Chronic but not acute oral L-arginine supplementation delays the ventilatory threshold during exercise in heart failure patients

Canadian Journal of Applied Physiology

Volumn 30, Issue 4, 2005, Pages 419-432

  Doutreleau, Stéphane ^a   Mettauer, Bertrand ^a   Piquard, François ^b   Schaefer, Adrien ^b   Lonsdorfer, Evelyne ^a   Richard, Ruddy ^a   Geny, Bernard ^a  

^a UNIVERSITY HOSPITAL OF STRASBOURG   (France)

^b UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

Heart device; Maximal exercise; Vasodilator

Indexed keywords

ARGININE; CARBON DIOXIDE; LACTIC ACID;

ANAEROBIC THRESHOLD; ARTICLE; BLOOD; BREATHING MECHANICS; DRUG ADMINISTRATION; DRUG EFFECT; ENDURANCE; EXERCISE; EXHALATION; FORWARD HEART FAILURE; HUMAN; MALE; MIDDLE AGED; OSMOLARITY; OXYGEN CONSUMPTION; PATHOPHYSIOLOGY; TIME;

ANAEROBIC THRESHOLD; ARGININE; CARBON DIOXIDE; CARDIAC OUTPUT, LOW; DRUG ADMINISTRATION SCHEDULE; EXERCISE; EXHALATION; HUMANS; LACTIC ACID; MALE; MIDDLE AGED; OSMOLAR CONCENTRATION; OXYGEN CONSUMPTION; PHYSICAL ENDURANCE; RESPIRATORY MECHANICS; TIME FACTORS;

EID: 32944460017     PISSN: 10667814     EISSN: 15432718     Source Type: Journal    
DOI: 10.1139/h05-131     Document Type: Article

References (55)

