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Volumn 138, Issue 6, 2005, Pages 781-790

Identification of Pex5pM, and retarded maturation of 3-ketoacyl-CoA thiolase and acyl-CoA oxidase in CHO cells expressing mutant Pex5p isoforms

Author keywords

acyl CoA oxidase; Mutant CHO cells; Peroxisomal targeting; Peroxisome; Pex5p; Thiolase

Indexed keywords

ACETYL COENZYME A ACYLTRANSFERASE; ACYL COENZYME A OXIDASE; PROTEIN PEX5P; RECEPTOR PROTEIN; UNCLASSIFIED DRUG;

EID: 32944474578     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/jb/mvi175     Document Type: Article
Times cited : (4)

References (46)
  • 2
    • 0034515057 scopus 로고    scopus 로고
    • The genetics of peroxisome biogenesis
    • Sacksteder, K.A. and Gould, S.J. (2000) The genetics of peroxisome biogenesis. Annu. Rev. Genet. 34, 623-652
    • (2000) Annu. Rev. Genet. , vol.34 , pp. 623-652
    • Sacksteder, K.A.1    Gould, S.J.2
  • 3
    • 0033787313 scopus 로고    scopus 로고
    • Import of peroxisomal matrix and membrane proteins
    • Subramani, S., Koller, A., and Snyder, W.B. (2000) Import of peroxisomal matrix and membrane proteins. Annu. Rev. Biochem. 63, 399-418
    • (2000) Annu. Rev. Biochem. , vol.63 , pp. 399-418
    • Subramani, S.1    Koller, A.2    Snyder, W.B.3
  • 5
    • 0036663192 scopus 로고    scopus 로고
    • Peroxisome biogenesis and protein import in plants, animals and yeasts: Enigma and variations?
    • Sparkes, I.A. and Baker, A. (2002) Peroxisome biogenesis and protein import in plants, animals and yeasts: enigma and variations? Mol. Membr. Biol. 19, 171-185
    • (2002) Mol. Membr. Biol. , vol.19 , pp. 171-185
    • Sparkes, I.A.1    Baker, A.2
  • 6
    • 0028817372 scopus 로고
    • Mutations in the PTS1 receptor gene, PXR1, define complementation group 2 of the peroxisome biogenesis disorders
    • Dodt, G., Braverman, N., Wong, C., Moser, A., Moser, H.W., Watkins, P., Valle, D., and Gould, S.J. (1995) Mutations in the PTS1 receptor gene, PXR1, define complementation group 2 of the peroxisome biogenesis disorders. Nat. Genet. 9, 115-125
    • (1995) Nat. Genet. , vol.9 , pp. 115-125
    • Dodt, G.1    Braverman, N.2    Wong, C.3    Moser, A.4    Moser, H.W.5    Watkins, P.6    Valle, D.7    Gould, S.J.8
  • 7
    • 0028916868 scopus 로고
    • Identification and characterization of the putative human peroxisomal C-terminal targeting signal import receptor
    • Fransen, M., Brees, C., Baumgart, E., Vanhooren, J.C.T., Baes, M., Mannaerts, G.P., and Van Veldhoven, P.P. (1995) Identification and characterization of the putative human peroxisomal C-terminal targeting signal import receptor. J. Biol. Chem. 270, 7731-7736
    • (1995) J. Biol. Chem. , vol.270 , pp. 7731-7736
    • Fransen, M.1    Brees, C.2    Baumgart, E.3    Vanhooren, J.C.T.4    Baes, M.5    Mannaerts, G.P.6    Van Veldhoven, P.P.7
  • 8
    • 0029024783 scopus 로고
    • Human peroxisomal targeting signal-1 receptor restores peroxisomal protein import in cells from patients with fatal peroxisomal disorders
