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195813 Efficacy and tolerability of multiple-dose SDZ IMM 125 in patients with severe psoriasis. Witkamp L, Zonneveld IM, Jung EG, Schopf RE, Christophers E, Grossman R, Meffert H, Belaich S, Mahrle G, Van Joost T BR J DERMATOL 1995 133 1 95-103
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195813 Efficacy and tolerability of multiple-dose SDZ IMM 125 in patients with severe psoriasis. Witkamp L, Zonneveld IM, Jung EG, Schopf RE, Christophers E, Grossman R, Meffert H, Belaich S, Mahrle G, Van Joost T BR J DERMATOL 1995 133 1 95-103
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282683 Cyclosporin A and tacrolimus FK-506, Immunosuppression through immunophilin-dependent inhibition of calcineurin function. Dumont FJ PRINCIPLES DRUG DEV TRANSPLANT AUTOIMMUN 1996 1 175-205
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282683 Cyclosporin A and tacrolimus (FK-506). Immunosuppression through immunophilin-dependent inhibition of calcineurin function. Dumont FJ PRINCIPLES DRUG DEV TRANSPLANT AUTOIMMUN 1996 1 175-205
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285453 Discovery of less nephrotoxic FK-506 analogs and determining immunophilin dependence of immunosuppressant nephrotoxicity with a novel single-dose rat cisplatin potentiation assay. Mollison KW, Fey TA, Krause RA, Andrews JM, Bretheim PT, Brandt JA, Kawai M, Wagner R, Hsieh GC, Luly JR J PHARMACOL EXP THER 1997 283 3 1509-1519
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285453 Discovery of less nephrotoxic FK-506 analogs and determining immunophilin dependence of immunosuppressant nephrotoxicity with a novel single-dose rat cisplatin potentiation assay. Mollison KW, Fey TA, Krause RA, Andrews JM, Bretheim PT, Brandt JA, Kawai M, Wagner R, Hsieh GC, Luly JR J PHARMACOL EXP THER 1997 283 3 1509-1519
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388807 Isotechnika Inc announces the development of ISAtx247 for the treatment of rheumatoid arthritis. Isotechnika Inc PRESS RELEASE 2000 November 07
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388807 Isotechnika Inc announces the development of ISAtx247 for the treatment of rheumatoid arthritis. Isotechnika Inc PRESS RELEASE 2000 November 07
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395645 Isotechnika Inc announces successful completion of phase I clinical trials for its new immunosuppressive drug ISAtx247. Isotechnika Inc PRESS RELEASE 2001 January 09
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395645 Isotechnika Inc announces successful completion of phase I clinical trials for its new immunosuppressive drug ISAtx247. Isotechnika Inc PRESS RELEASE 2001 January 09
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396944 Isotechnika Inc announces development of its new immunosupressive drug ISAtx247 in treatment of psoriasis. Isotechnika Inc PRESS RELEASE 2001 January 25
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396944 Isotechnika Inc announces development of its new immunosupressive drug ISAtx247 in treatment of psoriasis. Isotechnika Inc PRESS RELEASE 2001 January 25
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398373 New Drug for Prevention of Insulin-Dependent Diabetes. Isotechnika Inc PRESS RELEASE 2001 February 08
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398373 New Drug for Prevention of Insulin-Dependent Diabetes. Isotechnika Inc PRESS RELEASE 2001 February 08
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413607 Preclinical efficacy of a novel calcineurin inhibitor: ISAtx247. Abel MD, Aspeslet LJ, Freitag DG, Halloran PF, Kneteman NM, Naicker SS, Trepanier DJ, Foster RT, Yatscoff RW AM J TRANSPLANTATION 2001 1 1 Abs 1191
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413607 Preclinical efficacy of a novel calcineurin inhibitor: ISAtx247. Abel MD, Aspeslet LJ, Freitag DG, Halloran PF, Kneteman NM, Naicker SS, Trepanier DJ, Foster RT, Yatscoff RW AM J TRANSPLANTATION 2001 1 1 Abs 1191
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413608 ISAtx247: A novel calcineurin inhibitor with minimal renal toxicity. Abel MD, Aspeslet LJ, Freitag DJ, Halloran PF, Kneteman NT, Naicker SS, Trepanier DJ, Foster RT, Yatscoff RW AM J TRANSPLANTATION 2001 1 1 Abs 1192
