Poliovirus neurovirulence correlates with the presence of a cryptic AUG upstream of the initiator codon

Virology

Volumn 221, Issue 1, 1996, Pages 141-150

  Slobodskaya, Olga R ^a   Gmyl, Anatoly P ^a   Maslova, Svetlana V ^a   Tolskaya, Elena A ^a   Viktorova, Ekaterina G ^a   Agol, Vadim I ^a,b  

^a CHUMAKOV INSTITUTE OF POLIOMYELITIS AND VIRAL ENCEPHALITIDES   (Russian Federation)

^b MOSCOW STATE UNIVERSITY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

POLIOMYELITIS VACCINE; TRINUCLEOTIDE; VIRUS RNA;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DELETION MUTANT; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLIOMYELITIS VIRUS; PRIORITY JOURNAL; REVERTANT; RNA TRANSLATION; START CODON; VIRUS REPLICATION; VIRUS VIRULENCE;

EID: 0030199332     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1996.0360     Document Type: Article

References (36)

1. Agol, V. I. (1993). Poliovirus neurovirulence and its attenuation. In "Regulation of Gene Expression in Animal Viruses" (L. Carassco, N. Sonenberg, and E. Wimmer, Eds.,) pp. 305-321. Plenum, New York.
2. Agol, V. I., Drozdov, S. G., Ivannikova, T. A., Kolesnikova, M. S., Korolev, M. B., and Tolskaya, E. A. (1989). Restricted growth of attenuated poliovirus strains in cultured cells of a human neuroblastoma. J. Virol. 63, 4034-4038.
3. Beck, E., Forss, S., Strebel, K., Cattaneo, R., and Feil, G. (1983). Structure of the FMDV translation initiation site and of the structural proteins. Nucleic Acids Res. 11, 7873-7885.
4. Gmyl, A. P., Pilipenko, E. V., Maslova, S. V., Belov, G. A., and Agol, V. I. (1993). Functional and genetic plasticities of the poliovirus genome: Quasi-infectious RNAs modified in the 5′-untranslated region yield a variety of pseudorevertants. J. Virol. 67, 6309-6316.
5. Gromeier, M., Lu, H.-H., and Wimmer, E. (1995). Mouse neuropathogenic poliovirus strains cause damage in the central nervous system distinct from poliomyelitis. Microb. Pathog. 18, 253-265.
6. Haller, A. A., and Semler, B. L. (1992). Linker scanning mutagenesis of the internal ribosome entry site of poliovirus RNA. J. Virol. 66, 5075-5086.
7. Haller, A. A., Stewart, S. R., and Semler, B. L. (1996). Attenuation stemloop lesions in the 5′ noncoding region of poliovirus RNA: Neuronal cell-specific translation defects. J. Virol. 70, 1467-1474.
8. Iizuka, N., Kohara, M., Hagino-Yamagishi, K., Abe, S., Komatsu, T., Tago, K., Arita, M., and Nomoto, A. (1989). Construction of less neurovirulent polioviruses by introduction deletions into the 5′ noncoding sequence of the genome. J. Virol. 63, 5354-5363.
9. Jang, S. K., Krausslich, H.-G., Nicklin, M. J. H., Duke, G. M., Palmenberg, A. C., and Wimmer, E. (1988). A segment of the 5′ nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation. J. Virol. 62, 2636-2643.
10. Jang, S. K., and Wimmer, E. (1990). Cap-independent translation of encephalomyocarditis virus RNA: Structural elements of the internal ribosomal entry site and essential binding of a cellular 57 kDa protein. Genes Dev. 4, 1560-1572.
11. Jubelt, B., Gallez-Hawkins, B., Narayan, O., and Johnson, R. T. (1980). Pathogenesis of human poliovirus infection in mice. I. Clinical and pathological studies. J. Neuropathol. Exp. Neurol. 39, 138-148.
12. Jubelt, B., Ropka, S. L., Goldfarb, S., Waltenbaugh, C., and Oates, R. P. (1991). Susceptibility and resistance to poliovirus-induced paralysis of inbred mouse strains. J. Virol. 65, 1035-1040.
13. Kuge, S., and Nomoto, A. (1987). Construction of viable deletion and insertion mutants of the Sabin strain of type 1 poliovirus: Function of the 5′ noncoding sequence in viral replication. J. Virol. 61, 1478-1487.
14. La Monica, N., Almond, J. W., and Racaniello, V. R. (1987). A mouse model for poliovirus neurovirulence identifies mutations that attenuate the virus for human. J. Virol. 61, 2917-2920.
15. La Monica, N., and Racaniello, V. R. (1989). Differences in replication of attenuated and neurovirulent polioviruses in human neuroblastoma cell line SH-SY5Y. J. Virol. 63, 2357-2360.