    • Wiemer, E.A.C., Nuttley, W.M., Bertolaet, B.L., Li, X., Francke, U., Wheelock, M.J., Anne, U.K., Johnson, K.R., and Subramani, S. (1995) Human peroxisomal targeting signal-1 receptor restores peroxisomal protein import in cells from patients with fatal peroxisomal disorders. J. Cell Biol. 130, 51-65
    • (1995) J. Cell Biol. , vol.130 , pp. 51-65
    • Wiemer, E.A.C.1    Nuttley, W.M.2    Bertolaet, B.L.3    Li, X.4    Francke, U.5    Wheelock, M.J.6    Anne, U.K.7    Johnson, K.R.8    Subramani, S.9
  • 9
    • 0030946632 scopus 로고    scopus 로고
    • Human PEX7 encodes the peroxisomal PTS2 receptor and is responsible for rhizomelic chondrodysplasia punctata
    • Braverman, N., Steel, G., Obie, C., Moser, A., Moser, H., Gould, S.J., and Valle, D. (1997) Human PEX7 encodes the peroxisomal PTS2 receptor and is responsible for rhizomelic chondrodysplasia punctata. Nat. Genet. 15, 369-376
    • (1997) Nat. Genet. , vol.15 , pp. 369-376
    • Braverman, N.1    Steel, G.2    Obie, C.3    Moser, A.4    Moser, H.5    Gould, S.J.6    Valle, D.7
  • 11
    • 1842335689 scopus 로고    scopus 로고
    • Rhizomelic chondrodysplasia punctata is caused by deficiency of human PEX7, a homologue of the yeast PTS2 receptor
    • Purdue, P.E., Zhang, J.W., Skoneczny, M., and Lazarow, P.B. (1997) Rhizomelic chondrodysplasia punctata is caused by deficiency of human PEX7, a homologue of the yeast PTS2 receptor. Nat. Genet. 15, 381-384
    • (1997) Nat. Genet. , vol.15 , pp. 381-384
    • Purdue, P.E.1    Zhang, J.W.2    Skoneczny, M.3    Lazarow, P.B.4
  • 12
    • 0034635364 scopus 로고    scopus 로고
    • Interaction of Pex5p, the type 1 peroxisomal targeting signal receptor, with the peroxisomal membrane proteins Pex14p and Pex13p
    • Urquhart, A.J., Kennedy, D., Gould, S.J., and Crane, D.I. (2000) Interaction of Pex5p, the type 1 peroxisomal targeting signal receptor, with the peroxisomal membrane proteins Pex14p and Pex13p. J. Biol. Chem. 275, 4127-4136
    • (2000) J. Biol. Chem. , vol.275 , pp. 4127-4136
    • Urquhart, A.J.1    Kennedy, D.2    Gould, S.J.3    Crane, D.I.4
  • 13
    • 0035860787 scopus 로고    scopus 로고
    • The di-aromatic pentapeptide repeats of the human peroxisome import receptor PEX5 are separate high affinity binding sites for the peroxisomal membrane protein PEX14
    • Saidowsky, J., Dodt, G., Kirchberg, K., Wegner, A., Nastainczyk, W., Kunau, W.H., and Schliebs, W. (2001) The di-aromatic pentapeptide repeats of the human peroxisome import receptor PEX5 are separate high affinity binding sites for the peroxisomal membrane protein PEX14. J. Biol. Chem. 276, 34524-34529
    • (2001) J. Biol. Chem. , vol.276 , pp. 34524-34529
    • Saidowsky, J.1    Dodt, G.2    Kirchberg, K.3    Wegner, A.4    Nastainczyk, W.5    Kunau, W.H.6    Schliebs, W.7
  • 14
    • 0036179374 scopus 로고    scopus 로고
    • Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: Conserved Pex5p WXXXF/Y motifs are critical for matrix protein import
    • Otera, H., Setoguchi, K., Hamasaki, M., Kumashiro, T., Shimizu, N., and Fujiki, Y. (2002) Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein import. Mol. Cell. Biol. 22, 1639-1655
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 1639-1655
