Characterization of in vitro and in vivo phenotypes of poliovirus type 1 mutants with reduced viral protein synthesis activity

Journal of General Virology

Volumn 85, Issue 7, 2004, Pages 1933-1944

  Arita, Minetaro ^a   Shimizu, Hiroyuki ^a   Miyamura, Tatsuo ^a  

^a NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

POLYPROTEIN; SPACER DNA; VIRUS PROTEIN; VIRUS RECEPTOR; PRIMER DNA; VIRUS RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFECTION; CONTROLLED STUDY; DNA SEQUENCE; FEMALE; HELA CELL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; IN VIVO STUDY; INTERNAL RIBOSOME ENTRY SITE; MALE; MOUSE; NONHUMAN; OPEN READING FRAME; PHENOTYPE; POLIOMYELITIS; POLIOMYELITIS VIRUS 1; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RECEPTOR GENE; SPINAL CORD INFECTION; START CODON; TRANSGENIC MOUSE; VIRUS ATTENUATION; VIRUS CHARACTERIZATION; VIRUS INFECTION; VIRUS MUTANT; VIRUS PATHOGENESIS; VIRUS PLAQUE; VIRUS PURIFICATION; VIRUS REPLICATION; VIRUS STRAIN; VIRUS VIRULENCE; WILD TYPE; ANIMAL; CALORIMETRY; CHEMICAL STRUCTURE; CHEMISTRY; CLASSIFICATION; CONFORMATION; GENETICS; MOLECULAR GENETICS; MUTAGENESIS; NUCLEOTIDE SEQUENCE; POLIOMYELITIS VIRUS; REPLICON; TUMOR CELL LINE;

HUMAN POLIOVIRUS 1; MUS MUSCULUS; POLIOVIRUS;

ANIMALS; BASE SEQUENCE; CALORIMETRY; CELL LINE, TUMOR; DNA PRIMERS; HELA CELLS; HUMANS; MICE; MICE, TRANSGENIC; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS; NUCLEIC ACID CONFORMATION; PHENOTYPE; POLIOVIRUS; PROTEIN BIOSYNTHESIS; REPLICON; RNA, VIRAL; VIRAL PROTEINS;

EID: 3342983356     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/vir.0.19768-0     Document Type: Article

References (53)

