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Volumn 36, Issue 1, 2006, Pages 153-162

The appetite suppressant d-fenfluramine reduces water intake, but not food intake, in activity-based anorexia

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; DEXFENFLURAMINE; MELANOCORTIN; SEROTONIN 2C RECEPTOR; VASOPRESSIN;

EID: 33244460054     PISSN: 09525041     EISSN: None     Source Type: Journal    
DOI: 10.1677/jme.1.01887     Document Type: Article
Times cited : (19)

References (65)
  • 2
    • 0033103856 scopus 로고    scopus 로고
    • The Influence of Salt Loading on Vasopressin Gene Expression in Magno- and Parvocellular Hypothalamic Neurons: An Immunocytochemical and in Situ Hybridization Analysis
    • Amaya F, Tanaka M, Tamada Y, Tanaka Y, Nilaver G & Ibata Y 1999 The Influence of Salt Loading on Vasopressin Gene Expression in Magno- and Parvocellular Hypothalamic Neurons: an Immunocytochemical and in Situ Hybridization Analysis. Neuroscience 89 515-523.
    • (1999) Neuroscience , vol.89 , pp. 515-523
    • Amaya, F.1    Tanaka, M.2    Tamada, Y.3    Tanaka, Y.4    Nilaver, G.5    Ibata, Y.6
  • 3
    • 12844269274 scopus 로고    scopus 로고
    • Fenfluramine Treatment in Female Rats Accelerates the Weight Loss Associated With Activity-Based Anorexia
    • Atchley DP & Eckel LA 2005 Fenfluramine Treatment in Female Rats Accelerates the Weight Loss Associated With Activity-Based Anorexia. Pharmacology & Biochemisry of Behaviour 80 273-279.
    • (2005) Pharmacology & Biochemisry of Behaviour , vol.80 , pp. 273-279
    • Atchley, D.P.1    Eckel, L.A.2
  • 4
    • 15744394640 scopus 로고    scopus 로고
    • Plasma Tryptophan During Weight Restoration in Patients With Anorexia Nervosa
    • Attia E, Wolk S, Cooper T, Glasofer D & Walsh BT 2005 Plasma Tryptophan During Weight Restoration in Patients With Anorexia Nervosa. Biology of Psychiatry 57 674-678.
    • (2005) Biology of Psychiatry , vol.57 , pp. 674-678
    • Attia, E.1    Wolk, S.2    Cooper, T.3    Glasofer, D.4    Walsh, B.T.5
  • 5
    • 0024156796 scopus 로고
    • Long-Term Imipramine Treatment Differentially Affects Fenfluramine-Induced Suppression of Food Intake and Locomotor Activity
    • Aulakh CS, Wozniak KM, Hill JL & Murphy DL 1988 Long-Term Imipramine Treatment Differentially Affects Fenfluramine-Induced Suppression of Food Intake and Locomotor Activity. Pharmacology & Biochemisty of Behaviour 31 97-101.
    • (1988) Pharmacology & Biochemisty of Behaviour , vol.31 , pp. 97-101
    • Aulakh, C.S.1    Wozniak, K.M.2    Hill, J.L.3    Murphy, D.L.4
  • 6
    • 0033305646 scopus 로고    scopus 로고
    • Current and Potential Drugs for Treatment of Obesity
    • Bray GA & Greenway FL 1999 Current and Potential Drugs for Treatment of Obesity. Endocrine Reviews 20 805-875.
    • (1999) Endocrine Reviews , vol.20 , pp. 805-875
    • Bray, G.A.1    Greenway, F.L.2
  • 7
    • 0025899575 scopus 로고
    • The Influence of Semistarvation-Induced Hyperactivity on Hypothalamic Serotonin Metabolism
    • Broocks A, Schweiger U & Pirke KM 1991 The Influence of Semistarvation-Induced Hyperactivity on Hypothalamic Serotonin Metabolism. Physiology of Behaviour 50 385-388.
