HEN1 recognizes 21-24 nt small RNA duplexes and deposits a methyl group onto the 2′ OH of the 3′ terminal nucleotide

Nucleic Acids Research

Volumn 34, Issue 2, 2006, Pages 667-675

  Yang, Zhiyong ^a   Ebright, Yon W ^b   Yu, Bin ^a   Chen, Xuemei ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARABIDOPSIS PROTEIN; DOUBLE STRANDED RNA; HYDROXYL GROUP; METHYL GROUP; MICRORNA; NUCLEOTIDE; POLYNUCLEOTIDE ADENYLYLTRANSFERASE; PROTEIN HEN1; RIBOSE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE SILENCING; IN VITRO STUDY; MOLECULAR BIOLOGY; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RNA METHYLATION; YEAST;

ESCHERICHIA COLI PROTEINS; METHYLATION; METHYLTRANSFERASES; MICRORNAS; NUCLEOTIDES; POLYNUCLEOTIDE ADENYLYLTRANSFERASE; RNA, DOUBLE-STRANDED; RNA, SMALL INTERFERING; SUBSTRATE SPECIFICITY; YEASTS;

ARABIDOPSIS;

EID: 32644454064     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkj474     Document Type: Article

References (23)

1. Hammond,S.M. (2005) Dicing and slicing: The core machinery of the RNA interference pathway. FEBS Lett., 579, 5822-5829.
2. Matzke,M.A. and Birchler,J.A. (2005) RNAi-mediated pathways in the nucleus. Nature Rev. Genet., 6, 24-35.
3. Mette,M.F., Aufsatz,W., van der Winden,J., Matzke,M.A. and Matzke,A.J. (2000) Transcriptional silencing and promoter methylation triggered by double-stranded RNA. EMBO J., 19, 5194-5201.
4. Morel,J.B., Mourrain,P., Beclin,C. and Vaucheret,H. (2000) DNA methylation and chromatin structure affect transcriptional and post-transcriptional transgene silencing in Arabidopsis. Curr. Biol., 10, 1591-1594.
5. Hamilton,A., Voinnet,O., Chappell,L. and Baulcombe,D. (2002) Two classes of short interfering RNA in RNA silencing. EMBO J., 21, 4671-4679.
6. Llave,C., Kasschau,K.D., Rector,M.A. and Carrington,J.C. (2002) Endogenous and silencing-associated small RNAs in plants. Plant Cell, 14, 1605-1619.
7. Mette,M.F., van der Winden,J., Matzke,M. and Matzke,A.J. (2002) Short RNAs can identify new candidate transposable element families in Arabidopsis. Plant Physiol., 130, 6-9.
8. Peragine,A., Yoshikawa,M., Wu,G., Albrecht,H.L. and Poethig,R.S. (2004) SGS3 and SGS2/SDE1/RDR6 are required for juvenile development and the production of trans-acting siRNAs in Arabidopsis. Genes Dev., 18, 2368-2379.
9. Sunkar,R., Girke,T., Jain,P.K. and Zhu,J.K. (2005) Cloning and characterization of microRNAs from rice. Plant Cell, 17, 1397-1411.
10. Sunkar,R., Girke,T. and Zhu,J.K. (2005) Identification and characterization of endogenous small interfering RNAs from rice. Nucleic Acids Res., 33, 4443-4454.
11. Sunkar,R. and Zhu,J.K. (2004) Novel and stress-regulated microRNAs and other small RNAs from Arabidopsis. Plant Cell, 16, 2001-2019.
12. Vazquez,F., Vaucheret,H., Rajagopalan,R., Lepers,C., Gasciolli,V., Mallory,A.C., Hilbert,J.L., Bartel,D.P. and Crete,P. (2004) Endogenous trans-acting siRNAs regulate the accumulation of Arabidopsis mRNAs. Mol. Cell, 16, 69-79.
13. Kim,V.N. (2005) MicroRNA biogenesis: Coordinated cropping and dicing. Nature Rev. Mol. Cell Biol., 6, 376-385.
14. Ebhardt,H.A., Thi,E.P., Wang,M.B. and Unrau,P.J. (2005) Extensive 3′ modification of plant small RNAs is modulated by helper component-proteinase expression. Proc. Natl Acad. Sci. USA, 102, 13398-13403.
15. Li,J., Yang,Z., Yu,B., Liu,J. and Chen,X. (2005) Methylation protects miRNAs and siRNAs from a 3′ end uridylation activity in Arabidopsis. Curr. Biol., 15, 1501-1507.
16. Yu,B., Yang,Z., Li,J., Minakhina,S., Yang,M., Padgett,R.W., Steward,R. and Chen,X. (2005) Methylation as a crucial step in plant microRNA biogenesis. Science, 307, 932-935.
17. Bernstein,E., Caudy,A.A., Hammond,S.M. and Hannon,G.J. (2001) Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature, 409, 363-366.
18. Aravind,L. and Koonin,E.V. (1999) DNA polymerase beta-like nucleotidyltransferase superfamily: Identification of three new families, classification and evolutionary history. Nucleic Acids Res., 27, 1609-1618.
19. Ye,K., Malinina,L. and Patel,D.J. (2003) Recognition of small interfering RNA by a viral suppressor of RNA silencing. Nature, 426, 874-878.
20. Vargason,J.M., Szittya,G., Burgyan,J. and Tanaka Hall,T.M. (2003) Size selective recognition of siRNA by an RNA silencing suppressor. Cell, 115, 799-811.
21. Sijen,T., Fleenor,J., Simmer,F., Thijssen,K.L., Parrish,S., Timmons,L., Plasterk,R.H. and Fire,A. (2001) On the role of RNA amplification in dsRNA-triggered gene silencing. Cell, 107, 465-476.
22. Vaistij,F.E., Jones,L. and Baulcombe,D.C. (2002) Spreading of RNA targeting and DNA methylation in RNA silencing requires transcription of the target gene and a putative RNA-dependent RNA polymerase. Plant Cell, 14, 857-867.
23. Voinnet,O., Vain,P., Angell,S. and Baulcombe,D.C. (1998) Systemic spread of sequence-specific transgene RNA degradation in plants is initiated by localized introduction of ectopic promoterless DNA. Cell, 95, 177-187.