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413608 ISAtx247: A novel calcineurin inhibitor with minimal renal toxicity. Abel MD, Aspeslet LJ, Freitag DJ, Halloran PF, Kneteman NT, Naicker SS, Trepanier DJ, Foster RT, Yatscoff RW AM J TRANSPLANTATION 2001 1 1 Abs 1192
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413613 Ex vivo evaluation of the immunosuppressive effect of the novel calcineurin inhibitor ISAtx247 on whole blood lymphocytes of non-human primates. Bisran T, Dambrin C, Villanueva JC, Yatscoff RW, Morris RE AM J TRANSPLANTATION 2001 1 1 Abs 1199
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413613 Ex vivo evaluation of the immunosuppressive effect of the novel calcineurin inhibitor ISAtx247 on whole blood lymphocytes of non-human primates. Bisran T, Dambrin C, Villanueva JC, Yatscoff RW, Morris RE AM J TRANSPLANTATION 2001 1 1 Abs 1199
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413803 Phase 1 evaluation of a novel calcineurin inhibitor ISAtx247. Abel MD, Aspeslet LJ, Freitag DG, Halloran PF, Kneteman NM, Naicker S, Trepanier DJ, Foster RT, Yatscoff RW AM J TRANSPLANTATION 2001 1 1 Abs 1319
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413803 Phase 1 evaluation of a novel calcineurin inhibitor ISAtx247. Abel MD, Aspeslet LJ, Freitag DG, Halloran PF, Kneteman NM, Naicker S, Trepanier DJ, Foster RT, Yatscoff RW AM J TRANSPLANTATION 2001 1 1 Abs 1319
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414183 Isotechnika involved in $25 million special warrant financing. Isotechnika Inc PRESS RELEASE 2001 June 29
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414183 Isotechnika involved in $25 million special warrant financing. Isotechnika Inc PRESS RELEASE 2001 June 29
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417848 New drug tested in organ transplant patients, Isotechnika replaces Cyclosporine with ISAtx247 in phase II human trials. Isotechnika Inc PRESS RELEASE 2001 August 02
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417848 New drug tested in organ transplant patients - Isotechnika replaces Cyclosporine with ISAtx247 in phase II human trials. Isotechnika Inc PRESS RELEASE 2001 August 02
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420623 Isotechnika Inc announces second quarter 2001 financial results quarter highlighted by significant growth in diagnostic product sales, FDA and Health Canada approval to commence phase II human trials and signing of bought underwriting deal. Isotechnika Inc PRESS RELEASE 2001 August 29
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420623 Isotechnika Inc announces second quarter 2001 financial results quarter highlighted by significant growth in diagnostic product sales, FDA and Health Canada approval to commence phase II human trials and signing of bought underwriting deal. Isotechnika Inc PRESS RELEASE 2001 August 29
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422279 Prevention and treatment of antigen-induced arthritis by ISAtx247, a novel calcineurin inhibitor. Maksymowych WP, Aspeslet L, Abel M, Trepanier D, Naicker R J RHEUMATOL 2001 28 Suppl 63 92
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422279 Prevention and treatment of antigen-induced arthritis by ISAtx247, a novel calcineurin inhibitor. Maksymowych WP, Aspeslet L, Abel M, Trepanier D, Naicker R J RHEUMATOL 2001 28 Suppl 63 92
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422284 Amelioration of established collagen-induced arthritis by ISAtx247, a novel calcineurin inhibitor. Maksymowych WP, Aspeslet L, Abel M, Trepanier D, Naicker R J RHEUMATOL 2001 28 Suppl 63 93
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422284 Amelioration of established collagen-induced arthritis by ISAtx247, a novel calcineurin inhibitor. Maksymowych WP, Aspeslet L, Abel M, Trepanier D, Naicker R J RHEUMATOL 2001 28 Suppl 63 93
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422287 A novel calcineurin inhibitor with minimal renal toxicity: ISAtx247. Yatscoff RW, Abel M, Aspeslet L, Freitag DG, Naicker R J RHEUMATOL 2001 28 Suppl 63 109
