Identification of differentially expressed genes in papillary thyroid carcinomas with and without rearrangements of the tyrosine kinase receptors RET and/or NTRK1

Journal of Surgical Research

Volumn 131, Issue 1, 2006, Pages 15-25

  Musholt, Thomas J ^a   Brehm, Christoph ^b   Hanack, Julia ^b   Von Wasielewski, Reinhard ^b   Musholt, Petra B ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Chromosomal rearrangements; Differential gene expression; Genetic alterations; mRNA differential display; Papillary thyroid carcinoma

Indexed keywords

HYBRID PROTEIN; MESSENGER RNA; PROTEIN PATCHED 1; PROTEIN RET; RAB27A PROTEIN; TYROSINE KINASE RECEPTOR;

ACCURACY; ADOLESCENT; ADULT; AGED; ARTICLE; CARCINOGENICITY; CELL PROLIFERATION; CHIMERA; CLINICAL ARTICLE; CLONE; DIFFERENTIAL DISPLAY; DOWN REGULATION; FEMALE; FLUOROSCOPY; GENE EXPRESSION; GENE IDENTIFICATION; GENE REARRANGEMENT; HUMAN; HUMAN TISSUE; MALE; MUTATION; PAPILLARY CARCINOMA; PRIORITY JOURNAL; REPRODUCIBILITY; RNA SEQUENCE; RNA TRANSCRIPTION; THYROID CARCINOMA; TUMOR GROWTH;

ADOLESCENT; ADULT; AGED; CARCINOMA, PAPILLARY; CELL PROLIFERATION; DISEASE PROGRESSION; DOWN-REGULATION; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE REARRANGEMENT; HUMANS; MALE; MIDDLE AGED; PROTO-ONCOGENE PROTEINS C-RET; RECEPTOR, TRKA; THYROID NEOPLASMS; UP-REGULATION;

EID: 32444441392     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jss.2005.08.013     Document Type: Article

References (46)

