Quantitative trait locus analysis of longitudinal quantitative trait data in complex pedigrees

Genetics

Volumn 171, Issue 3, 2005, Pages 1365-1376

  Macgregor, Stuart ^a,b   Knott, Sara A ^a   White, Ian ^a   Visscher, Peter M ^a,c  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

^c QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AGE; ARTICLE; COVARIANCE; HEREDITY; MULTIVARIATE ANALYSIS; PEDIGREE; POPULATION GENETICS; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; SIMULATION; UNIVARIATE ANALYSIS;

CHROMOSOME MAPPING; COMPUTER SIMULATION; HUMANS; MODELS, GENETIC; PEDIGREE; QUANTITATIVE TRAIT LOCI; QUANTITATIVE TRAIT, HERITABLE;

EID: 32544445138     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: 10.1534/genetics.105.043828     Document Type: Article

References (47)

1. ALLISON, D. B., B. THIEL, P. ST. JEAN, R. C. ELSTON, M. C. INFANTE et al., 1998 Multiple phenotype modeling in gene-mapping studies of quantitative traits: power advantages. Am. J. Hum. Genet. 63: 1190-1201.
2. ALMASY, L., and J. BLANGERO, 1998 Multipoint quantitative-trait linkage analysis in general pedigrees. Am. J. Hum. Genet. 62: 1198-1211.
3. ALMASY, L., L. A. CUPPLES, E. W. DAW, D. LEVY, D. THOMAS et al., 2003 Genetic analysis workshop 13: introduction to workshop summaries. Genet. Epidemiol. 25: S1-S4.
4. AMOS, C. I., 1994 Robust variance-components approach for assessing genetic linkage in pedigrees. Am. J. Hum. Genet. 54: 535-543.
5. AMOS, C. I., R. C. ELSTON, G. E. BONNEY, B. J. B. KEATS and G. S. BERENSON, 1990 A multivariate method for detecting genetic-linkage, with application to a pedigree with an adverse lipoprotein phenotype. Am. J. Hum. Genet. 47: 247-254.
6. AMOS, C. I., M. DE ANDRADE and D. K. ZHU, 2001 Comparison of multivariate tests for genetic linkage. Hum. Hered. 51: 133-144.
7. BLANGERO, J., and L. W. KONIGSBERG, 1991 Multivariate segregation analysis using the mixed model. Genet. Epidemiol. 8: 299-316.
8. BOOMSMA, D. I., and C. V. DOLAN, 1998 A comparison of power to detect a QTL in sib-pair data using multivariate phenotypes, mean phenotypes, and factor scores. Behav. Genet. 28: 329-340.
9. DE ANDRADE, M., and C. OLSWOLD, 2003 Comparison of longitudinal variance components and regression based approaches for linkage detection on chromosome 17 for systolic blood pressure. BMC Genet. 4: S17.
10. DE ANDRADE, M., R. GUEGUEN, S. VISVIKIS, C. SASS, G. SIEST et al., 2002 Extension of variance components approach to incorporate temporal trends and longitudinal pedigree data analysis. Genet. Epidemiol. 22: 221-232.
11. DIEGO, V. P., L. ALMASY, T. D. DYER, J. M. P. SOLER and J. BLANGERO, 2003 Strategy and model building in the fourth dimension: a null model for genotype (x) age interaction as a gaussian stationary stochastic process. BMC Genet. 4: S34.
12. DUDBRIDGE, F., and B. P. C. KOELEMAN, 2004 Efficient computation of significance levels for multiple associations in large studies of correlated data, including genomewide association studies. Am. J. Hum. Genet. 75: 424-435.
13. EAVES, L. J., M. C. NEALE and H. MAES, 1996 Multivariate multipoint linkage analysis of quantitative trait loci. Behav. Genet. 26: 519-525.
14. GAUDERMAN, W. J., S. MACGREGOR, L. BRIOLLAIS, K. SCURRAH, M. TOBIN et al., 2003 Longitudinal data analysis in pedigree studies. Genet. Epidemiol. 25: S18-S28.
15. GEE, C., J. L. MORRISON, D. C. THOMAS and W. J. GAUDERMAN, 2003 Segregation and linkage analysis for longitudinal measurements of a quantitative trait. BMC Genet. 4: S21.
16. GEORGE, A. W., P. M. VISSCHER and C. S. HALEY, 2000 Mapping quantitative trait loci in complex pedigrees: a two-step variance component approach. Genetics 156: 2081-2092.
17. GILMOUR, A. R., B. J. GOGEL, B. R. CULLIS, S. J. WELHAM AND R. THOMPSON, 2002 ASREML User Guide Release 1.0. VSN International, Hemel Hempstead, UK.
18. GOLDGAR, D. E., 1990 Multipoint analysis of human quantitative genetic-variation. Am. J. Hum. Genet. 47: 957-967.
19. HASEMAN, J. K., and R. C. ELSTON, 1972 The investigation of linkage between a quantitative trait and a marker locus. Behav. Genet. 1: 11-19.
20. HOESCHELE, I., P. UIMARI, F. E. GRIGNOLA, Q. ZHANG and K. M. GAGE, 1997 Advances in statistical methods to map quantitative trait loci in outbred populations. Genetics 147: 1445-1457.