    • Otera, H.1    Setoguchi, K.2    Hamasaki, M.3    Kumashiro, T.4    Shimizu, N.5    Fujiki, Y.6
  • 15
    • 0035928730 scopus 로고    scopus 로고
    • Peroxisomes: The extended shuttle to the peroxisome matrix
    • Kunau, W.H. (2001) Peroxisomes: the extended shuttle to the peroxisome matrix. Current Biol. 11, 659-662
    • (2001) Current Biol. , vol.11 , pp. 659-662
    • Kunau, W.H.1
  • 16
    • 0035805208 scopus 로고    scopus 로고
    • Peroxisomal protein import: The paradigm shifts
    • Smith, M.D. and Schnell, D.J. (2001) Peroxisomal protein import: The paradigm shifts. Cell 105, 293-296
    • (2001) Cell , vol.105 , pp. 293-296
    • Smith, M.D.1    Schnell, D.J.2
  • 17
    • 0035917528 scopus 로고    scopus 로고
    • The human peroxisomal targeting signal receptor, Pex5p, is translocated into the peroxisomal matrix and recycled to the cytosol
    • Dammai, V. and Subramani, S. (2001) The human peroxisomal targeting signal receptor, Pex5p, is translocated into the peroxisomal matrix and recycled to the cytosol. Cell 105, 187-196
    • (2001) Cell , vol.105 , pp. 187-196
    • Dammai, V.1    Subramani, S.2
  • 18
    • 0026064431 scopus 로고
    • Restoration by a 35K membrane protein of peroxisome assembly in a peroxisome-deficient mammalian cell mutant
    • Tsukamoto, T., Miura, S., and Fujiki, Y. (1991) Restoration by a 35K membrane protein of peroxisome assembly in a peroxisome-deficient mammalian cell mutant. Nature 350, 77-81
    • (1991) Nature , vol.350 , pp. 77-81
    • Tsukamoto, T.1    Miura, S.2    Fujiki, Y.3
  • 19
    • 0031656796 scopus 로고    scopus 로고
    • Mutations in PEX10 is the cause of Zellweger peroxisome deficiency syndrome of complementation group B
    • Okumoto, K., Itoh, R., Shimozawa, N., Suzuki, Y., Tamura, S., Kondo, N., and Fujiki, Y. (1998) Mutations in PEX10 is the cause of Zellweger peroxisome deficiency syndrome of complementation group B. Hum. Mol. Genet. 7, 1399-1405
    • (1998) Hum. Mol. Genet. , vol.7 , pp. 1399-1405
    • Okumoto, K.1    Itoh, R.2    Shimozawa, N.3    Suzuki, Y.4    Tamura, S.5    Kondo, N.6    Fujiki, Y.7
  • 20
    • 0032231872 scopus 로고    scopus 로고
    • Identification of PEX10, the gene defective in complementation group 7 of the peroxisome-biogenesis disorders
    • Warren, D.S., Morrell, J.C., Moser, H.W., Valle, D., and Gould, S.J. (1998) Identification of PEX10, the gene defective in complementation group 7 of the peroxisome-biogenesis disorders. Am. J. Hum. Genet. 63, 347-359
    • (1998) Am. J. Hum. Genet. , vol.63 , pp. 347-359
    • Warren, D.S.1    Morrell, J.C.2    Moser, H.W.3    Valle, D.4    Gould, S.J.5
  • 21
    • 0030951104 scopus 로고    scopus 로고
    • Isolation of the human PEX12 gene, mutated in group 3 of the peroxisome biogenesis disorders
    • Chang, C.C., Lee, W.H., Moser, H., Valle, D., and Gould, S.J. (1997) Isolation of the human PEX12 gene, mutated in group 3 of the peroxisome biogenesis disorders. Nat. Genet. 15, 385-388
    • (1997) Nat. Genet. , vol.15 , pp. 385-388
    • Chang, C.C.1    Lee, W.H.2    Moser, H.3    Valle, D.4    Gould, S.J.5
  • 22
    • 0031862579 scopus 로고    scopus 로고
