DNA methylation, cell proliferation, and histopathology in rats following repeated inhalation exposure to dimethyl sulfate

Inhalation Toxicology

Volumn 16, Issue 9, 2004, Pages 581-592

  Mathison, Brian H ^a   Frame, S Randall ^a   Bogdanffy, Matthew S ^a  

^a DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLADENINE; 7 METHYLGUANINE; ALKYLATING AGENT; CARCINOGEN; DIMETHYL SULFATE; DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DNA METHYLATION; DOSIMETRY; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; IN VIVO STUDY; KINETICS; MALE; NONHUMAN; NOSE MUCOSA; OLFACTORY EPITHELIUM; PRIORITY JOURNAL; RAT; RESPIRATORY SYSTEM; RESPIRATORY TRACT MUCOSA; STEADY STATE; ULTRAVIOLET RADIATION; VAPOR;

ADENINE; ADMINISTRATION, INHALATION; ALKYLATING AGENTS; ANIMALS; BODY WEIGHT; CELL PROLIFERATION; DNA; DNA ADDUCTS; DNA METHYLATION; GUANINE; MALE; METHYLATION; MODELS, BIOLOGICAL; MUTAGENS; OLFACTORY MUCOSA; PURINES; RATS; RISK; SULFURIC ACID ESTERS;

ANIMALIA; RODENTIA;

EID: 3342877636     PISSN: 08958378     EISSN: None     Source Type: Journal    
DOI: 10.1080/08958370490464553     Document Type: Article

References (53)