1. Abe, S., Ota, Y., Koike, S., Kurata, T., Horie, H., Nomura, T., Hashizume, S. & Nomoto, A. (1995). Neurovirulence test for oral live poliovaccines using poliovirus-sensitive transgenic mice. Virology 206, 1075-1083.
2. Andino, R., Rieckhof, G. E. & Baltimore, D. (1990). A functional ribonucleoprotein complex forms around the 5′ end of poliovirus RNA. Cell 63, 369-380.
3. Borman, A. M., Deliat, F. G. & Kean, K. M. (1994). Sequences within the poliovirus internal ribosome entry segment control viral RNA synthesis. EMBO J 13, 3149-3157.
4. Bouchard, M. J., Lam, D. H. & Racaniello, V. R. (1995). Determinants of attenuation and temperature sensitivity in the type 1 poliovirus Sabin vaccine. J Virol 69, 4972-4978.
5. Burns, C. C., Richards, O. C. & Ehrenfeld, E. (1992). Temperature-sensitive polioviruses containing mutations in RNA polymerase. Virology 189, 568-582.
6. Cann, A. J., Stanway, G., Hughes, P. J., Minor, P. D., Evans, D. M., Schild, G. C. & Almond, J. W. (1984). Reversion to neurovirulence of the live-attenuated Sabin type 3 oral poliovirus vaccine. Nucleic Acids Res 12, 7787-7792.
7. Chappell, S. A., Edelman, G. M. & Mauro, V. P. (2000). A 9-nt segment of a cellular mRNA can function as an internal ribosome entry site (IRES) and when present in linked multiple copies greatly enhances IRES activity. Proc Natl Acad Sci U S A 97, 1536-1541.
8. Evans, D. M., Dunn, G., Minor, P. D., Schild, G. C., Cann, A. J., Stanway, G., Almond, J. W., Currey, K. & Maizel, J. V. (1985). Increased neurovirulence associated with a single nucleotide change in a noncoding region of the Sabin type 3 poliovaccine genome. Nature 314, 548-550.
9. Garcia-Barrio, M. T., Naranda, T., Vazquez de Aldana, C. R., Cuesta, R., Hinnebusch, A. G., Hershey, J. W. & Tamame, M. (1995). GCD10, a translational repressor of GCN4, is the RNA-binding subunit of eukaryotic translation initiation factor-3. Genes Dev 9, 1781-1796.
10. Gromeier, M., Alexander, L. & Wimmer, E. (1996). Internal ribosomal entry site substitution eliminates neurovirulence in intergeneric poliovirus recombinants. Proc Natl Acad Sci U S A 93, 2370-2375.
11. Gutierrez, A. L., Denova-Ocampo, M., Racaniello, V. R. & del Angel, R. M. (1997). Attenuating mutations in the poliovirus 5′ untranslated region alter its interaction with polypyrimidine tract-binding protein. J Virol 71, 3826-3833.
12. Haller, A. A., Stewart, S. R. & Semler, B. L. (1996). Attenuation stem-loop lesions in the 5′ noncoding region of poliovirus RNA: neuronal cell-specific translation defects. J Virol 70, 1467-1474.
13. Hellen, C. U., Pestova, T. V. & Wimmer, E. (1994). Effect of mutations downstream of the internal ribosome entry site on initiation of poliovirus protein synthesis. J Virol 68, 6312-6322.
14. Herold, J. & Andino, R. (2000). Poliovirus requires a precise 5′ end for efficient positive-strand RNA synthesis. J Virol 74, 6394-6400.
15. Horie, H., Koike, S., Kurata, T. & 7 other authors (1994). Transgenic mice carrying the human poliovirus receptor: new animal models for study of poliovirus neurovirulence. J Virol 68, 681-688.
16. Iizuka, N., Kohara, M., Hagino-Yamagishi, K., Abe, S., Komatsu, T., Tago, K., Arita, M. & Nomoto, A. (1989). Construction of less neurovirulent polioviruses by introducing deletions into the 5′ noncoding sequence of the genome. J Virol 63, 5354-5363.
17. Jang, S. K., Krausslich, H. G., Nicklin, M. J., Duke, G. M., Palmenberg, A. C. & Wimmer, E. (1988). A segment of the 5′ nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation. J Virol 62, 2636-2643.
18. Johansen, L. K. & Morrow, C. D. (2000). Inherent instability of poliovirus genomes containing two internal ribosome entry site (IRES) elements supports a role for the IRES in encapsidation. J Virol 74, 8335-8342.
19. Karber, G. (1931). Beitrag zur kollektiven Behandlung pharmakologischer Reihenversuche. Arch Exp Pathol Pharmakol 162, 480-483.
20. Kawamura, N., Kohara, M., Abe, S., Komatsu, T., Tago, K., Arita, M. & Nomoto, A. (1989). Determinants in the 5′ noncoding region of poliovirus Sabin 1 RNA that influence the attenuation phenotype. J Virol 63, 1302-1309.
21. Koike, S., Taya, C., Kurata, T., Abe, S., Ise, I., Yonekawa, H. & Nomoto, A. (1991). Transgenic mice susceptible to poliovirus. Proc Natl Acad Sci U S A 88, 951-955.
22. Koike, S., Taya, C., Aoki, J. & 7 other authors (1994). Characterization of three different transgenic mouse lines that carry human poliovirus receptor gene - influence of the transgene expression on pathogenesis. Arch Virol 139, 351-363.
23. Kozak, M. (1986). Influences of mRNA secondary structure on initiation by eukaryotic ribosomes. Proc Natl Acad Sci U S A 83, 2850-2854.
24. Kozak, M. (1987). Effects of intercistronic length on the efficiency of reinitiation by eucaryotic ribosomes. Mol Cell Biol 7, 3438-3445.
25. Kozak, M. (1999). Initiation of translation in prokaryotes and eukaryotes. Gene 234, 187-208.
26. Kuge, S. & Nomoto, A. (1987). Construction of viable deletion and insertion mutants of the Sabin strain of type 1 poliovirus: function of the 5′ noncoding sequence in viral replication. J Virol 61, 1478-1487.
27. Kuge, S., Kawamura, N. & Nomoto, A. (1989). Genetic variation occurring on the genome of an in vitro insertion mutant of poliovirus type 1. J Virol 63, 1069-1075.