    • PEX12, the pathogenic gene of group III Zellweger syndrome: CDNA cloning by functional complementation on a CHO cell mutant, patient analysis, and characterization of PEX12p
    • Okumoto, K., Shimozawa, N., Kawai, A., Tamura, S., Tsukamoto, T., Osumi, T., Moser, H., Wanders, R.J.A., Suzuki, Y., Kondo, N., and Fujiki, Y. (1998) PEX12, the pathogenic gene of group III Zellweger syndrome: cDNA cloning by functional complementation on a CHO cell mutant, patient analysis, and characterization of PEX12p. Mol. Cell. Biol. 18, 4324-4336
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 4324-4336
    • Okumoto, K.1    Shimozawa, N.2    Kawai, A.3    Tamura, S.4    Tsukamoto, T.5    Osumi, T.6    Moser, H.7    Wanders, R.J.A.8    Suzuki, Y.9    Kondo, N.10    Fujiki, Y.11
  • 23
    • 0033571690 scopus 로고    scopus 로고
    • PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import
    • Chang, C.C., Warren, D.S., Sacksteder, K.A., and Gould, S.J. (1999) PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import. J. Cell Biol. 147, 761-774
    • (1999) J. Cell Biol. , vol.147 , pp. 761-774
    • Chang, C.C.1    Warren, D.S.2    Sacksteder, K.A.3    Gould, S.J.4
  • 24
    • 0031854532 scopus 로고    scopus 로고
    • An isoform of Pex5p, the human PTS1 receptor, is required for the import of PTS2 proteins into peroxisomes
    • Braverman, N., Dodt, G., Gould, S.J., and Valle, D. (1998) An isoform of Pex5p, the human PTS1 receptor, is required for the import of PTS2 proteins into peroxisomes. Hum. Mol. Genet. 7, 1195-1205
    • (1998) Hum. Mol. Genet. , vol.7 , pp. 1195-1205
    • Braverman, N.1    Dodt, G.2    Gould, S.J.3    Valle, D.4
  • 26
    • 0034647529 scopus 로고    scopus 로고
    • Disruption of the interaction of the longer isoform of Pex5p, Pex5pL, with Pex7p abolishes peroxisome targeting signal type 2 protein import in mammals
    • Matsumura, T., Otera, H., and Fujiki, Y. (2000) Disruption of the interaction of the longer isoform of Pex5p, Pex5pL, with Pex7p abolishes peroxisome targeting signal type 2 protein import in mammals. J. Biol. Chem. 275, 21715-21721
    • (2000) J. Biol. Chem. , vol.275 , pp. 21715-21721
    • Matsumura, T.1    Otera, H.2    Fujiki, Y.3
  • 27
    • 0034678916 scopus 로고    scopus 로고
    • Rapid isolation and characterization of CHO mutants deficient in peroxisome biogenesis using the peroxisomal forms of fluorescent proteins
    • Ito, M., Ito, R., Huang, Y., Miura, S., Imamura, A., Suzuki, Y., and Shimozawa, N. (2000) Rapid isolation and characterization of CHO mutants deficient in peroxisome biogenesis using the peroxisomal forms of fluorescent proteins. Biochim. Biophys. Acta 1496, 232-242
    • (2000) Biochim. Biophys. Acta , vol.1496 , pp. 232-242
    • Ito, M.1    Ito, R.2    Huang, Y.3    Miura, S.4    Imamura, A.5    Suzuki, Y.6    Shimozawa, N.7
  • 28
    • 0037042381 scopus 로고    scopus 로고
    • Different accumulations of 3-ketoacyl-CoA thiolase precursor in peroxisomes of Chinese hamster ovary cells harboring a dysfunction in the PEX2 protein
