Multimerization of poly(rC) binding protein 2 is required for translation initiation mediated by viral IRES

RNA

Volumn 10, Issue 8, 2004, Pages 1266-1276

  Bedard, Kristin M ^a   Walter, Brandon L ^a,b   Semler, Bert L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

IRES; Multimerization; Poliovirus; Poly(rC) binding protein; Translation

Indexed keywords

BINDING PROTEIN; CELL PROTEIN; GLUTATHIONE TRANSFERASE; POLYCYTIDYLIC ACID; POLYCYTIDYLIC ACID BINDING PROTEIN 2; UNCLASSIFIED DRUG;

ARTICLE; GENE DELETION; INTERNAL RIBOSOME ENTRY SITE; POLIOMYELITIS VIRUS; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN RNA BINDING; PROTEIN STRUCTURE; RNA REPLICATION; RNA TRANSLATION; TRANSLATION INITIATION;

DNA-BINDING PROTEINS; HELA CELLS; HUMANS; MUTATION; PICORNAVIRIDAE; PICORNAVIRIDAE INFECTIONS; PROTEIN BIOSYNTHESIS; PROTEIN STRUCTURE, TERTIARY; RNA, MESSENGER; RNA-BINDING PROTEINS; TRANSCRIPTION FACTORS;

PICORNAVIRIDAE; POLIOVIRUS;

EID: 3342945036     PISSN: 13558382     EISSN: None     Source Type: Journal    
DOI: 10.1261/rna.7070304     Document Type: Article

References (34)

