Hypoxic suppression of E. coli-induced NF-κB and AP-1 transactivation by oxyradical signaling

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 287, Issue 2 56-2, 2004, Pages

  Matuschak, George M ^a,b,c   Lechner, Andrew J ^a   Chen, Zhoumou ^a   Todi, Subhash ^a,b   Doyle, Timothy M ^a   Loftis, Laura L ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ST JOHN S MERCY MEDICAL CENTER   (United States)

^c SAINT LOUIS UNIVERSITY HOSPITAL   (United States)

Author keywords

Complex systems; FosB; Gene regulation; Gram negative bacteremia; IL 1 ; JunB; Liver lung interactions; Posttraumatic sepsis; Reactive oxygen species; TNF ; Transcription factors; Transcription networks; Transcription protein DNA array

Indexed keywords

ANTIOXIDANT; GLUTATHIONE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; OXYGEN RADICAL; PHOSPHO I KAPPA B ALPHA; PHOSPHOPROTEIN; PROTEIN C JUN; PROTEIN FOS; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR FOSB; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; XANTHINE OXIDASE;

ADOLESCENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA MICROARRAY; ENZYME INHIBITION; ESCHERICHIA COLI; ESCHERICHIA COLI O55 B5; GEL MOBILITY SHIFT ASSAY; GENE CONTROL; GENETIC TRANSCRIPTION; GRAM NEGATIVE SEPSIS; HYPOXIA; INJURY; INTRACELLULAR TRANSPORT; LIVER; LIVER DYSFUNCTION; LUNG; MALE; MULTIPLE ORGAN FAILURE; NONHUMAN; OXIDATION REDUCTION REACTION; POSTTRAUMATIC SEPSIS; PRIORITY JOURNAL; PROTEIN MICROARRAY; PROTEIN SYNTHESIS INHIBITION; PROTEIN TRANSPORT; RAT; REOXYGENATION; SIGNAL TRANSDUCTION; TRANSACTIVATION;

ANIMALS; ANOXIA; CELL NUCLEUS; CYTOKINES; CYTOPLASM; ESCHERICHIA COLI INFECTIONS; GLUTATHIONE; GLUTATHIONE DISULFIDE; I-KAPPA B PROTEINS; LIVER; MALE; NF-KAPPA B; OXIDATION-REDUCTION; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION, GENETIC; XANTHINE OXIDASE;

EID: 3242808130     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00404.2003     Document Type: Article

References (36)

