Attenuating mutations in the poliovirus 5' untranslated region alter its interaction with polypyrimidine tract-binding protein

Journal of Virology

Volumn 71, Issue 5, 1997, Pages 3826-3833

  Gutiérrez, Ana Lorena ^a   Denova Ocampo, Monica ^a   Racaniello, Vincent R ^b   Del Angel, Rosa M ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

^b Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ORAL POLIOMYELITIS VACCINE; VIRUS RNA;

ARTICLE; HELA CELL; HUMAN; HUMAN CELL; PHENOTYPE; POLIOMYELITIS VIRUS; PRIORITY JOURNAL; PROTEIN INTERACTION; SERODIAGNOSIS; VIRUS MUTATION; VIRUS REPLICATION; VIRUS TYPING;

EID: 1842333235     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.5.3826-3833.1997     Document Type: Article

References (42)

1. Borman, A., M. T. Howell, J. G. Patton, and R. J. Jackson. 1993. The involvement of a spliceosome component in internal initiation of human rhinovirus RNA translation. J. Gen. Virol. 74:1775-1788.
2. Borman, A. M., F. G. Deliat, and K. M. Kean. 1994. Sequences within the poliovirus internal ribosome entry segment control viral RNA synthesis. EMBO J. 13:3149-3157.
3. Del Angel, R. M., A. G. Papavassiliou, C. Fernandez-Tomas, S. J. Silverstein, and V. R. Racaniello. 1989. Cell proteins bind to multiple sites within the 5′ untranslated region of poliovirus RNA. Proc. Natl. Acad. Sci. USA 86:8299-8303.
4. Ehrenfeld, E., and J. G. Gebhard. 1994. Interaction of cellular proteins with the poliovirus 5′ noncoding region. Arch. Virol. 9:269-277.
5. García-Blanco, M. A., S. F. Jamison, and P. A. Sharp. 1990. Identification and purification of a 62,000-dalton protein that binds specifically to the polypyrimidine tract introns. Genes Dev. 4:1874-1886.
6. Gebhard, J. R., and E. Ehrenfeld. 1992. Specific interactions of HeLa cell proteins with proposed translation domains of the poliovirus 5′ noncoding region. J. Virol. 66:3101-3109.
7. Gil, A., P. A. Sharp, S. F. Jamison, and M. A. Garcia-Blanco. 1991. Characterization of cDNAs encoding the polypyrimidine tract-binding protein Genes Dev. 5:1224-1236.
8. Gottlieb, E., and J. A. Steitz. 1489. The RNA binding protein La influences both the accuracy and the efficiency of RNA polymerase III transcription in vitro. EMBO J. 8:841-850.
9. Gottlieb, E., and J. A. Steitz. 1989. Function of the mammalian La protein: evidence for its action in transcription termination by RNA polymerase III. EMBO J. 8:851-861.
10. Gutierrez, A. L., and R. M. del Angel. Unpublished data.
11. Haller, A. A., and B. L. Semler. 1995. Stem-loop structure synergy in binding cellular proteins to the 5′ noncoding region of poliovirus RNA. Virology 206:923-934.
12. Hellen, C. U., G. S. Witherell, M. Schmid, H. S. Shin, T. V. Pestova, A. Gil, and E. Wimmer. 1993. A cytoplasmic 57 kDa protein that is required for translation of picornavirus RNA by internal ribosomal entry is identical to the nuclear pyrimidine tract-binding protein. Proc. Natl. Acad. Sci. USA 90:7642-7644.
13. Hellen, C. U. T., T. V. Pestova, M. Litterst, and E. Wimmer. 1994. The cellular polypeptide p57 (pyrimidine tract-binding protein) binds to multiple sites in the poliovirus 5′ nontranslated region. J. Virol. 68:941-950.
14. Hershey, J. W. B. 1989. Protein phosphorylation controls translation rates. J. Biol. Chem. 264:20823-20826.
15. Kaminski, A., S. L. Hunt, J. G. Patton, and R. J. Jackson. 1995. Direct evidence that polypyrimidine tract binding protein (PTB) is essential for internal initiation of translation of encephalomyocarditis virus RNA. RNA 1:924-938.
16. Kawamura, N., M. Kohara, S. Abe, T. Komatsu, K. Tago, M. Arita, and A. Nomoto. 1989. Determinants in the 5′ noncoding region of poliovirus Sabin 1 RNA that influence the attenuation phenotype. J. Virol. 63:1302-1309.
17. La Monica, N., J. W. Almond, and V. R. Racaniello. 1987. A mouse model for poliovirus neurovirulence identifies mutations that attenuate the virus for humans. J. Virol. 61:2917-2920.
18. La Monica, N., and V. R. Racaniello. 1989. Differences in replication of attenuated and neurovirulent poliovirus in human neuroblastoma cell line SH-SY5Y. J. Virol. 63:2357-2360.
19. London, I. M., D. H. Levin, R. L. Matts, N. S. B. Thomas, R. Petryshyn, and J. J. Chen. 1987. Regulation of protein synthesis. Enzymes 18:360-380.
