Nutraceutical effects of branched-chain amino acids on skeletal muscle

Journal of Nutrition

Volumn 136, Issue 2, 2006, Pages

  Shimomura, Yoshiharu ^a   Yamamoto, Yuko ^a   Bajotto, Gustavo ^a   Sato, Juichi ^b   Murakami, Taro ^c   Shimomura, Noriko ^d   Kobayashi, Hisamine ^e   Mawatari, Kazunori ^e  

^a NAGOYA INSTITUTE OF TECHNOLOGY   (Japan)

^b NAGOYA UNIVERSITY HOSPITAL   (Japan)

^c Chukyo Women's University   (Japan)

^d Chukyo Junior College   (Japan)

^e AJINOMOTO CO INC   (Japan)

Author keywords

BCKDH complex; Branched chain amino acids; Exercise; Muscle fatigue; Muscle soreness

Indexed keywords

2 OXOACID DEHYDROGENASE; BRANCHED CHAIN AMINO ACID; LEUCINE; MUSCLE PROTEIN;

AMINO ACID METABOLISM; CONFERENCE PAPER; DEPHOSPHORYLATION; DIET SUPPLEMENTATION; ENZYME ACTIVATION; ENZYME REGULATION; EXERCISE; HUMAN; MUSCLE FATIGUE; MUSCLE GROWTH; MUSCLE INJURY; MYALGIA; NONHUMAN; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; SKELETAL MUSCLE; TISSUE SPECIFICITY;

EID: 32444435999     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/136.2.529s     Document Type: Conference Paper

References (30)

