The adult "paraplegic" rat: Treatment with cell graftings

Surgical Neurology

Volumn 65, Issue 3, 2006, Pages 223-237

  Fernandez, Eduardo ^a   Mannino, Stefano ^a   Tufo, Tommaso ^a   Pallini, Roberto ^a   Lauretti, Liverana ^a   Albanese, Alessio ^a   Denaro, Luca ^a  

^a CATHOLIC UNIVERSITY   (Italy)

Author keywords

Axonal regeneration; Cellular transplantation; Functional recovery; Neurotrophic factors; Spinal cord injury; Stem cells

Indexed keywords

CELL ISOLATION; CELL POPULATION; CELL TRANSPLANTATION; IN VITRO STUDY; NERVE FIBER REGENERATION; NERVE REGENERATION; NEURAL STEM CELL; NONHUMAN; PARAPLEGIA; RAT; REVIEW; SPINAL CORD INJURY; STEM CELL TRANSPLANTATION;

ANIMALS; AXONS; NERVE GROWTH FACTORS; NERVE REGENERATION; NEURONS; PARAPLEGIA; RATS; SCHWANN CELLS; SPINAL CORD INJURIES; STEM CELL TRANSPLANTATION; TISSUE ENGINEERING;

EID: 32644479682     PISSN: 00903019     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.surneu.2005.06.039     Document Type: Review

References (46)