21. HOPPER, J. L., and J. D. MATHEWS, 1982 Extensions to multivariate normal-models for pedigree analysis. Ann. Hum. Genet. 46: 373-383.
22. HUANG, J. A., and Y. M. JIANG, 2003 Genetic linkage analysis of a dichotomous trait incorporating a tightly linked quantitative trait in affected sib pairs. Am. J. Hum. Genet. 72: 949-960.
23. JAFFREZIC, F., and S. D. PLETCHER, 2000 Statistical models for estimating the genetic basis of repeated measures and other function-valued traits. Genetics 156: 913-922.
24. JAMROZIK, J., L. R. SCHAEFFER and J. C. M. DEKKERS, 1997 Genetic evaluation of dairy cattle using test day yields and random regression model. J. Dairy Sci. 80: 1217-1226.
25. JIANG, C. J., and Z. B. ZENG, 1995 Multiple-trait analysis of genetic-mapping for quantitative trait loci. Genetics 140: 1111-1127.
26. KIRKPATRICK, M., D. LOFSVOLD and M. BULMER, 1990 Analysis of the inheritance, selection and evolution of growth trajectories. Genetics 124: 979-993.
27. KNOTT, S. A., and C. S. HALEY, 2000 Multitrait least squares for quantitative trait loci detection. Genetics 156: 899-911.
28. LANDER, E., and L. KRUGLYAK, 1995 Genetic dissection of complex traits - guidelines for interpreting and reporting linkage results. Nat. Genet. 11: 241-247.
29. LANGE, K., J. WESTLAKE and M. A. SPENCE, 1976 Extensions to pedigree analysis. III. Variance components by the scoring method. Ann. Hum. Genet. 39: 485-491.
30. LYNCH, M., and B. WALSH, 1998 Genetics and Analysis of Quantitative Traits. Sinauer Associates, Sunderland, MA.
31. MA, C. X., G. CASELLA and R. L. WU, 2002 Functional mapping of quantitative trait loci underlying the character process: a theoretical framework. Genetics 161: 1751-1762.
32. MACGREGOR, S., 2003 Genetic linkage analysis in complex pedigrees. Ph.D. Thesis, University of Edinburgh, Edinburgh.
33. MACGREGOR, S., S. A. KNOTT, I. WHITE and P. M. VISSCHER, 2003 Longitudinal variance-components analysis of the Framingham heart study data. BMC Genet. 4: S22.
34. MARLOW, A. J., S. E. FISHER, C. FRANCKS, I. L. MACPHIE, S. S. CHERNY et al., 2003 Use of multivariate linkage analysis for dissection of a complex cognitive trait. Am. J. Hum. Genet. 72: 561-570.
35. MEYER, K., 1998 Estimating covariance functions for longitudinal data using a random regression model. Genet. Sel. Evol. 30: 221-240.
36. MIREA, L., S. B. BULL and J. STAFFORD, 2003 Comparison of haseman-elston regression analyses using single, summary, and longitudinal measures of systolic blood pressure. BMC Genet. 4: S23.
37. MRODE, R. A., 1996 Linear Models for the Prediction of Animal Breeding Values. CAB International, Wallingford, UK.
38. PLETCHER, S. D., and C. J. GEYER, 1999 The genetic analysis of age-dependent traits: modeling the character process. Genetics 153: 825-835.
39. RAO, S. Q., L. LI, X. LI, K. L. MOSER, Z. GUO et al., 2003 Genetic linkage analysis of longitudinal hypertension phenotypes using three summary measures. BMC Genet. 4: S24.
40. SELF, S. G., and K. Y. LIANG, 1987 Asymptotic properties of maximum-likelihood estimators and likelihood ratio tests under nonstandard conditions. J. Am. Stat. Assoc. 82: 605-610.
41. SORENSEN, P., M. S. LUND, B. GULDBRANDTSEN, J. JENSEN AND D. SORENSEN, 2003 A comparison of bivariate and univariate qtl mapping in livestock populations. Genet. Sel. Evol. 35: 605-622.
42. STRAM, D. O., and J. W. LEE, 1994 Variance-components testing in the longitudinal mixed effects model. Biometrics 50: 1171-1177
43. [erratum: Biometrics 51: 1196 (1995)].
44. WANG, K., 2003 Mapping quantitative trait loci using multiple phenotypes in general pedigrees. Hum. Hered. 55: 1-15.
45. WU, R. L., C. X. MA, M. LIN and G. CASELLA, 2004a A general framework for analyzing the genetic architecture of developmental characteristics. Genetics 166: 1541-1551.
46. WU, R. L., Z. H. WANG, W. ZHAO and J. M. CHEVERUD, 2004b A mechanistic model for genetic machinery of ontogenetic growth. Genetics 168: 2383-2394.
47. YANG, Q., I. CHAZARO, J. CUI, C. Y. GUO, S. DEMISSIE et al., 2003 Genetic analyses of longitudinal phenotype data: a comparison of univariate methods and a multivariate approach. BMC Genet. 4: S29.