Analyses of dose-response curves to compare the antimicrobial activity of model cationic α-helical peptides highlights the necessity for a minimum of two activity parameters

Analytical Biochemistry

Volumn 350, Issue 1, 2006, Pages 81-90

  Rautenbach, Marina ^a   Gerstner, Gertrude D ^a   Vlok, N Marè ^a   Kulenkampff, Janine ^a   Westerhoff, Hans V ^b,c  

^a STELLENBOSCH UNIVERSITY   (South Africa)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Activity parameters; Antibacterial assay; Antimicrobial peptides; Dose response; Mechanism of action

Indexed keywords

ESCHERICHIA COLI;

ANTI-MICROBIAL ACTIVITY; ANTIMICROBIAL PEPTIDE; DOSE RESPONSE; DOSE-RESPONSE CURVES; INHIBITION CONCENTRATIONS; MECHANISM OF ACTION; MINIMUM BACTERICIDAL CONCENTRATIONS; MINIMUM INHIBITION CONCENTRATIONS;

PEPTIDES;

ANTIINFECTIVE AGENT; GLYCYLISOLEUCYLGLYCYLLYSYLPHENYLALANYLLEUCYLHISTIDYLSERYLALANYLLYSYLLYSYL PHENYLALANYLGLYCYLLYSYLALANYLPHENYLALANYL VALYLGLYCYLGLUTAMYLISOLEUCYLMETHIONYLASPARAGINYLSERINE; GLYCYLMETHIONYLALANYLSERYLLYSYLALANYLGLYCYLALANYLISOLEUCYLGLYCYLALANYL LYSYLISOLEUCYLALANYLLYSYLVALYLALANYLLEUCYLLYSYLALANYLLEUCYLAMIDE; LEUCYLLEUCYLLYSYLLEUCYLLEUCYLLEUCYLPROLYLLYSYLLEUCYLLYSYLGLYCYLLEUCYL LEUCYLPHENYLALANYLLYSYLLEUCYLAMIDE; LEUCYLLEUCYLPROLYLLYSYLLEUCYLLYSYLGLYCYLLEUCYLLEUCYLPHENYLALANYLLYSYL LEUCYLAMIDE; LYSYLLEUCYLLEUCYLLEUCYLPROLYLLYSYLLEUCYLLYSYLGLYCYLLEUCYLLEUCYL PHENYLALANYLLYSYLLEUCYLAMIDE; LYSYLLEUCYLLYSYLLEUCYLLEUCYLLEUCYLLEUCYLLEUCYLLYSYLLEUCYLLYSYLAMIDE; LYSYLLEUCYLLYSYLLEUCYLLEUCYLLEUCYLLEUCYLLYSYLLEUCYLLYSYLAMIDE; LYSYLLEUCYLLYSYLLEUCYLLEUCYLLEUCYLLYSYLLEUCYLLYSYLAMIDE; PHENYLALANYLPROLYLVALYLORNITHYLLEUCYLPHENYLALANYLPROLYLVALYLORNITHYLLEUCINE; POLYPEPTIDE ANTIBIOTIC AGENT; TYROSYLLYSYLLEUCYLLEUCYLLYSYLLEUCYLLEUCYLLEUCYLPROLYLLYSYLLEUCYLLYSYL GLYCYLLEUCYLLEUCYLPHENYLALANYLLYSYLLEUCYLAMIDE; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERICIDAL ACTIVITY; DOSE RESPONSE; DRUG ACTIVITY; DRUG INHIBITION; ESCHERICHIA COLI; GROWTH INHIBITION; IC 50; NONHUMAN; PARAMETER; PRIORITY JOURNAL;

ESCHERICHIA COLI;

EID: 32644457458     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2005.11.027     Document Type: Article

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