1. M.R. Andrews, and D.J. Stelzner Modification of a regenerative response of dorsal column axons by Olfactory ensheathing cells or peripheral axotomy in adult rat Exp Neurol 190 2004 311 327
2. D.P. Ankeny, D.M. McTigue, and L.B. Jakeman Bone marrow transplants provide tissue protection and directional guidance for axons after contusive spinal cord injury in rats Exp Neurol 190 2004 17 31
3. K. Barami, and F.G. Diaz Cellular transplantation and spinal cord injury Neurosurgery 47 2000 691 700
4. S.C. Barnett, and J.S. Riddell Olfactory ensheathing cells (OECs) and the treatment of CNS injury: advantages and possible caveats J Anat 204 2004 57 67
5. D.M. Basso, M.S. Beattie, and J.C. Bresnahan A sensitive and reliable locomotor rating scale for open field testing in rats J Neurotrauma 12 1995 1 21
6. M. Berkowitz, C. Harvey, C. Green, and S. Wilson The economic consequences of traumatic spinal cord injury 1992 Demos New York
7. A. Blesch, N. Diergardt, and M.H. Tuszynski Cellularly delivered GDNF induces robust growth of motor and sensory axons in the injured adult spinal cord Soc Neurosci Abstr 24 1998 555
8. A. Blesch, N. Diergardt, H.S. Uy, and M.H. Tuszynski Cellularly delivered NT-4/5 has axonal growth promoting effects in the injured adult rat spinal cord Soc Neurosci Abstr 25 1999 497
9. A. Blesch, H.S. Uy, R.J. Grill, J.G. Cheng, P.H. Patterson, and M.H. Tuszynski Leukemia inhibitory factor augments neurotrophin expression and corticospinal axon growth after adult CNS injury J Neurosci 19 1999 3556 3566
10. A. Blesch, P. Lu, and M.H. Tuszynski Neurotrophic factors, gene therapy, and neural stem cells for spinal cord repair Brain Res Bull 57 2002 833 838
11. A. Blesch, and M.H. Tuszynski Cellular GDNF delivery promotes growth of motor and dorsal column sensory axons after partial and complete spinal cord transections and induces remyelination J Comp Neurol 467 2003 403 417
12. M.B. Bunge Transplantation of purified populations of Schwann cells into lesioned adult rat spinal cord J Neurol 241 1994 S36 S39
13. Q. Cao, P. Zhang, R.M. Howard, W.M. Walters, P. Tsoulfas, and S.R. Whittemore Pluripotent stem cells engrafted into the normal or lesioned adult rat spinal cord are restricted to a glial lineage Exp Neurol 167 2001 48 58
14. H. Cheng, Y. Cao, and L. Olson Spinal cord repair in adult paraplegic rats: partial restoration of hind limb function Science 273 1996 510 513
15. M.I. Chuah, D. Choi-Lundberg, S. Weston, A.J. Vincent, R.S. Chung, J.C. Vickers, and A.K. West Olfactory ensheathing cells promote collateral axonal branching in the injured adult rat spinal cord Exp Neurol 185 2004 15 25
16. J.V. Coumans, T.T. Lin, H.N. Dai, L. MacArthur, M. McAtee, C. Nash, and B.S. Bregman Axonal regeneration and functional recovery after complete spinal cord transaction in rats by delayed treatment with transplants and neurotrophins J Neurosci 21 23 2001 9334 9344
17. D. Feraboli-Lohnherr, D. Orsal, A. Yakovleff, A. Giménez y Ribotta, and A. Privat Recovery of locomotor activity in the adult chronic spinal rat after sublesional transplantation of embryonic nervous cells: specific role of serotonergic neurons Exp Brain Res 113 1997 443 454
18. E. Fernandez, R. Pallini, E. Marchese, and G. Talamonti Experimental studies on spinal cord injuries in the last fifteen years Neurosurg Res 13 1991 138 159
19. R.J.M. Franklin, S.A. Bayley, R. Milner, C.F. Forench-Constant, and W.F. Blakemore Differentation of the O-2A progenitor cell line CG-4 into oligodendrocytes and astrocytes following transplantation into glia-deficient areas of CNS white matter Glia 13 1995 39 44
20. R. Franzen, J. Schoenen, P. Leprince, E. Joosten, G. Moonen, and D. Martin Effects of macrophage transplantation in the injured adult rat spinal cord: a combined immunocytochemical and biochemical study J Neurosci Res 51 1998 316 327
21. J.M. Garcia-Verdugo, and A. Alvarez-Buylla Stem cells, neurotrophins and transplantation: a new era in brain repair Brain Res Bull 57 2002 735 736
22. K.M. Giehl, and W. Tetzlaff BDNF and NT-3, but not NGF, prevent axotomy-induced death of rat corticospinal neurons in vivo Eur J Neurosci 8 1996 1167 1175
23. M. Giménez y Ribotta, C. Roudet, F. Sandillon, and A. Privat Transplantation of embryonic noradrenergic neurons in two models of adult rat spinal cord injury: ultrastructural immunocytochemical study Brain Res 707 1996 245 255
24. B.C. Hains, J.A. Yucra, M.J. Eaton, and C.E. Hulsebosch Intralesion transplantation of serotonergic precursors enhances locomotor recovery but has no effect on development of chronic central pain following hemisection injury in rats Neurosci Lett 324 2002 222 226
