Genetic linkage analysis of a dichotomous trait incorporating a tightly linked quantitative trait in affected sib pairs

American Journal of Human Genetics

Volumn 72, Issue 4, 2003, Pages 949-960

  Huang, Jian ^a   Jiang, Yanming ^b  

^a UNIVERSITY OF IOWA   (United States)

^b LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN E;

ALLELE; ARTICLE; ASTHMA; DISEASE PREDISPOSITION; GENETIC LINKAGE; HERITABILITY; LINKAGE ANALYSIS; PLEIOTROPY; PRIORITY JOURNAL; QUANTITATIVE TRAIT; SIBLING; SIMULATION; TECHNIQUE;

EID: 0037383889     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/374568     Document Type: Article

References (39)

1. Almasy L, Blangero J (2001) Endophenotypes as quantitative risk factors for psychiatric disease: rationale and study design. Am J Med Genet 105:42-44
2. Almasy L, Dyer TD, Blangero J (1997) Bivariate quantitative trait linkage analysis: pleiotropy versus co-incident linkages. Genet Epidemiol 14:953-958
3. Amos CI (1994) Robust variance-components approach for assessing genetic linkage in pedigrees. Am J Hum Genet 54:535-543
4. Blangero J, Almasy L, Williams JT, Porjesz B, Reich T, Begleiter H, COGA Collaborators (1997) Incorporating quantitative traits in genomic scans of psychiatric diseases: alcoholism and event-related potentials. Am J Med Genet 74:602
5. Collaborative Study on the Genetics of Asthma (1997) A genome-wide search for asthma susceptibility loci in ethnically diverse populations. Nat Genet 15:389-392
6. Daniels SE, Bhattacharrya S, James A, Leaves NI, Young A, Hill MR, Faux JA, Ryan GF, le Söuef PN, Lathrop GM, Musk AW, Cookson WOCM (1996) A genome-wide search for quantitative trait loci underlying asthma. Nature 383:247-250
7. Devlin B, Jones BL, Bacanu S-A, Roeder K (2002) Mixture models for linkage analysis of affected sibling pairs and covariates. Genet Epidemiol 22:52-65
8. Dold S, Wjst M, von Mutius E, Reitmeir P, Stiepel E (1992) Genetic risk for asthma, allergic rhinitis and atopic dermatitis. Arch Dis Child 67:1018-1022
9. Elston RC, Buxbaum S, Jacobs KB, Olson JM (2000) Haseman and Elston revisited. Genet Epidemiol 19:1-17
10. Gauderman WJ, Siegmund KD (2001) Gene-environment interaction and affected sib pair linkage analysis. Hum Hered 52:34-46
11. Goddard KAB, Witte JS, Suarez BK, Catalona WJ, Olson JM (2001) Model-free linkage analysis with covariates confirms linkage of prostate cancer to chromosomes 1 and 4. Am J Hum Genet 68:1197-1206
12. Goldgar DE (1990) Multipoint analysis of human quantitative genetic variation. Am J Hum Genet 47:957-967
13. Greenwood CMT, Bull SB (1999) Analysis of affected sib pairs, with covariates - with and without constraints. Am J Hum Genet 64:871-885
14. Haseman JK, Elston RC (1972) The investigation of linkage between a quantitative trait and a marker locus. Behavior Genetics 2:3-19
15. Holmans P (1993) Asymptomatic properties of affected-sibpair linkage analysis. Am J Hum Genet 52:362-374
16. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES (1996) Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet 58:1347-1363
17. Lalouel JM, Le Mignon L, Simon M, Facuchet R, Bourel M, Rao DC, Morton NE (1985) Genetic analysis of idiopathic hemochromatosis using both qualitative (disease status) and quantitative information. Am J Hum Genet 37:700-718
18. Lange K (1997) Mathematical and statistical methods for genetic analysis. Springer-Verlag, New York