20. Meerovitch, K., R. Nicholson, and N. Sonenberg. 1991. In vitro mutational analysis of cis-acting RNA translational elements within the poliovirus type 2 5′ untranslated region. J. Virol. 65:5895-5901.
21. Meerovitch, K., J. Pelletier, and N. Sonenberg. 1989. A cellular protein that binds to the 5′-noncoding region of poliovirus RNA: implications for internal translation initiation. Genes Dev. 3:1026-1034.
22. Meerovitch, K., Y. V. Svitkin, H. S. Lee, F. Lejbkowics, D. J. Kenan, E. K. L. Chan, V. I. Agol, J. D. Keene, and N. Sonenberg. 1993. La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate. J. Virol. 67:3798-3807.
23. Minor, P. D., A. J. Macadam, D. M. Stone, and J. W. Almond. 1993. Genetic basis of attenuation of the Sabin oral poliovirus vaccines. Biologicals 21:357-364.
24. Moss, E. G., R. E. O'Neill, and V. R. Racaniello. 1989. Mapping of attenuating sequences of an avirulent poliovirus type 2 strain. J. Virol. 63:1884-1890.
25. Najita, L., and P. Sarnow. 1990. Interaction of a cellular 50 kDa protein with an RNA hairpin in the 5′ noncoding region of the poliovirus genome: evidence of a transient covalent RNA-protein bond. Proc. Natl. Acad. Sci. USA 87:5846-5850.
26. Patton, J. G., S. A. Mayer, P. Tempst, and B. Nadal-Ginard. 1991. Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing. Genes Dev. 5:1237-1251.
27. Pelletier, J., G. Kaplan, V. R. Racaniello, and N. Sonenberg. 1988. Cap-independent translation of poliovirus mRNA is conferred by sequence elements within the 5′ noncoding region. Mol. Cell. Biol. 8:1103-1112.
28. Pelletier, J., and N. Sonenberg. 1988. Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA. Nature (London) 334:320-325.
29. Pestova, T. V., C. T. Hellen, and E. Wimmer. 1991. Translation of poliovirus RNA: role of an essential cis-acting oligopyrimidine element within the 5′ nontranslated region and involvement of a cellular 57-kilodalton protein. J. Virol. 65:6194-6204.
30. Pilipenko, E. V., V. M. Blinov, L. I. Romanova, A. N. Sinyakov, S. V. Maslova, and V. I. Agol. 1989. Conserved structural domains in the 5′-untranslated region of picornaviral genomes: an analysis of the segment controlling translation and neurovirulence. Virology 168:201-209.
31. Sabin, A. B. 1985. Oral poliovirus vaccine: history of its development and use and current challenge to eliminate poliomyelitis from the world. J. Infect. Dis. 151:420-436.
32. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
33. Skinner, M. A., V. R. Racaniello, G. Dunn, J. Cooper, P. D. Minor, and J. W. Almond. 1989. New model for the secondary structure of the 5′ non-coding RNA of poliovirus is supported by biochemical and genetic data that also show that RNA secondary structure is important in neurovirulence. J. Mol. Biol. 207:379-392.
34. Sonenberg, N., and K. Meerovitch. 1990. Translation of poliovirus mRNA. Enzymes 4:278-291.
35. Spinelli, W., K. Sonnenfeld, and D. Ishii. 1982. Effects of phorbol ester tumor promoters and nerve growth factors on neurite outgrowth in cultured neuroblastoma cells. Cancer Res. 42:5067-5073.
36. Svitkin, Y. V., S. V. Maslova, and V. I. Agol. 1985. The genomes of attenuated and virulent poliovirus strains differ in their in vitro translation efficiencies. Virology 147:243-252.
37. Svitkin, Y. V., T. V. Pestova, S. V. Maslova, and V. I. Agol. 1988. Point mutations modify the response of poliovirus RNA to a translation initiation factor: a comparison of neurovirulent and attenuated strains. Virology 166: 394-404.
38. 472-U. Virology 175:103-109.
39. Trono, D., R. Andino, and D. Baltimore. 1988. An RNA sequence of hundreds of nucleotides at the 5′ end of poliovirus RNA is involved in allowing viral protein synthesis. J. Virol. 62:2291-2299.
40. Westrop, G. D., K. A. Wareham, D. M. A. Evans, G. Dunn, P. D. Minor, D. I. Magrath, F. Taffs, S. Marsden, M. A. Skinner, G. C. Schild, and J. W. Almond. 1989. Genetic basis of attenuation of the Sabin type 3 oral poliovirus vaccine. J. Virol. 63:1338-1344.
41. Wimmer, E., C. U. T. Hellen, and X. Cao. 1993. Genetics of poliovirus. Annu. Rev. Genet. 27:353-436.
42. Witherell, G. W., A. Gil, and E. Wimmer. 1993. Interaction of polypyrimidine tract binding protein with the encephalomyocarditis virus mRNA internal ribosomal entry site. Biochemistry 32:8268-8275.