Increased site 1 affinity improves biopotency of porcine growth hormone: Evidence against diffusion dependent receptor dimerization

Journal of Biological Chemistry

Volumn 279, Issue 43, 2004, Pages 44775-44784

  Wan, Yu ^a   McDevitt, Andrew ^a   Shen, Bojiang ^a   Smythe, Mark L ^a   Waters, Michael J ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIOPHAGES; BIOCHEMISTRY; MUTAGENESIS; OPTIMIZATION; SIGNALING;

AFFINITY; BIOPOTENCY; GROWTH HORMONES (GH); TERNARY COMPLEXES;

HORMONES;

GROWTH HORMONE; GROWTH HORMONE RECEPTOR; HISTIDINE; LYSINE; TRYPTOPHAN;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; HORMONE ACTION; KINETICS; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; SUBSTITUTION REACTION;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BIOLOGICAL ASSAY; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; DIFFUSION; DIMERIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; GENETIC VECTORS; GROWTH HORMONE; KINETICS; LYSINE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; OXYGEN; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; SURFACE PLASMON RESONANCE; SWINE; TRYPTOPHAN;

PRIMATES; SUIDAE; UNIDENTIFIED BACTERIOPHAGE;

EID: 7244226345     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M406092200     Document Type: Article

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