25. C.E. Hill, C. Proschel, M. Noble, M. Mayer-Proschel, J.C. Gensel, M.S. Beattie, and J.C. Bresnahan Acute transplantation of glial-restricted precursor cells into spinal cord contusion injuries: survival, differentiation, and effects on lesion environment and axonal regeneration Exp Neurol 190 2004 289 310
26. D.W. Hoovler, and J.R. Wrathall Implantation of neuronal suspensions into contusive injury sites in the adult rat spinal cord Acta Neuropathol 81 1991 303 311
27. Y. Li, P.M. Field, and G. Raisman Repair of adult rat corticospinal tract by transplants of olfactory ensheathing cells Science 277 1997 2000 2002
28. Y. Liu, B.T. Himes, J. Solowska, J. Moul, S.Y. Chow, K.I. Park, A. Tessler, M. Murray, E.Y. Snyder, and I. Fisher Intraspinal delivery of neurotrophin-3 using neural stem cells genetically modified by recombinant retrovirus Exp Neurol 158 1999 9 26
29. J.W. McDonald, X.Z. Liu, Y. Qu, S. Liu, S.K. Mickey, D. Turetsky, D.I. Gottlieb, and D.W. Choi Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord Nat Med 5 1999 1410 1412
30. P. Menei, C. Montero-Menei, S.R. Whittemore, R.P. Bunge, and M.B. Bunge Schwann cells genetically modified to secrete human BDNF promote enhanced axonal regrowth across transected adult rat spinal cord Eur J Neurosci 10 1998 607 621
31. V. Munetòn Goméz, S. Averill, V. King, Q. Yang, E.D. Pérez, S.C. Chacòn, R. Ward, M. Nieto-Sampedro, J. Priestley, and J. Taylor Transplantation of Olfactory ensheathing cells fails to promote significant axonal regeneration from dorsal roots into the rat cervical cord J Neurocytol 32 2003 53 70
32. D.D. Pearse, F.C. Pereira, A.E. Marcillo, M.L. Bates, Y.A. Berrocal, M.T. Filbin, and M.B. Bunge cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury Nat Med 10 6 2004 610 616
33. K. Pfeifer, M. Vroemen, A. Blesch, and N. Weidner Adult neural progenitor cells provide a permissive guiding substrate for corticospinal axon growth following spinal cord injury Eur J Neurosci 20 2004 1695 1704
34. C.M.F. Prewitt, I.R. Niesman, C.J.M. Kane, and J.D. Houlé Activated macrophage/microglia cells can promote the regeneration of sensory axons into the injured spinal cord Exp Neurol 148 1997 433 443
35. L.M. Ramer, M.W. Richter, A.J. Roskams, W. Tetzlaff, and M.S. Ramer Peripherally-derived olfactory ensheathing cells do not promote primary afferent regeneration following dorsal root injury Glia 47 2004 189 206
36. A. Ramòn-Cueto, G.W. Plant, J. Avila, and M.B. Bunge Long-distance axonal regeneration in the transected adult rat spinal cord is promoted by olfactory ensheathing glia transplants J Neurosci 18 1998 3803 3815
37. O. Rapalino, O. Lazarov-Spiegler, E. Agranov, G.J. Velan, E. Yoles, M. Fraidakis, A. Solomon, R. Gepstein, A. Katz, M. Belkin, M. Hadani, and M. Schwartz Implantation of stimulated homologous macrophages results in partial recovery of paraplegic rats Nat Med 4 1998 814 821
38. T. Takami, M. Oudega, M.L. Bates, P.M. Wood, N. Kleitman, and M.B. Bunge Schwann cells but not olfactory ensheathing glia transplants improve hindlimb locomotor performance in the moderately contused adult rat thoracic spinal cord J Neurosci 22 2002 6670 6681
39. M.H. Tuszynski, D.A. Peterson, J. Ray, A. Baird, Y. Nakahara, and F.H. Gage Fibroblasts genetically modified to produce Nerve Growth Factor induce robust neuritic ingrowth after grafting to the spinal cord Exp Neurol 126 1994 1 14
40. M.H. Tuszynski, N. Weidner, M. McCormack, I. Miller, H. Powell, and J. Conner Grafts of genetically modified Schwann cells to the spinal cord: survival, axon growth and myelination Cell Transplant 7 1998 187 196
41. M. Vroemen, L. Aigner, J. Winkler, and N. Weidner Adult neural progenitor cell grafts survive after acute spinal cord injury and integrate along axonal pathways Eur J Neurosci 18 2003 743 751
42. S. Weiss, C. Dunne, J. Hewson, C. Wohl, M. Wheatley, A.C. Peterson, and B.A. Reynolds Multipotent CNS stem cells are present in the adult mammalian spinal cord and ventricular neuroaxis J Neurosci 16 1996 7599 7609
43. S. Wu, Y. Suzuki, M. Kitada, M. Kitaura, K. Kataoka, J. Takahashi, C. Ide, and Y. Nishimura Migration, integration and differentiation of hippocampus-derived neurosphere cells after transplantation into injured rat spinal cord Neurosci lett 312 2001 173 176
44. X.M. Xu, V. Guénard, N. Kleitman, and M.B. Bunge Axonal regeneration into Schwann cell-seeded guidance channels grafted into transected adult rat spinal cord J Comp Neurol 351 1995 145 160
45. X.M. Xu, A. Chen, V. Guénard, N. Kleitman, and M.B. Bunge Bridging Schwann cell transplants promote axonal regeneration from both the rostral and caudal stumps of transected adult rat spinal cord J Neurocytol 26 1997 1 16
46. E.A. Zompa, L.D. Cain, A.W. Everhart, M.P. Moyer, and C.E. Hulsebosch Transplant therapy: recovery of function after spinal cord injury J Neurotrauma 14 1997 479 506