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422287 A novel calcineurin inhibitor with minimal renal toxicity: ISAtx247. Yatscoff RW, Abel M, Aspeslet L, Freitag DG, Naicker R J RHEUMATOL 2001 28 Suppl 63 109
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424142 Isotechnika begins psoriasis trials. Isotechnika Inc PRESS RELEASE 2001 October 03
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424142 Isotechnika begins psoriasis trials. Isotechnika Inc PRESS RELEASE 2001 October 03
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440188 A tacrolimus-related immunosuppressant with reduced toxicity. Dumont FJ, Koprak S, Staruch MJ, Talento A, Koo G, Dasilva C, Sinclair PJ, Wong F, Woods J, Barker J, Pivnichny J et al TRANSPLANTATION 1998 65 1 18-26
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440188 A tacrolimus-related immunosuppressant with reduced toxicity. Dumont FJ, Koprak S, Staruch MJ, Talento A, Koo G, Dasilva C, Sinclair PJ, Wong F, Woods J, Barker J, Pivnichny J et al TRANSPLANTATION 1998 65 1 18-26
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446732 Isotechnika and Roche sign largest drug development agreement in Canadian history. Isotechnika Inc PRESS RELEASE 2002 April 09
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446732 Isotechnika and Roche sign largest drug development agreement in Canadian history. Isotechnika Inc PRESS RELEASE 2002 April 09
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446734 Roche strengthens its presence in transplantation medicine by signing agreement to co-develop Isotechnika's new drug. Hoffmann-La Roche Inc PRESS RELEASE 2002 April 09
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446734 Roche strengthens its presence in transplantation medicine by signing agreement to co-develop Isotechnika's new drug. Hoffmann-La Roche Inc PRESS RELEASE 2002 April 09
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449607 Presentations to investors, Roche R&D Day for investors, Munich/Penzberg, Germany. Roche Holding AG COMPANY PRESENTATION 2002 April 25-26
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449607 Presentations to investors - Roche R&D Day for investors, Munich/Penzberg, Germany. Roche Holding AG COMPANY PRESENTATION 2002 April 25-26
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449687 United States Federal Trade Commission approves global drug development agreement signed by Isotechnika and Roche. Isotechnika Inc PRESS RELEASE 2002 April 29
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449687 United States Federal Trade Commission approves global drug development agreement signed by Isotechnika and Roche. Isotechnika Inc PRESS RELEASE 2002 April 29
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450789 Isotechnika and Roche to focus development of ISAtx247 in transplantation. Isotechnika Inc/Roche PRESS RELEASE 2002 May 10
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450789 Isotechnika and Roche to focus development of ISAtx247 in transplantation. Isotechnika Inc/Roche PRESS RELEASE 2002 May 10
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454091 ISAtx247: A novel calcineurin inhibitor. Aspeslet L, Freitag D, Trepanier D, Abel M, Naicker S, Kneteman N, Foster R, Yatscoff R TRANSPLANT PROC 2001 33 1-2 1048-1051
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454091 ISAtx247: A novel calcineurin inhibitor. Aspeslet L, Freitag D, Trepanier D, Abel M, Naicker S, Kneteman N, Foster R, Yatscoff R TRANSPLANT PROC 2001 33 1-2 1048-1051
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465238 Isotechnika earns significant drug development milestone payment. Isotechnika Inc PRESS RELEASE 2002 September 26
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465238 Isotechnika earns significant drug development milestone payment. Isotechnika Inc PRESS RELEASE 2002 September 26
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465840 Isotechnika and Roche announce completion of patient recruitment for ISA247 phase IIa clinical trial in kidney transplantation. Isotechnika Inc/Roche PRESS RELEASE 2002 October 03