    • (1991) Physiology of Behaviour , vol.50 , pp. 385-388
    • Broocks, A.1    Schweiger, U.2    Pirke, K.M.3
  • 8
    • 0027293761 scopus 로고
    • Activity of the Hypothalamic-Pituitary-Adrenal Axis Is Elevated in Rats With Activity-Based Anorexia
    • Burden VR, White BD, Dean RG & Martin RJ 1993 Activity of the Hypothalamic-Pituitary-Adrenal Axis Is Elevated in Rats With Activity-Based Anorexia. Journal of Nutrition 123 1217-1225.
    • (1993) Journal of Nutrition , vol.123 , pp. 1217-1225
    • Burden, V.R.1    White, B.D.2    Dean, R.G.3    Martin, R.J.4
  • 9
    • 0032515550 scopus 로고    scopus 로고
    • Lack of Association Between 5-HT2A Gene Promoter Polymorphism and Susceptibility to Anorexia Nervosa
    • Campbell DA, Sundaramurthy D, Markham AF & Pieri LF 1998 Lack of Association Between 5-HT2A Gene Promoter Polymorphism and Susceptibility to Anorexia Nervosa. Lancet 351 499.
    • (1998) Lancet , vol.351 , pp. 499
    • Campbell, D.A.1    Sundaramurthy, D.2    Markham, A.F.3    Pieri, L.F.4
  • 11
    • 0037154791 scopus 로고    scopus 로고
    • Intermittent, Chronic Fenfluramine Administration to Rats Repeatedly Suppresses Food Intake Despite Substantial Brain Serotonin Reductions
    • Choi S, Jonak EM, Simpson L, Patil V & Fernstrom JD 2002 Intermittent, Chronic Fenfluramine Administration to Rats Repeatedly Suppresses Food Intake Despite Substantial Brain Serotonin Reductions. Brain Research 928 30-39.
    • (2002) Brain Research , vol.928 , pp. 30-39
    • Choi, S.1    Jonak, E.M.2    Simpson, L.3    Patil, V.4    Fernstrom, J.D.5
  • 12
    • 0033778106 scopus 로고    scopus 로고
    • Similarities in the Action of Ro 60-0175, a 5-HT2C Receptor Agonist and D-Fenfluramine on Feeding Patterns in the Rat
    • Clifton PG, Lee MD & Dourish CT 2000 Similarities in the Action of Ro 60-0175, a 5-HT2C Receptor Agonist and D-Fenfluramine on Feeding Patterns in the Rat. Psychopharmacology (Berlin) 152 256-267.
    • (2000) Psychopharmacology (Berlin) , vol.152 , pp. 256-267
    • Clifton, P.G.1    Lee, M.D.2    Dourish, C.T.3
  • 14
    • 0031561157 scopus 로고    scopus 로고
    • Association Between 5-HT2A Gene Promoter Polymorphism and Anorexia Nervosa
    • Collier DA, Arranz MJ, Li T, Mupita D, Brown N & Treasure J 1997 Association Between 5-HT2A Gene Promoter Polymorphism and Anorexia Nervosa. Lancet 350 412.
    • (1997) Lancet , vol.350 , pp. 412
    • Collier, D.A.1    Arranz, M.J.2    Li, T.3    Mupita, D.4    Brown, N.5    Treasure, J.6
  • 15
    • 0032772960 scopus 로고    scopus 로고
    • The Central Melanocortin System and Energy Homeostasis
    • Cone RD 1999 The Central Melanocortin System and Energy Homeostasis. Trends in Endocrinological Metabolism 10 211-216.
    • (1999) Trends in Endocrinological Metabolism , vol.10 , pp. 211-216
    • Cone, R.D.1
  • 17
    • 0029400158 scopus 로고
    • Multiple Serotonin Receptors: Opportunities for New Treatments for Obesity?
    • Dourish CT 1995 Multiple Serotonin Receptors: Opportunities for New Treatments for Obesity? Obesity Research 3 Suppl 4 449S-462S.
    • (1995) Obesity Research , vol.3 , Issue.SUPPL. 4
    • Dourish, C.T.1
  • 18
    • 0024162456 scopus 로고
    • The Effects of D-Fenfluramine on Saccharin Intake and Preference, and on Food and Water Intake
    • Fletcher PJ 1988 The Effects of D-Fenfluramine on Saccharin Intake and Preference, and on Food and Water Intake. Pharmacology & Biochemistry of Behaviour 29 687-691.