16. Martin, A., Wychowski, C., Couderc, T., Crainic, R., Hogle, J., and Girard, M. (1988). Engineering a poliovirus type 2 antigenic site on a type 1 capsid results in a chimaeric virus which is neurovirulent for mice. EMBO J. 7, 2839-2847.
17. Minor, P. D. (1992). The molecular biology of poliovaccines. J. Gen. Virol. 73, 3065-3077.
18. Murray, M. G., Bradley, J., Yang, X.-F., Wimmer, E., Moss, E. G., and Racaniello, V. R. (1988). Poliovirus host range is determined by a short amino acid sequence in neutralization antigenic site I. Science 241, 213-215.
19. Nicholson, R., Pelletier, J., Le, S.-Y., and Sonenberg, N. (1991). Structural and functional analysis of the ribosome landing pad of poliovirus type 2: In vivo translation studies. J. Virol. 65, 5886-5894.
20. Nomoto, A., Iizuka, N., Kohara, M., and Arita, M. (1988). Strategy for construction of live picornavirus vaccines. Vaccine 6, 134-137.
21. Nomoto, A., Koike, S., and Aoki, J. (1994). Tissue tropism and species specificity of poliovirus infection. Trends Microbiol. 2, 47-51.
22. Pelletier, J., Flynn, M. E., Kaplan, G., Racaniello, V. R., and Sonenberg, N. (1988). Mutational analysis of upstream AUG codon of poliovirus RNA. J. Virol. 62, 4486-4492.
23. Pelletier, J., and Sonenberg, N. (1988). Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA. Nature 334, 320-325.
24. Pilipenko, E. V., Blinov, V. M., and Agol, V. I. (1990). Gross rearrangement within the 5′-untranslated region of the picornaviral genomes. Nucleic Acids Res. 18, 3371-3375.
25. Pilipenko, E. V., Gmyl, A. P., Maslova, S. V., Svitkin, Y. V., Sinyakov, A. N., and Agol, V. I. (1992). Prokaryotic-like cis elements in the cap-independent internal initiation of translation on picornavirus RNA. Cell 68, 119-131.
26. Pilipenko, E. V., Gmyl, A. P., Maslova, S. V., Belov, G. A., Sinyakov, Y. V., Huang, M., Brown, T. D. K., and Agol, V. I. (1994). Starting window, a distinct element in the cap-independent internal initiation of translation on picornaviral RNA. J. Mol. Biol. 241, 398-414.
27. Pilipenko, E. V., Gmyl, A. P., Maslova, S. V., Khitrina, E. V., and Agol, V. I. (1995). Attenuation of Theiler's murine encephalomyelitis virus by modifications of the oligopypimidine/AUG tandem, a host-dependent translational cis-element. J. Virol. 69, 864-870.
28. Pöyry, T., Kinunnen, L., and Hovi, T. (1992). Genetic variation in vivo and proposed functional domains of the 5′ noncoding region of poliovirus RNA. J. Virol. 66, 5313-5319.
29. Reed, L. J., and Muench, H. (1938). A simple method of estimating fifty percent end point. Am. J. Hyg. 27, 493-497.
30. Ren, R., Constantini, F. C., Gorgacz, E. J., Lee, J. J., and Racaniello, V. R. (1990). Transgenic mice expressing a human poliovirus receptor: a new model for poliomyelitis. Cell 63, 353-362.
31. Romero, J. R., and Rotbart, H. A. (1995). Sequence analysis of the downstream 5′ nontranslated region of seven echoviruses with different neurovirulence phenotypes. J. Virol. 69, 1370-1375.
32. Skinner, M. A., Racaniello, V. R., Dunn, G., Cooper, J., Minor, P. D., and Almond, J. W. (1989). New model for the secondary structure of the 5′ non-coding RNA of poliovirus is supported by biochemical and genetic data that also show that RNA secondary structure is important in neurovirulence. J. Mol. Biol. 207, 379-392.
33. Svitkin, Y. V., Maslova, S. V., and Agol, V. I. (1985). The genomes of attenuated and virulent poliovirus strains differ in their in vitro translation efficiencies. Virology 147, 243-252.
34. Svitkin, Y. V., Pestova, T. V., Maslova, S. V., and Agol, V. I. (1988). Point mutation modify the response of poliovirus RNA to a translation initiation factor: A comparison of neurovirulent and attenuated strains. Virology 166, 394-404.
35. 472-U. Virology 175, 103-109.
36. Tardy-Panit, M., Blondel, B., Martin, A., Tekaia, F., Horaud, F., and Delpeyroux, F. (1993). A mutation in the RNA polymerase of poliovirus type 1 contributes to attenuation in mice. J. Virol. 67, 4630-4638.