1. Adamopoulos, S., Parissis, J., Karatzas, D., Kroupis, C., Georgiadis, M., Karavolias, G., Paraskevaidis, J., Koniavitou, K., Coats, A.J., and Kremastinos, D.T. (2002). Physical training modulates proinflammatory cytokines and the soluble Fas/soluble Fas ligand system in patients with chronic heart failure. J. Am. Coll. Cardiol. 39: 653-663.
2. Andersen, P., Adams, R.P., Sjogaard, G., Thorboe, A., and Saltin, B. (1985). Dynamic knee extension as model for study of isolated exercising muscle in humans. J. Appl. Physiol. 59: 1647-1653.
3. Andersen, P., and Saltin, B. (1985). Maximal perfusion of skeletal muscle in man. J. Physiol. 366: 233-249.
4. Andreassen, A.K., Kvernebo, K., Jorgensen, B., Simonsen, S., Kjekshus, J., and Gullestad, L. (1998). Exercise capacity in heart transplant recipients: Relation to impaired endothelium-dependent vasodilation of the peripheral microcirculation. Am. Heart J. 136: 320-328.
5. Balligand, J.L., Kobzik, L., Han, X., Kaye, D.M., Belhassen, L., O'Hara, D.S., Kelly, R.A., Smith, T.W., and Michel, T. (1995). Nitric oxide-dependent parasympathetic signaling is due to activation of constitutive endothelial (type III) nitric oxide synthase in cardiac myocytes. J. Biol. Chem. 270: 14582-14586.
6. 2 slope acutely in patients with severe chronic heart failure. Eur. J. Heart Fail. 1: 187-190.
7. Bocchi, E.A., Vilella de Moraes, A.V., Esteves-Filho, A., Bacal, F., Auler, J.O., Carmona, M.J., Bellotti, G., and Ramires, A.F. (2000). L-arginine reduces heart rate and improves hemodynamics in severe congestive heart failure. Clin. Cardiol. 23: 205-210.
8. Bode-Boger, S.M., Boger, R.H., Galland, A., Tsikas, D., and Frolich, J.C. (1998). L-arginine-induced vasodilation in healthy humans: Pharmacokinetic- pharmacodynamic relationship. Br. J. Clin. Pharmacol. 46: 489-497.
9. Brown, M.D., Srinivasan, M., Hogikyan, R.V., Dengel, D.R., Glickman, S.G., Galecki, A., and Supiano, M.A. (2000). Nitric oxide biomarkers increase during exercise-induced vasodilation in the forearm. Int. J. Sports Med. 21: 83-89.
10. Clark, A.L., Poole-Wilson, P.A., and Coats, A.J. (1994). Effects of motivation of the patient on indices of exercise capacity in chronic heart failure. Br. Heart J. 71: 162-165.
11. Coats, A.J., and Adamopoulos, S. (1994). Neurohormonal mechanisms and the role of angiotensin-converting enzyme (ACE) inhibitors in heart failure. Cardiovasc. Drugs Ther. 8: 685-692.
12. 2 French Study Group. Eur. Heart J. 12: 1055-1063.
13. Drexler, H., Fischell, T.A., Pinto, F.J., Chenzbraun, A., Botas, J., Cooke, J.P., and Alderman, E.L. (1994). Effect of L-arginine on coronary endothelial function in cardiac transplant recipients. Relation to vessel wall morphology. Circulation 89: 1615-1623.
14. Garrard, C.S., and Das, R. (1987). Sources of error and variability in the determination of anaerobic threshold in healthy humans. Respiration 51: 137-145.
15. Geny, B., Richard, R., Mettauer, B., Lonsdorfer, J., and Piquard, F. (2001). Cardiac natriuretic peptides during exercise and training after heart transplantation. Cardiovasc. Res. 51: 521-528.
16. Hambrecht, R., Hilbrich, L., Erbs, S., Gielen, S., Fiehn, E., Schoene, N., and Schuler, G. (2000). Correction of endothelial dysfunction in chronic heart failure: Additional effects of exercise training and oral L-arginine supplementation. J. Am. Coll. Cardiol. 35: 706-713.
17. Hare, J.M., Keaney, J.F., Jr., Balligand, J.L., Loscalzo, J., Smith, T.W., and Colucci, W.S. (1995). Role of nitric oxide in parasympathetic modulation of beta-adrenergic myocardial contractility in normal dogs. J. Clin. Invest. 95: 360-366.
18. Hirooka, Y., Imaizumi, T., Tagawa, T., Shiramoto, M., Endo, T., Ando, S., and Takeshita, A. (1994). Effects of L-arginine on impaired acetylcholine-induced and ischemic vasodilation of the forearm in patients with heart failure. Circulation 90: 658-668.
