Pathogen-specific TLR signaling in mucosa: Mutual contribution of microbial TLR agonists and virulence factors

European Journal of Immunology

Volumn 36, Issue 2, 2006, Pages 260-263

  Sirard, Jean Claude ^a   Bayardo, Mariela ^b   Didierlaurent, Arnaud ^c  

^a INSERM   (France)

^b FACULTAD DE CIENCIAS EXACTAS   (Argentina)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Commensal flora; Epithelium; Innate immunity; Pathogenic bacteria; Tool like receptor signaling

Indexed keywords

CD14 ANTIGEN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 4;

AGONIST; BACTERIAL VIRULENCE; BACTERIUM ADHERENCE; BACTERIUM DETECTION; BLADDER MUCOSA; EPITHELIUM; FIMBRIA; HUMAN; INFLAMMATION; INNATE IMMUNITY; NONHUMAN; NOTE; PRIORITY JOURNAL; RECEPTOR INTRINSIC ACTIVITY; SIGNAL TRANSDUCTION; URINARY TRACT INFECTION; UROPATHOGENIC ESCHERICHIA COLI;

ANIMALS; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; HUMANS; IMMUNITY, MUCOSAL; MUCOUS MEMBRANE; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; URINARY TRACT INFECTIONS; VIRULENCE FACTORS;

EID: 32944471107     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200535777     Document Type: Note

References (23)

1. Akira, S. and Takeda, K., Toll-like receptor signalling. Nat. Rev. Immunol. 2004. 4: 499-511.
2. Backhed, F and Hornef, M., Toll-like receptor 4-mediated signaling by epithelial surfaces: necessity or threat? Microbes Infect. 2003. 5: 951-959.
3. Ramos, H. C., Rumbo, M. and Sirard, J. C., Bacterial flagellins: mediators of pathogenicity and host immune responses in mucosa. Trends Microbiol. 2004. 12: 509-517.
4. Fischer, H., Yamamoto, M., Hoebe, K., Akira, S., Beutler, B. and Svanborg, C., Mechanism of pathogen specific TLR4 activation in the mucosa: Fimbriae, recognition receptors and adaptor protein selection. Eur. J. Immunol. 2006. DOI 10.1002/eji.200535149
5. Wullt, B., Bergsten, G., Connell, H., Rollano, P., Gebretsadik, N., Hull, R. and Svanborg, C., P fimbriae enhance the early establishment of Escherichia coli in the human urinary tract. Mol. Microbiol. 2000. 38: 456-464.
6. Godaly, G., Hang, R, Frendeus, B. and Svanborg, C., Transepithelial neutrophil migration is CXCR1 dependent in vitro and is defective in IL-8 receptor knockout mice. J. Immunol. 2000. 165: 5287-5294.
7. Frendeus, B., Godaly, G., Hang, L., Karpman, D., Lundstedt, A. C. and Svanborg, C., Interleukin 8 receptor deficiency confers susceptibility to acute experimental pyelonephritis and may have a human counterpart. J. Exp. Med. 2000. 192: 881-890.
8. Mulvey, M. A., Lopez-Boado, Y. S., Wilson, C. L., Roth, R., Parks, W. C., Heuser, J. and Hultgren, S. J., Induction and evasion of host defenses by type 1-piliated uropathogenic Escherichia coli. Science 1998. 282: 1494-1497.
9. Hedlund, M., Frendeus, B., Wachtler, C., Hang, L., Fischer, H. and Svanborg, C., Type 1 fimbriae deliver an LPS- and TLR4-dependent activation signal to CD14-negative cells. Mol. Microbiol. 2001. 39: 542-552.
10. Frendeus, B., Wachtler, C., Hedlund, M., Fischer, H., Samuelsson, P., Svensson, M. and Svanborg, C., Escherichia coli P fimbriae utilize the Toll-like receptor 4 pathway for cell activation. Mol. Microbiol. 2001. 40: 37-51.
11. Schilling, J. D., Martin, S. M., Hung, C. S., Lorenz, R. G. and Hultgren, S. J., Toll-like receptor 4 on stromal and hematopoietic cells mediates innate resistance to uropathogenic Escherichia coli. Proc. Natl. Acad. Sci. USA 2003. 100: 4203-4208.
12. Godaly, G., Frendeus, B., Proudfoot, A., Svensson, M., Klemm, P. and Svanborg, C., Role of fimbriae-mediated adherence for neutrophil migration across Escherichia coli-infected epithelial cell layers. Mol. Microbiol. 1998. 30: 725-735.
13. Triantafilou, M. and Triantafilou, K., Lipopolysaccharide recognition: CD14, TLRs and the LPS-activation cluster. Trends Immunol. 2002. 23: 301-304.
14. Samuelsson, P., Hang, L., Wullt, B., Irjala, H. and Svanborg, C., Toll-like receptor 4 expression and cytokine responses in the human urinary tract mucosa. Infect. Immun. 2004. 72: 3179-3186.
15. Jiang, Z., Georgel, P., Du, X., Shamel, L., Sovath, S., Mudd, S., Huber, M. et al., CD14 is required for MyD88-independent LPS signaling. Nat. Immunol. 2005. 6: 565-570.
16. Brown, G. D., Herre, J., Williams, D. L., Willment, J. A., Marshall, A. S. and Gordon, S., Dectin-1 mediates the biological effects of beta-glucans. J. Exp. Med. 2003. 197: 1119-1124.
17. Hohl, T. M., Van Epps, H. L., Rivera, A., Morgan, L. A., Chen, P. L., Feldmesser, M. and Pamer, E. G., Aspergillus fumigatus Triggers Inflammatory Responses by Stage-Specific beta-Glucan Display. PLoS Pathog. 2005. 1: e30.
18. Oshiumi, H., Matsumoto, M., Funami, K., Akazawa, T. and Seya, T., TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction. Nat. Immunol. 2003. 4: 161-167.
19. Fitzgerald, K. A., Rowe, D. C., Barnes, B. J., Caffrey, D. R., Visintin, A., Latz, E., Monks, B. et al., LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF. J. Exp. Med. 2003. 198: 1043-1055.
20. Neish, A. S., Gewirtz, A. T., Zeng, H., Young, A. N., Hobert, M. E., Karmali, V., Rao, A. S. and Madara, J. L., Prokaryotic regulation of epithelial responses by inhibition of I kappa B-alpha ubiquitination. Science 2000. 289: 1560-1563.
21. Kelly, D., Campbell, J. I., King, T. P., Grant, G., Jansson, E. A., Coutts, A. G., Pettersson, S. and Conway, S., Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-gamma and RelA. Nat. Immunol. 2004. 5: 104-112.
22. Andersen-Nissen, E., Smith, K. D., Strobe, K. L., Barrett, S. L., Cookson, B. T., Logan, S. M. and Aderem, A., Evasion of Toll-like receptor 5 by flagellated bacteria. Proc. Natl. Acad. Sci. USA 2005. 102: 9247-9252.
23. Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S. and Medzhitov, R., Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 2004. 118: 229-241.