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Volumn 30, Issue 3, 2001, Pages 105-111

The methylenetetrahydrofolate reductase (MTHFR) gene in colorectal cancer: Role in tumor development and significance of allelic loss in tumor progression

Author keywords

Colorectal cancer; Genetics; LOH; MTHFR; Polymorphism

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); GENOMIC DNA;

EID: 0035785560     PISSN: 01694197     EISSN: None     Source Type: Journal    
DOI: 10.1385/ijgc:30:3:105     Document Type: Article
Times cited : (30)

References (35)
  • 2
    • 0027286578 scopus 로고
    • Folate, methionine and alcohol intake and risk of colorectal adenoma
    • Giovannucci E, Stampfer M, Colditz G, et al. Folate, methionine and alcohol intake and risk of colorectal adenoma. J Natl Cancer Inst 1993;6685:875-884.
    • (1993) J Natl Cancer Inst , vol.6685 , pp. 875-884
    • Giovannucci, E.1    Stampfer, M.2    Colditz, G.3
  • 4
    • 0032491811 scopus 로고    scopus 로고
    • Folate intake, alcohol consumption, cigarette smoking, and risk of colorectal adenomas
    • Baron J, Sandler R, Haile R, Mandel J, Mott L, Greenberg E. Folate intake, alcohol consumption, cigarette smoking, and risk of colorectal adenomas. J Natl Cancer Inst 1998;90:57-62.
    • (1998) J Natl Cancer Inst , vol.90 , pp. 57-62
    • Baron, J.1    Sandler, R.2    Haile, R.3    Mandel, J.4    Mott, L.5    Greenberg, E.6
  • 5
    • 0032190337 scopus 로고    scopus 로고
    • Multivitamin use, folate, and colon cancer in women in the Nurses' Health Study
    • Giovannucci E, Stampfer M, Colditz G, et al. Multivitamin use, folate, and colon cancer in women in the Nurses' Health Study. Ann Int Med 1998;129:517-524.
    • (1998) Ann Int Med , vol.129 , pp. 517-524
    • Giovannucci, E.1    Stampfer, M.2    Colditz, G.3
  • 6
    • 0023856775 scopus 로고
    • Colorectal cancer in ulcerative colitis - A cohort study of primary referrals from three centres
    • Gyde S, Prior P, Allan R, et al. Colorectal cancer in ulcerative colitis - a cohort study of primary referrals from three centres. Gut 1988;29:206-217.
    • (1988) Gut , vol.29 , pp. 206-217
    • Gyde, S.1    Prior, P.2    Allan, R.3
  • 7
    • 0025092693 scopus 로고
    • Ulcerative colitis and colorectal cancer: A population-based study
    • Ekbom A, Helmick C, Zack M, Adami H. Ulcerative colitis and colorectal cancer: a population-based study. N Engl J Med 1990;323:1228-1233.
    • (1990) N Engl J Med , vol.323 , pp. 1228-1233
    • Ekbom, A.1    Helmick, C.2    Zack, M.3    Adami, H.4
  • 8
    • 0024413724 scopus 로고
    • The effect of folate supplementation on the incidence of dysplasia and cancer in chronic ulcerative colitis: A case-control study
    • Lashner B, Heidenreich P, Su G, Kano S, Hanauer S. The effect of folate supplementation on the incidence of dysplasia and cancer in chronic ulcerative colitis: a case-control study. Gastroenterology 1989;97:255-259.
    • (1989) Gastroenterology , vol.97 , pp. 255-259
    • Lashner, B.1    Heidenreich, P.2    Su, G.3    Kano, S.4    Hanauer, S.5
  • 9
    • 0031022797 scopus 로고    scopus 로고
    • Folate deficiency in rats induces DNA strand breaks and hypomethylation within p53 tumor suppressor gene
    • Kim I, Pogribny I, Basnakin A, et al. Folate deficiency in rats induces DNA strand breaks and hypomethylation within p53 tumor suppressor gene. Am J Clin Nutr 1997;65:46-52.
    • (1997) Am J Clin Nutr , vol.65 , pp. 46-52
    • Kim, I.1    Pogribny, I.2    Basnakin, A.3
  • 10
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon E, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990;61:759-767.