1. Harper AE, Miller RH, Block KP. Branched-chain amino acid metabolism. Annu Rev Nutr. 1984;4:409-54.
2. Rennie MJ. Influence of exercise on protein and amino acid metabolism. In: Rowell LB, Shepherd JT, editors. Handbook of physiology, section 12: exercise: regulation and integration of multiple systems. New York: Oxford University Press; 1996. p. 995-1035.
3. 13C]phenylalanine. J Nutr. 2003;133:1383-9.
4. Layman DK, Baum JI. Dietary protein impact on glycemic control during weight loss. J Nutr. 2004;134 (Suppl):S968-73.
5. Ahlborg G, Felig P, Hagenfeldt L, Hendler R, Wahren J. Substrate turnover during prolonged exercise in man. J Clin Invest. 1974;53:1080-90.
6. Wahren J, Felig P, Hagenfeldt L. Effect of protein ingestion on splanchnic and leg metabolism in normal man and in patients with diabetes mellitus. J Clin Invest. 1976;57:987-99.
7. Bolster DR, Jefferson LS, Kimball SR. Regulation of protein synthesis associated with skeletal muscle hypertrophy by insulin-, amino acid- and exercise-induced signalling. Proc Nutr Soc. 2004;63:351-6.
8. Mordier S, Deval C, Bechet D, Tassa A, Ferrara M. Leucine limitation induces autophagy and activation of lysosome-dependent proteolysis in C2C12 myotubes through a mammalian target of rapamycin-independent signaling pathway. J Biol Chem. 2000;275:29900-6.
9. Shimomura Y, Murakami T, Nakai N, Nagasaki M, Harris RA. Exercise promotes BCAA catabolism: effects of BCAA supplementation on skeletal muscle during exercise. J Nutr. 2004;134 (Suppl):S1583-7.
10. Harris RA, Zhang B, Goodwin GW, Kuntz MJ, Shimomura Y, Rougraff P, Dexter P, Zhao Y, Gibson R, Crabb DW. Regulation of the branched-chain α-ketoacid dehydrogenase and elucidation of a molecular basis for maple syrup urine disease. Adv Enzyme Regul. 1990;30:245-63.
11. Shimomura Y, Nanaumi N, Suzuki M, Popov KM, Harris RA. Purification and partial characterization of branched-chain α-ketoacid dehydrogenase kinase from rat liver and rat heart. Arch Biochem Biophys. 1990;283:293-9.
12. Popov KM, Zhao Y, Shimomura Y, Kuntz MJ, Harris RA. Branched-chain α-ketoacid dehydrogenase kinase: molecular cloning, expression, and sequence similarity with histidine protein kinases. J Biol Chem. 1992;267:13127-30.
13. Damuni Z, Reed LJ. Purification and properties of the catalytic subunit of the branched-chain α-keto acid dehydrogenase phosphatase from bovine kidney mitochondria. J Biol Chem. 1987;262:5129-32.
14. Shimomura Y, Obayashi M, Murakami T, Harris RA. Regulation of branched-chain amino acid catabolism: nutritional and hormonal regulation of activity and expression of the branched-chain α-keto acid dehydrogenase kinase. Curr Opin Clin Nutr Metab Care. 2001;4:419-23.
15. Suryawan A, Hawes JW, Harris RA, Shimomura Y, Jenkins AE, Hutson SM. A molecular model of human branched-chain amino acid metabolism. Am J Clin Nutr. 1998;68:72-81.
16. Shimomura Y, Fujii H, Suzuki M, Murakami T, Fujitsuka N, Nakai N. Branched-chain α-keto acid dehydrogenase complex in rat skeletal muscle: regulation of the activity and gene expression by nutrition and physical exercise. J Nutr. 1995;125 (Suppl):S1762-5.
17. Xu M, Nagasaki M, Obayashi M, Sato Y, Tamura T, Shimomura Y. Mechanism of activation of branched-chain α-keto acid dehydrogenase complex by exercise. Biochem Biophys Res Commun. 2001;287:752-6.
18. Paxton R, Harris RA. Regulation of branched-chain α-ketoacid dehydrogenase kinase. Arch Biochem Biophys. 1984;231:48-57.
19. Kobayashi R, Murakami T, Obayashi M, Nakai N, Jaskiewicz J, Fujiwara Y, Shimomura Y, Harris RA. Clofibric acid stimulates branched-chain amino acid catabolism by three mechanisms. Arch Biochem Biophys. 2002;407:231-40.
20. Teravainen H, Larsen A, Hillbom M. Clofibrate-induced myopathy in the rat. Acta Neuropathol (Berl). 1977;39:135-8.
21. Paul HS, Adibi SA. Paradoxical effects of clofibrate on liver and muscle metabolism in rats. Induction of myotonia and alteration of fatty acid and glucose oxidation. J Clin Invest. 1979;64:405-12.
22. Wagenmakers AJ, Brookes JH, Coakley JH, Reilly T, Edwards RH. Exercise-induced activation of the branched-chain 2-oxo acid dehydrogenase in human muscle. Eur J Appl Physiol Occup Physiol. 1989;59:159-67.
23. Kobayashi R, Shimomura Y, Murakami T, Nakai N, Otsuka M, Arakawa N, Shimizu K, Harris RA. Hepatic branched-chain α-keto acid dehydrogenase complex in female rats: activation by exercise and starvation. J Nutr Sci Vitaminol (Tokyo). 1999;45:303-9.
24. Shimomura Y, Fujii H, Suzuki M, Fujitsuka N, Naoi M, Sugiyama S, Harris RA. Branched-chain 2-oxo acid dehydrogenase complex activation by tetanic contractions in rat skeletal muscle. Biochim Biophys Acta. 1993;1157:290-6.
25. MacLean DA, Graham TE, Saltin B. Branched-chain amino acids augment ammonia metabolism while attenuating protein breakdown during exercise. Am J Physiol. 1994;267:E1010-22.
26. Coombes JS, McNaughton LR. Effects of branched-chain amino acid supplementation on serum creatine kinase and lactate dehydrogenase after prolonged exercise. J Sports Med Phys Fitness. 2000;40:240-6.
27. Report of a joint FAO/WHO/UNU Expert Consultation. Energy and protein requirements. World Health Organ Tech Rep Ser. 1985;724:1-206.
28. Tipton KD, Rasmussen BB, Miller SL, Wolf SE, Owens-Stovall SK, Petrini BE, Wolfe RR. Timing of amino acid-carbohydrate ingestion alters anabolic response of muscle to resistance exercise. Am J Physiol Endocrinol Metab. 2001;281:E197-206.
29. Shimomura Y, Murakami T, Nakai N, Nagasaki M, Obayashi M, Li Z, Xu M, Sato Y, Kato T, et al. Suppression of glycogen consumption during acute exercise by dietary branched-chain amino acids in rats. J Nutr Sci Vitaminol (Tokyo). 2000;46:71-7.
30. Nosaka K, Newton M, Sacco P. Muscle damage and soreness after exercise of the elbow flexors. Med Sci Sports Exerc. 2002;34:920-7.