    • Huang, Y., Ito, R., Imanaka, T., Usuda, N., and Ito, M. (2002) Different accumulations of 3-ketoacyl-CoA thiolase precursor in peroxisomes of Chinese hamster ovary cells harboring a dysfunction in the PEX2 protein. Biochim. Biophys. Acta 1589, 273-284
    • (2002) Biochim. Biophys. Acta , vol.1589 , pp. 273-284
    • Huang, Y.1    Ito, R.2    Imanaka, T.3    Usuda, N.4    Ito, M.5
  • 30
    • 0028332245 scopus 로고
    • Differential protein import deficiencies in human peroxisome assembly disorders
    • Motley, A., Hettema, E., Distel, B., and Tabak, H. (1994) Differential protein import deficiencies in human peroxisome assembly disorders. J. Cell Biol. 125, 755-767
    • (1994) J. Cell Biol. , vol.125 , pp. 755-767
    • Motley, A.1    Hettema, E.2    Distel, B.3    Tabak, H.4
  • 31
    • 0019363396 scopus 로고
    • Organization and expression of eucaryotic split genes coding for proteins
    • Breathnach, R. and Chambon, P. (1981) Organization and expression of eucaryotic split genes coding for proteins. Annu. Rev. Biochem. 50, 349-383
    • (1981) Annu. Rev. Biochem. , vol.50 , pp. 349-383
    • Breathnach, R.1    Chambon, P.2
  • 32
    • 0034647937 scopus 로고    scopus 로고
    • The mammalian peroxin Pex5pL, the longer isoform of the mobile peroxisome targeting signal (PTS) type 1 transporter, translocates the Pex7p-PTS2 protein complex into peroxisomes via its initial docking site, Pex14p
    • Otera, H., Harano, T., Honsho, M., Ghaedi, K., Mukai, S., Tanaka, A., Kawai, A., Shimizu, N., and Fujiki, Y. (2000) The mammalian peroxin Pex5pL, the longer isoform of the mobile peroxisome targeting signal (PTS) type 1 transporter, translocates the Pex7p-PTS2 protein complex into peroxisomes via its initial docking site, Pex14p. J. Biol. Chem. 275, 21703-21714
    • (2000) J. Biol. Chem. , vol.275 , pp. 21703-21714
    • Otera, H.1    Harano, T.2    Honsho, M.3    Ghaedi, K.4    Mukai, S.5    Tanaka, A.6    Kawai, A.7    Shimizu, N.8    Fujiki, Y.9
  • 33
    • 0025941962 scopus 로고
    • A novel, cleavable peroxisomal targeting signal at the amino-terminus of the rat 3-ketoacyl-CoA thiolase
    • Swinkels, B.W., Gould, S.J., Bodnar, A.G., Rachubinski, R.A., and Subramani, S. (1991) A novel, cleavable peroxisomal targeting signal at the amino-terminus of the rat 3-ketoacyl-CoA thiolase. EMBO J. 10, 3255-3262
    • (1991) EMBO J. , vol.10 , pp. 3255-3262
    • Swinkels, B.W.1    Gould, S.J.2    Bodnar, A.G.3    Rachubinski, R.A.4    Subramani, S.5
  • 35
    • 0019028350 scopus 로고
    • Purification and properties of acyl-CoA oxidase from rat liver
    • Osumi, T., Hashimoto, T., and Ui, N. (1980) Purification and properties of acyl-CoA oxidase from rat liver. J. Biochem. 87, 1735-1746
    • (1980) J. Biochem. , vol.87 , pp. 1735-1746
    • Osumi, T.1    Hashimoto, T.2    Ui, N.3
  • 37
    • 0037414755 scopus 로고    scopus 로고
    • Characterization of the peroxisomal cycling receptor, Pex5p, using a cell-free in vitro import system
    • Gouveia, A.M., Guimaraes, C.P., Oliveira, M.E., Reguenga, C., Sa-Miranda, C., and Azevedo, J.E. (2003) Characterization of the peroxisomal cycling receptor, Pex5p, using a cell-free in vitro import system. J. Biol. Chem. 278, 226-232
    • (2003) J. Biol. Chem. , vol.278 , pp. 226-232
