Preparation and preliminary biological evaluation of a 177Lu labeled sanazole derivative for possible use in targeting tumor hypoxia

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 23, 2004, Pages 6077-6084

  Das, Tapas ^a   Chakraborty, Sudipta ^a   Banerjee, Sharmila ^a   Mukherjee, Archana ^a   Samuel, Grace ^a   Sarma, H D ^a   Nair, C K K ^a   Kagiya, V T ^b   Venkatesh, Meera ^a  

^a BHABHA ATOMIC RESEARCH CENTRE   (India)

^b HEALTH RESEARCH FOUNDATION   (Japan)

Author keywords

177Lu; Hypoxia; Sanazole; Targeted tumor therapy

Indexed keywords

1,4,7,10 TETRAAZA 1 (4' AMINOBENZYLACETAMIDO)CYCLODODECANE 4,7,10 TRIACETIC ACID(4 AMINO 1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID ANILIDE); 1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID; CARBOXYLIC ACID DERIVATIVE; CHELATING AGENT; LUTETIUM; LUTETIUM 177; MACROCYCLIC COMPOUND; N 2' (CARBOXYETHYL) 2 (3' NITRO 1' TRIAZOLYL)ACETAMIDE; NITROIMIDAZOLE; RADIOISOTOPE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ARTICLE; BLOOD; CELL HYPOXIA; COMPLEX FORMATION; CONTROLLED STUDY; DRUG CONJUGATION; DRUG SCREENING; DRUG SYNTHESIS; DRUG TARGETING; DRUG UPTAKE; DRUG UTILIZATION; FIBROSARCOMA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPOXIA; INJECTION; IRRADIATION; ISOTOPE LABELING; LIPOPHILICITY; MOUSE; MUSCLE; NEUROTOXICITY; NONHUMAN; PAPER CHROMATOGRAPHY; TIME; TOXICITY; TUMOR;

ANIMALS; ANOXIA; ANTINEOPLASTIC AGENTS; DRUG DELIVERY SYSTEMS; FIBROSARCOMA; LUTETIUM; MICE; NEOPLASMS; RADIOISOTOPES; RADIOPHARMACEUTICALS; TISSUE DISTRIBUTION; TRIAZOLES;

EID: 7444255953     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.09.007     Document Type: Article

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