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Volumn 40, Issue 1, 1996, Pages 55-58

A Phase I study of a hypoxic cell sensitizer KU-2285 in combination with conventional radiotherapy

Author keywords

Clinical study; Fluorinated 2 nitroimidazole; Hypoxic cell sensitizer; KU 2285

Indexed keywords

2,2 DIFLUORO N (2 HYDROXYETHYL) 3 (2 NITRO 1 IMIDAZOLYL)PROPIONAMIDE; NITROIMIDAZOLE DERIVATIVE; RADIOSENSITIZING AGENT;

EID: 0030200968     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/0167-8140(96)01740-9     Document Type: Article
Times cited : (10)

References (16)
  • 1
    • 0020622749 scopus 로고
    • Factors influencing intracellular uptake and radiosensitization by 2-nitroimidazoles in vitro
    • [1] Brown, D.M., Gonzalez-Mendez, R. and Brown, J.M. Factors influencing intracellular uptake and radiosensitization by 2-nitroimidazoles in vitro. Radiat. Res. 93: 492-505, 1983.
    • (1983) Radiat. Res. , vol.93 , pp. 492-505
    • Brown, D.M.1    Gonzalez-Mendez, R.2    Brown, J.M.3
  • 2
    • 0026551295 scopus 로고
    • First-analysis on tumor regression for the European randomized trial of etanidazole combined with radiotherapy in head and neck carcinomas
    • [2] Chassagne, D., Charreau, I., Sancho-Garnier, H., Eschwege, F. and Malaise, E.P. First-analysis on tumor regression for the European randomized trial of etanidazole combined with radiotherapy in head and neck carcinomas. Int. J. Radiat. Oncol. Biol. Phys. 22: 581-584, 1992.
    • (1992) Int. J. Radiat. Oncol. Biol. Phys. , vol.22 , pp. 581-584
    • Chassagne, D.1    Charreau, I.2    Sancho-Garnier, H.3    Eschwege, F.4    Malaise, E.P.5
  • 4
    • 0028365451 scopus 로고
    • Radiosensitizing activity and pharmacokinetics of multiple dose administered KU-2285 in peripheral nerve tissue in mice
    • [4] Iwai, H., Matsuno, E., Sasai, K., Shibamoto, Y. and Abe, M. Radiosensitizing activity and pharmacokinetics of multiple dose administered KU-2285 in peripheral nerve tissue in mice. Int. J. Radiat. Oncol. Biol. Phys. 29: 591-594, 1994.
    • (1994) Int. J. Radiat. Oncol. Biol. Phys. , vol.29 , pp. 591-594
    • Iwai, H.1    Matsuno, E.2    Sasai, K.3    Shibamoto, Y.4    Abe, M.5
  • 6
    • 0028632781 scopus 로고
    • Clinical evaluation of nitroimidazoles as modifiers of hypoxia in solid tumors
    • [6] Overgaard, J. Clinical evaluation of nitroimidazoles as modifiers of hypoxia in solid tumors. Oncol. Res. 6: 509-518, 1994.
    • (1994) Oncol. Res. , vol.6 , pp. 509-518
    • Overgaard, J.1
  • 7
    • 0026089349 scopus 로고
    • Nimorazole as a hypoxic radiosensitizer in the treatment of supraglottic larynx and pharynx carcinoma. First report from the Danish head and neck cancer study (DAHANCA) protocol 5-85
    • [7] Overgaard, J., Sand Hansen, H., Lindelov, B., Overgaard, M., Jorgensen, K., Rasmusson, B. and Berthelsen, A. Nimorazole as a hypoxic radiosensitizer in the treatment of supraglottic larynx and pharynx carcinoma. First report from the Danish Head and Neck Cancer Study (DAHANCA) protocol 5-85. Radiother. Oncol. Suppl. 20: 143-149, 1991.
    • (1991) Radiother. Oncol. Suppl. , vol.20 , pp. 143-149