19. Lange K, Boehnke M (1983) Extensions to pedigree analysis. IV. Covariance components models for multivariate traits. Am J Med Genet 14:513-524
20. Litwin SD (ed)(1978) Genetic determinants of pulmonary disease. Dekker, New York
21. Lynch M, Walsh B (1998) Genetics and analysis of quantitative traits. Sinauer Associates, Sunderland, MA
22. Marsh DG, Neely JD, Breezeale DR, Ghosh B, Freidhoff LR, Ehrlich-Kautzky E, Schou C, Krishnaswamy G, Beaty TH (1994) Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations. Science 264:1152-1156
23. Meyers DA, Postma DS, Panhuysen CIM, Xu J, Amelung PJ, Levitt RC, Bleecker ER (1994) Evidence for a locus regulating total serum IgE levels mapping to chromosome 5. Genomics 23:464-470
24. Moldin SO, Rice JP, Van Eerdewegh P, Gottesman II, Erlenmeyer-Kimling L (1990) Estimation of disease risk under bivariate models of multifactorial inheritance. Genet Epidemiol 7:371-386
25. Olson JM (1999) A general conditional-logistic model for affected-relative-pair linkage studies. Am J Hum Genet 65:1760-1769
26. Ott J (1995) Linkage analysis with biological markers. Hum Hered 45:169-174
27. Palmer LJ, Daniels SE, Rye PJ, Gibson NA, Tay GK, Cookson WOCM, Goldblatt J, Burton PR, LeSouëf PN (1998) Linkage of chromosome 5q and 11q markers to asthma-associated quantitative traits in Australian children. Am J Respir Crit Care Med 158:1825-1830
28. Piven J (2001) The broad autism phenotype: a complementary strategy for molecular genetic studies of autism. Am J Med Genet 105:34-35
29. Risch N (1990) Linkage strategies for genetically complex traits. III. The effect of marker polymorphism on analysis of affected relative pairs. Am J Hum Genet 46:242-253
30. Schork NJ (1993) Extended multipoint identity-by-descent analysis of human quantitative traits: efficiency, power and modeling considerations. Am J Hum Gener 53:1306-1319
31. Self SG, Liang K-Y (1987) Asymptotic properties of maximum likelihood estimators and likelihood ratio rests under nonstandard conditions. J Am Statist Assoc 82:605-610
32. Sheffer AL (1995) Management of the adult asthma patient. Allergy Proc 16:1-4
33. Whittemore AS (1996) Genome scanning for linkage: an overview. Am J Hum Genet 59:704-716
34. Wilkinson J, Grimly S, Collins A, Thomas NS, Holgate ST, Morton N (1998) Linkage of asthma to markers on chromosome 12 in a sample of 240 families using quantitative phenotype scores. Genomics 53:251-259
35. Williams JT, Eerdewegh PV, Almasy L, Blangero J (1999a) Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. I. Likelihood formulation and simulation studies. Am J Hum Genet 65:1134-1147
36. _ (1999b) Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. II. Alcoholism and event-related potentials. Am J Hum Genet 65:1148-1160
37. Wjst M, Fisher G, Immervoll T, Jung M, Saar K, Rueschendorf F, Reis A, et al (1999) A genome-wide search for linkage to asthma. Genomics 58:1-8
38. Xu X, Fang Z, Wang B, Chen C, Guang W, Jin Y, Yang J, Lewitzky S, Aelony A, Parker A, Meyer J, Weiss ST, Xu XP (2001) A genomewide search for quantitative-trait loci underlying asthma. Am J Hum Genet 69:1271-1277
39. Yokouchi Y, Nukaga Y, Shibasaki M, Noguchi E, Kimura K, Ito S, Nixhihara M, Yamakawa-Koyayashi K, Takeda K, Imoto N, Ichikawa K, Matsui A, Hamaguchi H, Arinami T (2000) Significant evidence for linkage of mite-sensitive childhood asthma to chromosome 5q31-g33 near the interleukin 12 B locus by a genome-wide search in Japanese families. Genomics 66:152-160