The role of HIF-1α in maintaining cartilage homeostasis and during the pathogenesis of osteoarthritis

Arthritis Research and Therapy

Volumn 8, Issue 1, 2006, Pages

  Pfander, David ^a   Swoboda, Bernd ^a   Cramer, Thorsten ^b  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; GLUCOSE TRANSPORTER; HYPOXIA INDUCIBLE FACTOR 1ALPHA; OXYGEN; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; VASCULOTROPIN A;

ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CELL PROLIFERATION; CELL SURVIVAL; CELLULAR DISTRIBUTION; HOMEOSTASIS; HUMAN; OSTEOARTHRITIS; PATHOGENESIS; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEOGLYCAN SYNTHESIS; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; PHYSIOLOGY;

CARTILAGE, ARTICULAR; HOMEOSTASIS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; OSTEOARTHRITIS;

EID: 33144461484     PISSN: 14786354     EISSN: None     Source Type: Journal    
DOI: 10.1186/ar1894     Document Type: Article

References (15)

1. Yudoh K, Nakamura H, Masuko-Hongo K, Kato T, Nishioka K: Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1a in articular chondrocytes: involvement of HIF-1a in the pathogenesis of osteoarthritis. Arthritis Res Ther 2005, 7:R904-R914.
2. Silver IA: Measurement of pH and ionic composition of pericellular sites. Philos Trans R Soc Lond B Biol Sci 1975, 271: 261-272.
3. Schneider U, Miltner O, Thomsen M, Graf J, Niethard F: Intraartikuläre Sauerstoffpartialdruckmesung unter funtionellen Bedingungen. Z Orthop 1996, 134:422-425.
4. Lund-Olesen K: Oxygen tension in synovial fluids. Arthritis Rheum 1970, 13:769-776.
5. Semenza GL: Hif-1, o(2), and the 3 phds. How animal cells signal hypoxia to the nucleus. Cell 2001, 107:1-3.
6. Semenza GL: Regulation of hypoxia-induced angiogenesis: a chaperone escorts VEGF to the dance. J Clin Invest 2001, 108: 39-40.
7. Cramer T, Yamanishi Y, Clausen BE, Forster I, Pawlinski R, Mackman N, Haase VH, Jaenisch R, Corr M, Nizet V, et al.: HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell 2003, 112:645-657.
8. Pfander D, Cramer T, Swoboda B: Hypoxia and HIF-1alpha in osteoarthritis. Int Orthop 2005, 29:6-9.
9. Pfander D, Kortje D, Zimmermann R, Weseloh G, Kirsch T, Gesslein M, Cramer T, Swoboda B: Vascular endothelial growth factor in articular cartilage of healthy and osteoarthritic human knee joints. Ann Rheum Dis 2001, 60:1070-1073.
10. Pufe T, Petersen W, Tillmann B, Mentlein R: The splice variants VEGF121 and VEGF189 of the angiogenic peptide vascular endothelial growth factor are expressed in osteoarthritic cartilage. Arthritis Rheum 2001, 44:1082-1088.
11. Pfander D, Cramer T, Schipani E, Johnson RS: HIF-1alpha controls extracellular matrix synthesis by epiphyseal chondrocytes. J Cell Sci 2003, 116:1819-1826.
12. Lin C, McGough RM, Aswad B, Block JA, Terek R: Hypoxia induces HIF-1a and VEGF expression in chondrosarcoma cells and chondrocytes. J Orthop Res 2004, 22:1175-1181.
13. Coimbra IB, Jimenez SA, Hawkins DF, Piera-Velazquez S, Stokes DG: Hypoxia-inducible factor 1alpha expression in human normal and osteoarthritic chondrocytes. Osteoarthritis Cartilage 2004, 12:336-345.
14. Pufe T, Lemke A, Kurz B, Petersen W, Tillmann B, Grodzinsky AJ, Mentlein R: Mechanical overload induces VEGF in cartilage discs via hypoxia-inducible factor. Am J Pathol 2004, 164:185-192.
15. Schipani E, Ryan HE, Didrickson S, Kobayashi T, Knight M, Johnson RS: Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival. Genes Dev 2001, 15: 2865-2876.