    • (1988) Pharmacology & Biochemistry of Behaviour , vol.29 , pp. 687-691
    • Fletcher, P.J.1
  • 20
    • 0027296519 scopus 로고
    • D-Fenfluramine- and D-Norfenfluramine-Induced Hypophagia: Differential Mechanisms and Involvement of Postsynaptic 5-HT Receptors
    • Gibson EL, Kennedy AJ & Curzon G 1993 D-Fenfluramine- and D-Norfenfluramine-Induced Hypophagia: Differential Mechanisms and Involvement of Postsynaptic 5-HT Receptors. European Journal of Pharmacology 242 83-90.
    • (1993) European Journal of Pharmacology , vol.242 , pp. 83-90
    • Gibson, E.L.1    Kennedy, A.J.2    Curzon, G.3
  • 22
    • 0029401072 scopus 로고
    • Clinical Studies With Dexfenfluramine: From Past to Future
    • Guy-Grand B 1995 Clinical Studies With Dexfenfluramine: From Past to Future. Obesity Research 3 491S-496S.
    • (1995) Obesity Research , vol.3
    • Guy-Grand, B.1
  • 26
    • 25144520856 scopus 로고    scopus 로고
    • a-MSH Enhances Activity-Based Anorexia
    • Hillebrand JJ, Kas MJ & Adan RA 2005b a-MSH Enhances Activity-Based Anorexia. Peptides 26 1690-1696.
    • (2005) Peptides , vol.26 , pp. 1690-1696
    • Hillebrand, J.J.1    Kas, M.J.2    Adan, R.A.3
  • 28
    • 0037526427 scopus 로고    scopus 로고
    • Association of the 5-HT2c Gene With Susceptibility and Minimum Body Mass Index in Anorexia Nervosa
    • Hu X, Giotakis O, Li T, Karwautz A, Treasure J & Collier DA 2003 Association of the 5-HT2c Gene With Susceptibility and Minimum Body Mass Index in Anorexia Nervosa. Neuroreport 14 781-783.
    • (2003) Neuroreport , vol.14 , pp. 781-783
    • Hu, X.1    Giotakis, O.2    Li, T.3    Karwautz, A.4    Treasure, J.5    Collier, D.A.6
  • 29
    • 0022390391 scopus 로고
    • Meet of Substances Influencing Brain Serotonergic Transmission on Plasma Vasopressin Levels in the Rat
    • Iovino M & Steardo L 1985 Meet of Substances Influencing Brain Serotonergic Transmission on Plasma Vasopressin Levels in the Rat. European Journal of Pharmacology 113 99-103.
    • (1985) European Journal of Pharmacology , vol.113 , pp. 99-103
    • Iovino, M.1    Steardo, L.2
  • 30
    • 0032893155 scopus 로고    scopus 로고
    • D-Fenfluramine Induces Serotonin-Mediated Fos Expression in Corticotropin-Releasing Factor and Oxytocin Neurons of the Hypothalamus, and Serotonin-Independent Fos Expression in Enkephalin and Neurotensin Neurons of the Amygdala
    • Javed A, Kamradt MC, Van de Kar LD & Gray TS 1999 D-Fenfluramine Induces Serotonin-Mediated Fos Expression in Corticotropin-Releasing Factor and Oxytocin Neurons of the Hypothalamus, and Serotonin-Independent Fos Expression in Enkephalin and Neurotensin Neurons of the Amygdala. Neuroscience 90 851-8581.
    • (1999) Neuroscience , vol.90 , pp. 851-8581
    • Javed, A.1    Kamradt, M.C.2    Van de Kar, L.D.3    Gray, T.S.4
  • 33
    • 0025740316 scopus 로고
    • Altered Serotonin Activity in Anorexia Nervosa After Long-Term Weight Restoration. Does Elevated Cerebrospinal Fluid 5-Hydroxyindoleacetic Acid Level Correlate With Rigid and Obsessive Behavior?
    • Kaye WH, Gwirtsman HE, Gorge DT & Ebert MH 1991 Altered Serotonin Activity in Anorexia Nervosa After Long-Term Weight Restoration. Does Elevated Cerebrospinal Fluid 5-Hydroxyindoleacetic Acid Level Correlate With Rigid and Obsessive Behavior? Archives of General Psychiatry 48 556-562.