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465840 Isotechnika and Roche announce completion of patient recruitment for ISA247 phase IIa clinical trial in kidney transplantation. Isotechnika Inc/Roche PRESS RELEASE 2002 October 03
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481300 Isotechnika's phase II clinical trial of ISA247 in patients with psoriasis yields impressive results. Isotechnika Inc PRESS RELEASE 2003 March 10
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481300 Isotechnika's phase II clinical trial of ISA247 in patients with psoriasis yields impressive results. Isotechnika Inc PRESS RELEASE 2003 March 10
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489872 Isotechnika earns $21,900,000 CDN drug development milestone payment. Isotechnika Inc PRESS RELEASE 2003 May 15
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489872 Isotechnika earns $21,900,000 CDN drug development milestone payment. Isotechnika Inc PRESS RELEASE 2003 May 15
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492349 Isotechnika releases final results of phase IIa kidney transplant trial at American Transplant Congress. Isotechnika Inc PRESS RELEASE 2003 June 04
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492349 Isotechnika releases final results of phase IIa kidney transplant trial at American Transplant Congress. Isotechnika Inc PRESS RELEASE 2003 June 04
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509752 Roche Holding AG, product pipeline. Roche Holding AG COMPANY WORLD WIDE WEB SITE 2003 October 16
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509752 Roche Holding AG - product pipeline. Roche Holding AG COMPANY WORLD WIDE WEB SITE 2003 October 16 http://www.roche.com
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515386 Development of the novel immunosuppressive agent ISAtx247 using a pharmacodynamic approach. Freitag G, Abel D, Aspeslet J, Trepanier J, Mayo R, Halloran PF, Kneteman NT, Morris RE, Gregory CR, Foster RT TOXICOL SCI 2003 72 1 Suppl 4
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515386 Development of the novel immunosuppressive agent ISAtx247 using a pharmacodynamic approach. Freitag G, Abel D, Aspeslet J, Trepanier J, Mayo R, Halloran PF, Kneteman NT, Morris RE, Gregory CR, Foster RT TOXICOL SCI 2003 72 1 Suppl 4
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515398 Amelioration of accelerated collagen induced arthritis by a novel calcineurin inhibitor, ISAtx247. Maksymowych WP, Jhangri GS, Aspeslet L, Abel MD, Trepanier DJ, Naicker S, Freitag DG, Cooper BL, Foster RT, Yatscoff RW J RHEUMATOL 2002 29 8 1646-1652
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515398 Amelioration of accelerated collagen induced arthritis by a novel calcineurin inhibitor, ISAtx247. Maksymowych WP, Jhangri GS, Aspeslet L, Abel MD, Trepanier DJ, Naicker S, Freitag DG, Cooper BL, Foster RT, Yatscoff RW J RHEUMATOL 2002 29 8 1646-1652
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515401 Amelioration of established collagen-induced arthritis by ISAtx247, a novel calcineurin inhibitor. Maksymowych WP, Jhangri G, Aspeslet L, Abel M, Trepanier D, Naicker R, Freitag D, Foster R, Yatscoff RW ARTHRITIS RHEUM 2001 44 9 Suppl S367
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515401 Amelioration of established collagen-induced arthritis by ISAtx247, a novel calcineurin inhibitor. Maksymowych WP, Jhangri G, Aspeslet L, Abel M, Trepanier D, Naicker R, Freitag D, Foster R, Yatscoff RW ARTHRITIS RHEUM 2001 44 9 Suppl S367
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523826 Isotechnika Inc, FDA agrees to manufacturing plans for ISA247. Isotechnika Inc PRESS RELEASE 2004 February 19
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523826 Isotechnika Inc - FDA agrees to manufacturing plans for ISA247. Isotechnika Inc PRESS RELEASE 2004 February 19
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524578 FDA agrees to clinical development plans for ISA-247. Isotechnika Inc PRESS RELEASE 2004 February 25
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524578 FDA agrees to clinical development plans for ISA-247. Isotechnika Inc PRESS RELEASE 2004 February 25
