Effects of additives and processing parameters on the initial burst release of protein from poly(lactic-co-glycolic acid) microspheres

PDA Journal of Pharmaceutical Science and Technology

Volumn 60, Issue 1, 2006, Pages 54-59

  Zheng, Cai Hong ^a,b   Gao, Jian Qing ^a   Liang, Wen Quan ^a   Yu, He Yong ^b   Zhang, Yi Li ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Additives; Burst; Microspheres; Morphology; Poly(lactic co glycotic acid)

Indexed keywords

BETA CYCLODEXTRIN; BOVINE SERUM ALBUMIN; DRUG ADDITIVE; EMULSIFYING AGENT; GLYCEROL; INORGANIC SALT; MACROGOL 6000; MICROSPHERE; POLYGLACTIN; POLYSORBATE 20; POLYVINYL ALCOHOL; PROTEIN; SORBITOL; WATER OIL CREAM;

AQUEOUS SOLUTION; ARTICLE; CONCENTRATION (PARAMETERS); DESICCATION; DRUG FORMULATION; DRUG MANUFACTURE; DRUG RELEASE; EMULSION; ENCAPSULATION; EVAPORATION; HYDROPHILICITY; IN VITRO STUDY; LOW TEMPERATURE; MORPHOLOGY; PARTICLE SIZE; POROSITY; SCANNING ELECTRON MICROSCOPY; SOLVENT EXTRACTION; SURFACE PROPERTY;

BETA-CYCLODEXTRINS; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; EXCIPIENTS; GLYCOLATES; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POROSITY; PROTEINS; SERUM ALBUMIN, BOVINE; SOLUBILITY; SORBITOL; SURFACE PROPERTIES; TECHNOLOGY, PHARMACEUTICAL; TIME FACTORS;

EID: 33144471897     PISSN: 10797440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Y. Yeo and K. Park, Control of encapsulation efficiency and initial burst in polymeric microparticle systems. Arch. Pharm. Res., 27, 1 (2004).
2. H. B. Ravivarapu, K. Burton, and P. P. Deluca, Polymer and microsphere blending to alter the release of a peptide from PLGA microspheres. Eur. J. Pharm. Biopharm., 50, 263 (2000).
3. M. Diwan and T. G. Park, Pegylation enhances protein stability stability during encapsulation in PLGA microspheres. J. Controlled Release, 73, 233 (2001).
4. G. Jiang, B. H. Woo, F. Kang, J. Singh, and P. P. Deluca, Assessment of protein release kinetics, stability and protein polymer interaction of lysozyme encapsulated poly(d,1-lactide-co-glycolide) microspheres. J. Controlled Release, 79, 137 (2002).
5. X. Huang and C. S. Brazel, On the importance and mechanisms of burst release in matrix-controlled drug delivery systems. J. Controlled Release, 73, 121 (2001).
6. F. Kang and J. Singh, Effect of additives on the release of a model protein from PLGA microspheres. AAPS Pharm. Sci. Tech., 2, 30 (2001).
7. Y. Y. Yang, T. S. Chung, and N. P. Ng, Morphology, drug distribution, and in vitro release profiles of biodegradable polymeric microspheres containing protein fabricated by double-emulsion solvent extraction/evaporation method. Biomaterials, 22, 231 (2001).
8. C. H. Zheng, J. Q. Gao, T. P. Zhang, and W. Q. Liang, A protein delivery system: biodegradable alginate-chitosan-poly (lactic-co-glycolic acid) composite microspheres. Biochem. Biophys. Res. Commun., 323, 1321 (2004).
9. C. H. Zheng, W. Q. Liang, H. Y. Yu, and H. L. Chen, Evaluation of different methods to determine the loading of proteins in PLGA microspheres. Pharmazie, 59, 232 (2004).
10. M. Van de weert, R. Van't Hof, J. Van der weerd, R. M. A. Heeren, G. Posthuma, W. E. Hennink, and D. J. A. Crommelin, Lysozyme distribution and conformation in a biodegradable polymer matrix as determined by FTIR techniques. J. Controlled Release, 68, 31 (2000).
11. P. Sansdrap and A. J. Moes, Influence of additives on the release profile of nifedipine from poly (DL-lactide-co-glycolide) microspheres. J. Microencapsul., 15, 545 (1998).
12. T. Morita, Y. Horikiri, T. Suzuki, and H. Yoshino, Applicability of various amphiphilic polymers to the modification of protein release kinetics from biodegradable reservoir-type microspheres. Eur. J. Pharm. Biopharm., 51, 45 (2001).
13. P. Ahlin, J. Kristl, A. Kristl, and F. Vrecer, Investigation of polymeric nanoparticles as carriers of enalaprilat for oral administration. Int. J. Pharm., 239, 113 (2002).
14. M. Igartua, R. M. Hemandez, A. Esquisabel, A. R. Gascon, M. B. Calvo, and J. L. Pedraz, Influence of formulation variables on the in vitro release of albumin from biodegradable microparticulate systems. J. Microencapsul., 14, 349 (1997).
15. Y. Yamaguchi, M. Takenaga, A. Kitagawa, Y. Ogawa, Y. Mizushima, and R. Igarashi, Insulin-loaded biodegradable PLGA microcapsules: initial burst release controlled by hydrophilic additives. J. Controlled Release, 81, 235 (2002).