1. H.G. Suarez Molecular basis of epithelial thyroid tumorigenesis C. R. Acad. Sci. III 323 2000 519
2. B. Corvilain, J. Van Sande, J.E. Dumont Somatic and germline mutations of the TSH receptor and thyroid diseases Clin. Endocrinol. (Oxf.) 55 2001 143
3. F. Basolo, M.A. Caligo, A. Pinchera Cyclin D1 overexpression in thyroid carcinomas relation with clinico-pathological parameters, retinoblastoma gene product, and Ki67 labeling index Thyroid 10 2000 741
4. R. Holm, J.M. Nesland Retinoblastoma and p53 tumour suppressor gene protein expression in carcinomas of the thyroid gland J. Pathol. 172 1994 267 272
5. G. Tallini, S.L. Asa RET oncogene activation in papillary thyroid carcinoma Adv. Anat. Pathol. 8 2001 345
6. M. Santoro, R.M. Melillo, F. Carlomagno Molecular mechanisms of RET activation in human cancer Ann. NY Acad. Sci. 963 2002 116
7. M. Santoro, F. Carlomagno, I.D. Hay Ret oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype J. Clin. Invest. 89 1992 1517
8. S. Sadetzki, R. Calderon-Margalit, B. Modan Ret/PTC activation in benign and malignant thyroid tumors arising in a population exposed to low-dose external-beam irradiation in childhood J. Clin. Endocrinol. Metab. 89 2004 2281
9. V. Saenko, T. Rogounovitch, Y. Shimizu-Yoshida Novel tumorigenic rearrangement, Delta rfp/ret, in a papillary thyroid carcinoma from externally irradiated patient Mutat. Res. 527 2003 81
10. R.M. Melillo, M.D. Castellone, V. Guarino The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells J. Clin. Invest. 115 2005 1068
11. E.T. Kimura, M.N. Nikiforova, Z. Zhu High prevalence of BRAF mutations in thyroid cancer genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma Cancer Res. 63 2003 1454
12. X. Xu, R.M. Quiros, P. Gattuso High prevalence of BRAF gene mutation in papillary thyroid carcinomas and thyroid tumor cell lines Cancer Res. 63 2003 4561
13. E. Puxeddu, S. Moretti, R. Elisei BRAF(V599E) mutation is the leading genetic event in adult sporadic papillary thyroid carcinomas J. Clin. Endocrinol. Metab. 89 2004 2414
14. T.J. Musholt, P.B. Musholt, N. Khaladj Prognostic significance of RET and NTRK1 rearrangements in sporadic papillary thyroid carcinoma Surgery 128 2000 984
15. M.A. Pierotti, P. Vigneri, I. Bongarzone Rearrangements of RET and NTRK1 tyrosine kinase receptors in papillary thyroid carcinomas Recent Results Cancer Res. 154 1998 237
16. H. Namba, S. Yamashita, H.C. Pei Lack of PTC gene (ret proto-oncogene rearrangement) in human thyroid tumors Endocrinol. Jpn. 38 1991 627
17. R. Elisei, C. Romei, T. Vorontsova RET/PTC rearrangements in thyroid nodules studies in irradiated and not irradiated, malignant and benign thyroid lesions in children and adults J. Clin. Endocrinol. Metab. 86 2001 32116
18. G. Portella, D. Vitagliano, C. Borselli Human N-ras, TRK-T1, and RET/PTC3 oncogenes, driven by a thyroglobulin promoter, differently affect the expression of differentiation markers and the proliferation of thyroid epithelial cells Oncol. Res. 11 1999 421
19. F. Basolo, R. Giannini, A. Toniolo Establishment of a non-tumorigenic papillary thyroid cell line (FB-2) carrying the RET/PTC1 rearrangement Int. J. Cancer 97 2002 608
20. F. Basolo, R. Giannini, C. Monaco Potent mitogenicity of the RET/PTC3 oncogene correlates with its prevalence in tall-cell variant of papillary thyroid carcinoma Am. J. Pathol. 160 2002 247
21. S. Klugbauer, E. Lengfelder, E.P. Demidchik High prevalence of RET rearrangement in thyroid tumors of children from Belarus after the Chernobyl reactor accident Oncogene 11 1995 2459
22. T.J. Musholt, P.B. Musholt, T. Petrich Familial papillary thyroid carcinoma genetics, criteria for diagnosis, clinical features, and surgical treatment World J. Surg. 24 2000 1409
23. T.J. Musholt, J. Hanack, C. Brehm Searching for non-RET molecular alterations in medullary thyroid carcinoma expression analysis by mRNA differential display World J. Surg. 29 2005 472
24. T.J. Musholt, P.J. Goodfellow, G.F. Scheumann Differential display in primary and metastatic medullary thyroid carcinoma J. Surg. Res. 69 1997 94
25. T. Takano, N. Amino Cancer-specific mRNAs in thyroid carcinomas detection, use, and their implication in thyroid carcinogenesis Endocr. J. 49 2002 97
26. N. O'Donovan, A. Fischer, E.M. Abdo Differential expression of IgG Fc binding protein (FcgammaBP) in human normal thyroid tissue, thyroid adenomas and thyroid carcinomas J. Endocrinol. 174 2002 517
27. R. Gonsky, J.A. Knauf, R. Elisei Identification of rapid turnover transcripts overexpressed in thyroid tumors and thyroid cancer cell lines use of a targeted differential RNA display method to select for mRNA subsets Nucleic Acids Res. 25 1997 3823
28. D.R. Haugen, O. Fluge, L.J. Reigstad Increased expression of genes encoding mitochondrial proteins in papillary thyroid carcinomas Thyroid 13 2003 613
29. Y. Yano, N. Uematsu, T. Yashiro Gene expression profiling identifies platelet-derived growth factor as a diagnostic molecular marker for papillary thyroid carcinoma Clin. Cancer Res. 10 2004 2035
30. B. Jarzab, M. Wiench, K. Fujarewicz Gene expression profile of papillary thyroid cancer sources of variability and diagnostic implications Cancer Res. 65 2005 1587
31. D.J. Finley, N. Arora, B. Zhu 3rd molecular profiling distinguishes papillary carcinoma from benign thyroid nodules J. Clin. Endocrinol. Metab. 89 2004 3214
32. S. Chevillard, N. Ugolin, P. Vielh Gene expression profiling of differentiated thyroid neoplasms diagnostic and clinical implications Clin. Cancer Res. 10 2004 6586
33. Y. Huang, M. Prasad, W.J. Lemon Gene expression in papillary thyroid carcinoma reveals highly consistent profiles Proc. Natl. Acad. Sci. USA 98 2001 15044
34. V.B. Wreesmann, E.M. Sieczka, N.D. Socci Genome-wide profiling of papillary thyroid cancer identifies MUC1 as an independent prognostic marker Cancer Res. 64 2004 3780
35. O. Baris, D. Mirebeau-Prunier, F. Savagner Gene profiling reveals specific oncogenic mechanisms and signaling pathways in oncocytic and papillary thyroid carcinoma Oncogene 24 2005 4155
36. M. Frattini, C. Ferrario, P. Bressan Alternative mutations of BRAF, RET and NTRK1 are associated with similar but distinct gene expression patterns in papillary thyroid cancer Oncogene 23 2004 7436
37. H. Hermeking The 14-3-3 cancer connection Nat. Rev. Cancer 3 2003 931
38. A. Sugiyama, Y. Miyagi, Y. Komiya Forced expression of antisense 14-3-3beta RNA suppresses tumor cell growth in vitro and in vivo Carcinogenesis 24 2003 1549
39. S.L. Spence, B.R. Dey, C. Terry Interaction of 14-3-3 proteins with the insulin-like growth factor I receptor (IGFIR) evidence for a role of 14-3-3 proteins in IGFIR signaling Biochem. Biophys. Res. Commun. 312 2003 1060
40. H. Gydee, J.T. O'Neill, A. Patel Differentiated thyroid carcinomas from children and adolescents express IGF-I and the IGF-I receptor (IGF-I-R). Cancers with the most intense IGF-I-R expression may be more aggressive Pediatr. Res. 55 2004 709
41. T. Kawabe G2 checkpoint abrogators as anticancer drugs Mol. Cancer Ther. 3 2004 513
42. A.N. Hume, L.M. Collinson, A. Rapak Rab27a regulates the peripheral distribution of melanosomes in melanocytes J. Cell Biol. 152 2001 795
43. J.C. Stinchcombe, D.C. Barral, E.H. Mules Rab27a is required for regulated secretion in cytotoxic T lymphocytes J. Cell Biol. 152 2001 825
44. S.R. Sennoune, K. Bakunts, G.M. Martinez Vacuolar H+-ATPase in human breast cancer cells with distinct metastatic potential Distribution and functional activity Am. J. Physiol. Cell Physiol. 286 2004 1443
45. T. Horibe, M. Gomi, D. Iguchi Different contributions of the three CXXC motifs of human protein-disulfide isomerase-related protein to isomerase activity and oxidative refolding J. Biol. Chem. 279 2004 4604
46. M. Li, W. Ren, X.X. Weng Nucleotide sequence analysis of a transforming gene isolated from nasopharyngeal carcinoma cell line CNE2 an aberrant human immunoglobulin kappa light chain which lacks variable region DNA Seq. 12 2001 331