    • (1991) Archives of General Psychiatry , vol.48 , pp. 556-562
    • Kaye, W.H.1    Gwirtsman, H.E.2    Gorge, D.T.3    Ebert, M.H.4
  • 36
    • 0023894791 scopus 로고
    • Evidence That MCPP May Have Behavioural Effects Mediated by Central 5-HT1C Receptors
    • Kennett GA & Curzon G 1988 Evidence That MCPP May Have Behavioural Effects Mediated by Central 5-HT1C Receptors. British Journal of Pharmacology 94 137-147.
    • (1988) British Journal of Pharmacology , vol.94 , pp. 137-147
    • Kennett, G.A.1    Curzon, G.2
  • 38
    • 0035988416 scopus 로고    scopus 로고
    • 5-HT1B Receptors Modulate Components of Satiety in the Rat: Behavioural and Pharmacological Analyses of the Selective Serotonin1B Agonist CP-94,253
    • Lee MD, Kennett GA, Dourish CT & Clifton PG 2002 5-HT1B Receptors Modulate Components of Satiety in the Rat: Behavioural and Pharmacological Analyses of the Selective Serotonin1B Agonist CP-94,253. Psychopharmacology (Berlin) 164 49-60.
    • (2002) Psychopharmacology (Berlin) , vol.164 , pp. 49-60
    • Lee, M.D.1    Kennett, G.A.2    Dourish, C.T.3    Clifton, P.G.4
  • 39
    • 8644255831 scopus 로고    scopus 로고
    • Reduced Hypophagic Effects of D-Fenfluramine and the 5-HT(2C) Receptor Agonist MCPP in 5-HT(1B) Receptor Knockout Mice
    • Lee MD, Somerville EM, Kennett GA, Dourish CT & Clifton PG 2004 Reduced Hypophagic Effects of D-Fenfluramine and the 5-HT(2C) Receptor Agonist MCPP in 5-HT(1B) Receptor Knockout Mice. Psychopharmacology (Berlin) 176 39-49.
    • (2004) Psychopharmacology (Berlin) , vol.176 , pp. 39-49
    • Lee, M.D.1    Somerville, E.M.2    Kennett, G.A.3    Dourish, C.T.4    Clifton, P.G.5
  • 40
    • 0032527896 scopus 로고    scopus 로고
    • Absence of Fenfluramine-Induced Anorexia and Reduced C-Fos Induction in the Hypothalamus and Central Amygdaloid Complex of Serotonin 1B Receptor Knock-Out Mice
    • Lucas JJ, Yamamoto A, Scearce-Levie K, Saudou F & Hen R 1998 Absence of Fenfluramine-Induced Anorexia and Reduced C-Fos Induction in the Hypothalamus and Central Amygdaloid Complex of Serotonin 1B Receptor Knock-Out Mice. Journal of Neuroscience 18 5537-5544.
    • (1998) Journal of Neuroscience , vol.18 , pp. 5537-5544
    • Lucas, J.J.1    Yamamoto, A.2    Scearce-Levie, K.3    Saudou, F.4    Hen, R.5
  • 41
    • 0033404424 scopus 로고    scopus 로고
    • Pulmonary Hypertension, Anorexigens and 5-HT: Pharmacological Synergism in Action?
    • MacLean MR 1999 Pulmonary Hypertension, Anorexigens and 5-HT: Pharmacological Synergism in Action? Trends in Pharmacological Science 20 490-495.
    • (1999) Trends in Pharmacological Science , vol.20 , pp. 490-495
    • MacLean, M.R.1
  • 42
    • 0028303938 scopus 로고
    • Treatment of Post-Herpetic Neuralgia: Antidepressants
    • Max MB 1994 Treatment of Post-Herpetic Neuralgia: Antidepressants. Annals of Neurology 35 S50-S53.