19. Jones, N.L., and Ehrsam, R.E. (1982). The anaerobic threshold. Exerc. Sport Sci. Rev. 10: 49-83.
20. Joyner, M.J., and Dietz, N.M. (1997). Nitric oxide and vasodilation in human limbs. J. Appl. Physiol. 83: 1785-1796.
21. Joyner, M.J., and Tschakovsky, M.E. (2003). Nitric oxide and physiologic vasodilation in human limbs: Where do we go from here? Can. J. Appl. Physiol. 28: 475-490.
22. Jungersten, L., Ambling, A., Wall, B., and Wennmalm, A. (1997). Both physical fitness and acute exercise regulate nitric oxide formation in healthy humans. J. Appl. Physiol. 82: 760-764.
23. Kanaya, Y., Nakamura, M., Kobayashi, N., and Hiramori, K. (1999). Effects of L-arginine on lower limb vasodilator reserve and exercise capacity in patients with chronic heart failure. Heart 81: 512-517.
24. Katz, S.D., Khan, T., Zeballos, G.A., Mathew, L., Potharlanka, P., Knecht, M., and Whelan, J. (1999). Decreased activity of the L-arginine-nitric oxide metabolic pathway in patients with congestive heart failure. Circulation 99: 2113-2117.
25. Katz, S.D., Maskin, C., Jondeau, G., Cocke, T., Berkowitz, R., and LeJemtel, T. (2000). Near-maximal fractional oxygen extraction by active skeletal muscle in patients with chronic heart failure. J. Appl. Physiol. 88: 2138-2142.
26. Koifman, B., Wollmann, Y., Bogomolny, N., Chernichowsky, T., Finkelstein, A., Peer, G., Scherez, J., Blum, M., Laniado, S., Iaina, A., et al. (1995). Improvement of cardiac performance by intravenous infusion of L-arginine in patients with moderate congestive heart failure. J. Am. Coll. Cardiol. 26: 1251-1256.
27. Leiper, J., and Vallance, P. (1999). Biological significance of endogenous methylarginines that inhibit nitric oxide synthases. Cardiovasc. Res. 43: 542-548.
28. Lerman, A., Burnett, J.C., Jr., Higano, S.T., McKinley, L.J., and Holmes, D.R., Jr. (1998). Long-term L-arginine supplementation improves small-vessel coronary endothelial function in humans. Circulation 97: 2123-2138.
29. Marechal, G., and Gailly, P. (1999). Effects of nitric oxide on the contraction of skeletal muscle. Cell. Mol. Life Sci. 55: 1088-1102.
30. Maxwell, A.J., Anderson, B.E., and Cooke, J.P. (2000). Nutritional therapy for peripheral arterial disease: A double-blind, placebo-controlled, randomized trial of HeartBar. Vasc. Med. 5: 11-19.
31. Maxwell, A.J., and Cooke, J.P. (1998). Cardiovascular effects of L-arginine. Curr. Opin. Nephrol. Hypertens. 7: 63-70.
32. Maxwell, A.J., Zapien, M.P., Pearce, G.L., MacCallum, G., and Stone, P.H. (2002). Randomized trial of a medical food for the dietary management of chronic, stable angina. J. Am. Coll. Cardiol. 39: 37-45.
33. Mettauer, B., Zoll, J., Sanchez, H., Lampert, E., Ribera, F., Veksler, V., Bigard, X., Mateo, P., Epailly, E., Lonsdorfer, J., and Ventura-Clapier, R. (2001). Oxidative capacity of skeletal muscle in heart failure patients versus sedentary or active control subjects. J. Am. Coll. Cardiol. 38: 947-954.
34. Mills, P.C., Marlin, D.J., Scott, C.M., and Smith, N.C. (1999). Metabolic effects of nitric oxide synthase inhibition during exercise in the horse. Res. Vet. Sci. 66: 135-138.
35. Nagaya, N., Uematsu, M., Oya, H., Sato, N., Sakamaki, F., Kyotani, S., Ueno, K., Nakanishi, N., Yamagishi, M., and Miyatake, K. (2001). Short-term oral administration of L-arginine improves hemodynamics and exercise capacity in patients with precapillary pulmonary hypertension. Am. J. Respir. Crit. Care Med. 163: 887-891.
36. Patel, A.R., Kuvin, J.T., DeNofrio, D., Kinan, D., Sliney, K.A., Eranki, K.P., Pandian, N.G., Udelson, J.E., Konstam, M.A., and Karas, R.H. (2003). Peripheral vascular endothelial function correlates with exercise capacity in cardiac transplant recipients. Am. J. Cardiol. 91: 897-899.
