101:4576-4582.
-
(2003)
Blood
, vol.101
, pp. 4576-4582
-
-
Nasr, R.1
Rosenwald, A.2
El-Sabban, M.E.3
Arnulf, B.4
Zalloua, P.5
Lepelletier, Y.6
Bex, F.7
Hermine, O.8
Staudt, L.9
De The, H.10
Bazarbachi, A.11
-
34
-
-
0032585237
-
Randomised trial of interferon alpha2b plus ribavirin for 48 weeks or for 24 weeks versus interferon alpha2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus
-
Poynard, T., P. Marcellin, S. S. Lee, C. Niederau, G. S. Minuk, G. Ideo, V. Bain, J. Heathcote, S. Zeuzem, C. Trepo, J. Albrecht, et al. 1998. Randomised trial of interferon alpha2b plus ribavirin for 48 weeks or for 24 weeks versus interferon alpha2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus. Lancet 352:1426-1432.
-
(1998)
Lancet
, vol.352
, pp. 1426-1432
-
-
Poynard, T.1
Marcellin, P.2
Lee, S.S.3
Niederau, C.4
Minuk, G.S.5
Ideo, G.6
Bain, V.7
Heathcote, J.8
Zeuzem, S.9
Trepo, C.10
Albrecht, J.11
-
35
-
-
0141632671
-
Dynamics of subgenomic hepatitis C virus replicon RNA levels in Huh-7 cells after exposure to nucleoside antimetabolites
-
Stuyver, L. J., T. R. McBrayer, P. M. Tharnish, A. E. Hassan, C. K. Chu, K. W. Pankiewicz, K. A. Watanabe, R. F. Schinazi, and M. J. Otto. 2003. Dynamics of subgenomic hepatitis C virus replicon RNA levels in Huh-7 cells after exposure to nucleoside antimetabolites. J. Virol. 77:10689-10694.
-
(2003)
J. Virol.
, vol.77
, pp. 10689-10694
-
-
Stuyver, L.J.1
McBrayer, T.R.2
Tharnish, P.M.3
Hassan, A.E.4
Chu, C.K.5
Pankiewicz, K.W.6
Watanabe, K.A.7
Schinazi, R.F.8
Otto, M.J.9
-
36
-
-
0033636884
-
Hepatitis C virus and interferon resistance
-
Taylor, D. R., S. T. Shi, and M. M. Lai. 2000. Hepatitis C virus and interferon resistance. Microbes Infect. 2:1743-1756.
-
(2000)
Microbes Infect.
, vol.2
, pp. 1743-1756
-
-
Taylor, D.R.1
Shi, S.T.2
Lai, M.M.3
-
37
-
-
0035038845
-
History of the development of arsenic derivatives in cancer therapy
-
Waxman, S., and K. C. Anderson. 2001. History of the development of arsenic derivatives in cancer therapy. Oncologist 6(Suppl. 2):3-10.
-
(2001)
Oncologist
, vol.6
, Issue.SUPPL. 2
, pp. 3-10
-
-
Waxman, S.1
Anderson, K.C.2
-
38
-
-
0031567749
-
Hepatitis C: Global prevalence
-
World Health Organization. 1997. Hepatitis C: global prevalence. Wkly. Epidemiol. Rec. 72:341-344.
-
(1997)
Wkly. Epidemiol. Rec.
, vol.72
, pp. 341-344
-
-
-
39
-
-
0034761577
-
Identification of a hepatic factor capable of supporting hepatitis C virus replication in a nonpermissive cell line
-
Yeh, C. T., H. Y. Lai, T. C. Chen, C. M. Chu, and Y. F. Liaw. 2001. Identification of a hepatic factor capable of supporting hepatitis C virus replication in a nonpermissive cell line. J. Virol. 75:11017-11024.
-
(2001)
J. Virol.
, vol.75
, pp. 11017-11024
-
-
Yeh, C.T.1
Lai, H.Y.2
Chen, T.C.3
Chu, C.M.4
Liaw, Y.F.5
-
40
-
-
0036715589
-
Timeline: How acute promyelocytic leukaemia revived arsenic
-
Zhu, J., Z. Chen, V. Lallemand-Breitenbach, and H. De The. 2002. Timeline: how acute promyelocytic leukaemia revived arsenic. Nat. Rev. Cancer 2:705-714.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 705-714
-
-
Zhu, J.1
Chen, Z.2
Lallemand-Breitenbach, V.3
De The, H.4
-
41
-
-
0036464602
-
Synergic effects of arsenic trioxide and cAMP during acute promyelocytic leukemia cell maturation subtends a novel signaling cross-talk
-
Zhu, Q., J. W. Zhang, H. Q. Zhu, Y. L. Shen, M. Flexor, P. M. Jia, Y. Yu, X. Cai, S. Waxman, M. Lanotte, S. J. Chen, Z. Chen, and J. H. Tong. 2002. Synergic effects of arsenic trioxide and cAMP during acute promyelocytic leukemia cell maturation subtends a novel signaling cross-talk. Blood 99:1014-1022.
-
(2002)
Blood
, vol.99
, pp. 1014-1022
-
-
Zhu, Q.1
Zhang, J.W.2
Zhu, H.Q.3
Shen, Y.L.4
Flexor, M.5
Jia, P.M.6
Yu, Y.7
Cai, X.8
Waxman, S.9
Lanotte, M.10
Chen, S.J.11
Chen, Z.12
Tong, J.H.13
|