    • (1994) Annals of Neurology , vol.35
    • Max, M.B.1
  • 43
    • 0030978891 scopus 로고    scopus 로고
    • Selective Serotonin Reuptake Inhibitors Dissociate Fenfluramine's Anorectic and Neurotoxic Effects: Importance of Dose, Species and Drug
    • McCann UD, Yuan J, Hatzidimitriou G & Ricaurte GA 1997 Selective Serotonin Reuptake Inhibitors Dissociate Fenfluramine's Anorectic and Neurotoxic Effects: Importance of Dose, Species and Drug. Journal of Pharmacology & Experimental Therapy 281 1487-1498.
    • (1997) Journal of Pharmacology & Experimental Therapy , vol.281 , pp. 1487-1498
    • McCann, U.D.1    Yuan, J.2    Hatzidimitriou, G.3    Ricaurte, G.A.4
  • 44
    • 0033373076 scopus 로고    scopus 로고
    • D-Fenfluramine Activates Rat Oxytocinergic and Vasopressinergic Neurons Through Different Mechanisms
    • Mikkelsen JD, Jensen JB, Engelbrecht T & Mork A 1999 D-Fenfluramine Activates Rat Oxytocinergic and Vasopressinergic Neurons Through Different Mechanisms. Brain Research 851 247-251.
    • (1999) Brain Research , vol.851 , pp. 247-251
    • Mikkelsen, J.D.1    Jensen, J.B.2    Engelbrecht, T.3    Mork, A.4
  • 45
    • 0028215250 scopus 로고
    • Circadian Food-Anticipatory Activity: Formal Models and Physiological Mechanisms
    • Mistlberger RE 1994 Circadian Food-Anticipatory Activity: Formal Models and Physiological Mechanisms. Neuroscience Biobehavior Reviews 18 171-195.
    • (1994) Neuroscience Biobehavior Reviews , vol.18 , pp. 171-195
    • Mistlberger, R.E.1
  • 48
    • 0028089784 scopus 로고
    • Weight Cycling Alters the Effects of D-Fenfluramine on Susceptibility to Activity-Based Anorexia
    • Rieg TS, Maestrello AM & Aravich PF 1994 Weight Cycling Alters the Effects of D-Fenfluramine on Susceptibility to Activity-Based Anorexia. American Journal of Clinical Nutrition 60 494-500.
    • (1994) American Journal of Clinical Nutrition , vol.60 , pp. 494-500
    • Rieg, T.S.1    Maestrello, A.M.2    Aravich, P.F.3
  • 49
    • 0031965658 scopus 로고    scopus 로고
    • Efficacy of Administration of Dexfenfluramine and Phentermine, Alone and in Combination, on Ingestive Behavior and Body Weight in Rats
    • Roth JD & Rowland NE 1998 Efficacy of Administration of Dexfenfluramine and Phentermine, Alone and in Combination, on Ingestive Behavior and Body Weight in Rats. Psychopharmacology (Berlin) 137 99-106.
    • (1998) Psychopharmacology (Berlin) , vol.137 , pp. 99-106
    • Roth, J.D.1    Rowland, N.E.2
  • 51
    • 0022540417 scopus 로고
    • Neurobiology of an Anorectic Drug: Fenfluramine
    • Rowland NE & Carlton J 1986 Neurobiology of an Anorectic Drug: Fenfluramine. Progress in Neurobiology 27 13-62.
    • (1986) Progress in Neurobiology , vol.27 , pp. 13-62
    • Rowland, N.E.1    Carlton, J.2
  • 54
    • 7144227374 scopus 로고    scopus 로고
    • Serotonergic Control of the Organization of Feeding and Safety
    • Simansky KJ 1996 Serotonergic Control of the Organization of Feeding and Satiety. Behavioural Brain Research 73 37-42.
    • (1996) Behavioural Brain Research , vol.73 , pp. 37-42
    • Simansky, K.J.1
  • 55
    • 0036122441 scopus 로고    scopus 로고
    • Parabrachial Infusion of D-Fenfluramine Reduces Food Intake. Blockade by the 5-HT(1B) Antagonist SB-216641
    • Simansky KJ & Nicklous DM 2002 Parabrachial Infusion of D-Fenfluramine Reduces Food Intake. Blockade by the 5-HT(1B) Antagonist SB-216641. Pharmacology & Biochemistry of Behaviour 71 681-690.