    • Gouveia, A.M.1    Guimaraes, C.P.2    Oliveira, M.E.3    Reguenga, C.4    Sa-Miranda, C.5    Azevedo, J.E.6
  • 38
    • 0035805574 scopus 로고    scopus 로고
    • Recognition of peroxisomal targeting signal type 1 by the import receptor Pex5p
    • Klein, A.T.J., Barnett, P., Bottger, G., Konings, D., Tabak, H.F., and Distel, B. (2001) Recognition of peroxisomal targeting signal type 1 by the import receptor Pex5p. J. Biol. Chem. 276, 15034-15041
    • (2001) J. Biol. Chem. , vol.276 , pp. 15034-15041
    • Klein, A.T.J.1    Barnett, P.2    Bottger, G.3    Konings, D.4    Tabak, H.F.5    Distel, B.6
  • 39
    • 0034693260 scopus 로고    scopus 로고
    • Characterization of peroxisomal Pex5p from rat liver. Pex5p in the Pex5p-Pex14p membrane complex is a transmembrane protein
    • Gouveia, A.M.M., Reguenga, C., Oliveira, M.E.M., Sa-Miranda, C., and Azevedo, J.E. (2000) Characterization of peroxisomal Pex5p from rat liver. Pex5p in the Pex5p-Pex14p membrane complex is a transmembrane protein. J. Biol. Chem. 275, 32444-32451
    • (2000) J. Biol. Chem. , vol.275 , pp. 32444-32451
    • Gouveia, A.M.M.1    Reguenga, C.2    Oliveira, M.E.M.3    Sa-Miranda, C.4    Azevedo, J.E.5
  • 40
    • 0035839442 scopus 로고    scopus 로고
    • Characterization of the mammalian peroxisomal import machinery: Pex2p, Pex5p, Pex12p, and Pex14p are subunits of the same protein assembly
    • Reguenga, C., Oliveira, M.E.M., Gouveia, A.M.M., Sa-Miranda, C., and Azevedo, J.E. (2001) Characterization of the mammalian peroxisomal import machinery: Pex2p, Pex5p, Pex12p, and Pex14p are subunits of the same protein assembly. J. Biol. Chem. 276, 29935-29942
    • (2001) J. Biol. Chem. , vol.276 , pp. 29935-29942
    • Reguenga, C.1    Oliveira, M.E.M.2    Gouveia, A.M.M.3    Sa-Miranda, C.4    Azevedo, J.E.5
  • 43
    • 0028110118 scopus 로고
    • Saccharomyces cerevisiae peroxisomal thiolase is imported as a dimer
    • Glover, J.R., Andrews, D.W., and Rachubinski, R.A. (1994) Saccharomyces cerevisiae peroxisomal thiolase is imported as a dimer. Proc. Natl. Acad. Sci. USA 91, 10541-10545
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 10541-10545
    • Glover, J.R.1    Andrews, D.W.2    Rachubinski, R.A.3
  • 44
    • 0028033934 scopus 로고
    • An oligomeric protein is imported into peroxisomes in vivo
    • McNew, J.A. and Goodman, J.M. (1994) An oligomeric protein is imported into peroxisomes in vivo. J. Cell Biol. 127, 1245-1257
    • (1994) J. Cell Biol. , vol.127 , pp. 1245-1257
    • McNew, J.A.1    Goodman, J.M.2
  • 46
    • 0345791524 scopus 로고    scopus 로고
    • Proteomic analysis of rat liver peroxisome. Presence of peroxisome-specific isozyme of lon protease
    • Kikuchi, M., Hatano, N., Yokota, S., Shimozawa, N., Imanaka, T., and Taniguchi, H. (2004) Proteomic analysis of rat liver peroxisome. Presence of peroxisome-specific isozyme of lon protease. J. Biol. Chem. 279, 421-428
    • (2004) J. Biol. Chem. , vol.279 , pp. 421-428
    • Kikuchi, M.1    Hatano, N.2    Yokota, S.3    Shimozawa, N.4    Imanaka, T.5    Taniguchi, H.6


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