N-acetylcysteine improves nitric oxide and α-adrenergic pathways in mesenteric beds of spontaneously hypertensive rats

American Journal of Hypertension

Volumn 16, Issue 7, 2003, Pages 577-584

  Girouard, Hélène ^a   Chulak, Chantal ^a   Wu, Lingyun ^a   Lejossec, Mireille ^a   De Champlain, Jacques ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Adrenergic agonists; Antioxidants; Free radicals; N acetylcysteine; Nitric oxide synthase

Indexed keywords

ACETYLCYSTEINE; ALPHA ADRENERGIC RECEPTOR; CALCIMYCIN; N(G) NITROARGININE; NITRIC OXIDE;

ADRENERGIC SYSTEM; ANIMAL CELL; ANIMAL MODEL; ARTICLE; ATTENUATION; CONTROLLED STUDY; HEART MUSCLE RELAXATION; HEART RATE; HEART STIMULATION; HYPERTENSION; IN VITRO STUDY; MESENTERIC ARTERY; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; VASODILATATION;

EID: 0038235849     PISSN: 08957061     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0895-7061(03)00863-X     Document Type: Article

References (22)

1. Husken BC, Hendriks MG, Pfaffendorf M, Van Zwieten PA: Effects of aging and hypertension on the reactivity of isolated conductance and resistance vessels. Microvasc Res 1994;48:303-315.
2. Fujimoto S, Dohi Y, Aoki K, Asano M, Matsuda T: Diminished beta-adrenoceptor-mediated relaxation of arteries from spontaneously hypertensive rats before and during development of hypertension. Eur J Pharmacol 1987;136:179-187.
3. Sim MK, Singh M: Decreased responsiveness of the aorta of hypertensive rats to acetylcholine, histamine and noradrenaline. Br J Pharmacol 1987;90:147-150.
4. Tesfamariam B, Halpern W: Endothelium-dependent and endothelium-independent vasodilation in resistance arteries from hypertensive rats. Hypertension 1988;11:440-444.
5. Lopez BL, Snyder JW, Birendaum DS, Ma XI: N-acetylcysteine enhances endothelium-dependent vasorelaxation in isolated rat mesenteric artery. Ann Emerg Med 1988;32:405-410.
6. Cabassi A, Dumont EC, Girouard H, Bouchard J-F, Lejossec M, Lamontagne D, Besner J-G, de Champlain J: Effects of chronic N-acetylcysteine treatment on the actions of peroxynitrite on aortic vascular reactivity in hypertensive rats. J Hypertens 2001;19:1233-1244.
7. Lahera V, Khraibi AA, Romero JC: Sulfhydryl group donors potentiate the hypotensive effect of acetylcholine in rats. Hypertension 1993;22:156-160.
8. Ruiz FJ, Salom MG, Ingles AC, Quesada T, Vicente E, Carbonell LF: N-acetyl-L-cysteine potentiates depressor response to captopril and enalaprilat in SHRs. Am J Physiol 1994;267:R767-R772.
9. Priest RM, Hucks D, Ward JPT: Potentiation of cyclic AMP-mediated vasorelaxation by phenylephrine in pulmonary arteries of the rat. Br J Pharmacol 1999;127:291-299.
10. Wu L, de Champlain J: Superoxide anion-induced formation of inositol phosphates involves tyrosine kinase activation in smooth muscle cells from rat mesenteric artery. Biochem Biophys Res Commun 1999;259:239-243.
11. Liang C, Rounds NK, Dong E, Stevens SY, Shite J, Qin F: Alterations by norepinephrine of cardiac sympathetic nerve terminal function and myocardial beta-adrenergic receptor sensitivity in the ferret: normalization by antioxidant vitamins. Circulation 2000;102:96-103.
12. Girouard H, Chulak C, Lejossec M, Lamontagne D, de Champlain J: Vasorelaxant effects of the chronic treatment with melatonin on mesenteric artery and aorta of spontaneously hypertensive rats. J Hypertens 2001;19:1369-1377.
13. Wu L, de Champlain J: Inhibition by cyclic AMP of basal and induced inositol phosphate production in cultured aortic smooth cells from Wistar-Kyoto and spontaneously hypertensive rats. J Hypertens 1996;14:593-599.
14. Gorren ACF, List BM, Schrammel A, Pitters E, Hemmens B, Wemer ER, Schrnidt K, Mayer B: Tetrahydrobiopterin-free neuronal nitric oxide synthase: evidence for two identical highly anticooperative pteridine binding sites. Biochemistry 1996;35:16735-16745.
15. Cotgreave I, Moldeus P, Schuppe I: The metabolism of N-acetylcysteine by human endothelial cells. Biochem Pharmacol 1991;42:13-16.
16. Vericel E, Narce M, Ulmann L, Poisson JP, Lagarde M: Age-related changes in antioxidant defense mechanism and peroxidation in isolated hepatocytes from spontaneously hypertensive and normotensive rats. Mol Cell Biochem 1994;132:25-29.
17. Bouloumié A, Bauersachs J, Linz W, Schölkens BA, Wiemer G, Fleming I, Busse R: Endothelial dysfunction coincides with an enhanced nitric oxide synthase expression and superoxide anion production. Hypertension 1997;30:934-941.
18. Bauersachs J, Bouloumié A, Mülsch A, Wiemer G, Fleming I, Busse: Vasodilator dysfunction in aged spontaneously hypertensive rats: changes in NO synthase III and soluble guanylyl cyclase expression, and in superoxide anion production. Cardiovasc Res 1998;37:772-779.
19. Cosentino F, Patton S, D'uscio LV, Werner ER, Werner-Felmayer G, Moreau P, Malinski T, Lüscher TF: Tetrahydrobiopterine alters superoxide and nitric oxide release in prehypertensive rats. J Clin Invest 1998;101:1530-1537.
20. Wu R, Millette E, Wu L, de Champlain J: Enhanced superoxide anion formation in vascular tissues from spontaneously hypertensive and desoxycorticosterone acetate-salt hypertensive rats. J Hypertens 2001;19:741-748.
21. Girouard H, Chulak C, LeJossec M, Lamontagne D, de Champlain J: Chronic antioxidant treatment improves sympathetic functions and β-adrenergic pathway in the spontaneously hypertensive rats. J Hypertens 2003;21:179-188.
22. Fenoy FJ, Tornel J, Madrid MI, Lopez E, Garcia-Salom M: Effects of Nω-nitro-L-arginine and N-acetyl-L-cysteine on the reversal of one-kidney, one-clip hypertension. Am J Hypertens 1997;10:1208-1215.