28. Li, X., Lu, H. H., Mueller, S. & Wimmer, E. (2001). The C-terminal residues of poliovirus proteinase 2A(pro) are critical for viral RNA replication but not for cis- or trans-proteolytic cleavage. J Gen Virol 82, 397-408.
29. Lu, H. H., Alexander, L. & Wimmer, E. (1995). Construction and genetic analysis of dicistronic polioviruses containing open reading frames for epitopes of human immunodeficiency virus type 1 gp120. J Virol 69, 4797-4806.
30. Luukkonen, B. G., Tan, W. & Schwartz, S. (1995). Efficiency of reinitiation of translation on human immunodeficiency virus type 1 mRNAs is determined by the length of the upstream open reading frame and by intercistronic distance. J Virol 69, 4086-4094.
31. Macadam, A. J., Pollard, S. R., Ferguson, G., Dunn, G., Skuce, R., Almond, J. W. & Minor, P. D. (1991). The 5′ noncoding region of the type 2 poliovirus vaccine strain contains determinants of attenuation and temperature sensitivity. Virology 181, 451-458.
32. Macadam, A. J., Pollard, S. R., Ferguson, G., Skuce, R., Wood, D., Almond, J. W. & Minor, P. D. (1993). Genetic basis of attenuation of the Sabin type 2 vaccine strain of poliovirus in primates. Virology 192, 18-26.
33. Macadam, A. J., Stone, D. M., Almond, J. W. & Minor, P. D. (1994). The 5′ noncoding region and virulence of poliovirus vaccine strains. Trends Microbiol 2, 449-454.
34. Malnou, C. E., Poyry, T. A., Jackson, R. J. & Kean, K. M. (2002). Poliovirus internal ribosome entry segment structure alterations that specifically affect function in neuronal cells: molecular genetic analysis. J Virol 76, 10617-10626.
35. Minor, P. D. (1992). The molecular biology of poliovaccines. J Gen Virol 73, 3065-3077.
36. Muzychenko, A. R., Lipskaya, G., Maslova, S. V., Svitkin, Y. V., Pilipenko, E. V., Nottay, B. K., Kew, O. M. & Agol, V. I. (1991). Coupled mutations in the 5′-untranslated region of the Sabin poliovirus strains during in vivo passages: structural and functional implications. Virus Res 21, 111-122.
37. Omata, T., Kohara, M., Kuge, S. & 7 other authors (1986). Genetic analysis of the attenuation phenotype of poliovirus type 1. J Virol 58, 348-358.
38. Pelletier, J. & Sonenberg, N. (1988). Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA. Nature 334, 320-325.
39. Pilipenko, E. V., Viktorova, E. G., Guest, S. T., Agol, V. I. & Roos, R. P. (2001). Cell-specific proteins regulate viral RNA translation and virus-induced disease. EMBO J 20, 6899-6908.
40. Poyry, T. A., Hentze, M. W. & Jackson, R. J. (2001). Construction of regulatable picornavirus IRESes as a test of current models of the mechanism of internal translation initiation. RNA 7, 647-660.
41. Ren, R. & Racaniello, V. R. (1992). Human poliovirus receptor gene expression and poliovirus tissue tropism in transgenic mice. J Virol 66, 296-304.
42. Rowe, A., Burlison, J., Macadam, A. J. & Minor, P. D. (2001). Functional formation of domain V of the poliovirus noncoding region: significance of unpaired bases. Virology 289, 45-53.
43. Sabin, A. B. (1965). Oral poliovirus vaccine. History of its development and prospects for eradication of poliomyelitis. JAMA (J Am Med Assoc) 194, 872-876.
44. Sambrook, J. & Russell, D. W. (2001). In Molecular Cloning: a Laboratory Manual, 3rd edn, pp. 13.19-13.25. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
45. Shiroki, K., Kato, H., Koike, S., Odaka, T. & Nomoto, A. (1993). Temperature-sensitive mouse cell factors for strand-specific initiation of poliovirus RNA synthesis. J Virol 67, 3989-3996.
46. Shiroki, K., Ishii, T., Aoki, T., Kobashi, M., Ohka, S. & Nomoto, A. (1995). A new cis-acting element for RNA replication within the 5′ noncoding region of poliovirus type 1 RNA. J Virol 69, 6825-6832.
47. Shiroki, K., Ishii, T., Aoki, T. & 8 other authors (1997). Host range phenotype induced by mutations in the internal ribosomal entry site of poliovirus RNA. J Virol 71, 1-8.
48. Slobodskaya, O. R., Gmyl, A. P., Maslova, S. V., Tolskaya, E. A., Viktorova, E. G. & Agol, V. I. (1996). Poliovirus neurovirulence correlates with the presence of a cryptic AUG upstream of the initiator codon. Virology 221, 141-150.
49. Stewart, S. R. & Semler, B. L. (1999). Pyrimidine-rich region mutations compensate for a stem-loop V lesion in the 5′ noncoding region of poliovirus genomic RNA. Virology 264, 385-397.
50. Svitkin, Y. V., Maslova, S. V. & Agol, V. I. (1985). The genomes of attenuated and virulent poliovirus strains differ in their in vitro translation efficiencies. Virology 147, 243-252.
51. Svitkin, Y. V., Cammack, N., Minor, P. D. & Almond, J. W. (1990). Translation deficiency of the Sabin type 3 poliovirus genome: association with an attenuating mutation C472-U. Virology 175, 103-109.
52. Yoneyama, T., Yoshida, H., Shimizu, H., Yoshii, K., Nagata, N., Kew, O. & Miyamura, T. (2001). Neurovirulence of Sabin 1-derived polioviruses isolated from an immunodeficient patient with prolonged viral excretion. Dev Biol (Basel) 105, 93-98.
53. Zhao, W. D. & Wimmer, E. (2001). Genetic analysis of a poliovirus/hepatitis C virus chimera: new structure for domain II of the internal ribosomal entry site of hepatitis C virus. J Virol 75, 3719-3730.