37. Pina, I.L., Apstein, C.S., Balady, G.J., Belardinelli, R., Chaitman, B.R., Duscha, B.D., Fletcher, B.J., Fleg, J.L., Myers, J.N., and Sullivan, M.J. (2003). Exercise and heart failure: A statement from the American Heart Association Committee on Exercise, Rehabilitation, and Prevention. Circulation 107: 1210-1225.
38. Radegran, G. (1997). Ultrasound Doppler estimates of femoral artery blood flow during dynamic knee extensor exercise in humans. J. Appl. Physiol. 83: 1383-1388.
39. Radegran, G. (1999). Limb and skeletal muscle blood flow measurements at rest and during exercise in human subjects. Proc. Nutr. Soc. 58: 887-898.
40. Radegran, G., and Saltin, B. (1998). Muscle blood flow at onset of dynamic exercise in humans. Am. J. Physiol. 274: H314-H322.
41. Rector, T.S., Bank, A.J., Mullen, K.A., Tschumperlin, L.K., Sih, R., Pillai, K., and Kubo, S.H. (1996). Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure. Circulation 93: 2135-2141.
42. Sargent, C., Scroop, G.C., Nemeth, P.M., Burnet, R.B., and Buckley, J.D. (2002). Maximal oxygen uptake and lactate metabolism are normal in chronic fatigue syndrome. Med. Sci. Sports Exerc. 34: 51-56.
43. Schaefer, A., Piquard, F., Doutreleau, S., Mettauer, B., Epailly, E., Eisenmann, B., Lonsdorfer, J., and Geny, B. (2001). Reduced exercise capacity is associated with reduced nitric oxide production after heart transplantation. J. Thorac. Cardiovasc. Surg. 122: 821-822.
44. Schaefer, A., Piquard, F., Geny, B., Doutreleau, S., Lampert, E., Mettauer, B., and Lonsdorfer, J. (2002). L-arginine reduces exercise-induced increase in plasma lactate and ammonia. Int. J. Sports Med. 23: 403-407.
45. Sheriff, D.D., Nelson, C.D., and Sundermann, R.K. (2000). Does autonomic blockade reveal a potent contribution of nitric oxide to locomotion-induced vasodilation? Am. J. Physiol. Heart Circ. Physiol. 279: H726-H732.
46. Simonton, C.A., Higginbotham, M.B., and Cobb, F.R. (1988). The ventilatory threshold: Quantitative analysis of reproducibility and relation to arterial lactate concentration in normal subjects and in patients with chronic congestive heart failure. Am. J. Cardiol. 62: 100-107.
47. Spriet, L.L., Howlett, R.A., and Heigenhauser, G.J. (2000). An enzymatic approach to lactate production in human skeletal muscle during exercise. Med. Sci. Sports Exerc. 32: 756-763.
48. Sullivan, M.J., and Cobb, F.R. (1990). The anaerobic threshold in chronic heart failure. Relation to blood lactate, ventilatory basis, reproducibility, and response to exercise training. Circulation 81: II 47-II 58.
49. Treasure, C.B., and Alexander, R.W. (1993). The dysfunctional endothelium in heart failure. J. Am. Coll. Cardiol. 22: 129A-134A.
50. Vallance, P. (2001). Importance of asymmetrical dimethylarginine in cardiovascular risk. Lancet 358: 2096-2097.
51. Wasserman, K., Stringer, W.W., Casaburi, R., Koike, A., and Cooper, C.B. (1994). Determination of the anaerobic threshold by gas exchange: Biochemical considerations, methodology and physiological effects. Z. Kardiol. 83(Suppl. 3): 1-12.
52. Wilson, J.R., Martin, J.L., and Ferraro, N. (1984). Impaired skeletal muscle nutritive flow during exercise in patients with congestive heart failure: Role of cardiac pump dysfunction as determined by the effect of dobutamine. Am. J. Cardiol. 53: 1308-1315.
53. Yamabe, H., Itoh, K., Yasaka, Y., Takata, T., and Yokoyama, M. (1995). The role of cardiac output response in blood flow distribution during exercise in patients with chronic heart failure. Eur. Heart J. 16: 951-960.
54. Zelis, R., Sinoway, L.I., Musch, T.I., Davis, D., and Just, H. (1988). Regional blood flow in congestive heart failure: Concept of compensatory mechanisms with short and long time constants. Am. J. Cardiol. 62: 2E-8E.
55. Zoll, J., Koulmann, N., Bahi, L., Ventura-Clapier, R., and Bigard, A.X. (2003). Quantitative and qualitative adaptation of skeletal muscle mitochondria to increased physical activity. J. Cell Physiol. 194: 186-193.