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.1    Vogelstein, B.2
  • 11
    • 0031428480 scopus 로고    scopus 로고
    • Presence and consequence of uracil in preneoplastic DNA from folate/methyl-deficient rats
    • Pogribny I, Muskhelishvili L, Miller B, James S. Presence and consequence of uracil in preneoplastic DNA from folate/methyl-deficient rats. Carcinogenesis 1997;18:2071-2076.
    • (1997) Carcinogenesis , vol.18 , pp. 2071-2076
    • Pogribny, I.1    Muskhelishvili, L.2    Miller, B.3    James, S.4
  • 12
    • 0031427093 scopus 로고    scopus 로고
    • Apoptosis and proliferation under conditions of deoxynucleotide pool imbalance in liver of folate/methyl deficient rats
    • James S, Miller B, Basnakian A, Pogribny I, Pogribna M, Muskhelishvili L. Apoptosis and proliferation under conditions of deoxynucleotide pool imbalance in liver of folate/methyl deficient rats. Carcinogenesis 1997;18:287-293.
    • (1997) Carcinogenesis , vol.18 , pp. 287-293
    • James, S.1    Miller, B.2    Basnakian, A.3    Pogribny, I.4    Pogribna, M.5    Muskhelishvili, L.6
  • 13
    • 0030979178 scopus 로고    scopus 로고
    • Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: Implications for cancer and neuronal damage
    • Blount B, Mack M, Wehr C, et al. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci 1997;94:3290-3295.
    • (1997) Proc Natl Acad Sci , vol.94 , pp. 3290-3295
    • Blount, B.1    Mack, M.2    Wehr, C.3
  • 14
    • 0029049553 scopus 로고
    • A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase
    • Frosst P, Blom H, Milos R. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995;10:111-113.
    • (1995) Nat Genet , vol.10 , pp. 111-113
    • Frosst, P.1    Blom, H.2    Milos, R.3
  • 15
    • 0029806746 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphisms, plasma folate, homocysteine and risk of myocardial infarction in US physicians
    • Ma J, Stampfer M, Selhub J, et al. Methylenetetrahydrofolate reductase polymorphisms, plasma folate, homocysteine and risk of myocardial infarction in US physicians. Circulation 1996;94:2410-2416.
    • (1996) Circulation , vol.94 , pp. 2410-2416
    • Ma, J.1    Stampfer, M.2    Selhub, J.3
  • 16
    • 0030955502 scopus 로고    scopus 로고
    • Thermolabile variant of 5,10-methylenetetrahydrofolate reductase associated with low red-cell folates: Implications for folate intake recommendations
    • Molloy A, Daly S, Mills J, et al. Thermolabile variant of 5,10-methylenetetrahydrofolate reductase associated with low red-cell folates: implications for folate intake recommendations. Lancet 1997;349((9065)):1591-1593.
    • (1997) Lancet , vol.349 , Issue.9065 , pp. 1591-1593
    • Molloy, A.1    Daly, S.2    Mills, J.3
  • 17
    • 0033846460 scopus 로고    scopus 로고
    • Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals whho are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene
    • Stern L, Mason J, Selhub J, Choi S. Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals whho are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene. Cancer Epidemiol Biomarkers Prev 2000;9:849-853.
    • (2000) Cancer Epidemiol Biomarkers Prev , vol.9 , pp. 849-853
    • Stern, L.1    Mason, J.2    Selhub, J.3    Choi, S.4
  • 18
    • 0028844492 scopus 로고
    • Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida
    • van der Put N, Steegers-Theunissen R, Frosst P, et al. Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida. Lancet 1995;346:1070-1071.
    • (1995) Lancet , vol.346 , pp. 1070-1071