    • Overgaard, J.1    Sand Hansen, H.2    Lindelov, B.3    Overgaard, M.4    Jorgensen, K.5    Rasmusson, B.6    Berthelsen, A.7
  • 8
    • 0027370858 scopus 로고
    • In vivo radiosensitization efficacy of KU-2285 and etanidazole at clinically relevant low radiation doses
    • [8] Oya, N., Shibamoto, Y., Sasai, K., Sugiyama, T. and Abe, M. In vivo radiosensitization efficacy of KU-2285 and etanidazole at clinically relevant low radiation doses. Int. J. Radiat. Oncol. Biol. Phys. 27: 1113-1119, 1993.
    • (1993) Int. J. Radiat. Oncol. Biol. Phys. , vol.27 , pp. 1113-1119
    • Oya, N.1    Shibamoto, Y.2    Sasai, K.3    Sugiyama, T.4    Abe, M.5
  • 9
    • 0028148447 scopus 로고
    • Combined cytokinesis-block micronucleus and chromosomal aberration assay for the evaluation of radiosensitizers at low radiation doses
    • [9] Oya, N., Shibamoto, Y., Shibata, T., Sasai, K., Sugiyama, T. and Abe, M. Combined cytokinesis-block micronucleus and chromosomal aberration assay for the evaluation of radiosensitizers at low radiation doses. Int. J. Radiat. Oncol. Biol. Phys. 30: 1153-1159, 1994.
    • (1994) Int. J. Radiat. Oncol. Biol. Phys. , vol.30 , pp. 1153-1159
    • Oya, N.1    Shibamoto, Y.2    Shibata, T.3    Sasai, K.4    Sugiyama, T.5    Abe, M.6
  • 11
    • 0026056373 scopus 로고
    • In vivo radiosensitizing activity of a new fluorinated hypoxic cell radiosensitizer, KU-2285, in combination with radiation dose fractionation
    • [11] Sasai, K., Fushiki, M., Yukawa, Y., Suyama, S., Iwai, H., Shibamoto, Y., Nishimoto, S., Takahashi, M. and Abe, M. In vivo radiosensitizing activity of a new fluorinated hypoxic cell radiosensitizer, KU-2285, in combination with radiation dose fractionation. Int. J. Radiat. Oncol. Biol. Phys. 21: 1231-1234, 1991.
    • (1991) Int. J. Radiat. Oncol. Biol. Phys. , vol.21 , pp. 1231-1234
    • Sasai, K.1    Fushiki, M.2    Yukawa, Y.3    Suyama, S.4    Iwai, H.5    Shibamoto, Y.6    Nishimoto, S.7    Takahashi, M.8    Abe, M.9
  • 13
    • 0023232996 scopus 로고
    • Evaluation of various types of new hypoxic cell sensitizers using the EMT6 single cell-spheroid-solid tumour system
    • [13] Shibamoto, Y., Nishimoto, S., Mi, F., Sasai, K., Kagiya, T. and Abe, M. Evaluation of various types of new hypoxic cell sensitizers using the EMT6 single cell-spheroid-solid tumour system. Int. J. Radiat. Biol. 52: 347-357, 1987.
    • (1987) Int. J. Radiat. Biol. , vol.52 , pp. 347-357
    • Shibamoto, Y.1    Nishimoto, S.2    Mi, F.3    Sasai, K.4    Kagiya, T.5    Abe, M.6
  • 15
    • 0026589976 scopus 로고
    • Radiosensitization efficacy of KU-2285, RP-170 and etanidazole at low radiation doses: Assessment by in vitro cytokinesis-block micronucleus assay
    • [15] Shibamoto, Y., Streffer, C., Sasai, K., Oya, N. and Abe, M. Radiosensitization efficacy of KU-2285, RP-170 and etanidazole at low radiation doses: assessment by in vitro cytokinesis-block micronucleus assay. Int. J. Radiat. Biol. 61: 473-478, 1992.
    • (1992) Int. J. Radiat. Biol. , vol.61 , pp. 473-478
    • Shibamoto, Y.1    Streffer, C.2    Sasai, K.3    Oya, N.4    Abe, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.