1. Abate C, Patel L, Rauscher FJ, and Curran T. Redox regulation of Fos and Jun DNA-binding activity in vitro. Science 249: 499-522, 1990.
2. Abid MR, Tsai JC, Spokes KC, Deshpande SS, Irani K, and Aird WC. Vascular endothelial growth factor induces manganese-superoxide dismutase expression in endothelial cells by a Rac1-regulated NADPH oxidase-dependent mechanism. FASEB J 15: 2548-2550, 2001.
3. Arenzana-Seisdedos F, Thompson J, Rodriguez MS, Bachelerie F, Thomas D, and Hay RT. Inducible nuclear expression of newly synthesized IκBα negatively regulates DNA-binding and transcriptional activities of NF-κB. Mol Cell Biol 15: 2689-2696, 1995.
4. Bautista AP and Spitzer JJ. Superoxide anion generation by in situ perfused rat liver: effect of in vivo endotoxin. Am J Physiol Gastrointest Liver Physiol 259: G907-G912, 1990.
5. Blackwell TS, Blackwell TR, Holden EP, Christman BW, and Christman JW. In vivo antioxidant treatment suppress nuclear factor-κB activation and neutrophilic lung inflammation. J Immunol 157: 1630-1637, 1996.
6. Chandel NS, Trzyna WC, McClintock DS, and Schumacker PT. Role of oxidants in NF-κB activation and TNF-α gene transcription induced by hypoxia and endotoxin. J Immunol 165: 1013-1021, 2000.
7. Dahn MS, Wilson RF, Lange MP, Stone A, and Jacobs LA. Hepatic parenchymal oxygen tension following injury and sepsis. Arch Surg 125: 441-443, 1990.
8. Douzinas EE, Tsidemiadou PD, Pitaridis MT, Andrianakis I, Bobota-Chloraki A, Katsouyanni K, Sfyras D, Malagari K, and Roussos C. The regional production of cytokines and lactate in sepsis-related multiple organ failure. Am J Respir Crit Care Med 155: 53-59, 1997.
9. Droge W, Schulze-Osthoff K, Mihm S, Galter D, Schenk H, Eck H, Roth S, and Gmunder H. Functions of glutathione and glutathione disulfide in immunology and immunopathology. FASEB J 8: 1131-1138, 1994.
10. Epperly NA, Lechner AJ, Johanns CA, Webster RO, and Matuschak GM. Bidirectional effects of hepatic ischemia/reperfusion on E. coli-induced TNF gene expression. Am J Physiol Regul Integr Comp Physiol 270: R289-R297, 1996.
11. Essani NA, McGuire GM, Manning AM, and Jaeschke H. Endotoxin-induced activation of the nuclear transcription factor κB and expression of E-selectin messenger RNA in hepatocytes, Kupffer cells, and endothelial cells in vivo. J Immunol 156: 2956-2963, 1996.
12. Fong Y, Marano MA, Moldawer LL, Wei H, Calvano SE, Kenney JS, Allison AC, Cerami A, Shires GT, and Lowry SF. The acute splanchnic and peripheral tissue metabolic response to endotoxin in humans. J Clin Invest 85: 1896-1904, 1990.
13. Holland JH. Hidden Order: How Adaptation Builds Complexity. Cambridge, MA: Perseus, 1995, p. 15-25.
14. Jaeschke H and Mitchell JR. Mitochondria and xanthine oxidase both generate reactive oxygen species in isolated perfused rat liver after hypoxic injury. Biochem Biophys Res Commun 160: 140-147, 1989.
15. Janssen-Heininger YM, Poynter ME, and Bauerle PA. Recent advances towards understanding redox mechanisms in the activation of nuclear factor κB. Free Radic Biol Med 28: 1317-1327, 2000.
16. Kato A, Edwards MJ, and Lentsch AB. Gene deletion of NF-κB p50 does not alter the hepatic inflammatory response to ischemia/reperfusion. J Hepatol 37: 48-55, 2002.
17. Kunsch C, Ruben SM, and Rosen CA. Selection of optimal κB/Rel DNA-binding motifs: interaction of both subunits of NF-κB with DNA is required for transcriptional activation. Mol Cell Biol 12: 4412-44221, 1992.
18. Loftis LL, Chen Z, Doyle TM, Lechner AJ, and Matuschak GM. Hepatic GSH depletion potentiates hypoxia-mediated reductions in E. coli-induced NF-κB and AP-1 activation (Abstract). Am J Respir Crit Care Med 167: A555, 2003.
19. Loftis LL, Johanns CA, Lechner AJ, and Matuschak GM. Brief hypoxic stress suppresses postbacteremic NF-κB activation and TNF-α bioactivity in perfused liver. Am J Physiol Regul Integr Comp Physiol 279: R99-R108, 2000.
20. Mathews JR, Wakasugi N, Virelizier JL, Yodoi J, and Hay RT. Thioredoxin regulates the DNA binding activity of NF-κB by reduction of a disulfide bond involving cysteine 62. Nucleic Acids Res 20: 3821-3830, 1992.
21. Matsumura T, Yoshihara H, Jeffs R, Takei Y, Nukina S, Hijioka T, Kaufmann FC, and Thurman RG. Hormones increase oxygen uptake in periportal and pericentral regions of the liver lobule. Am J Physiol Gastrointest Liver Physiol 262: G645-G650, 1992.
22. Matuschak GM, Johanns CA, Chen Z, Gaynor J, and Lechner AJ. Brief hypoxic stress downregulates E. coli-induced IL-1α and IL-1β gene expression in perfused liver. Am J Physiol Regul Integr Comp Physiol 271: R1311-RI318, 1996.
23. 2 and antioxidants have opposite effects on activation of NF-κB and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor. EMBO J 5: 2005-2015, 1993.
24. Miller PR, Croce MA, Kilgo PD, Scott J, and Fabian TC. Acute respiratory distress syndrome in blunt trauma: identification of independent risk factors. Am Surg 68: 845-850, 2002.
25. Mitomoto K, Nakayama K, Fujimoto K, Sun X, Seki S, and Yamamoto K. Two different cellular redox systems regulate the DNA binding activity of the p50 subunit of NF-κB in vitro. Gene 5: 197-203, 1994.
26. Nishi T, Shimizu N, Hiramoto M, Sato I, Yamaguchi Y, Hasegawa M, Tanaka H, Kataoka K, Watanabe H, and Handa H. Spatial redox regulation of a critical cysteine residue of NF-κB in vivo. J Biol Chem 277: 44548-44556, 2002.
27. Ordway JM, Eberhart D, and Curran T. Cysteine 64 of Ref-1 is not essential for redox regulation of AP-1 DNA binding. Mol Cell Biol 23: 4257-4256, 2003.
28. Rader L, Siems W, Muller M, and Gerber G. Formation of activated oxygen in the hypoxic rat liver. Cell Biochem Funct 3: 289-296, 1985.
29. Renards P, Percherancier M, Kroll M, Thomas D, Virelizier JL, Arenzana-Seisdedos F, and Bachelerie F. Inducible NF-κB activation is permitted by simultaneous degradation of nuclear IκBα. J Biol Chem 19: 15193-15199, 2000.
30. Shaulian E and Michael K. AP-1 as a regulator of cell life and death. Nat Cell Biol 4: E131-EI36, 2002.
31. Shi HP, Deitch EA, Da Xu Z, Lu Q, and Hauser CJ. Hypertonic saline improves intestinal mucosal barrier function and lung injury after trauma-hemorrhagic shock. Shock 17: 496-501, 2002.
32. Tacchini L, Fusar-Poli D, and Bernelli-Zazzera A. Activation of transcription factors by drugs inducing oxidative stress in rat liver. Biochem Pharamcol 15: 139-148, 2002.
33. Takeyama N, Shoji Y, Ohashi K, and Tanaka T. Role of reactive oxygen intermediates in lipopolysaccharide-mediated hepatic injury in the rat. J Surg Res 60: 258-262, 1996.
34. Tietze F. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem 27: 502-522, 1969.
35. Wang P, Ba ZF, Burkhardt J, and Chaudry IH. Measurement of hepatic blood flow after severe hemorrhage: lack of restoration despite adequate resuscitation. Am J Physiol Gastrointest Liver Physiol 262: G92-G98, 1992.
36. Williams DL, Ha T, Li C, Kalbfleisch JH, and Ferguson DA. Early activation of NFκB and NF-IL6 in polymicrobial sepsis correlates with bacteremia, cytokine expression, and mortality. Ann Surg 230: 95-104, 1999.