    • Van der Put, N.1    Steegers-Theunissen, R.2    Frosst, P.3
  • 19
    • 0026633925 scopus 로고
    • Hyperhomocysteinaemia as a risk factor for occlusive vascular disease
    • Kang S, Wong P, Malinow M. Hyperhomocysteinaemia as a risk factor for occlusive vascular disease. Ann Rev Nutr 1992;12:279-98.
    • (1992) Ann Rev Nutr , vol.12 , pp. 279-298
    • Kang, S.1    Wong, P.2    Malinow, M.3
  • 20
    • 0029975240 scopus 로고    scopus 로고
    • Genetic analysis of thermolabile methylenetetrahydrofolate reductase as a risk factor for myocardial infarction
    • Adams M, Smith P, Martin D, Thompson J, Lodwick D, Samana N. Genetic analysis of thermolabile methylenetetrahydrofolate reductase as a risk factor for myocardial infarction. Quart J Med 1996;89:437-444.
    • (1996) Quart J Med , vol.89 , pp. 437-444
    • Adams, M.1    Smith, P.2    Martin, D.3    Thompson, J.4    Lodwick, D.5    Samana, N.6
  • 21
    • 0033370552 scopus 로고    scopus 로고
    • Colorectal adenomas and the C677T MTHFR polymorphism: Evidence for gene-environment interaction
    • Ulrich C, Kampmann E, Bigler J, et al. Colorectal Adenomas and the C677T MTHFR Polymorphism: Evidence for gene-Environment Interaction. Cancer, Epidemiol, Biomark, Prev 1999;8:659-668.
    • (1999) Cancer, Epidemiol, Biomark, Prev , vol.8 , pp. 659-668
    • Ulrich, C.1    Kampmann, E.2    Bigler, J.3
  • 22
    • 0034647021 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphism and the risk of colorectal adenomas
    • Marugame T, Tsuji E, Inoue H, et al. Methylenetetrahydrofolate reductase polymorphism and the risk of colorectal adenomas. Cancer Lett 2000;151:181-186.
    • (2000) Cancer Lett , vol.151 , pp. 181-186
    • Marugame, T.1    Tsuji, E.2    Inoue, H.3
  • 23
    • 0032434823 scopus 로고    scopus 로고
    • A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma
    • Chen J, Giovannucci E, Hankinson S, et al. A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma. Carcinogenesis 1998;19(12):2129-32.
    • (1998) Carcinogenesis , vol.19 , Issue.12 , pp. 2129-2132
    • Chen, J.1    Giovannucci, E.2    Hankinson, S.3
  • 25
    • 0029855024 scopus 로고    scopus 로고
    • A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer
    • Chen J, Giovannucci E, Kelsey K, et al. A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer. Cancer Res 1996;56(21):4862-4.
    • (1996) Cancer Res , vol.56 , Issue.21 , pp. 4862-4864
    • Chen, J.1    Giovannucci, E.2    Kelsey, K.3
  • 26
    • 0030615085 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer
    • Ma J, Stampfer M, Giovannucci E, et al. Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer. Cancer Res 1997;57(6):1098-1102.
    • (1997) Cancer Res , vol.57 , Issue.6 , pp. 1098-1102
    • Ma, J.1    Stampfer, M.2    Giovannucci, E.3
  • 27
    • 0031431662 scopus 로고    scopus 로고
    • Germ line polymorphisms in cytochrome-P450 1A1 (C4887 CYP1A1) and methylenetatrahydrofolate reductase (MTHFR) genes and endometrial cancer susceptibility
    • Esteller M, Garcia A, Matrinez-Palones J, Xercavins J, Raventos J. Germ line polymorphisms in cytochrome-P450 1A1 (C4887 CYP1A1) and methylenetatrahydrofolate reductase (MTHFR) genes and endometrial cancer susceptibility. Carcinogenesis 1997;18(12):2307-2311.
    • (1997) Carcinogenesis , vol.18 , Issue.12 , pp. 2307-2311
    • Esteller, M.1    Garcia, A.2    Matrinez-Palones, J.3    Xercavins, J.4    Raventos, J.5
  • 28
    • 0029991547 scopus 로고    scopus 로고
    • Deletions at chromosome 1p by fluorescence in situ hybridisation are an early event in human colorectal tumorigenesis
