Mapping quantitative trait loci using multiple phenotypes in general pedigrees

Human Heredity

Volumn 55, Issue 1, 2003, Pages 1-15

  Wang, Kai ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

Likelihood ratio statistic; Linkage analysis; Pleiotropy; QTL; Score statistic

Indexed keywords

ARTICLE; COVARIANCE; FACTORIAL ANALYSIS; GENE MAPPING; MATHEMATICAL MODEL; MULTIVARIATE ANALYSIS OF VARIANCE; PARAMETER; PEDIGREE; PHENOTYPE; QUANTITATIVE TRAIT LOCUS; REGRESSION ANALYSIS; SCORING SYSTEM; SIMULATION; STATISTICS;

ALGORITHMS; CHROMOSOME MAPPING; COMPUTER SIMULATION; DATA INTERPRETATION, STATISTICAL; HUMANS; LIKELIHOOD FUNCTIONS; LINKAGE (GENETICS); MODELS, GENETIC; PEDIGREE; PHENOTYPE; QUANTITATIVE TRAIT LOCI;

EID: 0042173045     PISSN: 00015652     EISSN: None     Source Type: Journal    
DOI: 10.1159/000071805     Document Type: Article

References (25)

1. Almasy L, Dyer TD, Blangero J: Bivariate quantitative trait linkage analysis: pleiotropy versus co-incident linkages. Genet Epidemiol 1997;14:953-958.
2. Elston RC. Genetic analysis of multivariate traits; in Anderson VE, Hauser WA, Leppik IE, Noebels JL, Rich SS (eds): Genetic Strategies in Epilepsy Research (Epilepsy Res. Suppl 4). pp 161-171. Elsevier Science Publishers B. V. 1991.
3. Amos CI, Elston RC, Bonney GE, Keats BJB, Berenson GS: A multivariate method for detecting genetic linkage, with application to a pedigree with an adverse lipoprotein phenotype. Am J Hum Genet 1990;47:247-254.
4. Allison DB, Thiel B, Jean PS, Elston RC, Infante MC, Schork NJ: Multiple phenotype modeling in gene-mapping studies of quantitative traits: power advantages. Am J Hum Genet 1998;63:1190-1201.
5. Eaves LJ, Neale MC, Maes H: Multivariate multipoint linkage analysis of quantitative trait loci. Behav Genet 1996;26:519-525.
6. Todorov AA, Vogler GP, Gu C, Province MA, Li Z, Heath AC, Rao DC: Testing causal hypotheses in multivariate linkage analysis of quantitative traits: general formulation and application to sibpair data. Genet Epidemiol 1998;15:263-278.
7. Lange K: Mathematical and statistical methods for genetic analysis, Springer, ed 2., 2002.
8. de Andrade M, Thiel TJ, Yu L, Amos CI: Assessing linkage in chromosome 5 using components of variance approach: univariate versus multivariate. Genet Epidemiol 1997;14:773-778.
9. Comuzzie AG, Mahaney MC, Almasy L, Dyer TD, Blangero J: Exploiting pleiotropy to map genes for oligogenic phenotypes using extended pedigree data. Genet Epidemiol 1997;14:975-980.
10. Vogler GP, Tang W, Nelson TL, Hofer SM, Grant JD, Tarantino LM, Fernandez JR: A multivariate model for the analysis of sibship covariance structure using marker information and multiple quantitative traits. Genet Epidemiol 1997;14:921-926.
11. Haseman JK, Elston RC: The investigation of linkage between a quantitative trait and a marker locus. Behav Genet 1972;2:3-19.
12. Amos CI: Robust variance-components approach for assessing genetic linkage in pedi-gees. Am J Hum Genet 1994;54:535-543.
13. Almasy L, Blangero J: Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 1998;62:1198-1211.
14. Amos CI, de Andrade M, Zhu DK: Comparison of multivariate tests for genetic linkage. Hum Hered 2001;51:133-144.
15. Tang HK, Siegmund D: Mapping quantitative trait loci in oligogenic models. Biostatistics 2001;2:147-162.
16. Wang K: Efficient score statistics for mapping quantittive trait loci with extended pedigrees. Hum Hered 2002;54:57-68.
17. Lange K, Boehnke M: Extensions to pedigree analysis IV. Covariance components models for multivariate traits. Am J Med Genet 1983;14:513-524.
18. Wang K, Huang J: A score-statistic approach for mapping quantitative-trait loci with sibships of arbitrary size. Am J Hum Genet 2002;70:412-424.
19. Chernoff H, Lander E: Asymptotic distribution of the likelihood ratio test that a mixture of two binomials is a single binomial. Journal of Statistical Planning and Inference 1995;43:10-40.
20. Huang J, Vieland VJ: The null distribution of the heterogeneity lod score does depend on the assumed genetic model for the trait. Hum Hered 2001;52:217-222.
21. Davies RB: Hypothesis testing when a nuisance parameter is present only under the alternative. Biometrica 1977;64:247-254.
22. Lemdani M, Pons O: Likelihood ratio tests for genetic linkage. Statistics and Probability Letters 1997;33:15-22.
23. Self SG, Liang KY: Asymptotic properties of maximum likelihood estimators and likelihood ratio tests under nonstandard conditions. JASA 1987;82:605-610.
24. Jiang C, Zeng ZB: Multiple trait analysis of genetic mapping for quantitative trait loci. Genetics 1995;140:1111-1127.
25. Wang K, Huang J: Score test for mapping quantitative-trait loci with sibships of arbitrary size when the dominance effect is not negligible. Genet Epidemiol 2002;23:398-412.