Conformational analysis of a potent SSTR3-selective somatostatin analogue by NMR in water solution

Journal of Peptide Science

Volumn 12, Issue 2, 2006, Pages 82-91

  Gairí, Margarida ^a   Saiz, Pilar ^b   Madurga, Sergio ^b   Roig, Xavier ^b   Erchegyi, Judit ^c   Koerber, Steven C ^c   Reubi, Jean Claude ^d   Rivier, Jean E ^c   Giralt, Ernest ^a,b  

^a UNIVERSITY OF BARCELONA   (Spain)

^b BELLVITGE BIOMEDICAL RESEARCH INSTITUTE IDIBELL   (Spain)

^c SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^d UNIVERSITY OF BERN   (Switzerland)

Author keywords

Betidamino acid; Cis trans conformational isomers; Molecular dynamics; NMR; Pharmacophore; Somatostatin analogues; SSTR3 selectivity

Indexed keywords

PROTON; SOMATOSTATIN; SOMATOSTATIN DERIVATIVE; SOMATOSTATIN RECEPTOR 1; SOMATOSTATIN RECEPTOR 2; SOMATOSTATIN RECEPTOR 3; SOMATOSTATIN RECEPTOR 4; SOMATOSTATIN RECEPTOR 5; WATER;

ARTICLE; CIS TRANS ISOMERISM; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN MOTIF; PROTON NUCLEAR MAGNETIC RESONANCE; SIMULATION; STRUCTURE ANALYSIS; THREE DIMENSIONAL IMAGING;

AMINO ACID SEQUENCE; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION; RECEPTORS, SOMATOSTATIN; SOLUTIONS; SOMATOSTATIN; WATER;

EID: 32544432358     PISSN: 10752617     EISSN: None     Source Type: Journal    
DOI: 10.1002/psc.743     Document Type: Article

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