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526549 The mechanism of action of cyclosporin A and FK-506. Schreiber SL, Crabtree GR IMMUNOL TODAY 1992 13 4 136-142
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526549 The mechanism of action of cyclosporin A and FK-506. Schreiber SL, Crabtree GR IMMUNOL TODAY 1992 13 4 136-142
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526551 Ca2+/calcineurin signalling in cells of the immune system. Feske S, Okamura H, Hogan Rao A BIOCHEM BIOPHYS RES COMMUN 2003 311 4 1117-1132
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2+/calcineurin signalling in cells of the immune system. Feske S, Okamura H, Hogan PG, Rao A BIOCHEM BIOPHYS RES COMMUN 2003 311 4 1117-1132
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526552 Cyclosporine nephrotoxicity. Burdmann EA, Andoh TF, Yu L, Bennett WM SEMIN NEPHROL 2003 23 5 465-476
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526561 The immunosuppressive and toxic effects of FK-506 are mechanistically related: Pharmacology of a novel antagonist of FK-506 and rapamycin. Dumont FJ, Staruch MJ, Koprak SL, Siekierka JJ, Lin CS, Harrison R, Sewell T, Kindt VM, Beattie TR, Wyvratt M, Sigal NH J EXP MED 1992 176 3 751-760
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526561 The immunosuppressive and toxic effects of FK-506 are mechanistically related: Pharmacology of a novel antagonist of FK-506 and rapamycin. Dumont FJ, Staruch MJ, Koprak SL, Siekierka JJ, Lin CS, Harrison R, Sewell T, Kindt VM, Beattie TR, Wyvratt M, Sigal NH J EXP MED 1992 176 3 751-760
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526576 Cyclosporine- and FK-506-induced sympathetic activation correlates with calcineurin-mediated inhibition of T-cell signaling. Lyson T, Ermel LD, Belshaw PJ, Alberg DG, Schreiber SL, Victor RG CIRC RES 1993 73 3 596-602
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526576 Cyclosporine- and FK-506-induced sympathetic activation correlates with calcineurin-mediated inhibition of T-cell signaling. Lyson T, Ermel LD, Belshaw PJ, Alberg DG, Schreiber SL, Victor RG CIRC RES 1993 73 3 596-602
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526578 Nephrotoxicity of cyclosporin A and FK-506: Inhibition of calcineurin phosphatase. Su Q, Weber L, Le HM, Zenke G, Ryffel B REN PHYSIOL BIOCHEM 1995 18 3 128-139
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526583 A randomized pilot study of cyclosporin G in renal transplantation. Ohlman S, Lindholm A, Gabel H, Wilczek H, Tyden G, Reinholt F, Sawe J, Groth CG TRANSPLANT INT 1992 5 Suppl 1 S464-S469
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526583 A randomized pilot study of cyclosporin G in renal transplantation. Ohlman S, Lindholm A, Gabel H, Wilczek H, Tyden G, Reinholt F, Sawe J, Groth CG TRANSPLANT INT 1992 5 Suppl 1 S464-S469
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526705 A tacrolimus-related immunosuppressant with biochemical properties distinct from those of tacrolimus. Peterson LB, Cryan JG, Rosa R, Martin MM, Wilusz MB, Sinclair PJ, Wong F, Parsons JN, O'Keefe SJ, Parsons WH, Wyvratt M et al TRANSPLANTATION 1998 65 1 10-18
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526705 A tacrolimus-related immunosuppressant with biochemical properties distinct from those of tacrolimus. Peterson LB, Cryan JG, Rosa R, Martin MM, Wilusz MB, Sinclair PJ, Wong F, Parsons JN, O'Keefe SJ, Parsons WH, Wyvratt M et al TRANSPLANTATION 1998 65 1 10-18
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526709 Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. Fruman DA, Klee CB, Bierer BE, Burakoff SJ PROC NATL ACAD SCI USA 1992 89 9 3686-3690
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526709 Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. Fruman DA, Klee CB, Bierer BE, Burakoff SJ PROC NATL ACAD SCI USA 1992 89 9 3686-3690
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526711 Calcineurin activity is only partially inhibited in leukocytes of cyclosporine-treated patients. Batiuk TD, Pazderka F, Halloran PF TRANSPLANTATION 1995 59 10 1400-1404