1. American Council of Governmental Industrial Hygienists. 2002. Threshold limit values (TLVs™) for chemical substances and physical agents and biological exposure indicies (BEIs™). Cincinnati, OH: ACGIH.
2. Belinsky, S. A., White, C. M., Boucheron, J. A., Richardson, F. C., Swenberg, J. A., and Anderson, M. 1986. Accumulation and persistence of DNA adducts in respiratory tissue of rats following multiple administrations of the tobacco specific carcinogen 5-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone. Cancer Res. 46:1280-1284.
3. Belinsky, S. A., White, Catherine M., Devereux, T. R., Swenberg, J. A., and Anderson, M. W. 1987. Cell selective alkylation of DNA in rat lung following low dose exposure to the tobacco specific carcinogen 4-(N-methyl-N- nitrosoamino-)-3-pyridyl)-1-butanone. Cancer Res. 47:6058-6065.
4. Beranek, D. T. 1990. Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents. Mutat. Res. 231:11-30.
5. Beranek, D. T., Weis, C. C., and Swenson, D. H. 1980. A comprehensive quantitative analysis of methylated and ethylated DNA using high pressure liquid chromatography. Carcinogenesis 1:595-606.
6. Blin, N., and Stafford, D. W. 1971. A general method for the isolation of high molecular weight DNA from eukaryotes. Nucleic Acids Res. 3:2303-2313.
7. Bogdanffy, M. S., Randall, H. W., and Morgan, K. T. 1987. Biochemical quantitation and histochemical localization of carboxylesterase in the nasal passages of the Fisher-344 rat and B6C3F1 mouse. Toxicol. Appl. Pharmacol. 88:183-194.
8. Bogdanffy, M. W., Mathison, B. H., Kuykendall, J. R., and Harman, A. E. 1997. Critical factors in assessing risk from exposure to nasal carcinogens. Mutat. Res. 380:125-141.
9. Bush, M. L., Frederick, C. B., Kimbell, J. S., and Ultman, J. S. 1998. A CFD-PBPK hybrid model for simulating gas and vapor uptake in the rat nose. Toxicol. Appl. Pharmacol. 150:133-145.
10. Casanova, M., Morgan, K. T., Gross, E. A., Moss, O. R., and Heck, H., d'A. 1994. DNA-protein cross-links and cell replication at specific sites in the nose of F344 rats exposed subchronically to formaldehyde. Fundam. Appl. Toxicol. 23:525-536.
11. Connolly, K. M., and Bogdanffy, M. S. 1993. Evaluation of proliferating cell nuclear antigen (PCNA) as an endogenous marker of cell proliferation in rat liver: A dual-stain comparison with 5-bromo-2′-deoxyuridine. J. Histochem. Cytochem. 41:1-6.
12. Dahl, A. R., and Hadley, W. M. 1983. Formaldehyde production promoted by rat nasal cytochrome P-450-dependent monooxygenases with nasal decongestants, essences, solvents, air pollutants, nicotine, and cocaine as substrates. Toxicol. Appl. Pharmacol. 67:200-205.
13. Druckrey, H., Preussmann, R., Nashed, N., and Ivankovic, S. 1966. Carcinogene alkylierende Substanzen, I. Dimethylsulfat, carcinogene Wirkung an Ratten und wahrscheinliche Ursache von Berufskrebs. Z. Krebsforch. 68:103-111.
14. Druckrey, H., Kruse, H., Preussman, R., Ivankovic, S., and Landschütz, C. 1970. Carcinogene alkylierends Substanzen, I., Dimethylsulfat, carcinogene Wirkung and Ratten und wahrscheinliche Ursache von Berufskrebs. Z. Krebforsch. 74:241-273.
15. Druckrey, H., Gimmy, J., and Landschütz, C. 1973. Cancerogenicity of di-isopropylsulfate and non-cancerogenicity of monomethylsulphate in bd-rats. Z. Krebforsch. 79:135-140.
16. Drouin, R., Therrien, J. P., Angers, M., and Ouellet, S. 2001. In vivo DNA analysis. Methods Mol. Biol. 148:175-219.
17. Eatough, D. J., Lee, M. L., Later, D. W., Richter, B. E., Eatough, N. L., and Hansen, L. D. 1981. Dimethyl sulfate in particulate matter from coal- and oil-fired power Plants. Environ. Sci. Technol. 15:1502-1506.
18. Ezaz-Nikpay, K., and Verdine, G. L. 1994. The effects of N7-methylguanine on duplex DNA structure. Chem. Biol. 1:235-240.
19. Frenkel, K., Zhong, Z., Weis, H., Karkoszka, J., Patel, U., Rashid, K., Georgescu, M., and Solomon, J. J. 1991. Quantitative high-performance liquid chromatography analysis of DNA oxidized in vitro and in vivo. Anal. Biochem. 196:126-136.
20. 6-methylguanine formation and persistence in rats. Anal. Biochem. 100:58-62.
21. Hoffman, G. R. 1980. Genetic effects of dimethyl sulfate, diethyl sulfate, and related compounds. Mutat. Res. 75:63-129.
22. Ibeanu, G., Hartgenstein, B., Dunn, W. C., Chang, L. Y., Hofmann, E., Coquerelle, T., Mitra, S., and Kaina, B. 1992. Overexpression of human DNA repair protein N-methylpurine-DNA glycosylase results in the increased removal on N-methylpurines in DNA without a concomitant increase in resistence to alkylating agents in Chinese hamster ovary cells. Carcinogenesis 13:1989-1995.
23. International Agency for Research on Cancer. 1974. Some aromatic amines, hydrazines, and related substances, N-nitroso compounds and miscellaneous alkylating agents. IARC Monogr. Eval. Carcinogen. 4:271-276.
24. International Agency for Research on Cancer. 1987. Overall evaluation of carcinogenicity: An updating of IARC Monographs, Vol. 1-42. IARC Monogr. Eval. Carcinogen. Risks. Hum. Suppl. 7:131-133, 200-201.
25. International Agency for Research on Cancer. 1999. IARC Monogr. Eval. Carcinogen. Risks Hum. 71 Part 2:575-588.