    • Di Vinci A, Infusini E, Peveri C, Risio M, Rossini FP, Giaretti W. Deletions at chromosome 1p by fluorescence in situ hybridisation are an early event in human colorectal tumorigenesis. Gastroenterology 1996;111:102-107.
    • (1996) Gastroenterology , vol.111 , pp. 102-107
    • Di Vinci, A.1    Infusini, E.2    Peveri, C.3    Risio, M.4    Rossini, F.P.5    Giaretti, W.6
  • 29
    • 0030993597 scopus 로고    scopus 로고
    • Loss of heterozygosity at the 5,10-methylenetetrahydrofolate reductase locus in human ovarian carcinomas
    • Viel A, Dall'Agnese L, Simone F, et al. Loss of heterozygosity at the 5,10-methylenetetrahydrofolate reductase locus in human ovarian carcinomas. Br J Cancer 1997;75(8):1105-1110.
    • (1997) Br J Cancer , vol.75 , Issue.8 , pp. 1105-1110
    • Viel, A.1    Dall'Agnese, L.2    Simone, F.3
  • 30
    • 0033125654 scopus 로고    scopus 로고
    • Loss of heterozygosity of methylenetetrahydrofolate reductase in colon carcinomas
    • Pereira P, Stanton V, Jothy S, Tomlinson I, Foulkes W, Rozen R. Loss of heterozygosity of methylenetetrahydrofolate reductase in colon carcinomas. Oncol Rep 1999;6(3):597-599.
    • (1999) Oncol Rep , vol.6 , Issue.3 , pp. 597-599
    • Pereira, P.1    Stanton, V.2    Jothy, S.3    Tomlinson, I.4    Foulkes, W.5    Rozen, R.6
  • 31
    • 0032802054 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase thermolabile variant and oral clefts
    • Mills J, Kirke P, Molloy A, et al. Methylenetetrahydrofolate reductase thermolabile variant and oral clefts. Am J Med Genet 1999;86:71-74.
    • (1999) Am J Med Genet , vol.86 , pp. 71-74
    • Mills, J.1    Kirke, P.2    Molloy, A.3
  • 32
    • 0023143941 scopus 로고
    • Analysis of DNA extracted from formalin-fixed, paraffin-embedded tissues by enzymatic amplification and hybridisation with sequence-specific oligonucleotides
    • Impraim C, Saiki R, Erlich H, Teplitz R. Analysis of DNA extracted from formalin-fixed, paraffin-embedded tissues by enzymatic amplification and hybridisation with sequence-specific oligonucleotides. Biochem Bio Res Comm 1987;142:710-716.
    • (1987) Biochem Bio Res Comm , vol.142 , pp. 710-716
    • Impraim, C.1    Saiki, R.2    Erlich, H.3    Teplitz, R.4
  • 33
    • 0000262278 scopus 로고
    • GENEPOP (version 1.2): Population genetics software for exact tests and ecumenicism
    • Raymond M, Rousset F. GENEPOP (version 1.2): population genetics software for exact tests and ecumenicism. J Heredity 1995;86:248-249.
    • (1995) J Heredity , vol.86 , pp. 248-249
    • Raymond, M.1    Rousset, F.2
  • 34
    • 0025975010 scopus 로고
    • Modulation of glutathione content and the effect on methionine auxotrophy and cellular distribution of homocysteine and cysteine in mouse cell lines
    • Djurhuus D, Svardal A, Mansoor M, Usland P. Modulation of glutathione content and the effect on methionine auxotrophy and cellular distribution of homocysteine and cysteine in mouse cell lines. Carcinogenesis 1991;12:241-247.
    • (1991) Carcinogenesis , vol.12 , pp. 241-247
    • Djurhuus, D.1    Svardal, A.2    Mansoor, M.3    Usland, P.4
  • 35
    • 0031971515 scopus 로고    scopus 로고
    • A second common mutation in the methylenetetrahydrofolate reductase gene: An additional risk for neural tube defects
    • van der Put N, Gabreels F, Stevens E, et al. A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk for neural tube defects. Am J Hum Genet 1998;62:1044-1051.
    • (1998) Am J Hum Genet , vol.62 , pp. 1044-1051
    • Van der Put, N.1    Gabreels, F.2    Stevens, E.3


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