1. Andino, R., Rieckhof, G.E., and Baltimore, D. 1990. A functional ribonucleoprotein complex forms around the 5′ end of poliovirus RNA. Cell 63: 369-380.
2. Andino, R., Rieckhof, G.E., Achacoso, P.L., and Baltimore, D. 1993. Poliovirus RNA synthesis utilizes an RNP complex formed around the 5′-end of viral RNA. EMBO J. 12: 3587-3598.
3. Barton, D.J. and Flanegan, J.B. 1993. Coupled translation and replication of poliovirus RNA in vitro: Synthesis of functional 3D polymerase and infectious virus. J. Virol. 67: 822-831.
4. Blyn, L.B., Swiderek, K.M., Richards, O., Stahl, D.C., Semler, B.L., and Ehrenfeld, E. 1996. Poly(rC) binding protein 2 binds to stem-loop IV of the poliovirus RNA 5′ noncoding region: Identification by automated liquid chromatography-tandem mass spectrometry. Proc. Natl. Acad. Sci. 93: 11115-11120.
5. Blyn, L.B., Towner, J.S., Semler, B.L., and Ehrenfeld, E. 1997. Requirement of poly(rC) binding protein 2 for translation of poliovirus RNA. J. Virol. 71: 6243-6246.
6. Brown, B.A. and Ehrenfeld, E. 1979. Translation of poliovirus RNA in vitro: Changes in cleavage pattern and initiation sites by ribosomal salt wash. Virology 97: 396-405.
7. Dildine, S.L. and Semler, B.L. 1992. Conservation of RNA-protein interactions among picornaviruses. J. Virol. 66: 4364-4376.
8. Funke, B., Zuleger, B., Benavente, R., Schuster, T., Goller, M., Stevenin, J., and Horak, I. 1996. The mouse poly(C)-binding protein exists in multiple isoforms and interacts with several RNA-binding proteins. Nucleic Acids Res. 24: 3821-3828.
9. Gamarnik, A.V. and Andino, R. 1997. Two functional complexes formed by KH domain containing proteins with the 5′ noncoding region of poliovirus RNA. RNA 3: 882-892.
10. -. 2000. Interactions of viral protein 3CD and poly(rC) binding protein with the 5′ untranslated region of the poliovirus genome. J. Virol. 74: 2219-2226.
11. Git, A. and Standart, N. 2002. The KH domains of Xenopus Vg1RBP mediate RNA binding and self-association. RNA 8: 1319-1333.
12. Hellen, C.U. and Sarnow, P. 2001. Internal ribosome entry sites in eukaryotic mRNA molecules. Genes & Dev. 15: 1593-1612.
13. Holcik, M. and Liebhaber, S.A. 1997. Four highly stable eukaryotic mRNAs assemble 3′ untranslated region RNA-protein complexes sharing cis and trans components. Proc. Natl. Acad. Sci. 94: 2410-2414.
14. Jackson, R.J. 2002. Proteins involved in the function of Picornavirus internal ribosome entry sites. In Molecular biology of picornaviruses (eds. B.L. Semler and E. Wimmer), pp. 171-183. ASM Press, Washington, DC.
15. Jang, S.K., Krausslich, H.G., Nicklin, M.J., Duke, G.M., Palmenberg, A.C., and Wimmer, E. 1988. A segment of the 5′ nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation. J. Virol. 62: 2636-2643.
16. Kiledjian, M., Wang, X., and Liebhaber, S.A. 1995. Identification of two KH domain proteins in the α-globin mRNP stability complex. EMBO J. 14: 4357-4364.
17. Kim, J.H., Hahm, B., Kim, Y.K., Choi, M., and Jang, S.K. 2000. Protein-protein interaction among hnRNPs shuttling between nucleus and cytoplasm. J. Mol. Biol. 298: 395-405.
18. Lindquist, J.N., Kauschke, S.G., Stefanovic, B., Burchardt, E.R., and Brenner, D.A. 2000. Characterization of the interaction between alphaCP(2) and the 3′-untranslated region of collagen alpha1(I) mRNA. Nucleic Acids Res. 28: 4306-4316.
19. Makeyev, A.V. and Liebhaber, S.A. 2000. Identification of two novel mammalian genes establishes a subfamily of KH-domain RNA-binding proteins. Genomics 67: 301-316.
20. -. 2002. The poly(C)-binding proteins: A multiplicity of functions and a search for mechanisms. RNA 8: 265-278.
21. Musco, G., Stier, G., Joseph, C., Castiglione Morelli, M.A., Nilges, M., Gibson, T.J., and Pastore, A. 1996. Three-dimensional structure and stability of the KH domain: Molecular insights into the fragile X syndrome. Cell 85: 237-245.
22. Musco, G., Kharrat, A., Stier, G., Fraternali, F., Gibson, T.J., Nilges, M., and Pastore, A. 1997. The solution structure of the first KH domain of FMR1, the protein responsible for the fragile X syndrome. Nat. Struct. Biol. 4: 712-716.
23. Ostareck-Lederer, A., Ostareck, D.H., Standart, N., and Thiele, B.J. 1994. Translation of 15-lipoxygenase mRNA is inhibited by a protein that binds to a repeated sequence in the 3′ untranslated region. EMBO J. 13: 1476-1481.
24. Parsley, T.B., Towner, J.S., Blyn, L.B., Ehrenfeld, E., and Semler, B.L. 1997. Poly (rC) binding protein 2 forms a ternary complex with the 5′-terminal sequences of poliovirus RNA and the viral 3CD proteinase. RNA 3: 1124-1134.
25. Pelletier, J., Kaplan, G., Racaniello, V.R., and Sonenberg, N. 1988. Cap-independent translation of poliovirus mRNA is conferred by sequence elements within the 5′ noncoding region. Mol. Cell Biol. 8: 1103-1112.
26. Shnyreva, M., Schullery, D.S., Suzuki, H., Higaki, Y., and Bomsztyk, K. 2000. Interaction of two multifunctional proteins, heterogeneous nuclear ribonucleoprotein K and Y-box-binding protein 1. J. Biol. Chem. 275: 15498-15503.
27. Silvera, D., Gamarnik, A.V., and Andino, R. 1999. The N-terminal K homology domain of the Poly(rC)-binding protein is a major determinant for binding to the poliovirus 5′-untranslated region and acts as an inhibitor of viral translation. J. Biol. Chem. 274: 38163-38170.
28. Siomi, H., Matunis, M.J., Michael, W.M., and Dreyfuss, G. 1993. The pre-mRNA binding K protein contains a novel evolutionarily conserved motif. Nucleic. Acids. Res. 21: 1193-1198.
29. Stefanovic, B., Hellerbrand, C., Holcik, M., Briendl, M., Liebhaber, S., and Brenner, D.A. 1997. Posttranscriptional regulation of collagen alphal (I) mRNA in hepatic stellate cells. Mol. Cell Biol. 17: 5201-5209.
30. Tommerup, N. and Leffers, H. 1996. Assignment of the human genes encoding 14,3-3 Eta (YWHAH) to 22q12, 14-3-3 zeta (YWHAZ) to 2p25.1-p25.2, and 14-3-3 β (YWHAB) to 20q13.1 by in situ hybridization. Genomics 33: 149-150.
31. Walter, B.L., Nguyen, J.H., Ehrenfeld, E., and Semler, B.L. 1999. Differential utilization of poly(rC) binding protein 2 in translation directed by picornavirus IRES elements. RNA 5: 1570-1585.
32. Walter, B.L., Parsley, T.B., Ehrenfeld, E., and Semler, B.L. 2002. Distinct poly(rC) binding protein KH domain determinants for poliovirus translation initiation and viral RNA replication. J. Virol. 76: 12008-12022.
33. Weiss, I.M. and Liebhaber, S.A. 1994. Erythroid cell-specific determinants of α-globin mRNA stability. Mol. Cell Biol. 14: 8123-8132.
34. -. 1995. Erythroid cell-specific mRNA stability elements in the α 2-globin 3′ nontranslated region. Mol. Cell Biol. 15: 2457-2465.