26. Kaina, B., Ochs, K., Grosch, S., Fritz, G., Lips, J., Tomicic, M., Dunkern, T., and Christmann, M. 2001. BER, MGMT, and MMR in defense against alkylation-induced genotoxicity and apoptosis. Prog. Nucleic Acid Res. Mol. Biol. 68:41-54.
27. Kimbell, J. S., Gross, E. A., Joyner, D. R., Godo, M. N., and Morgan, K. T. 1993. Application of computational fluid dynamics to regional dosimetry of inhaled chemicals in the upper respiratory tract of the rat. Toxicol. Appl. Pharmacol. 121:253-263.
28. Klungland, A., Gairbairn, L., Watson, A. J., Margison, G. P., and Seeberg. E. 1992. Expression of the E. coli 3-methyladenine DNA glycosylase I gene in mammalian cells reduces the toxic and mutagenic effects of methylating agents. EMBO J. 11:4439-4444.
29. Lawley, P. D. 1966. Effects of some chemical mutagens and carcinogens on nucleic acids, Prog. Nuc. Acid Res. Mol. Biol. 5:89-131.
30. Lee, M. L., Later, D. W., Rollins, D. K., Eatough, D. J., and Hansen, L. D. 1980. Dimethyl and monomethyl sulfate: Presence in coal fly ash and airborne particulate matter. Science 207:186-188.
31. Lindahl, T., Sedgwick, B., Sekiguchi, M., and Nakabeppu, Y. 1988. Regulation and expression and the adaptive response to alkylating agents. Annu. Rev. Biochem. 57:133-157.
32. Löfroth, G., Osterman-Golkar, S., and Wennerberg, R. 1974. Urinary excretion of methylated purines following inhalation of dimethyl sulphate. Experientia 30:641-642.
33. Mathison, B. H., Said. B., and Shank, R. C. 1993. Effects of 5-methylcytosine as a neighboring base on N-methyle-N-nitrosourea binding to DNA guanine. Carcinogenesis 14:323-327.
34. Mathison, B. H., Taylor, M. L., and Bogdanffy, M. S. 1995. Dimethyl sulfate uptake and methylation of DNA in rat respiratory tissues following acute inhalation. Fundam. Appl. Toxicol. 28:255-263.
35. Miller, M. C., Mohrenweiser, H. W., and Bell, D. A. 2001. Genetic variability in susceptibility and response to toxicants. Toxicol Lett. 120:269-280.
36. Monticello, T. M., and Morgan, K. T. 1997. Chemically-induced nasal carcinogenesis and epithelial cell proliferation: A brief review. Mutat. Res. 380:27-32.
37. Morris, J. B., Hassett, D. N., and Blanchard, K. T. 1993. A physiologically-based pharmacokinetic model for nasal uptake and metabolism of nonreactive vapors. Toxicol. Appl. Pharmacol. 123:120-129.
38. Newbold, R. F., Warren, W., Medcalf, A. S. C., and Amos, J. 1980. Mutagenicity of carcinogenic methylating agents is associated with a specific DNA modification. Nature 283:596-599.
39. NOES. 1997. National Occupational Exposure Survey 1981-83, Unpublished data as of November 1997. Cincinnati, OH: U.S. Department of Health and Human Services. Public Health Service, National Institute of Occupational Safety and Health.
40. OSHA. 1996. Updating permissible exposure limits (PELS) for air contaminants; Meeting. Fed. Reg. 61:1947-1950.
41. Pell, S. 1972. Epidemiologic study of dimethyl sulfate and cancer of the respiratory system. Wilmington, DE: E. I. du Pont de Nemours & Co.
42. Plowchalk, D. R., Andersen, M. E., and Bogdanffy, M. S. 1997. Physiologically based modeling of vinyl acetate uptake, metabolis, and intracellular pH changes in the rat nasal cavity. Toxicol. Appl. Pharmacol. 142:386-400.
43. Ronen, A., and Glickman, B. W. 2001. Human DNA repair genes. Environ. Mol. Mutagen. 37:241-283.
44. Saffhill, R., Margison, G. P., and O'Connor, P. J. 1985. Mechanisms of carcinogenesis induced by alkylating agents. Biochim. Biophys. Acta 823:111-145.
45. Schlögel, F. A. 1972. Carcinogenicity and chronic toxicity of inhaled dimethyl sulfate. In Institute of pharmacology and toxicology, p. 95. Wurzburg: University of Wurzburg.
46. Swain, C. G., and Scott, C. B. 1953. Quantitative correlation of relative rates. Comparison of hydroxide ion with other nucleophilic reagents toward alkyl halides, esters, epoxides and acyl halides. J. Am. Chem. Soc. 75:141-147.
47. Swann, P. F. 1968. The ratre of breakdown of methyl methanesulphonate, dimethyl sulphate and N-methyl-N-nitrosourea in the rat. Biochem. J. 110:49-52.
48. Swann, P. F., and Magee, P. N. 1968. Nitrosamine-induced carcinogenesis. The alkylation of nucleic acids of the rat by N-methyl-N-nitrosourea, dimethylnitrosamine, dimethyl sulphate and methyl methanesulphonate. Biochem. J. 110:37-47.
49. Swenson, D. H., and Lawley, P. D. 1978. Alkylation of deoxyribonucleic acid by carcinogens dimethyl sulphate, ethyl methane-sulphonate, N-ethyl-N-nitrosourea, and N-methyl-N-nitrosourea (relative reactivity of the phosphodiester site thymidylyl (3′-5′)thymidine). Biohem. J. 171:575.
50. U.S. National Library of Medicine. 1997. Hazardous substance data bank (HDSB). Bethesda, MD. Record No. 528.
51. Wells, S. E., Hughes, J. M., Igel, A. G., and Ares, M., Jr. 2000. Use of dimethyl sulfate to probe RNA structure in vivo. Methods Enzymol. 318:479-493.
52. Ye, N., Holmquist, G. P., and O'Connor, T. R. 1998. Heterogeneous repair of N-methylpurines at the nucleotide level in normal human cells. J. Mol. Biol. 284:269-285.
53. Young, J. T. 1981. Histopathologic examination of the rat nasal cavity. Fundam. Appl. Toxicol. 1:309-312.