    • (2002) Pharmacology & Biochemistry of Behaviour , vol.71 , pp. 681-690
    • Simansky, K.J.1    Nicklous, D.M.2
  • 58
    • 0023089673 scopus 로고
    • Oxytocin Gene Expression in Discrete Hypothalamic Magnocellular Cell Groups Is Stimulated by Prolonged Salt Loading
    • van Tol HH, Voorhuis DT & Burbach JP 1987 Oxytocin Gene Expression in Discrete Hypothalamic Magnocellular Cell Groups Is Stimulated by Prolonged Salt Loading. Endocrinology 120 71-76.
    • (1987) Endocrinology , vol.120 , pp. 71-76
    • van Tol, H.H.1    Voorhuis, D.T.2    Burbach, J.P.3
  • 59
  • 60
    • 0033914588 scopus 로고    scopus 로고
    • Comparative Effects of Continuous Infusion of MCPP, Ro 60-0175 and D-Fenfluramine on Food Intake, Water Intake, Body Weight and Locomotor Activity in Rats
    • Vickers SP, Benwell KR, Porter RH, Bickerdike MJ, Kennett GA & Dourish CT 2000 Comparative Effects of Continuous Infusion of MCPP, Ro 60-0175 and D-Fenfluramine on Food Intake, Water Intake, Body Weight and Locomotor Activity in Rats. British Journal of Pharmacology 130 1305-1314.
    • (2000) British Journal of Pharmacology , vol.130 , pp. 1305-1314
    • Vickers, S.P.1    Benwell, K.R.2    Porter, R.H.3    Bickerdike, M.J.4    Kennett, G.A.5    Dourish, C.T.6
  • 61
    • 0034899208 scopus 로고    scopus 로고
    • Evidence That Hypophagia Induced by D-Fenfluramine and D-Norfenfluramine in the Rat Is Mediated by 5-HT2C Receptors
    • Vickers SP, Dourish CT & Kennett GA 2001 Evidence That Hypophagia Induced by D-Fenfluramine and D-Norfenfluramine in the Rat Is Mediated by 5-HT2C Receptors. Neuropharmacology 41 200-209.
    • (2001) Neuropharmacology , vol.41 , pp. 200-209
    • Vickers, S.P.1    Dourish, C.T.2    Kennett, G.A.3
  • 62
    • 0038513394 scopus 로고    scopus 로고
    • Oral Administration of the 5-HT2 Creceptor Agonist, MCPP, Reduces Body Weight Gain in Rats Over 28 Days As a Result of Maintained Hypophagia
    • Vickers SP, Easton N, Webster LJ, Wyatt A, Bickerdike MJ, Dourish CT & Kennett GA 2003 Oral Administration of the 5-HT2 Creceptor Agonist, MCPP, Reduces Body Weight Gain in Rats Over 28 Days As a Result of Maintained Hypophagia. Pychopharmacology (Berlin) 167 274-280.
    • (2003) Pychopharmacology (Berlin) , vol.167 , pp. 274-280
    • Vickers, S.P.1    Easton, N.2    Webster, L.J.3    Wyatt, A.4    Bickerdike, M.J.5    Dourish, C.T.6    Kennett, G.A.7
  • 63
    • 0032577351 scopus 로고    scopus 로고
    • Eating Disorders: Progress and
    • Walsh BT & Devlin MJ 1998 Eating Disorders: Progress and Problems. Science 280 1387-1390.
    • (1998) Problems Science , vol.280 , pp. 1387-1390
    • Walsh, B.T.1    Devlin, M.J.2
  • 65
    • 0026613795 scopus 로고
    • Activation of 5-HT1C-Receptors Suppresses Excessive Wheel Running Induced by Semi-Starvation in the Rat
    • Wilckens T, Schweiger U & Pirke KM 1992 Activation of 5-HT1C-Receptors Suppresses Excessive Wheel Running Induced by Semi-Starvation in the Rat. Psychopharmacology (Berl) 109 77-84.
    • (1992) Psychopharmacology (Berl) , vol.109 , pp. 77-84
    • Wilckens, T.1    Schweiger, U.2    Pirke, K.M.3


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