Field effect of human colon carcinoma on normal mucosa: Relevance of carcinoembryonic antigen expression

Tumor Biology

Volumn 17, Issue 1, 1996, Pages 58-64

  Jothy, Serge ^a   Ślesak, Barbara ^b   Harłozińska, Antonina ^b   Lapińska, Jadwiga ^b   Adarniak, Jolanta ^b   Rabczyński, Jerzy ^b  

^a MCGILL UNIVERSITY   (Canada)

^b WROCLAW MEDICAL UNIVERSITY   (Poland)

Author keywords

Carcinoembryonic antigen; Colon Carcinoma; D14 monoclonal antibody; Field effect; Immunohistochemistry

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; MONOCLONAL ANTIBODY D14; UNCLASSIFIED DRUG;

ARTICLE; CLINICAL ARTICLE; COLON CARCINOMA; COLON MUCOSA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL;

EID: 0029655379     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1159/000217967     Document Type: Article

References (15)

1. Thibodeau SN, Bren G, Schaid D: Microsatellitc instability in cancer of the proximal colon. Science 1993; 260:816-819.
2. Jothy S, Yuan S, Shirota K: Transcription of carcinoembryonic antigen in normal colon and colon carcinoma: In situ hybridization study and implication for a new in vivo functional model. Am J Pathol 1993;143:250-257.
3. Jothy S, Brazinsky SA, Chin-A-Loy M, Haggarty A, Krantz MJ. Cheung M, Fuks A: Characterization of monoclonal antibodies to carcinoembryonic antigen with increased tumor specificity. Lab Invest 1986; 54:108-117.
4. Burtin P, Martin E, Sabine MC, von Kleist S: Immunological study of polyps of the colon. J Natl Cancer Inst 1972;48:25-32.
5. Slcsak B, Hartozüiska A, Lapüiska J: Comparison of CEA, p53 and Ki67 expression in colorectal cancer and ulcerative colitis. Cancer Mol Biol 1994;1:199-205.
6. Denk H, Pappeiner G, Eckerstorfer R, Holzner JH: Carcinoembryonic antigen (CEA) in gastrointestinal and extragastrointcstinal tumors and its relationship to tumor-cell differentiation. Int J Cancer 1992; 10:262-272.
7. Graves P, Filipe MI, Abbas A, Ormerou MG: Sialomucins and carcinoembryonic antigen in the evolution of colorectal cancer. Histopathology 1984;8:825-834.
8. Haggarty A, Legler C, Krantz MJ, Fuks A: Epitopes of carcinoembryonic antigen defined by monoclonal antibodies prepared from mice immunized with purified car-cinocmbryonic antigen or HCT-8R cells. Cancer Res 1986:46:300-309.
9. Pavelic ZP, Petrellii NJ, Herrera L, Vaughan MM, Peacock J, Pavelic L: D-14 monoclonal antibody to carcinoembryonic antigen: Immunohis-tochcmical analysis of formalin-fixed, paraffin-embedded human colorectal carcinoma, tumors of non-colorectal origin and normal tissues. J Cancer Res Clin Oncol 1990;116:5-56.
10. Benchimol S, Fuks A, Jothy S, Beauchemin N, Shirota K, Stanners CP: Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule. Cell 1989;57:327-334.
11. Ngoi SS, Staiano-Coico L, Godwin TA, Wong RJ, Decosse JJ: Abnormal DNA ploidy and proliferative patterns in superficial colonic epithelium adjacent to colorectal cancer. Cancer 1990;66:953-959.
12. Slesak B, Harloziriska A, Adamiak J: Field effect of CEA Ki67 and evaluation of local immune response in colon cancer. Anal Cell Pathol 1994: 6:286-287.
13. Al-Sheneber I, Shibata H, Sampalis J, Jothy S: Prognostic significance of proliferating cell nuclear antigen (PCNA) expression in colorectal cancer. Cancer 1993;71:1954-1959.
14. Baytner S, Mitmaker B, Gordon PH, Wang E: Immunohistochcmical expression of mutant p53 oncogene in transitional mucosa adjacent to human colon cancer. Clin Invest Med 1993:16:379-385.
15. Minamoto T, Ronai Z, Yamashita N, Ochiai A, Sugimura T, Mai M, Esumi H: Detection of Ki-ras mutation in non-neoplastic mucosa of Japanese patients with colorectal cancers. Int J Oncol 1994;4:397-401.