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526711 Calcineurin activity is only partially inhibited in leukocytes of cyclosporine-treated patients. Batiuk TD, Pazderka F, Halloran PF TRANSPLANTATION 1995 59 10 1400-1404
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526713 The temporal profile of calcineurin inhibition by cyclosporine in vivo. Halloran PF, Helms L, Kung L, Noujaim J TRANSPLANTATION 1999 68 9 1356-1361
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526713 The temporal profile of calcineurin inhibition by cyclosporine in vivo. Halloran PF, Helms L, Kung L, Noujaim J TRANSPLANTATION 1999 68 9 1356-1361
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526714 In vivo evaluation of the novel calcineurin inhibitor ISAtx247 in non-human primates. Stalder M, Birsan T, Hubble RW, Paniagua RT, Morris RE J HEART LUNG TRANSPLANT 2003 22 12 1343-1352
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526714 In vivo evaluation of the novel calcineurin inhibitor ISAtx247 in non-human primates. Stalder M, Birsan T, Hubble RW, Paniagua RT, Morris RE J HEART LUNG TRANSPLANT 2003 22 12 1343-1352
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526718 ISAtx247: Phase I clinical trial results of the novel calcineurin inhibitor. Yatscoff RW, Abel MD, Aspeslet L, Freitag DG, Naicker SS, Trepanier DJ, Foster RT J RHEUMATOL 2001 28 63 Suppl Abs W109
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526725 Phase 2, randomized, multicenter, open-label study of ISA247 and Neoral in post-renal transplant patients. Yatscoff RW, Abel MD, Aspeslet LJ, Foster RT, Freitag DG, Huizinga RB, Mayo PR, Trepanier DJ AM J TRANSPLANT 2003 Abs 1215
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526725 Phase 2, randomized, multicenter, open-label study of ISA247 and Neoral in post-renal transplant patients. Yatscoff RW, Abel MD, Aspeslet LJ, Foster RT, Freitag DG, Huizinga RB, Mayo PR, Trepanier DJ AM J TRANSPLANT 2003 Abs 1215
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526729 Chronic cyclosporine-induced nephrotoxicity: A rabbit model. Thliveris JA, Yatscoff RW, Mihatsch MJ TRANSPLANTATION 1994 57 5 774-776
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526729 Chronic cyclosporine-induced nephrotoxicity: A rabbit model. Thliveris JA, Yatscoff RW, Mihatsch MJ TRANSPLANTATION 1994 57 5 774-776
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526730 Psoriasis. Lebwohl M LANCET 2003 361 9364 1197-1204
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526731 Cyclosporine in severe psoriasis. Results of a meta-analysis in 579 patients. Faerber L, Braeutigam M, Weidinger G, Mrowietz U, Christophers E, Schulze HJ, Mahrle G, Meffert H, Drechsler S AM J CLIN DERMATOL 2001 2 1 41-47
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526731 Cyclosporine in severe psoriasis. Results of a meta-analysis in 579 patients. Faerber L, Braeutigam M, Weidinger G, Mrowietz U, Christophers E, Schulze HJ, Mahrle G, Meffert H, Drechsler S AM J CLIN DERMATOL 2001 2 1 41-47
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526733 Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes. Huai Q, Kim HY, Liu Y, Zhao Y, Mondragon A, Liu JO, Ke H PROC NATL ACAD SCI USA 2002 99 19 12037-12042
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526733 Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes. Huai Q, Kim HY, Liu Y, Zhao Y, Mondragon A, Liu JO, Ke H PROC NATL ACAD SCI USA 2002 99 19 12037-12042
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526737 Is cyclophilin involved in the immunosuppressive and nephrotoxic mechanism of action of cyclosporin A? Sigal NH, Dumont F, Durette P, Siekierka JJ, Peterson L, Rich DH, Dunlap BE, Staruch MJ, Melino MR, Koprak SL J EXP MED 1991 173 3 619-628
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526737 Is cyclophilin involved in the immunosuppressive and nephrotoxic mechanism of action of cyclosporin A? Sigal NH, Dumont F, Durette P, Siekierka JJ, Peterson L, Rich DH, Dunlap BE, Staruch MJ, Melino MR, Koprak SL J EXP MED 1991 173 3 619-628
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